Capacity of omega-3 fatty acids or eicosapentaenoic acid to counteract weightlessness-induced bone loss by inhibiting NF-κB activation: From cells to bed rest to astronauts

Journal of Bone and Mineral Research

Volumn 25, Issue 5, 2010, Pages 1049-1057

  Zwart, Sara R ^a   Pierson, Duane ^b   Mehta, Satish ^c   Gonda, Steve ^b   Smith, Scott M ^b  

^a UNIVERSITIES SPACE RESEARCH ASSOCIATION   (United States)

^b NASA JOHNSON SPACE CENTER   (United States)

^c Enterprise Advisory Services Inc   (United States)

Author keywords

Eicosapentaenoic acid; Osteoclasts; Receptor activator of nuclear factor b; Weightlessness; Weightlessness simulation

Indexed keywords

AMINO TERMINAL TELOPEPTIDE; ICOSAPENTAENOIC ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; OMEGA 3 FATTY ACID; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ANIMAL CELL; ARTICLE; BED REST; BONE DENSITY; CELL DIFFERENTIATION; CONTROLLED STUDY; COSMONAUT; FEMALE; FISH; HUMAN; MACROPHAGE; MALE; MONOCYTE; MOUSE; NONHUMAN; OSTEOLYSIS; PROTEIN EXPRESSION; SPACE FLIGHT; WEIGHTLESSNESS;

ADULT; ANIMALS; BED REST; BONE RESORPTION; CELL DIFFERENTIATION; CELL LINE; EICOSAPENTAENOIC ACID; FATTY ACIDS, OMEGA-3; FEMALE; HUMANS; MACROPHAGES; MALE; MICE; MIDDLE AGED; NF-KAPPA B; OSTEOCLASTS; RANK LIGAND; SPACE FLIGHT; TUMOR NECROSIS FACTOR-ALPHA; WEIGHTLESSNESS;

EID: 77953529587     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.091041     Document Type: Article

References (61)

