메뉴 건너뛰기




Volumn 48, Issue 10, 2017, Pages 2799-2804

Neuropathology of white matter lesions, blood-brain barrier dysfunction, and dementia

Author keywords

Dementia; Fibrinogen; Leukoaraiosis; Neuropathology; Vascular cognitive impairment; White matter

Indexed keywords

CD68 ANTIGEN; FIBRINOGEN; IMMUNOGLOBULIN G ANTIBODY; MONOCLONAL ANTIBODY; POLYCLONAL ANTIBODY;

EID: 85031089034     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.117.018101     Document Type: Article
Times cited : (79)

References (34)
  • 1
    • 84924650926 scopus 로고    scopus 로고
    • White matter hyperintensities, cognitive impairment and dementia: An update
    • Prins ND, Scheltens P. White matter hyperintensities, cognitive impairment and dementia: an update. Nat Rev Neurol. 2015;11:157-165. doi: 10.1038/nrneurol.2015.10.
    • (2015) Nat Rev Neurol. , vol.11 , pp. 157-165
    • Prins, N.D.1    Scheltens, P.2
  • 2
    • 0037338557 scopus 로고    scopus 로고
    • Is breakdown of the blood-brain barrier responsible for lacunar stroke, leukoaraiosis, and dementia?
    • Wardlaw JM, Sandercock PA, Dennis MS, Starr J. Is breakdown of the blood-brain barrier responsible for lacunar stroke, leukoaraiosis, and dementia? Stroke. 2003;34:806-812. doi: 10.1161/01. STR.0000058480.77236. B3.
    • (2003) Stroke , vol.34 , pp. 806-812
    • Wardlaw, J.M.1    Sandercock, P.A.2    Dennis, M.S.3    Starr, J.4
  • 3
    • 84885018413 scopus 로고    scopus 로고
    • Blood-brain barrier dysfunction as a cause and consequence of Alzheimer's disease
    • Erickson MA, Banks WA. Blood-brain barrier dysfunction as a cause and consequence of Alzheimer's disease. J Cereb Blood Flow Metab. 2013;33:1500-1513. doi: 10.1038/jcbfm.2013.135.
    • (2013) J Cereb Blood Flow Metab. , vol.33 , pp. 1500-1513
    • Erickson, M.A.1    Banks, W.A.2
  • 5
    • 79961208538 scopus 로고    scopus 로고
    • Blood-brain barrier permeability abnormalities in vascular cognitive impairment
    • Taheri S, Gasparovic C, Huisa BN, Adair JC, Edmonds E, Prestopnik J, et al. Blood-brain barrier permeability abnormalities in vascular cognitive impairment. Stroke. 2011;42:2158-2163. doi: 10.1161/STROKEAHA.110.611731.
    • (2011) Stroke , vol.42 , pp. 2158-2163
    • Taheri, S.1    Gasparovic, C.2    Huisa, B.N.3    Adair, J.C.4    Edmonds, E.5    Prestopnik, J.6
  • 6
    • 76549093011 scopus 로고    scopus 로고
    • Blood-brain barrier permeability is increased in normal-appearing white matter in patients with lacunar stroke and leucoaraiosis
    • Topakian R, Barrick TR, Howe FA, Markus HS. Blood-brain barrier permeability is increased in normal-appearing white matter in patients with lacunar stroke and leucoaraiosis. J Neurol Neurosurg Psychiatry. 2010;81:192-197. doi: 10.1136/jnnp. 2009.172072.
    • (2010) J Neurol Neurosurg Psychiatry , vol.81 , pp. 192-197
    • Topakian, R.1    Barrick, T.R.2    Howe, F.A.3    Markus, H.S.4
  • 7
    • 84940399069 scopus 로고    scopus 로고
    • Long-term blood-brain barrier permeability changes in Binswanger disease
    • Huisa BN, Caprihan A, Thompson J, Prestopnik J, Qualls CR, Rosenberg GA. Long-term blood-brain barrier permeability changes in Binswanger disease. Stroke. 2015;46:2413-2418. doi: 10.1161/STROKEAHA.115.009589.
