Falls and fall-prevention in older persons: Geriatrics meets spaceflight!

Frontiers in Physiology

Volumn 8, Issue OCT, 2017, Pages

  Goswami, Nandu ^a,b  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

^b Alma Mater Europea University   (Slovenia)

Author keywords

Aging; Bedrest; Countermeasures; Falls; Fraility; Immobilization; Orthostatic intolerance; Spaceflight

Indexed keywords

AGED; AGED HOSPITAL PATIENT; AGING; ARTICLE; BED REST; BODY POSITION; BRAIN FUNCTION; CARDIOVASCULAR EFFECT; CARDIOVASCULAR FUNCTION; COSMONAUT; EXERCISE; FALLING; FRAILTY; GERIATRIC PATIENT; GRAVITATIONAL STRESS; HEALTH CARE COST; HUMAN; IMMOBILIZATION; MICROGRAVITY; MUSCLE FUNCTION; MUSCLE STRENGTH; MUSCULOSKELETAL FUNCTION; NUTRITION; ORTHOSTATIC INTOLERANCE; SENSORIMOTOR FUNCTION; SPACE FLIGHT;

EID: 85031035710     PISSN: None     EISSN: 1664042X     Source Type: Journal    
DOI: 10.3389/fphys.2017.00603     Document Type: Article

References (76)

