메뉴 건너뛰기




Volumn 8, Issue 1, 2017, Pages

The gut microbiome in atherosclerotic cardiovascular disease

(42)  Jie, Zhuye a,b   Xia, Huihua a,b   Zhong, Shi Long c   Feng, Qiang a,b,d,e,o   Li, Shenghui a   Liang, Suisha a,b   Zhong, Huanzi a,b,e   Liu, Zhipeng a,f   Gao, Yuan a,b   Zhao, Hui a   Zhang, Dongya a   Su, Zheng a   Fang, Zhiwei a   Lan, Zhou a   Li, Junhua a,b,g   Xiao, Liang a,b,d   Li, Jun a   Li, Ruijun h   Li, Xiaoping a,b   Li, Fei a,b,f   more..


Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ATORVASTATIN; CITRATE POTASSIUM; CLOPIDOGREL; FONDAPARINUX; HEPARIN; ISOSORBIDE DINITRATE; ISOSORBIDE MONONITRATE; METFORMIN; METOPROLOL; PERINDOPRIL; POTASSIUM CHLORIDE;

EID: 85031012310     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/s41467-017-00900-1     Document Type: Article
Times cited : (1072)

References (62)
  • 1
    • 84958837712 scopus 로고    scopus 로고
    • The gut microbiome, diet, and links to cardiometabolic and chronic disorders
    • Aron-Wisnewsky, J. & Clement, K. The gut microbiome, diet, and links to cardiometabolic and chronic disorders. Nat. Rev. Nephrol. 12, 169-181 (2016).
    • (2016) Nat. Rev. Nephrol. , vol.12 , pp. 169-181
    • Aron-Wisnewsky, J.1    Clement, K.2
  • 2
    • 84858376593 scopus 로고    scopus 로고
    • The impact of the gut microbiota on human health: An integrative view
    • Clemente, J. C., Ursell, L. K., Parfrey, L. W. & Knight, R. The impact of the gut microbiota on human health: an integrative view. Cell 148, 1258-1270 (2012).
    • (2012) Cell , vol.148 , pp. 1258-1270
    • Clemente, J.C.1    Ursell, L.K.2    Parfrey, L.W.3    Knight, R.4
  • 3
    • 84978127724 scopus 로고    scopus 로고
    • Metagenome-wide association studies: Fine-mining the microbiome
    • Wang, J. & Jia, H. Metagenome-wide association studies: fine-mining the microbiome. Nat. Rev. Microbiol. 14, 508-522 (2016).
    • (2016) Nat. Rev. Microbiol. , vol.14 , pp. 508-522
    • Wang, J.1    Jia, H.2
  • 4
    • 84867074831 scopus 로고    scopus 로고
    • A metagenome-wide association study of gut microbiota in type 2 diabetes
    • Qin, J. et al. A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature 490,55-60 (2012).
    • (2012) Nature , vol.490 , pp. 55-60
    • Qin, J.1
  • 5
    • 84878709716 scopus 로고    scopus 로고
    • Gut metagenome in European women with normal, impaired and diabetic glucose control
    • Karlsson, F. H. et al. Gut metagenome in European women with normal, impaired and diabetic glucose control. Nature 498,99-103 (2013).
    • (2013) Nature , vol.498 , pp. 99-103
    • Karlsson, F.H.1
  • 6
    • 84949772416 scopus 로고    scopus 로고
    • Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota
    • Forslund, K. et al. Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota. Nature 528, 262-266 (2015).
    • (2015) Nature , vol.528 , pp. 262-266
    • Forslund, K.1
  • 7
    • 84883057637 scopus 로고    scopus 로고
    • Dietary intervention impact on gut microbial gene richness
    • Cotillard, A. et al. Dietary intervention impact on gut microbial gene richness. Nature 500, 585-588 (2013).
    • (2013) Nature , vol.500 , pp. 585-588
    • Cotillard, A.1
  • 8
    • 84883110880 scopus 로고    scopus 로고
    • Richness of human gut microbiome correlates with metabolic markers
    • Le Chatelier, E. et al. Richness of human gut microbiome correlates with metabolic markers. Nature 500, 541-546 (2013).