    • (2015) Stroke , vol.46 , pp. 2413-2418
    • Huisa, B.N.1    Caprihan, A.2    Thompson, J.3    Prestopnik, J.4    Qualls, C.R.5    Rosenberg, G.A.6
  • 8
    • 85011263099 scopus 로고    scopus 로고
    • Blood-brain barrier leakage is more widespread in patients with cerebral small vessel disease
    • Zhang CE, Wong SM, van de Haar HJ, Staals J, Jansen JF, Jeukens CR, et al. Blood-brain barrier leakage is more widespread in patients with cerebral small vessel disease. Neurology. 2017;88:426-432. doi: 10.1212/WNL.0000000000003556.
    • (2017) Neurology , vol.88 , pp. 426-432
    • Zhang, C.E.1    Wong, S.M.2    Van De Haar, H.J.3    Staals, J.4    Jansen, J.F.5    Jeukens, C.R.6
  • 9
    • 78049377229 scopus 로고    scopus 로고
    • Alterations of the blood-brain barrier in cerebral white matter lesions in the ageing brain
    • Simpson JE, Wharton SB, Cooper J, Gelsthorpe C, Baxter L, Forster G, et al. Alterations of the blood-brain barrier in cerebral white matter lesions in the ageing brain. Neurosci Lett. 2010;486:246-251. doi: 10.1016/j.neulet.2010.09.063.
    • (2010) Neurosci Lett. , vol.486 , pp. 246-251
    • Simpson, J.E.1    Wharton, S.B.2    Cooper, J.3    Gelsthorpe, C.4    Baxter, L.5    Forster, G.6
  • 10
    • 0029804231 scopus 로고    scopus 로고
    • Alterations of the blood-brain barrier and glial cells in whitematter lesions in cerebrovascular and Alzheimer's disease patients
    • Tomimoto H, Akiguchi I, Suenaga T, Nishimura M, Wakita H, Nakamura S, et al. Alterations of the blood-brain barrier and glial cells in whitematter lesions in cerebrovascular and Alzheimer's disease patients. Stroke. 1996;27:2069-2074.
    • (1996) Stroke , vol.27 , pp. 2069-2074
    • Tomimoto, H.1    Akiguchi, I.2    Suenaga, T.3    Nishimura, M.4    Wakita, H.5    Nakamura, S.6
  • 11
    • 84916224368 scopus 로고    scopus 로고
    • Blood-brain barrier dysfunction and cerebral small vessel disease (arteriolosclerosis) in brains of older people
    • Bridges LR, Andoh J, Lawrence AJ, Khoong C H L, Poon W, Esiri MM, et al. Blood-brain barrier dysfunction and cerebral small vessel disease (arteriolosclerosis) in brains of older people. J Neuropathol Exp Neurol. 2014;73:1026-1033. doi: 10.1097/NEN.0000000000000124.
    • (2014) J Neuropathol Exp Neurol. , vol.73 , pp. 1026-1033
    • Bridges, L.R.1    Andoh, J.2    Lawrence, A.J.3    Khoong, C.H.L.4    Poon, W.5    Esiri, M.M.6
  • 12
    • 53049101053 scopus 로고    scopus 로고
    • Neuropathologic correlates of white matter hyperintensities
    • Young VG, Halliday GM, Kril JJ. Neuropathologic correlates of white matter hyperintensities. Neurology. 2008;71:804-811. doi: 10.1212/01. wnl.0000319691.50117.54.
    • (2008) Neurology , vol.71 , pp. 804-811
    • Young, V.G.1    Halliday, G.M.2    Kril, J.J.3
  • 13
    • 66249141245 scopus 로고    scopus 로고
    • Age, neuropathology, and dementia
    • Medical Research Council Cognitive Function and Ageing Study
    • Savva GM, Wharton SB, Ince PG, Forster G, Matthews FE, Brayne C; Medical Research Council Cognitive Function and Ageing Study. Age, neuropathology, and dementia. N Engl J Med. 2009;360:2302-2309. doi: 10.1056/NEJMoa0806142.
    • (2009) N Engl J Med. , vol.360 , pp. 2302-2309
    • Savva, G.M.1    Wharton, S.B.2    Ince, P.G.3    Forster, G.4    Matthews, F.E.5    Brayne, C.6
  • 14
    • 84863554633 scopus 로고    scopus 로고
    • The neuropathology of vascular disease in the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS)
    • Richardson K, Stephan BC, Ince PG, Brayne C, Matthews FE, Esiri MM. The neuropathology of vascular disease in the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS). Curr Alzheimer Res. 2012;9:687-696.