1. Antonutto, G., and di Prampero, P. E. (2003). Cardiovascular deconditioning in microgravity: some possible countermeasures. Eur. J. Appl. Physiol. 90, 283-291. doi: 10.1007/s00421-003-0884-5
2. Arzeno, N. M., Stenger, M. B., Lee, S. M. C., Ploutz- Snyder, R., and Platts, S. H. (2013). Sex differences in blood pressure control during 6° head-down tilt bed rest. Am. J. Physiol. Heart Circ. Physiol. 304, H1114-H1123. doi: 10.1152/ajpheart.00391.2012
3. Blaber, A. P., Goswami, N., Bondar, R. L., and Kassam, M. S. (2011). Impairment of cerebral blood flow regulation in astronauts with orthostatic intolerance after flight. Stroke 42, 1844-1850. doi: 10.1161/STROKEAHA.110.610576
4. Blaber, A. P., Landrock, C. K., and Souvestre, P. A. (2009). Cardio-postural deconditioning: a model for post flight orthostatic intolerance. Respir. Physiol. Neurobiol. 169, S21-S25. doi: 10.1016/j.resp.2009.04.007
5. Blaber, A. P., Zuj, K., and Goswami, N. (2013). Space physiology III: cerebrovascular autoregulation: lessons learned from space flight research. Eur. J. Appl. Physiol. 113, 1909-1917. doi: 10.1007/s00421-012-2539-x
6. Blain, H., Masud, T., Dargent-Molina, P., Martin, F. C., Rosendahl, E., van der Velde, N., et al. (2016). EUGMS falls and fracture interest group; European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO), Osteoporosis Research and Information Group (GRIO), and International osteoporosis Foundation (IOF). A comprehensive fracture prevention strategy in older adults: the European Union Geriatric Medicine Society (EUGMS) Statement. J. Nutr. Health Aging 20, 647-652. doi: 10.1007/s12603-016-0741-y
7. Blomqvist, C. G. (1983). Cardiovascular adaptations to weightlessness. Med. Sci. Sports Exerc. 15, 428-431. doi: 10.1249/00005768-198315050-00015
8. Bousquet, J., Bewick, M., Cano, A., Eklund, P., Fico, G., Goswami, N., et al. (2017). Building bridges for innovation in ageing: synergies between action groups of the EIP on AHA. J. Nutr. Health Aging 21, 92-104. doi: 10.1007/s12603-016-0803-1
9. Brown, C. J., Friedkin, R. J., and Inouye, S. K. (2004). Prevalence and outcomes of low mobility in hospitalized older patients. J. Am. Geriatr. Soc. 52, 1263-1270. doi: 10.1111/j.1532-5415.2004.52354.x
10. Brown, C. J., Redden, D. T., Flood, K. L., and Allman, R. M. (2009). The underrecognized epidemic of low mobility during hospitalization of older adults. J. Am. Geriatr. Soc. 57, 1660-1665. doi: 10.1111/j.1532-5415.2009.02393.x
11. Buckey, J. C., Lane, L. D., Levine, B. D., Watenpaugh, D. E., Wright, S. J., Moore, W. E., et al. (1996). Orthostatic intolerance after spaceflight. J. Appl. Physiol. 81, 7-18.
12. Bungo, M. W., and Johnson, P. C. (1983). Cardiovascular examinations and observations of deconditioning during the Space Shuttle orbital flight test program. Aviat. Space Environ. Med. 54, 1001-1004.
13. Campbell, M. R., and Charles, J. B. (2015). Historical review of lower body negative pressure research in space medicine. Aerosp. Med. Hum. Perform. 86, 633-640. doi: 10.3357/AMHP.4246.2015
14. Convertino, V. (2007). Blood volume response to physical activity and inactivity. Am. J. Med. Sci. 334, 72-79. doi: 10.1097/MAJ.0b013e318063c6e4
15. Cvirn, G., Waha, J. E., Ledinski, G., Schlagenhauf, A., Leschnik, B., Koestenberger, M., et al. (2015). Bed rest does not induce hypercoagulability. Eur. J. Clin. Invest. 45, 63-69. doi: 10.1111/eci.12383
16. Daly, R. M., O'Connell, S. L., Mundell, N. L., Grimes, C. A., Dunstan, D. W., and Nowson, C. A. (2014). Protein-enriched diet, with the use of lean red meat, combined with progressive resistance training enhances lean tissue mass and muscle strength and reduces circulating IL-6 concentrations in elderly women: a cluster randomized controlled trial. Am. J. Clin. Nutr. 99, 899-910. doi: 10.3945/ajcn.113.064154
17. Dittmer, D. K., and Teasell, R. (1993). Complications of immobilization and bed rest. Part 1: musculoskeletal and cardiovascular complications. Can. Fam. Physician 39, 1428-1432.
18. European Commission (2012). Project Report: Report on the Socio-Economic Determinants of Food Choices and Preferences of the Elderly. NU-AGE. Available online at: www.nu-age.eu
19. European Innovative Partnership Active Healthy Aging (2013). Report: Prevention and Early Diagnosis of Frailty and Functional Decline, Both Physical and Cognitive, in Older People (Action Group A3). Available online at: https://ec.europa.eu/research/innovation-union/pdf/active-healthy-ageing/gp_a3.pdf