1. Sibonga JD, Cavanagh PR, Lang TF, et al. Adaptation of the skeletal system during long-duration spaceflight. Clin Rev Bone Miner Metab. 2008;5:249-261.
2. LeBlanc AD, Spector ER, Evans HJ, Sibonga JD. Skeletal responses to space flight and the bed rest analog: a review. J Musculoskelet Neuronal Interact. 2007;7:33-47.
3. Trappe S, Costill D, Gallagher P, et al. Exercise in space: human skeletal muscle after 6 months aboard the International Space Station. J Appl Physiol. 2009;106:1159-1168.
4. Durham WJ, Li YP, Gerken E, et al. Fatiguing exercise reduces DNA binding activity of NF-κB in skeletal muscle nuclei. J Appl Physiol. 2004;97:1740-1745. (Pubitemid 39425991)
5. Judge AR, Koncarevic A, Hunter RB, Liou HC, Jackman RW, Kandarian SC. Role for IκBα, but not c-Rel, in skeletal muscle atrophy. Am J Physiol Cell Physiol. 2007;292:C372-382. (Pubitemid 46115145)
6. Hunter RB, Stevenson E, Koncarevic A, Mitchell-Felton H, Essig DA, Kandarian SC. Activation of an alternative NF-κB pathway in skeletal muscle during disuse atrophy. FASEB J. 2002;16:529-538. (Pubitemid 34273236)
7. Farid M, Reid MB, Li YP, Gerken E, Durham WJ. Effects of dietary curcumin or N-acetylcysteine on NF-κB activity and contractile performance in ambulatory and unloaded murine soleus. Nutr Metab. 2005;2:20-28. (Pubitemid 41317459)
8. Rahman MM, Bhattacharya A, Fernandes G. Docosahexaenoic acid is more potent inhibitor of osteoclast differentiation in RAW 264.7 cells than eicosapentaenoic acid. J Cell Physiol. 2008;214:201-209. (Pubitemid 350225482)
9. Fernandes G, Bhattacharya A, Rahman M, Zaman K, Banu J. Effects of n-3 fatty acids on autoimmunity and osteoporosis. Front Biosci. 2008;13:4015-4020. (Pubitemid 351599674)
10. Galliera E, Locati M, Mantovani A, Corsi MM. Chemokines and bone remodeling. Int J Immunopathol Pharmacol. 2008;21:485-491.
11. Tilg H, Moschen AR, Kaser A, Pines A, Dotan I. Gut, inflammation and osteoporosis: basic and clinical concepts. Gut. 2008;57:684-694. (Pubitemid 351579985)
12. Whitehouse AS, Smith HJ, Drake JL, Tisdale MJ. Mechanism of attenuation of skeletal muscle protein catabolism in cancer cachexia by eicosapentaenoic acid. Cancer Res. 2001;61:3604-3609.
13. Wigmore SJ, Barber MD, Ross JA, Tisdale MJ, Fearon KC. Effect of oral eicosapentaenoic acid on weight loss in patients with pancreatic cancer. Nutr Cancer. 2000;36:177-184.
14. Riediger ND, Othman RA, Suh M, Moghadasian MH. A systemic review of the roles of n-3 fatty acids in health and disease. J Am Diet Assoc. 2009;109:668-679.
15. Smith HJ, Lorite MJ, Tisdale MJ. Effect of a cancer cachectic factor on protein synthesis/degradation in murine C2C12 myoblasts: modulation by eicosapentaenoic acid. Cancer Res. 1999;59:5507-5513.
16. Alexander JW. Immunonutrition: the role of omega-3 fatty acids. Nutrition. 1998;14:627-633. (Pubitemid 28345462)
17. Sun D, Krishnan A, Zaman K, Lawrence R, Bhattacharya A, Fernandes G. Dietary n-3 fatty acids decrease osteoclastogenesis and loss of bone mass in ovariectomized mice. J Bone Miner Res. 2003;18:1206-1216. (Pubitemid 37294913)
18. Fernandes G, Lawrence R, Sun D. Protective role of n-3 lipids and soy protein in osteoporosis. Prostaglandins Leukot Essent Fatty Acids. 2003;68:361-372. (Pubitemid 36724027)
19. Yaqoob P, Calder PC. N-3 polyunsaturated fatty acids and inflammation in the arterial wall. Eur J Med Res. 8: 2003; 337-354.
20. Micallef MA, Munro IA, Garg ML. An inverse relationship between plasma n-3 fatty acids and C-reactive protein in healthy individuals. Eur J Clin Nutr (May 19). 2009;1-5.
21. Moon DO, Kim KC, Jin CY, et al. Inhibitory effects of eicosapentaenoic acid on lipopolysaccharide-induced activation in BV2 microglia. Int Immunopharmacol. 2007;7:222-229. (Pubitemid 46037561)