    • (2013) Nature , vol.500 , pp. 541-546
    • Le Chatelier, E.1
  • 9
    • 84947812071 scopus 로고    scopus 로고
    • Personalized nutrition by prediction of glycemic responses
    • Zeevi, D. et al. Personalized nutrition by prediction of glycemic responses. Cell 163, 1079-1094 (2015).
    • (2015) Cell , vol.163 , pp. 1079-1094
    • Zeevi, D.1
  • 10
    • 84871814687 scopus 로고    scopus 로고
    • Symptomatic atherosclerosis is associated with an altered gut metagenome
    • Karlsson, F. H. et al. Symptomatic atherosclerosis is associated with an altered gut metagenome. Nat. Commun. 3, 1245 (2012).
    • (2012) Nat. Commun. , vol.3 , pp. 1245
    • Karlsson, F.H.1
  • 11
    • 79953733693 scopus 로고    scopus 로고
    • Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
    • Wang, Z. et al. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature 472,57-63 (2011).
    • (2011) Nature , vol.472 , pp. 57-63
    • Wang, Z.1
  • 12
    • 84876563088 scopus 로고    scopus 로고
    • Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk
    • Tang, W. H. et al. Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. N. Engl. J. Med. 368, 1575-1584 (2013).
    • (2013) N. Engl. J. Med. , vol.368 , pp. 1575-1584
    • Tang, W.H.1
  • 13
    • 84877331372 scopus 로고    scopus 로고
    • Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis
    • Koeth, R. A. et al. Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat. Med. 19, 576-585 (2013).
    • (2013) Nat. Med. , vol.19 , pp. 576-585
    • Koeth, R.A.1
  • 14
    • 84950297830 scopus 로고    scopus 로고
    • Non-lethal Inhibition of gut microbial trimethylamine production for the treatment of atherosclerosis
    • Wang, Z. et al. Non-lethal Inhibition of gut microbial trimethylamine production for the treatment of atherosclerosis. Cell 163, 1585-1595 (2015).
    • (2015) Cell , vol.163 , pp. 1585-1595
    • Wang, Z.1
  • 15
    • 33645064033 scopus 로고    scopus 로고
    • Detection of diverse bacterial signatures in atherosclerotic lesions of patients with coronary heart disease
    • Ott, S. J. et al. Detection of diverse bacterial signatures in atherosclerotic lesions of patients with coronary heart disease. Circulation 113, 929-937 (2006).
    • (2006) Circulation , vol.113 , pp. 929-937
    • Ott, S.J.1
  • 16
    • 79952758083 scopus 로고    scopus 로고
    • Human oral, gut, and plaque microbiota in patients with atherosclerosis
    • Koren, O. et al. Human oral, gut, and plaque microbiota in patients with atherosclerosis. Proc. Natl Acad. Sci. USA 108, 4592-4598 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 4592-4598
    • Koren, O.1
  • 17
    • 84904015626 scopus 로고    scopus 로고
    • Bacteria present in carotid arterial plaques are found as biofilm deposits which may contribute to enhanced risk of plaque rupture
    • Lanter, B. B., Sauer, K. & Davies, D. G. Bacteria present in carotid arterial plaques are found as biofilm deposits which may contribute to enhanced risk of plaque rupture. MBio 5, e01206-e01214 (2014).
    • (2014) MBio , vol.5 , pp. e01206-e01214
    • Lanter, B.B.1    Sauer, K.2    Davies, D.G.3
  • 18
    • 84905730165 scopus 로고    scopus 로고
    • An integrated catalog of reference genes in the human gut microbiome
    • Li, J. et al. An integrated catalog of reference genes in the human gut microbiome. Nat. Biotechnol. 32, 834-841 (2014).
    • (2014) Nat. Biotechnol. , vol.32 , pp. 834-841
    • Li, J.1
  • 19
    • 84905730761 scopus 로고    scopus 로고
    • Identification and assembly of genomes and genetic elements in complex metagenomic samples without using reference genomes
    • Nielsen, H. B. et al. Identification and assembly of genomes and genetic elements in complex metagenomic samples without using reference genomes. Nat. Biotechnol. 32, 822-828 (2014).
