-
1
-
-
84875423827
-
The ATM protein kinase: Regulating the cellular response to genotoxic stress, and more
-
Shiloh, Y. & Ziv, Y. The ATM protein kinase: regulating the cellular response to genotoxic stress, and more. Nat. Rev. Mol. Cell Biol. 14, 197-210 (2013).
-
(2013)
Nat. Rev. Mol. Cell Biol.
, vol.14
, pp. 197-210
-
-
Shiloh, Y.1
Ziv, Y.2
-
2
-
-
84866741381
-
Crosstalk between chromatin state and DNA damage response in cellular senescence and cancer
-
Sulli, G., Di Micco, R. & d'Adda di Fagagna, F. Crosstalk between chromatin state and DNA damage response in cellular senescence and cancer. Nat. Rev. Cancer 12, 709-720 (2012).
-
(2012)
Nat. Rev. Cancer
, vol.12
, pp. 709-720
-
-
Sulli, G.1
Di Micco, R.2
D'Adda Di Fagagna, F.3
-
3
-
-
36949026694
-
Activation and regulation of ATM kinase activity in response to DNA double-strand breaks
-
Lee, J. H. & Paull, T. T. Activation and regulation of ATM kinase activity in response to DNA double-strand breaks. Oncogene 26, 7741-7748 (2007).
-
(2007)
Oncogene
, vol.26
, pp. 7741-7748
-
-
Lee, J.H.1
Paull, T.T.2
-
4
-
-
68249096784
-
Persistent DNA damage signalling triggers senescenceassociated inflammatory cytokine secretion
-
Rodier, F. et al. Persistent DNA damage signalling triggers senescenceassociated inflammatory cytokine secretion. Nat. Cell Biol. 11, 973-979 (2009).
-
(2009)
Nat. Cell Biol.
, vol.11
, pp. 973-979
-
-
Rodier, F.1
-
5
-
-
84860914325
-
Nutrient deprivation regulates DNA damage repair in cardiomyocytes via loss of the base-excision repair enzyme OGG1
-
Siggens, L., Figg, N., Bennett, M. & Foo, R. Nutrient deprivation regulates DNA damage repair in cardiomyocytes via loss of the base-excision repair enzyme OGG1. FASEB J. 26, 2117-2124 (2012).
-
(2012)
FASEB J.
, vol.26
, pp. 2117-2124
-
-
Siggens, L.1
Figg, N.2
Bennett, M.3
Foo, R.4
-
6
-
-
33947520124
-
P53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload
-
Sano, M. et al. p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload. Nature 446, 444-448 (2007).
-
(2007)
Nature
, vol.446
, pp. 444-448
-
-
Sano, M.1
-
7
-
-
84455180756
-
BRCA1 is an essential regulator of heart function and survival following myocardial infarction
-
Shukla, P. C. et al. BRCA1 is an essential regulator of heart function and survival following myocardial infarction. Nat. Commun. 2, 593 (2011).
-
(2011)
Nat. Commun.
, vol.2
, pp. 593
-
-
Shukla, P.C.1
-
8
-
-
0031281259
-
Protection against myocardial ischemia and reperfusion injury by 3- aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase
-
Zingarelli, B., Cuzzocrea, S., Zsengeller, Z., Salzman, A. L. & Szabo, C. Protection against myocardial ischemia and reperfusion injury by 3- aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase. Cardiovasc. Res. 36, 205-215 (1997).
-
(1997)
Cardiovasc. Res.
, vol.36
, pp. 205-215
-
-
Zingarelli, B.1
Cuzzocrea, S.2
Zsengeller, Z.3
Salzman, A.L.4
Szabo, C.5
-
9
-
-
0032190895
-
Detection of oxidative DNA damage to ischemic reperfused rat hearts by 8-hydroxydeoxyguanosine formation
-
Cordis, G. A., Maulik, G., Bagchi, D., Riedel, W. & Das, D. K. Detection of oxidative DNA damage to ischemic reperfused rat hearts by 8-hydroxydeoxyguanosine formation. J. Mol. Cell. Cardiol. 30, 1939-1944 (1998).
-
(1998)
J. Mol. Cell. Cardiol.
, vol.30
, pp. 1939-1944
-
-
Cordis, G.A.1
Maulik, G.2
Bagchi, D.3
Riedel, W.4
Das, D.K.5
-
10
-
-
34250654965
-
The comet assay: A method to measure DNA damage in individual cells
-
Olive, P. L. & Banath, J. P. The comet assay: a method to measure DNA damage in individual cells. Nat. Protoc. 1, 23-29 (2006).