22. Tisdale MJ. The ubiquitin-proteasome pathway as a therapeutic target for muscle wasting. J Support Oncol. 2005;3:209-217. (Pubitemid 40852404)
23. Kim HH, Lee Y, Eun HC, Chung JH. Eicosapentaenoic acid inhibits TNF-α-induced matrix metalloproteinase-9 expression in human keratinocytes, HaCaT cells. Biochem Biophys Res Comm. 2008;368:343-349.
24. Camandola S, Leonarduzzi G, Musso T, et al. Nuclear factor κB is activated by arachidonic acid but not by eicosapentaenoic acid. Biochem Biophys Res Comm. 1996;229:643-647. (Pubitemid 27029084)
25. Rucci N, Migliaccio S, Zani BM, Taranta A, Teti A. Characterization of the osteoblast-like cell phenotype under microgravity conditions in the NASA-approved Rotating Wall Vessel bioreactor (RWV). J Cell Biochem. 2002;85:167-179. (Pubitemid 34204079)
26. Molnar G, Schroedl NA, Gonda SR, Hartzell CR. Skeletal muscle satellite cells cultured in simulated microgravity. In Vitro Cell Dev Biol Anim. 1997;33:386-391. (Pubitemid 27276343)
27. Pavy-Le Traon A, Heer M, Narici MV, Rittweger J, Vernikos J. From space to earth: advances in human physiology from 20 years of bed rest studies. (1986-2006). Eur J Appl Physiol. 2007;101:143-194.
28. Markwell MA, Haas SM, Bieber LL, Tolbert NE. A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. Anal Biochem. 1978;87:206-210.
29. Zwart SR, Lewis BJ. Optimization of detection and quantification of proteins on membranes in very high and very low abundance using avidin and streptavidin. Methods Mol Biol. 2008;418:25-34.
30. Mehta SK, Kaur I, Grimm EA, Smid C, Feeback DL, Pierson DL. Decreased non-MHC-restricted (CD56+) killer cell cytotoxicity after spaceflight. J Appl Physiol. 2001;91:1814-1818. (Pubitemid 32900376)
31. Stowe RP, Sams CF, Mehta SK, et al. Leukocyte subsets and neutrophil function after short-term spaceflight. J Leuk Biol. 1999;65:179-186.
32. Bharti AC, Donato N, Aggarwal BB. Curcumin (diferuloylmethane) inhibits constitutive and IL-6-inducible STAT3 phosphorylation in human multiple myeloma cells. J Immunol. 2003;171:3863-3871. (Pubitemid 37254592)
33. Smith SM, Davis-Street JE, Rice BL, Nillen JL, Gillman PL, Block G. Nutritional status assessment in semiclosed environments: ground-based and space flight studies in humans. J Nutr. 2001;131:2053-2061. (Pubitemid 32661079)
34. Smith SM, Zwart SR, Block G, Rice BL, Davis-Street JE. The nutritional status of astronauts is altered after long-term space flight aboard the International Space Station. J Nutr. 2005;135:437-443. (Pubitemid 40365200)
35. Soller BR, Cabrera M, Smith SM, Sutton JP. Smart medical systems with application to nutrition and fitness in space. Nutrition. 2002;18:930-936. (Pubitemid 35292268)
36. Meck JV, Dreyer S, Warren L. Long-duration head-down bed rest: Project overview, vital signs, and fluid balance. Aviat Space Environ Med. 2009;80 (5, Supplement):A1-A8.
37. Zwart SR, Oliver SM, Fesperman JV, et al. Nutritional status assessment before, during, and after long-duration head-down bed rest. Aviat Space Environ Med. 2009;80:A15-A22.
38. Inniss AM, Rice BL, Smith SM. Dietary support of long-duration head-down bed rest. Aviat Space Environ Med. 2009;80:A9-A14.
39. Schakel SF, Sievert YA, Buzzard IM. Sources of data for developing and maintaining a nutrient database. J Am Diet Assoc. 1988;88:1268-1271.
40. Spector ER, Smith SM, Sibonga JD. Skeletal effects of long-duration head-down bed rest. Aviat Space Environ Med. 2009;80:A23-A28.
41. Kang JX, Weylandt KH. Modulation of inflammatory cytokines by omega-3 fatty acids. Subcell Biochem. 2008;49:133-143.