20. Florian, J. P., Baisch, F. J., Heer, M., and Pawelczyk, J. A. (2015). Caloric restriction decreases orthostatic tolerance independently from 6° head-down bedrest. PLoS ONE 10:e0118812. doi: 10.1371/journal.pone.0118812
21. Gangavati, A., Hajjar, I., Quach, L., Jones, R. N., Kiely, D. K., Gagnon, P., et al. (2011). Hypertension, orthostatic hypotension, and the risk of falls in a community-dwelling elderly population: the maintenance of balance, independent living, intellect, and zest in the elderly of Boston study. J. Am. Geriatr. Soc. 59, 383-389. doi: 10.1111/j.1532-5415.2011.03317.x
22. Gazenko, O. G., Genin, A. M., and Egorov, A. D. (1981). Summary of medical investigations in the USSR manned space missions. Acta Astronaut. 8, 907-917. doi: 10.1016/0094-5765(81)90061-8
23. Gazenko, O. G., Shulzhenko, E. B., and Egorov, A. D. (1986). Cardiovascular changes in prolonged space flights. Acta Physiol. Pol. 37, 53-68.
24. Goswami, N., Batzel, J. J., Clement, G., Stein, P. T., Hargens, A. R., Sharp, K. S., et al. (2013). Maximizing information from space data resources: a case for expanding integration across research disciplines. Eur. J. Appl. Physiol. 113, 1645-1654. doi: 10.1007/s00421-012-2507-5
25. Goswami, N., Batzel, J. J., and Valenti, G. (2015a). "Human systems physiology," in Generation and Application of Extra-Terrestrial Environments on Earth, eds D. A. Beysens, and J. J. W. A. van Loon (Aalborg: River Publishers), 255-263.
26. Goswami, N., Kavcic, V., Marusic, U., Simunic, B., Rössler, A., Hinghofer-Szalkay, H., et al. (2015b). Effect of computerized cognitive training with virtual spatial navigation task during bed rest immobilization and recovery on vascular function: a pilot study. Clin. Interv. Aging 10, 453-459. doi: 10.2147/CIA.S76028
27. Goswami, N., Roma, P. G., De Boever, P., Clément, P. G., Hargens, A. R., Loeppky, J. A., et al. (2012). Using the moon as a high-fidelity environment to study biological and behavioural effects of long-duration space exploration. Planet. Space Sci. 74, 111-120. doi: 10.1016/j.pss.2012.07.030
28. Hackney, K. J., Scott, J. M., Hanson, A. M., English, K. L., Downs, M. E., and Ploutz-Snyder, L. L. (2015). The astronaut-athlete: optimizing human performance in space. J. Strength Cond. Res. 29, 3531-3545. doi: 10.1519/JSC.0000000000001191
29. Hamilton, D. R. (2008). "Cardiovascular disorders," in Principles of Clinical Medicine for Space Flight, eds M. R. Barratt and S. L. Pool (New York, NY: Springer), 339.
30. Han, X., and Ren, J. (2010). Caloric restriction and heart function: is there a sensible link? Acta Pharmacol. Sin. 31, 1111-1117. doi: 10.1038/aps.2010.146
31. Hargens, A. R., Bhattacharya, R., and Schneider, S. M. (2013). Space physiology VI: exercise, artificial gravity, and countermeasure development for prolonged space flight. Eur. J. Appl. Physiol. 113, 2183-2192. doi: 10.1007/s00421-012-2523-5
32. Heinrich, S., Rapp, K., Rissmann, U., Becker, C., and König, H. H. (2010). Cost of fall in old age: a systematic review. Osteoporosis Int. 21, 891-902. doi: 10.1007/s00198-009-1100-1
33. Hirsch, C. H., Sommers, L., Olsen, A., Mullen, L., and Winograd, C. H. (1990). The natural history of functional morbidity in hospitalized older patients. J. Am. Geriatr. Soc. 38, 1296-1303. doi: 10.1111/j.1532-5415.1990.tb03451.x
34. Jost, P. D. (2008). Simulating human space physiology with bed rest. Hippokratia 12(Suppl. 1), 37-40.
35. Kaiser, M. J., Bauer, J. M., Rämsch, C., Uter, W., Guigoz, Y., Cederholm, T., et al. (2010). Frequency of malnutrition in older adults: a multinational perspective using the mini nutritional assessment. J. Am. Geriatr. Soc. 58, 1734-1738. doi: 10.1111/j.1532-5415.2010.03016.x
36. Kortebein, P., Symons, T. B., Ferrando, A., Paddon-Jones, D., Ronsen, O., Protas, E., et al. (2008). Functional impact of 10 days of bed rest in healthy older adults. J. Gerontol. A Biol. Sci. Med. Sci. 63, 1076-1081. doi: 10.1093/gerona/63.10.1076
37. Lazarus, B. A., Murphy, J. B., Coletta, E. M., McQuade, W. H., and Culpepper, L. (1991). The provision of physical activity to hospitalized elderly patients. Arch. Intern. Med. 151, 2452-2456. doi: 10.1001/archinte.1991.00400120090017
