Comparison of the pathology of cerebral white matter with post-mortem magnetic resonance imaging (MRI) in the elderly brain

Neuropathology and Applied Neurobiology

Volumn 30, Issue 4, 2004, Pages 385-395

  Fernando, M S ^a   O'Brien, J T ^b   Perry, R H ^b,c   English, P ^c   Forster, G ^a   McMeekin, W ^c   Slade, J Y ^b   Golkhar, A ^c   Matthews, F E ^d   Barber, R ^b   Kalaria, R N ^b   Ince, P G ^a,e  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c NEWCASTLE UPON TYNE HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^e ROYAL HALLAMSHIRE HOSPITAL   (United Kingdom)

Author keywords

Brain ageing; Leukoaraiosis; Magnetic resonance imaging; Neuropathology; White matter lesions

Indexed keywords

MYELIN;

ADULT; AGED; AGING; ARTICLE; AUTOPSY; BRAIN CORTEX LESION; BRAIN INFARCTION; CELL ACTIVATION; CLINICAL ARTICLE; CONTROLLED STUDY; DEMOGRAPHY; DISEASE SEVERITY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; INTERMETHOD COMPARISON; MALE; MICROGLIA; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; WHITE MATTER;

AGED; AGED, 80 AND OVER; BRAIN; CEREBRAL INFARCTION; COLORING AGENTS; FALSE NEGATIVE REACTIONS; FEMALE; FORMALDEHYDE; HUMANS; IMMUNOHISTOCHEMISTRY; MAGNETIC RESONANCE IMAGING; MALE; MYELIN SHEATH; TISSUE FIXATION;

EID: 4344677622     PISSN: 03051846     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2990.2004.00550.x     Document Type: Article

References (27)