    • (2012) Curr Alzheimer Res. , vol.9 , pp. 687-696
    • Richardson, K.1    Stephan, B.C.2    Ince, P.G.3    Brayne, C.4    Matthews, F.E.5    Esiri, M.M.6
  • 15
    • 33745148241 scopus 로고    scopus 로고
    • White matter lesions in an unselected cohort of the elderly: Molecular pathology suggests origin from chronic hypoperfusion injury
    • Fernando MS, Simpson JE, Matthews F, Brayne C, Lewis CE, Barber R, et al; MRC Cognitive Function and Ageing Neuropathology Study Group. White matter lesions in an unselected cohort of the elderly: molecular pathology suggests origin from chronic hypoperfusion injury. Stroke. 2006;37:1391-1398. doi: 10.1161/01. STR.0000221308.94473.14.
    • (2006) Stroke , vol.37 , pp. 1391-1398
    • Fernando, M.S.1    Simpson, J.E.2    Matthews, F.3    Brayne, C.4    Lewis, C.E.5    Barber, R.6
  • 16
    • 72949090601 scopus 로고    scopus 로고
    • Epidemiological pathology of dementia: Attributable-risks at death in the Medical Research Council Cognitive Function and Ageing Study
    • Matthews FE, Brayne C, Lowe J, McKeith I, Wharton SB, Ince P. Epidemiological pathology of dementia: attributable-risks at death in the Medical Research Council Cognitive Function and Ageing Study. PLoS Med. 2009;6:e1000180. doi: 10.1371/journal.pmed.1000180.
    • (2009) PLoS Med. , vol.6 , pp. e1000180
    • Matthews, F.E.1    Brayne, C.2    Lowe, J.3    McKeith, I.4    Wharton, S.B.5    Ince, P.6
  • 17
    • 4344677622 scopus 로고    scopus 로고
    • Comparison of the pathology of cerebral white matter with post-mortem magnetic resonance imaging (MRI) in the elderly brain
    • Fernando MS, O'Brien JT, Perry RH, English P, Forster G, McMeekin W, et al; Neuropathology Group of MRC CFAS. Comparison of the pathology of cerebral white matter with post-mortem magnetic resonance imaging (MRI) in the elderly brain. Neuropathol Appl Neurobiol. 2004;30:385-395. doi: 10.1111/j.1365-2990.2004.00550.x.
    • (2004) Neuropathol Appl Neurobiol. , vol.30 , pp. 385-395
    • Fernando, M.S.1    O'Brien, J.T.2    Perry, R.H.3    English, P.4    Forster, G.5    McMeekin, W.6
  • 18
    • 52649157170 scopus 로고    scopus 로고
    • Cerebral small vessel disease-induced apolipoprotein E leakage is associated with Alzheimer disease and the accumulation of amyloid beta-protein in perivascular astrocytes
    • Utter S, Tamboli I Y, Walter J, Upadhaya AR, Birkenmeier G, Pietrzik CU, et al. Cerebral small vessel disease-induced apolipoprotein E leakage is associated with Alzheimer disease and the accumulation of amyloid beta-protein in perivascular astrocytes. J Neuropathol Exp Neurol. 2008;67:842-856. doi: 10.1097/NEN.0b013e3181836a71.
    • (2008) J Neuropathol Exp Neurol. , vol.67 , pp. 842-856
    • Utter, S.1    Tamboli, I.Y.2    Walter, J.3    Upadhaya, A.R.4    Birkenmeier, G.5    Pietrzik, C.U.6
  • 19
    • 84881181605 scopus 로고    scopus 로고
    • The APOE ϵ4/ϵ4 genotype potentiates vascular fibrin (ogen) deposition in amyloid-laden vessels in the brains of Alzheimer's disease patients
    • Hultman K, Strickland S, Norris EH. The APOE ϵ4/ϵ4 genotype potentiates vascular fibrin (ogen) deposition in amyloid-laden vessels in the brains of Alzheimer's disease patients. J Cereb Blood Flow Metab. 2013;33:1251-1258. doi: 10.1038/jcbfm.2013.76.