    • (2014) Nat. Biotechnol. , vol.32 , pp. 822-828
    • Nielsen, H.B.1
  • 20
    • 9144260143 scopus 로고    scopus 로고
    • Ribosomal DNA sequence analysis of mucosa-associated bacteria in Crohn's disease
    • Prindiville, T., Cantrell, M. & Wilson, K. H. Ribosomal DNA sequence analysis of mucosa-associated bacteria in Crohn's disease. Inflamm. Bowel. Dis. 10, 824-833 (2004).
    • (2004) Inflamm. Bowel. Dis. , vol.10 , pp. 824-833
    • Prindiville, T.1    Cantrell, M.2    Wilson, K.H.3
  • 21
    • 78649686679 scopus 로고    scopus 로고
    • A pyrosequencing study in twins shows that gastrointestinal microbial profiles vary with inflammatory bowel disease phenotypes
    • e1
    • Willing, B. P. et al. A pyrosequencing study in twins shows that gastrointestinal microbial profiles vary with inflammatory bowel disease phenotypes. Gastroenterology 139, 1844-1854.e1 (2010).
    • (2010) Gastroenterology , vol.139 , pp. 1844-1854
    • Willing, B.P.1
  • 22
    • 79953748870 scopus 로고    scopus 로고
    • Dysbiosis of the faecal microbiota in patients with Crohn's disease and their unaffected relatives
    • Joossens, M. et al. Dysbiosis of the faecal microbiota in patients with Crohn's disease and their unaffected relatives. Gut 60, 631-637 (2011).
    • (2011) Gut , vol.60 , pp. 631-637
    • Joossens, M.1
  • 23
  • 24
    • 84880439384 scopus 로고    scopus 로고
    • Predicting and manipulating cardiac drug inactivation by the human gut bacterium
    • Haiser, H. J. et al. Predicting and manipulating cardiac drug inactivation by the human gut bacterium Eggerthella lenta. Science 341, 295-298 (2013).
    • (2013) Eggerthella Lenta. Science , vol.341 , pp. 295-298
    • Haiser, H.J.1
  • 25
    • 84938817346 scopus 로고    scopus 로고
    • The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment
    • Zhang, X. et al. The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment. Nat. Med. 21 , 895-905 (2015).
    • (2015) Nat. Med. , vol.21 , pp. 895-905
    • Zhang, X.1
  • 26
    • 84961392884 scopus 로고    scopus 로고
    • Strain-level microbial epidemiology and population genomics from shotgun metagenomics
    • Scholz, M. et al. Strain-level microbial epidemiology and population genomics from shotgun metagenomics. Nat. Methods 13, 435-438 (2016).
    • (2016) Nat. Methods , vol.13 , pp. 435-438
    • Scholz, M.1
  • 27
    • 84861904854 scopus 로고    scopus 로고
    • VFDB 2012 update: Toward the genetic diversity and molecular evolution of bacterial virulence factors
    • Chen, L., Xiong, Z., Sun, L., Yang, J. & Jin, Q. VFDB 2012 update: toward the genetic diversity and molecular evolution of bacterial virulence factors. Nucleic Acids Res. 40, D641-D645 (2012).
    • (2012) Nucleic Acids Res. , vol.40 , pp. D641-D645
    • Chen, L.1    Xiong, Z.2    Sun, L.3    Yang, J.4    Jin, Q.5
  • 28
    • 23744504984 scopus 로고    scopus 로고
    • Recognition of antimicrobial peptides by a bacterial sensor kinase
    • Bader, M. W. et al. Recognition of antimicrobial peptides by a bacterial sensor kinase. Cell 122, 461-472 (2005).
    • (2005) Cell , vol.122 , pp. 461-472
    • Bader, M.W.1
  • 29
    • 84907855825 scopus 로고    scopus 로고
    • The influence of whole grain products and red meat on intestinal microbiota composition in normal weight adults: A randomized crossover intervention trial
    • Foerster, J. et al. The influence of whole grain products and red meat on intestinal microbiota composition in normal weight adults: a randomized crossover intervention trial. PLoS ONE 9, e109606 (2014).