-
(2006)
Nat. Protoc.
, vol.1
, pp. 23-29
-
-
Olive, P.L.1
Banath, J.P.2
-
11
-
-
79952202405
-
In situ ligation: A decade and a half of experience
-
Hornsby, P. J. & Didenko, V. V. In situ ligation: a decade and a half of experience. Methods Mol. Biol. 682, 49-63 (2011).
-
(2011)
Methods Mol. Biol.
, vol.682
, pp. 49-63
-
-
Hornsby, P.J.1
Didenko, V.V.2
-
12
-
-
31144471460
-
The role of NBS1 in DNA double strand break repair, telomere stability, and cell cycle checkpoint control
-
Zhang, Y., Zhou, J. & Lim, C. U. The role of NBS1 in DNA double strand break repair, telomere stability, and cell cycle checkpoint control. Cell Res. 16, 45-54 (2006).
-
(2006)
Cell Res.
, vol.16
, pp. 45-54
-
-
Zhang, Y.1
Zhou, J.2
Lim, C.U.3
-
13
-
-
77950023283
-
PARP inhibition: PARP1 and beyond
-
Rouleau, M., Patel, A., Hendzel, M. J., Kaufmann, S. H. & Poirier, G. G. PARP inhibition: PARP1 and beyond. Nat. Rev. Cancer 10, 293-301 (2010).
-
(2010)
Nat. Rev. Cancer
, vol.10
, pp. 293-301
-
-
Rouleau, M.1
Patel, A.2
Hendzel, M.J.3
Kaufmann, S.H.4
Poirier, G.G.5
-
14
-
-
48249095920
-
Single-strand break repair and genetic disease
-
Caldecott, K. W. Single-strand break repair and genetic disease. Nat. Rev. Genet. 9, 619-631 (2008).
-
(2008)
Nat. Rev. Genet.
, vol.9
, pp. 619-631
-
-
Caldecott, K.W.1
-
15
-
-
84901687870
-
Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes
-
Katyal, S. et al. Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes. Nat. Neurosci. 17, 813-821 (2014).
-
(2014)
Nat. Neurosci.
, vol.17
, pp. 813-821
-
-
Katyal, S.1
-
16
-
-
0041378046
-
XRCC1 and DNA strand break repair
-
Caldecott, K. W. XRCC1 and DNA strand break repair. DNA Repair 2, 955-969 (2003).
-
(2003)
DNA Repair
, vol.2
, pp. 955-969
-
-
Caldecott, K.W.1
-
17
-
-
0033561152
-
Requirement for the Xrcc1 DNA base excision repair gene during early mouse development
-
Tebbs, R. S. et al. Requirement for the Xrcc1 DNA base excision repair gene during early mouse development. Dev. Biol. 208, 513-529 (1999).
-
(1999)
Dev. Biol.
, vol.208
, pp. 513-529
-
-
Tebbs, R.S.1
-
18
-
-
68149161604
-
The genesis of cerebellar interneurons and the prevention of neural DNA damage require XRCC1
-
Lee, Y. et al. The genesis of cerebellar interneurons and the prevention of neural DNA damage require XRCC1. Nat. Neurosci. 12, 973-980 (2009).
-
(2009)
Nat. Neurosci.
, vol.12
, pp. 973-980
-
-
Lee, Y.1
-
19
-
-
33645736981
-
Cardiac-specific deletion of Gata4 reveals its requirement for hypertrophy, compensation, and myocyte viability
-
Oka, T. et al. Cardiac-specific deletion of Gata4 reveals its requirement for hypertrophy, compensation, and myocyte viability. Circ. Res. 98, 837-845 (2006).
-
(2006)
Circ. Res.
, vol.98
, pp. 837-845
-
-
Oka, T.1
-
20
-
-
13744258586
-
The accumulation of MMS-induced single strand breaks in G1 phase is recombinogenic in DNA polymerase beta defective mammalian cells
-
Pascucci, B., Russo, M. T., Crescenzi, M., Bignami, M. & Dogliotti, E. The accumulation of MMS-induced single strand breaks in G1 phase is recombinogenic in DNA polymerase beta defective mammalian cells. Nucleic Acids Res. 33, 280-288 (2005).
-
(2005)
Nucleic Acids Res.
, vol.33
, pp. 280-288
-
-
Pascucci, B.1
Russo, M.T.2
Crescenzi, M.3
Bignami, M.4
Dogliotti, E.5
-
21
-
-
45849099050
-
Living on a break: Cellular senescence as a DNA-damage response
-
d'Adda di Fagagna, F. Living on a break: cellular senescence as a DNA-damage response. Nat. Rev. Cancer 8, 512-522 (2008).