    • (2013) J Cereb Blood Flow Metab. , vol.33 , pp. 1251-1258
    • Hultman, K.1    Strickland, S.2    Norris, E.H.3
  • 20
  • 21
    • 84883796045 scopus 로고    scopus 로고
    • Relationship between cyclophilin a levels and matrix metalloproteinase 9 activity in cerebrospinal fluid of cognitively normal apolipoprotein e4 carriers and blood-brain barrier breakdown
    • Halliday MR, Pomara N, Sagare AP, Mack WJ, Frangione B, Zlokovic BV. Relationship between cyclophilin a levels and matrix metalloproteinase 9 activity in cerebrospinal fluid of cognitively normal apolipoprotein e4 carriers and blood-brain barrier breakdown. JAMA Neurol. 2013;70:1198-1200. doi: 10.1001/jamaneurol.2013.3841.
    • (2013) JAMA Neurol. , vol.70 , pp. 1198-1200
    • Halliday, M.R.1    Pomara, N.2    Sagare, A.P.3    Mack, W.J.4    Frangione, B.5    Zlokovic, B.V.6
  • 22
    • 84985896386 scopus 로고    scopus 로고
    • The antibody aducanumab reduces Aβ plaques in Alzheimer's disease
    • Sevigny J, Chiao P, Bussière T, Weinreb PH, Williams L, Maier M, et al. The antibody aducanumab reduces Aβ plaques in Alzheimer's disease. Nature. 2016;537:50-56. doi: 10.1038/nature19323.
    • (2016) Nature , vol.537 , pp. 50-56
    • Sevigny, J.1    Chiao, P.2    Bussière, T.3    Weinreb, P.H.4    Williams, L.5    Maier, M.6
  • 23
    • 19744365810 scopus 로고    scopus 로고
    • Immunohistochemical and ultrastructural findings related to the blood-brain barrier in the blood vessels of the cerebral white matter in aged dogs
    • Morita T, Mizutani Y, Sawada M, Shimada A. Immunohistochemical and ultrastructural findings related to the blood-brain barrier in the blood vessels of the cerebral white matter in aged dogs. J Comp Pathol. 2005;133:14-22. doi: 10.1016/j.jcpa.2005.01.001.
    • (2005) J Comp Pathol. , vol.133 , pp. 14-22
    • Morita, T.1    Mizutani, Y.2    Sawada, M.3    Shimada, A.4
  • 25
    • 84944881561 scopus 로고    scopus 로고
    • Lack of widespread BBB disruption in Alzheimer's disease models: Focus on therapeutic antibodies
    • Bien-Ly N, Boswell CA, Jeet S, Beach TG, Hoyte K, Luk W, et al. Lack of widespread BBB disruption in Alzheimer's disease models: focus on therapeutic antibodies. Neuron. 2015;88:289-297. doi: 10.1016/j. neuron. 2015.09.036.
    • (2015) Neuron , vol.88 , pp. 289-297
    • Bien-Ly, N.1    Boswell, C.A.2    Jeet, S.3    Beach, T.G.4    Hoyte, K.5    Luk, W.6
  • 26
    • 85002972264 scopus 로고    scopus 로고
    • Perivascular macrophages mediate the neurovascular and cognitive dysfunction associated with hypertension
    • Faraco G, Sugiyama Y, Lane D, Garcia-Bonilla L, Chang H, Santisteban MM, et al. Perivascular macrophages mediate the neurovascular and cognitive dysfunction associated with hypertension. J Clin Invest. 2016;126:4674-4689. doi: 10.1172/JCI86950.
    • (2016) J Clin Invest. , vol.126 , pp. 4674-4689
    • Faraco, G.1    Sugiyama, Y.2    Lane, D.3    Garcia-Bonilla, L.4    Chang, H.5    Santisteban, M.M.6
  • 27
    • 84901269974 scopus 로고    scopus 로고
    • Mfsd2a is critical for the formation and function of the blood-brain barrier
    • Ben-Zvi A, Lacoste B, Kur E, Andreone BJ, Mayshar Y, Yan H, et al. Mfsd2a is critical for the formation and function of the blood-brain barrier. Nature. 2014;509:507-511. doi: 10.1038/nature13324.