38. Levy, M. N., and Talbot, J. M. (1983). Cardiovascular deconditioning of spaceflight. Physiologist 26, 297-303.
39. Lillywhite, H. B. (1988). Snakes, blood circulation and gravity. Sci. Am. 256, 92-98. doi: 10.1038/scientificamerican1288-92
40. Lillywhite, H. B., Ballard, R. E., Hargens, A. R., and Rosenberg, H. I. (1997). Cardiovascular responses of snakes to hypergravity. Gravit. Space Biol. Bull. 10, 145-152.
41. Mahoney, J. E. (1998). Immobility and falls. Clin. Geriatr. Med. 14, 699-726.
42. Mano, T. (2005). Autonomic neural functions in space. Curr. Pharm. Biotechnol. 6, 319-324. doi: 10.2174/1389201054553743
43. Martínez-Velilla, N., Casas-Herrero, A., Zambom-Ferraresi, F., Suárez, N., Alonso-Renedo, J., Contín, K. C., et al. (2015). Functional and cognitive impairment prevention through early physical activity for geriatric hospitalized patients: study protocol for a randomized controlled trial. BMC Geriatr. 15:112. doi: 10.1186/s12877-015-0109-x
44. Martone, A. M., Onder, G., Vetrano, D. L., Ortolani, E., Tosato, M., Marzetti, E., et al. (2013). Anorexia of aging: a modifiable risk factor for frailty. Nutrients 5, 4126-4133. doi: 10.3390/nu5104126
45. Marusic, U., Giordani, B., Moffat, S. D., Petric, M., Dolenc, P., Pisot, R., et al. (2016). Computerized cognitive training during physical inactivity improves executive functioning in older adults. Neuropsychol. Dev. Cogn. B Aging Neuropsychol. Cogn. 12, 1-21. doi: 10.1080/13825585.2016.1263724
46. Meck, J. V., Waters, W. W., Ziegler, M. G., deBlock, H. F., Mills, P. J., Robertson, D., et al. (2004). Mechanisms of postspaceflight orthostatic hypotension: low alpha1-adrenergic receptor responses before flight and central autonomic dysregulation postflight. Am. J. Physiol. Heart Circ. Physiol. 286, H1486-H1495. doi: 10.1152/ajpheart.00740.2003
47. Morey-Holton, E. R. (2003). "The impact of gravity on life," in Evolution on Planet Earth: the Impact of the Physical Environment, eds L. Rothschild and A. Lister (New York, NY: Academic), 143.
48. Mühlberg, W., and Sieber, C. (2004). Sarcopenia and frailty in geriatric patients: implications for training and prevention. Z. Gerontol. Geriatr. 37, 2-8. doi: 10.1007/s00391-004-0203-8
49. Muscaritoli, M., Krznaric, Z., Barazzoni, R., Cederholm, T., Golay, A., Van Gossum, A., et al. (2016). Effectiveness and efficacy of nutritional therapy - a cochrane systematic review. Clin. Nutr. 36, 939-957. doi: 10.1016/j.clnu.2016.06.022
50. Olanrewaju, O., Kelly, S., Cowan, A., Brayne, C., and Lafortune, L. (2016). Physical activity in community dwelling older people: a systematic review of reviews of interventions and context. PLoS ONE 11:e0168614. doi: 10.1371/journal.pone.0168614
51. O'Shea, D., Lackner, H. K., Rössler, A., Green, D. A., Gauger, P., Mulder, E., et al. (2015). Influence of bed rest on plasma galanin and adrenomedullin at presyncope. Eur. J. Clin. Invest. 45, 679-685. doi: 10.1111/eci.12455
52. Pavy-Le Traon, A., Heer, M., Narici, M., Rittweger, J., and Vernikos, J. (2007). From space to earth: advances in human physiology from 20 years of bed rest studies (1986-2006) Eur. J. Appl. Physiol. 101, 143-194. doi: 10.1007/s00421-007-0474-z
53. Pedersen, M. M., Bodilsen, A. C., Petersen, J., Beyer, N., Andersen, O., Lawson-Smith, L., et al. (2013). Twenty-four-hour mobility during acute hospitalization in older medical patients. J. Gerontol. A Biol. Sci. Med. Sci. 68, 319-337. doi: 10.1093/gerona/gls165
54. Petersen, N., Jaekel, P., Rosenberger, A., Weber, T., Scott, J., Castrucci, F., et al. (2016). Exercise in space: the European Space Agency approach to in-flight exercise countermeasures for long-duration missions on ISS. Extrem. Physiol. Med. 5:9. doi: 10.1186/s13728-016-0050-4
55. Pirlich, M., Schütz, T., Norman, K., Gastell, S., Lübke, H. J., Bischoff, S. C., et al. (2006). The German hospital malnutrition study. Clin. Nutr. 25, 563-572. doi: 10.1016/j.clnu.2006.03.005
56. Rapp, K., Becker, C., Cameron, I. D., König, H. H., and Büchele, G. (2012). Epidemiology of falls in residential aged care: analysis of more than 70,000 falls from residents of bavarian nursing homes. J. Am. Med. Dir. Assoc. 13:187. doi: 10.1016/j.jamda.2011.06.011
57. Sandler, H., and Vernikos, J. (eds.) (1986). Inactivity: Physiological Effects. New York, NY: Academic Press.
58. Saunders, J., Smith, T., and Stroud, M. (2015). Malnutrition and undernutrition. Medicine 42, 112-118. doi: 10.1016/j.mpmed.2014.11.015