1. Pantoni L, Garcia J. The significance of white-matter abnormalities 100 years after Binswanger's report. Stroke 1995; 26: 1293-301
2. Marshall V, Bradley W, Marshall C, Bhoopat T, Rhodes R. Deep white matter infarction: correlation of MR imaging and histopathologic findings. Radiology 1988; 167: 517-22
3. Moore G, Leung E, MacKay A, Vavasour I, Whittal K, Cover K, Li D, Hashimoto S, Oger J, Sprinkle T, Paty D. A pathology-MRI study of the short-T2 component in formalin-fixed multiple sclerosis brain. Neurology 2000; 55: 1506-10
4. Scarpelli M, Salvolini U, Diamanthi L, Montironi R, Chiaromoni L, Maricotti M. MRI and pathological examination of post-mortem brains: the problem of white matter high signal areas. Neuroradiol 1994; 36: 393-8
5. Scheltens P, Barkhof F, Leys D, Wolters E, Ravid R, Kamphorst W. Histopathologic correlates of white matter changes on MRI in Alzheimer's disease and normal aging. Neurology 1995; 45: 883-8
6. Braffman B, Zimmerman R, Trojanowski J, Gonatas N, Hickey W, Schalaepfer W, Brian M. Pathologic correlation with gross histopathology. 2. Hyperintense white-matter foci in the elderly. Am J Neuroradiol 1988; 9: 629-36
7. Englund E, Brun A. Frontal lobe degeneration of non-Alzheimer type: IV White matter changes. Arch Gerontol Geriatr 1987; 6: 235-43
8. Englund E, Brun A, Alling C. White matter changes in dementia of Alzheimer's type - biochemical and neuropathological changes. Brain 1988; 111: 1425-39
9. Englund E. Neuropathology of white matter changes in Alzheimer's disease and vascular dementia. Dementia Geriatr Cogn Disord 1998; 9 (Suppl. 1): 6-12
10. Haglund M, Englund E. Cerebral amyloid angiopathy, white matter lesions and Alzheimer encephalopathy - a histopathological assessment. Dementia Geriatr Cogn Disord 2002; 14: 161-6
11. Kirkpatrick J, Hayman L. White matter lesions in MR imaging of clinically healthy brains of elderly subjects: possible pathological basis. Radiology 1987; 162: 509-11
12. Awad I, Johnson P, Spetzler R, Hodak J. Incidental subcortical lesions identified on magnetic resonance imaging in the elderly, II: postmortem pathological correlations. Stroke 1986; 17: 1090-7
13. Grafton S, Sumi S, Stimac G, Alvord E, Shaw C, Nochlin D. Comparison of postmortem magnetic resonance imaging and neuropathologic findings in the cerebral white matter. Arch Neurol 1991; 48: 293-8
14. van Swieten J, van den Howt J, van Ketel B, Hijdra A, Wokke J, van Gijn J. Periventricular lesions in the white matter on magnetic resonance imaging in the elderly. A morphometric correlation with arteriosclerosis and dilated perivascular spaces. Brain 1991; 114: 761-4
15. Fazekas F, Kleinert R, Offenbacher H, Schmidt R, Kleinert G, Payer F, Radner H, Lechner H. Pathologic correlates of incidental MRI white matter signal hyperintensities. Neurology 1993; 43: 1683-9
16. Mirra S, Heyman A, McKeel D, Sumi S, Crain B, Brownlee L, Vogel F, Hughes J, van Belle G, Xxxx LB. The consortium to establish a registry of Alzheimer's disease (CERAD) Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 1991; 41: 479-86
17. MRC CFAS Neuropathology study group. Neuropathological correlates of dementia in an elderly community sample. Lancet 2001; 357: 169-75
18. Ince P, McArthur F, Bjertness E, Torvik A, Candy J, Edwardson J. Neuropathological diagnoses in elderly patients in Oslo: Alzheimer's disease, Lewy body disease and vascular lesions. Dementia Geriatr Cogn Disord 1995; 6: 162-8
19. Scheltens P, Barkhof F, Leys D, Pruvo J, Nauta J, Vermersch P, Steinling M, Valk J. Semiquantative rating scale for the assessment of signal hyperintensities on magnetic resonance imaging. J Neurol Sci 1993; 114: 7-12
20. Chimowitz M, Estes M, Furlan A, Awad I. Further observations on the pathology of subcortical lesions identified on magnetic resonance imaging. Arch Neurol 1992; 49: 747-52
21. Smith C, Snowdon D, Markesbery W. Periventricular white matter hyperintensities on MRI: correlation with neuropathologic findings. J Neuroimaging 2000; 10: 13-6
22. Bronge L, Bogdanovic N, Wahlund L-O. Postmortem MRI and histopathology of white matter changes in Alzheimer brains. Dementia Geriatr Cogn Disord 2002; 13: 205-12
23. Hanyu H, Sakurai H, Iwamoto T, Takasaki M, Shindo H, Abe K. Diffusion-weighted MR imaging of the hippocampus and temporal white matter in Alzheimer's disease. J Neurol Sci 1998; 156: 195-200
24. Kantarci K, Jack C, Xu Y, Campeau N, O'Brien P, Smith G, Invik R, Boeve B, Kokmen E, Tanglos E, Petersen R. Mild cognitive impairment and Alzheimer's disease: regional diffusivity of water. Radiology 2001; 219: 101-7
25. Loevner L, Grossman R, Cohen J, Lexa F, Kessler D, Kolson D. Microscopic disease in normal-appearing white matter on conventional MR images in patients with multiple sclerosis: assessment with magnetization-transfer measurements. Radiology 1995; 196: 511-5
26. Tanabe J, Ezekiel F, Jagust W, Reed B, Norman D, Schuff N, Weiner M, Chu H, Fein G. Magnetization transfer ratio of white matter hyperintensities in subcortical ischemic vascular dementia. Am J Neuroradiol 1999; 20: 839-44
27. Fazekas F, Kleimert R, Offenbacher H, Payer F, Schmidt R, Kleinert G, Radner H, Lechner H. The morphologic correlate of incidental punctate white matter hyperintensities on MR images. Am J Neuroradiol 1991; 12: 915-21