    • (2014) Nature , vol.509 , pp. 507-511
    • Ben-Zvi, A.1    Lacoste, B.2    Kur, E.3    Andreone, B.J.4    Mayshar, Y.5    Yan, H.6
  • 29
    • 84876288324 scopus 로고    scopus 로고
    • Deficiency in mural vascular cells coincides with blood-brain barrier disruption in Alzheimer's disease
    • Sengillo JD, Winkler EA, Walker CT, Sullivan JS, Johnson M, Zlokovic B V. Deficiency in mural vascular cells coincides with blood-brain barrier disruption in Alzheimer's disease. Brain Pathol. 2013;23:303-310. doi: 10.1111/bpa.12004.
    • (2013) Brain Pathol. , vol.23 , pp. 303-310
    • Sengillo, J.D.1    Winkler, E.A.2    Walker, C.T.3    Sullivan, J.S.4    Johnson, M.5    Zlokovic, B.V.6
  • 30
    • 34547791784 scopus 로고    scopus 로고
    • Fibrin deposition accelerates neurovascular damage and neuroinflammation in mouse models of Alzheimer's disease
    • Paul J, Strickland S, Melchor J P. Fibrin deposition accelerates neurovascular damage and neuroinflammation in mouse models of Alzheimer's disease. J Exp Med. 2007;204:1999-2008. doi: 10.1084/jem.20070304.
    • (2007) J Exp Med. , vol.204 , pp. 1999-2008
    • Paul, J.1    Strickland, S.2    Melchor, J.P.3
  • 31
    • 84870815173 scopus 로고    scopus 로고
    • Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation
    • Davalos D, Ryu JK, Merlini M, Baeten KM, Le Moan N, Petersen MA, et al. Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation. Nat Commun. 2012;3:1227. doi: 10.1038/ncomms2230.
    • (2012) Nat Commun. , vol.3 , pp. 1227
    • Davalos, D.1    Ryu, J.K.2    Merlini, M.3    Baeten, K.M.4    Le Moan, N.5    Petersen, M.A.6
  • 32
    • 84864603265 scopus 로고    scopus 로고
    • Clusters of activated microglia in normal-appearing white matter show signs of innate immune activation
    • van Horssen J, Singh S, van der Pol S, Kipp M, Lim JL, Peferoen L, et al. Clusters of activated microglia in normal-appearing white matter show signs of innate immune activation. J Neuroinflammation. 2012;9:156. doi: 10.1186/1742-2094-9-156.
    • (2012) J Neuroinflammation. , vol.9 , pp. 156
    • Van Horssen, J.1    Singh, S.2    Van Der Pol, S.3    Kipp, M.4    Lim, J.L.5    Peferoen, L.6
  • 33
    • 0037648580 scopus 로고    scopus 로고
    • Sizeselective loosening of the blood-brain barrier in claudin-5-deficient mice
    • Nitta T, Hata M, Gotoh S, Seo Y, Sasaki H, Hashimoto N, et al. Sizeselective loosening of the blood-brain barrier in claudin-5-deficient mice. J Cell Biol. 2003;161:653-660. doi: 10.1083/jcb.200302070.
    • (2003) J Cell Biol. , vol.161 , pp. 653-660
    • Nitta, T.1    Hata, M.2    Gotoh, S.3    Seo, Y.4    Sasaki, H.5    Hashimoto, N.6
  • 34
    • 84903362501 scopus 로고    scopus 로고
    • Ex vivo T2 relaxation: Associations with age-related neuropathology and cognition
    • Dawe RJ, Bennett DA, Schneider JA, Leurgans SE, Kotrotsou A, Boyle PA, et al. Ex vivo T2 relaxation: associations with age-related neuropathology and cognition. Neurobiol Aging. 2014;35:1549-1561. doi: 10.1016/j.neurobiolaging.2014.01.144.
    • (2014) Neurobiol Aging. , vol.35 , pp. 1549-1561
    • Dawe, R.J.1    Bennett, D.A.2    Schneider, J.A.3    Leurgans, S.E.4    Kotrotsou, A.5    Boyle, P.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.