59. Schneider, S. M., Lee, S. M. C., Macias, B. M., Watenpaugh, D. E., and Hargens, A. R. (2009). WISE-2005: exercise and nutrition countermeasures for upright VO2pk during bed rest. Med. Sci. Sports Exerc. 41, 2165-2176. doi: 10.1249/MSS.0b013e3181aa04e5
60. Singh, M., Alexander, K., Roger, V. L., Rihal, C. S., Whitson, H. E., Lerman, A., et al. (2008). Frailty and its potential relevance to cardiovascular care. Mayo Clin. Proc. 83, 1146-1153. doi: 10.4065/83.10.1146
61. Smith, S. M., Heer, M. A., Shackelford, L. C., Sibonga, J. D., Ploutz-Snyder, L., and Zwart, S. R. (2012). Benefits for bone from resistance exercise and nutrition in long-duration spaceflight: evidence from biochemistry and densitometry. J. Bone Miner. Res. 27, 1896-1906. doi: 10.1002/jbmr.1647
62. Smith, S. M., Rice, B. L., and Zwart, S. R. (2013). Assessment of nutritional intake during space flight and space flight analogs. Procedia Food Sci. 2, 27-34. doi: 10.1016/j.profoo.2013.04.006
63. Smith, S. M., Zwart, S. R., Block, G., Rice, B. L., and Davis-Street, J. E. (2005). The nutritional status of astronauts is altered after long-term space flight aboard the international space station. J. Nutr. 135, 437-443.
64. Smith, S. M., Zwart, S. R., Kloeris, V., and Heer, M. (2009). Nutritional Biochemistry of Space Flight. New York, NY: Nova Science Publishers.
65. Strandberg, E., Edholm, P., Ponsot, E., Wåhlin-Larsson, B., Hellmén, E., Nilsson, A., et al. (1985). Influence of combined resistance training and healthy diet on muscle mass in healthy elderly women: a randomized controlled trial. J. Appl. Physiol. 119, 918-925. doi: 10.1152/japplphysiol.00066.2015
66. Stuempfle, K. J., and Drury, D. G. (2007). The physiological consequences of bed rest. J. Exerc. Physiol. 10, 32-41.
67. Suetta, C., Hvid, L. G., Justesen, L., Christensen, U., Neergaard, K., Simonsen, L., et al. (2009). Effects of aging on human skeletal muscle after immobilization and retraining. J. Appl. Physiol. 107, 1172-1180. doi: 10.1152/japplphysiol.00290.2009
68. Trappe, T. A., Burd, N. A., Louis, E. S., Lee, G. A., and Trappe, S. W. (2007). Influence of concurrent exercise or nutrition countermeasures on thigh and calf muscle size and function during 60 days of bed rest in women. Acta Physiol. (Oxf). 191, 147-159. doi: 10.1111/j.1748-1716.2007.01728.x
69. Verghese, J., Mahoney, J., Ambrose, A. F., Wang, C. L., and Holtzer, R. (2010). Effect of cognitive remediation on gait in sedentary seniors. J. Gerontol. Biol. Sci. Med. Sci. 65, 1338-1343. doi: 10.1093/gerona/glq127
70. Vernikos, J., and Schneider, S. V. (2010). Space, gravity and the physiology of aging: parallel or convergent disciplines? A mini-review. Gerontology 56, 157-166. doi: 10.1159/000252852
71. Waha, J. E., Goswami, N., Schlagenhauf, A., Leschnik, B., Koestenberger, M., Reibnegger, G., et al. (2015). Effects of exercise and nutrition on the coagulation system during bedrest immobilization. Medicine 94:e1555. doi: 10.1097/MD.0000000000001555
72. Watenpaugh, D. E., and Hargens, A. R. (1996). "The cardiovascular system in microgravity," in Handbook of Physiology. Environmental Physiology, eds M. J. Fregley and C. M. Blatteis (New York, NY: Oxford University Press), 33.
73. Waters, W. W., Platts, S. H., Mitchell, B. M., Whitson, P. A., and Meck, J. V. (2005). Plasma volume restoration with salt tablets and water after bed rest prevents orthostatic hypotension and changes in supine hemodynamic and endocrine variables. Am. J. Physiol. Heart Circ. Physiol. 288, H839-H847. doi: 10.1152/ajpheart.00220.2004
74. Weiss, A., Chagnac, A., Beloosesky, Y., Weinstein, T., Grinblat, J., and Grossman, E. (2004). Orthostatic hypotension in the elderly: are the diagnostic criteria adequate? J. Hum. Hypertens. 18, 301-305. doi: 10.1038/sj.jhh.1001668
75. Zwart, S. R., Booth, S. L., Peterson, J. W., Wang, Z., and Smith, S. M. (2011). Vitamin K status in spaceflight and ground-based models of spaceflight. J. Bone Miner. Res. 26, 948-954. doi: 10.1002/jbmr.289
76. Zwart, S. R., Pierson, D., Mehta, S., Gonda, S., and Smith, S. M. (2010). Capacity of omega-3 fatty acids or eicosapentaenoic acid to counteract weightlessness-induced bone loss by inhibiting NF-kappaB activation: from cells to bed rest to astronauts. J. Bone Miner. Res. 25, 1049-1057. doi: 10.1359/jbmr.091041