    • (2014) PLoS ONE , vol.9 , pp. e109606
    • Foerster, J.1
  • 30
    • 85031042137 scopus 로고    scopus 로고
    • Effects of the dietary approaches to stop hypertension (DASH) diet and sodium intake on serum uric acid
    • Juraschek, S. P., Gelber, A. C., Choi, H. K., Appel, L. J. & Miller, E. R. Effects of the dietary approaches to stop hypertension (DASH) diet and sodium intake on serum uric acid. Arthritis Rheumatol. 11, 300-308 (2016).
    • (2016) Arthritis Rheumatol. , vol.11 , pp. 300-308
    • Juraschek, S.P.1    Gelber, A.C.2    Choi, H.K.3    Appel, L.J.4    Miller, E.R.5
  • 31
    • 84858983547 scopus 로고    scopus 로고
    • KEGG for integration and interpretation of large-scale molecular data sets
    • Kanehisa, M., Goto, S., Sato, Y., Furumichi, M. & Tanabe, M. KEGG for integration and interpretation of large-scale molecular data sets. Nucleic Acids Res. 40, D109-D114 (2012).
    • (2012) Nucleic Acids Res. , vol.40 , pp. D109-D114
    • Kanehisa, M.1    Goto, S.2    Sato, Y.3    Furumichi, M.4    Tanabe, M.5
  • 33
    • 84876014848 scopus 로고    scopus 로고
    • Characterization of platelet aminophospholipid externalization reveals fatty acids as molecular determinants that regulate coagulation
    • Clark, S. R. et al. Characterization of platelet aminophospholipid externalization reveals fatty acids as molecular determinants that regulate coagulation. Proc. Natl Acad. Sci. USA 110, 5875-5880 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 5875-5880
    • Clark, S.R.1
  • 34
    • 84968901892 scopus 로고    scopus 로고
    • Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity
    • Zhernakova, A. et al. Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity. Science 352, 565-569 (2016).
    • (2016) Science , vol.352 , pp. 565-569
    • Zhernakova, A.1
  • 35
    • 85021320590 scopus 로고    scopus 로고
    • Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug
    • Wu, H. et al. Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug. Nat. Med. 23, 850-858 (2017).
    • (2017) Nat. Med. , vol.23 , pp. 850-858
    • Wu, H.1
  • 36
    • 84922392216 scopus 로고    scopus 로고
    • Systems biology analysis of omeprazole therapy in cirrhosis demonstrates significant shifts in gut microbiota composition and function
    • Bajaj, J. S. et al. Systems biology analysis of omeprazole therapy in cirrhosis demonstrates significant shifts in gut microbiota composition and function. Am. J. Physiol. Gastrointest. Liver Physiol. 307, G951-G957 (2014).
    • (2014) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.307 , pp. G951-G957
    • Bajaj, J.S.1
  • 37
    • 84963837637 scopus 로고    scopus 로고
    • Proton pump inhibitors affect the gut microbiome
    • Imhann, F. et al. Proton pump inhibitors affect the gut microbiome. Gut 2015, 310376 (2015).
    • (2015) Gut , vol.2015 , pp. 310376
    • Imhann, F.1
  • 38
    • 84966680487 scopus 로고    scopus 로고
    • Proton pump inhibitors alter the composition of the gut microbiota
    • Jackson, M. A. et al. Proton pump inhibitors alter the composition of the gut microbiota. Gut 2015, 310861 (2015).
    • (2015) Gut , vol.2015 , pp. 310861
    • Jackson, M.A.1
  • 39
    • 0035133496 scopus 로고    scopus 로고
    • Fitting multivariate models to community data: A comment on distance-based redundancy analysis
    • McArdle, B. H. & Anderson, M. J. Fitting multivariate models to community data: a comment on distance-based redundancy analysis. Ecology 82, 290-297 (2001).