-
(2008)
Nat. Rev. Cancer
, vol.8
, pp. 512-522
-
-
D'Adda Di Fagagna, F.1
-
22
-
-
84901288438
-
The role of senescent cells in ageing
-
van Deursen, J. M. The role of senescent cells in ageing. Nature 509, 439-446 (2014).
-
(2014)
Nature
, vol.509
, pp. 439-446
-
-
Van Deursen, J.M.1
-
23
-
-
84891713034
-
Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor
-
Coppe, J. P. et al. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol. 6, 2853-2868 (2008).
-
(2008)
PLoS Biol.
, vol.6
, pp. 2853-2868
-
-
Coppe, J.P.1
-
24
-
-
77957374335
-
ATM- and NEMO-dependent ELKS ubiquitination coordinates TAK1-mediated IKK activation in response to genotoxic stress
-
Wu, Z. H. et al. ATM- and NEMO-dependent ELKS ubiquitination coordinates TAK1-mediated IKK activation in response to genotoxic stress. Mol. Cell 40, 75-86 (2010).
-
(2010)
Mol. Cell
, vol.40
, pp. 75-86
-
-
Wu, Z.H.1
-
25
-
-
77957333810
-
A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-kappaB activation
-
Hinz, M. et al. A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-kappaB activation. Mol. Cell 40, 63-74 (2010).
-
(2010)
Mol. Cell
, vol.40
, pp. 63-74
-
-
Hinz, M.1
-
26
-
-
79960352030
-
A cytosolic ATM/NEMO/RIP1 complex recruits TAK1 to mediate the NF-kappaB and p38 mitogen-activated protein kinase (MAPK)/ MAPK-activated protein 2 responses to DNA damage
-
Yang, Y. et al. A cytosolic ATM/NEMO/RIP1 complex recruits TAK1 to mediate the NF-kappaB and p38 mitogen-activated protein kinase (MAPK)/ MAPK-activated protein 2 responses to DNA damage. Mol. Cell. Biol. 31, 2774-2786 (2011).
-
(2011)
Mol. Cell. Biol.
, vol.31
, pp. 2774-2786
-
-
Yang, Y.1
-
27
-
-
77958191599
-
ATM activation by oxidative stress
-
Guo, Z., Kozlov, S., Lavin, M. F., Person, M. D. & Paull, T. T. ATM activation by oxidative stress. Science 330, 517-521 (2010).
-
(2010)
Science
, vol.330
, pp. 517-521
-
-
Guo, Z.1
Kozlov, S.2
Lavin, M.F.3
Person, M.D.4
Paull, T.T.5
-
28
-
-
15844426692
-
Atm-deficient mice: A paradigm of ataxia telangiectasia
-
Barlow, C. et al. Atm-deficient mice: a paradigm of ataxia telangiectasia. Cell 86, 159-171 (1996).
-
(1996)
Cell
, vol.86
, pp. 159-171
-
-
Barlow, C.1
-
29
-
-
0032948849
-
Atm haploinsufficiency results in increased sensitivity to sublethal doses of ionizing radiation in mice
-
Barlow, C., Eckhaus, M. A., Schaffer, A. A. & Wynshaw-Boris, A. Atm haploinsufficiency results in increased sensitivity to sublethal doses of ionizing radiation in mice. Nat. Genet. 21, 359-360 (1999).
-
(1999)
Nat. Genet.
, vol.21
, pp. 359-360
-
-
Barlow, C.1
Eckhaus, M.A.2
Schaffer, A.A.3
Wynshaw-Boris, A.4
-
30
-
-
33746731657
-
Elevated levels of oxidative DNA damage in serum and myocardium of patients with heart failure
-
Kono, Y. et al. Elevated levels of oxidative DNA damage in serum and myocardium of patients with heart failure. Circ. J. 70, 1001-1005 (2006).
-
(2006)
Circ. J.
, vol.70
, pp. 1001-1005
-
-
Kono, Y.1
-
31
-
-
18644386254
-
Mutation of TDP1, encoding a topoisomerase I-dependent DNA damage repair enzyme, in spinocerebellar ataxia with axonal neuropathy
-
Takashima, H. et al. Mutation of TDP1, encoding a topoisomerase I-dependent DNA damage repair enzyme, in spinocerebellar ataxia with axonal neuropathy. Nat. Genet. 32, 267-272 (2002).
-
(2002)
Nat. Genet.