42. Chopra V, Fadl AA, Sha J, Chopra S, Galindo CL, Chopra AK. Alterations in the virulence potential of enteric pathogens and bacterial-host cell interactions under simulated microgravity conditions. J Toxicol Environ Health A. 2006;69:1345-1370.
43. Bakos A, Varkonyi A, Minarovits J, Batkai L. Effect of simulated microgravity on human lymphocytes. J Gravit Physiol. 2001;8:P69-70.
44. Ulbrich C, Westphal K, Baatout S, et al. Effects of basic fibroblast growth factor on endothelial cells under conditions of simulated microgravity. J Cell Biochem. 2008;104:1324-1341.
45. Granet C, Boutahar N, Vico L, Alexandre C, Lafage-Proust MH. MAPK and SRC-kinases control EGR-1 and NF-κB inductions by changes in mechanical environment in osteoblasts. Biochem Biophys Res Commun. 2001;284:622-631.
46. Kwon O, Tranter M, Jones WK, Sankovic JM, Banerjee RK. Differential translocation of nuclear factor-κB in a cardiac muscle cell line under gravitational changes. J Biomech Eng. 2009;131:064503-064507.
47. Wise KC, Manna SK, Yamauchi K, et al. Activation of nuclear transcription factor-κB in mouse brain induced by a simulated microgravity environment. In Vitro Cell Dev Biol Anim. 2005;41:118-123.
48. Bar-Shai M, Carmeli E, Reznick AZ. The role of NF-κB in protein breakdown in immobilization, aging, and exercise: from basic processes to promotion of health. Ann N Y Acad Sci. 2005;1057:431-447.
49. Visioli F, Rise P, Barassi MC, Marangoni F, Galli C. Dietary intake of fish vs. formulations leads to higher plasma concentrations of n-3 fatty acids. Lipids. 2003;38:415-418.
50. Rousseau JH, Kleppinger A, Kenny AM. Self-reported dietary intake of omega-3 fatty acids and association with bone and lower extremity function. J Am Geriatr Soc. 2009; 57: 1781-1788.
51. Griel AE, Kris-Etherton PM, Hilpert KF, Zhao G, West SG, Corwin RL. An increase in dietary n-3 fatty acids decreases a marker of bone resorption in humans. Nutr J. 2007;6:2-10.
52. Bhattacharya A, Rahman M, Sun D, Fernandes G. Effect of fish oil on bone mineral density in aging C57BL/6 female mice. J Nutr Biochem. 2007;18:372-379.
53. Tisdale MJ. Mechanisms of cancer cachexia. Physiol Rev. 2009;89:381-410.
54. Fearon KC, Barber MD, Moses AG, et al. Double-blind, placebo-controlled, randomized study of eicosapentaenoic acid diester in patients with cancer cachexia. J Clin Oncol. 2006;24:3401-3407.
55. Khal J, Tisdale MJ. Downregulation of muscle protein degradation in sepsis by eicosapentaenoic acid (EPA). Biochem Biophys Res Commun. 2008;375:238-240.
56. Turner ND, Braby LA, Ford J, Lupton JR. Opportunities for nutritional amelioration of radiation-induced cellular damage. Nutrition. 2002;18:904-912.
57. Davidson LA, Nguyen DV, Hokanson RM, et al. Chemopreventive n-3 polyunsaturated fatty acids reprogram genetic signatures during colon cancer initiation and progression in the rat. Cancer Res. 2004;64:6797-6804.
58. Chapkin RS, Davidson LA, Ly L, Weeks BR, Lupton JR, McMurray DN. Immunomodulatory effects of (n-3) fatty acids: putative link to inflammation and colon cancer. J Nutr. 2007;137:200S-204S.
59. Hong MY, Bancroft LK, Turner ND, et al. Fish oil decreases oxidative DNA damage by enhancing apoptosis in rat colon. Nutr Cancer. 2005;52:166-175.
60. Sanders LM, Henderson CE, Hong MY, et al. An increase in reactive oxygen species by dietary fish oil coupled with the attenuation of antioxidant defenses by dietary pectin enhances rat colonocyte apoptosis. J Nutr. 2004;134:3233-3238.
61. Vanamala J, Glagolenko A, Yang P, et al. Dietary fish oil and pectin enhance colonocyte apoptosis in part through suppression of PPARd/PGE2 and elevation of PGE3. Carcinogenesis. 2008;29:790-796.