    • (2001) Ecology , vol.82 , pp. 290-297
    • McArdle, B.H.1    Anderson, M.J.2
  • 40
  • 41
    • 84920464091 scopus 로고    scopus 로고
    • Metagenomic heterogeneity explains dual immune effects of endotoxins
    • Brix, S., Eriksen, C., Larsen, J. M. & Bisgaard, H. Metagenomic heterogeneity explains dual immune effects of endotoxins. J. Allergy Clin. Immunol. 135, 277-280 (2015).
    • (2015) J. Allergy Clin. Immunol. , vol.135 , pp. 277-280
    • Brix, S.1    Eriksen, C.2    Larsen, J.M.3    Bisgaard, H.4
  • 42
    • 84959922537 scopus 로고    scopus 로고
    • Gut microbial metabolite TMAO enhances platelet hyperreactivity and thrombosis risk
    • Zhu, W. et al. Gut microbial metabolite TMAO enhances platelet hyperreactivity and thrombosis risk. Cell 165, 111-124 (2016).
    • (2016) Cell , vol.165 , pp. 111-124
    • Zhu, W.1
  • 44
    • 43749087841 scopus 로고    scopus 로고
    • Human metabolic phenotype diversity and its association with diet and blood pressure
    • Holmes, E. et al. Human metabolic phenotype diversity and its association with diet and blood pressure. Nature. 453, 396-400 (2008).
    • (2008) Nature. , vol.453 , pp. 396-400
    • Holmes, E.1
  • 45
    • 84969492201 scopus 로고    scopus 로고
    • Genetic determinants of the gut microbiome in UK twins
    • Goodrich, J. K. et al. Genetic determinants of the gut microbiome in UK twins. Cell Host. Microbe. 19, 731-743 (2016).
    • (2016) Cell Host. Microbe. , vol.19 , pp. 731-743
    • Goodrich, J.K.1
  • 46
    • 84907225684 scopus 로고    scopus 로고
    • Alterations of the human gut microbiome in liver cirrhosis
    • Qin, N. et al. Alterations of the human gut microbiome in liver cirrhosis. Nature 513,59-64 (2014).
    • (2014) Nature , vol.513 , pp. 59-64
    • Qin, N.1
  • 47
    • 85023608430 scopus 로고    scopus 로고
    • Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention
    • Liu, R. et al. Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention. Nat. Med. 23, 859-868 (2017).
    • (2017) Nat. Med. , vol.23 , pp. 859-868
    • Liu, R.1
  • 48
    • 84862141704 scopus 로고    scopus 로고
    • Human gut microbiome viewed across age and geography
    • Yatsunenko, T. et al. Human gut microbiome viewed across age and geography. Nature 486, 222-227 (2012).
    • (2012) Nature , vol.486 , pp. 222-227
    • Yatsunenko, T.1
  • 49
    • 84884700405 scopus 로고    scopus 로고
    • A mechanical signal transmitted by the flagellum controls signalling in Bacillus subtilis
    • Cairns, L. S., Marlow, V. L., Bissett, E., Ostrowski, A. & Stanley-Wall, N. R. A mechanical signal transmitted by the flagellum controls signalling in Bacillus subtilis. Mol. Microbiol. 90,6-21 (2013).
    • (2013) Mol. Microbiol. , vol.90 , pp. 6-21
    • Cairns, L.S.1    Marlow, V.L.2    Bissett, E.3    Ostrowski, A.4    Stanley-Wall, N.R.5
  • 50
    • 84959573656 scopus 로고    scopus 로고
    • Integrated metabolomics and metagenomics analysis of plasma and urine identified microbial metabolites associated with coronary heart disease
    • Feng, Q. et al. Integrated metabolomics and metagenomics analysis of plasma and urine identified microbial metabolites associated with coronary heart disease. Sci. Rep. 6, 22525 (2016).
    • (2016) Sci. Rep. , vol.6 , pp. 22525
    • Feng, Q.1
  • 51
    • 0032967877 scopus 로고    scopus 로고
    • Distance-based redundancy analysis: Testing multispecies responses in multifactorial ecological experiments
    • Legendre, P. & Anderson, M. J. Distance-based redundancy analysis: testing multispecies responses in multifactorial ecological experiments. Ecol. Monogr. 69, 1 (1999).