, vol.32
, pp. 267-272
-
-
Takashima, H.1
-
32
-
-
14544268980
-
Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1
-
El-Khamisy, S. F. et al. Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1. Nature 434, 108-113 (2005).
-
(2005)
Nature
, vol.434
, pp. 108-113
-
-
El-Khamisy, S.F.1
-
33
-
-
36248984333
-
TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo
-
Katyal, S. et al. TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo. EMBO J. 26, 4720-4731 (2007).
-
(2007)
EMBO J.
, vol.26
, pp. 4720-4731
-
-
Katyal, S.1
-
34
-
-
84939462768
-
Deficiency of ataxia telangiectasia mutated kinase delays inflammatory response in the heart following myocardial infarction
-
Daniel, L. L. et al. Deficiency of ataxia telangiectasia mutated kinase delays inflammatory response in the heart following myocardial infarction. J. Am. Heart Assoc. 3, e001286 (2014).
-
(2014)
J. Am. Heart Assoc.
, vol.3
, pp. e001286
-
-
Daniel, L.L.1
-
35
-
-
84892659200
-
Deficiency of ataxia telangiectasia mutated kinase modulates cardiac remodeling following myocardial infarction: Involvement in fibrosis and apoptosis
-
Foster, C. R. et al. Deficiency of ataxia telangiectasia mutated kinase modulates cardiac remodeling following myocardial infarction: involvement in fibrosis and apoptosis. PLoS ONE 8, e83513 (2013).
-
(2013)
PLoS ONE
, vol.8
, pp. e83513
-
-
Foster, C.R.1
-
36
-
-
33745867638
-
Poly(ADP-ribose): Novel functions for an old molecule
-
Schreiber, V., Dantzer, F., Ame, J. C. & de Murcia, G. Poly(ADP-ribose): novel functions for an old molecule. Nat. Rev. Mol. Cell Biol. 7, 517-528 (2006).
-
(2006)
Nat. Rev. Mol. Cell Biol.
, vol.7
, pp. 517-528
-
-
Schreiber, V.1
Dantzer, F.2
Ame, J.C.3
De Murcia, G.4
-
37
-
-
33845301167
-
Poly(ADP-ribose) (PAR) polymer is a death signal
-
Andrabi, S. A. et al. Poly(ADP-ribose) (PAR) polymer is a death signal. Proc. Natl Acad. Sci. USA 103, 18308-18313 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 18308-18313
-
-
Andrabi, S.A.1
-
38
-
-
79953840957
-
Poly(ADP-ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1-dependent cell death (parthanatos)
-
Wang, Y. et al. Poly(ADP-ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1-dependent cell death (parthanatos). Sci. Signal. 4, ra20 (2011).
-
(2011)
Sci. Signal.
, vol.4
, pp. ra20
-
-
Wang, Y.1
-
39
-
-
80055101553
-
Transverse aortic constriction in mice
-
deAlmeida, A. C., van Oort, R. J. & Wehrens, X. H. Transverse aortic constriction in mice. J. Vis. Exp. 38, 1729 (2010).
-
(2010)
J. Vis. Exp.
, vol.38
, pp. 1729
-
-
Dealmeida, A.C.1
Van Oort, R.J.2
Wehrens, X.H.3
-
40
-
-
0023726219
-
Prenatal ethylene glycol monomethyl ether (EGME) exposure produces electrocardiographic changes in the rat
-
Toraason, M. & Breitenstein, M. Prenatal ethylene glycol monomethyl ether (EGME) exposure produces electrocardiographic changes in the rat. Toxicol. Appl. Pharmacol. 95, 321-327 (1988).
-
(1988)
Toxicol. Appl. Pharmacol.
, vol.95
, pp. 321-327
-
-
Toraason, M.1
Breitenstein, M.2
-
41
-
-
74949085470
-
Cardiac mast cells cause atrial fibrillation through PDGF-Amediated fibrosis in pressure-overloaded mouse hearts
-
Liao, C. H. et al. Cardiac mast cells cause atrial fibrillation through PDGF-Amediated fibrosis in pressure-overloaded mouse hearts. J. Clin. Invest. 120, 242-253 (2010).
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 242-253
-
-
Liao, C.H.1
-
42
-
-
26444570832
-
Expression of immunological molecules by cardiomyocytes and inflammatory and interstitial cells in rat autoimmune myocarditis
-
Yoshida, T. et al. Expression of immunological molecules by cardiomyocytes and inflammatory and interstitial cells in rat autoimmune myocarditis. Cardiovasc. Res. 68, 278-288 (2005).
-
(2005)
Cardiovasc. Res.
, vol.68
, pp. 278-288
-
-
Yoshida, T.1
|