MerTK cleavage on resident cardiac macrophages compromises repair after myocardial ischemia reperfusion injury

Circulation Research

Volumn 121, Issue 8, 2017, Pages 930-940

  DeBerge, Matthew ^a   Yeap, Xin Yi ^a   Dehn, Shirley ^a   Zhang, Shuang ^a   Grigoryeva, Lubov ^a   Misener, Sol ^a   Procissi, Daniel ^a   Zhou, Xin ^a   Lee, Daniel C ^a   Muller, William A ^a   Luo, Xunrong ^a   Rothlin, Carla ^c   Tabas, Ira ^b   Thorp, Edward B ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Efferocytosis; Inflammation; Ischemia reperfusion injury; Macrophage; Phagocytosis

Indexed keywords

CHEMOKINE RECEPTOR CCR2; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MYELOID EPITHELIAL REPRODUCTIVE TYROSINE KINASE; PROTEIN TYROSINE KINASE; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; CCR2 PROTEIN, MOUSE; CYTOKINE; HLA ANTIGEN CLASS 2; MERTK PROTEIN, HUMAN; MERTK PROTEIN, MOUSE; ONCOPROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BIOACCUMULATION; CELL INFILTRATION; CELL PHAGOCYTOSIS; CONTROLLED STUDY; CYTOKINE RELEASE; DEBRIDEMENT; ENZYME DEFICIENCY; HEART INFARCTION; HEART INFARCTION SIZE; HUMAN; HUMAN CELL; INNATE IMMUNITY; MACROPHAGE FUNCTION; MONOCYTE; MOUSE; MYOCARDIAL ISCHEMIA REPERFUSION INJURY; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; SYSTOLE; TISSUE REPAIR; ANIMAL; C57BL MOUSE; CARDIAC MUSCLE; DEFICIENCY; DISEASE MODEL; ENZYMOLOGY; FEMALE; GENETIC PREDISPOSITION; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; MACROPHAGE; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY; PATHOPHYSIOLOGY; PHAGOCYTOSIS; PHENOTYPE; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; TIME FACTOR;

ANIMALS; APOPTOSIS; CYTOKINES; DISEASE MODELS, ANIMAL; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; IMMUNITY, INNATE; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MIDDLE AGED; MONOCYTES; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; PHAGOCYTOSIS; PHENOTYPE; PROTEOLYSIS; PROTO-ONCOGENE PROTEINS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, CCR2; SIGNAL TRANSDUCTION; ST ELEVATION MYOCARDIAL INFARCTION; TIME FACTORS;

EID: 85031097910     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.117.311327     Document Type: Article

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