    • (1999) Ecol. Monogr. , vol.69 , pp. 1
    • Legendre, P.1    Anderson, M.J.2
  • 52
    • 14544268137 scopus 로고    scopus 로고
    • Uncovering transcriptional regulation of metabolism by using metabolic network topology
    • Patil, K. R. & Nielsen, J. Uncovering transcriptional regulation of metabolism by using metabolic network topology. Proc. Natl Acad. Sci. USA 102, 2685-2689 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 2685-2689
    • Patil, K.R.1    Nielsen, J.2
  • 53
    • 84924690678 scopus 로고    scopus 로고
    • Gut microbiome development along the colorectal adenoma-carcinoma sequence
    • Feng, Q. et al. Gut microbiome development along the colorectal adenoma-carcinoma sequence. Nat. Commun. 6, 6528 (2015).
    • (2015) Nat. Commun. , vol.6 , pp. 6528
    • Feng, Q.1
  • 54
    • 84929297936 scopus 로고    scopus 로고
    • Dynamics and stabilization of the human gut microbiome during the first year of life
    • Backhed, F. et al. Dynamics and stabilization of the human gut microbiome during the first year of life. Cell Host. Microbe. 17, 690-703 (2015).
    • (2015) Cell Host. Microbe. , vol.17 , pp. 690-703
    • Backhed, F.1
  • 55
    • 0001677717 scopus 로고
    • Controlling the false discovery rate: A practical and powerful approach to multiple testing
    • Benjamini, Y. & Hochberg, Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. R. Stat. Soc. Series B 57, 289-300 (1995).
    • (1995) J. R. Stat. Soc. Series B , vol.57 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 56
    • 84864722033 scopus 로고    scopus 로고
    • Gut microbiota composition correlates with diet and health in the elderly
    • Claesson, M. J. et al. Gut microbiota composition correlates with diet and health in the elderly. Nature 488, 178-184 (2016).
    • (2016) Nature , vol.488 , pp. 178-184
    • Claesson, M.J.1
  • 57
    • 84871837954 scopus 로고    scopus 로고
    • Microbial conversion of choline to trimethylamine requires a glycyl radical enzyme
    • Craciun, S. & Balskus, E. P. Microbial conversion of choline to trimethylamine requires a glycyl radical enzyme. Proc. Natl Acad. Sci. USA 109, 21307-21312 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 21307-21312
    • Craciun, S.1    Balskus, E.P.2
  • 58
    • 84896537331 scopus 로고    scopus 로고
    • Carnitine metabolism to trimethylamine by an unusual Rieske-type oxygenase from human microbiota
    • Zhu, Y. et al. Carnitine metabolism to trimethylamine by an unusual Rieske-type oxygenase from human microbiota. Proc. Natl Acad. Sci. USA 111 , 4268-4273 (2014).
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. 4268-4273
    • Zhu, Y.1
  • 59
    • 84910129274 scopus 로고    scopus 로고
    • γ-butyrobetaine is a proatherogenic intermediate in gut microbial metabolism ofL-carnitine to TMAO
    • Koeth, R. A. et al. γ-butyrobetaine is a proatherogenic intermediate in gut microbial metabolism ofL-carnitine to TMAO. Cell Metab. 20, 799-812 (2014).
    • (2014) Cell Metab. , vol.20 , pp. 799-812
    • Koeth, R.A.1
  • 61
    • 33845900991 scopus 로고    scopus 로고
    • Multivariate regression analysis of distance matrices for testing associations between gene expression patterns and related variables
    • Zapala, M. A. & Schork, N. J. Multivariate regression analysis of distance matrices for testing associations between gene expression patterns and related variables. Proc. Natl Acad. Sci. USA 103, 19430-19435 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 19430-19435
    • Zapala, M.A.1    Schork, N.J.2
  • 62
    • 84866549438 scopus 로고    scopus 로고
    • Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment
    • Morgan, X. C. et al. Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment. Genome Biol. 13, R79 (2012).
    • (2012) Genome Biol. , vol.13 , pp. R79
    • Morgan, X.C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.