메뉴 건너뛰기




Volumn 14, Issue 5, 2017, Pages 5671-5680

Immune-related adverse events during anticancer immunotherapy: Pathogenesis and management

Author keywords

Cytotoxic T lymphocyte associated antigen 4; Immune related adverse events; Immunotherapy; Management; Programmed cell death protein 1; Programmed cell death protein ligand 1

Indexed keywords

ANTINEOPLASTIC AGENT; BUDESONIDE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4 ANTIBODY; INFLIXIMAB; LOPERAMIDE; METHYLPREDNISOLONE; MYCOPHENOLATE MOFETIL; PROGRAMMED DEATH 1 RECEPTOR INHIBITOR; TACROLIMUS; UNCLASSIFIED DRUG;

EID: 85030172706     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2017.6919     Document Type: Review
Times cited : (65)

References (69)
  • 1
    • 84941655113 scopus 로고    scopus 로고
    • Cancer immunotherapy: Harnessing the immune system to battle cancer
    • Yang Y: Cancer immunotherapy: Harnessing the immune system to battle cancer. J Clin Invest 125: 3335-3337, 2015
    • (2015) J Clin Invest , vol.125 , pp. 3335-3337
    • Yang, Y.1
  • 3
    • 84886698315 scopus 로고    scopus 로고
    • Innate and adaptive immune cells in the tumor microenvironment
    • Gajewski TF, Schreiber H and Fu YX: Innate and adaptive immune cells in the tumor microenvironment. Nat Immunol 14: 1014-1022, 2013
    • (2013) Nat Immunol , vol.14 , pp. 1014-1022
    • Gajewski, T.F.1    Schreiber, H.2    Fu, Y.X.3
  • 4
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • Pardoll DM: The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer 12: 252-264, 2012
    • (2012) Nat Rev Cancer , vol.12 , pp. 252-264
    • Pardoll, D.M.1
  • 5
    • 85119037788 scopus 로고    scopus 로고
    • CTLA-4 and PD-1 pathway blockade: Combinations in the clinic
    • Callahan MK, Postow MA and Wolchok JD: CTLA-4 and PD-1 pathway blockade: Combinations in the clinic. Front Oncol 4: 385, 2015
    • (2015) Front Oncol , vol.4 , pp. 385
    • Callahan, M.K.1    Postow, M.A.2    Wolchok, J.D.3
  • 8
    • 84930730522 scopus 로고    scopus 로고
    • Current state of anti-PD-L1 and anti-PD-1 agents in cancer therapy
    • Swaika A, Hammond WA and Joseph RW: Current state of anti-PD-L1 and anti-PD-1 agents in cancer therapy. Mol Immunol 67: 4-17, 2015
    • (2015) Mol Immunol , vol.67 , pp. 4-17
    • Swaika, A.1    Hammond, W.A.2    Joseph, R.W.3
  • 10
    • 84890288009 scopus 로고    scopus 로고
    • Immune-mediated adverse events associated with ipilimumab ctla-4 blockade therapy: The underlying mechanisms and clinical management
    • 2013
    • Tarhini A: Immune-mediated adverse events associated with ipilimumab ctla-4 blockade therapy: The underlying mechanisms and clinical management. Scientifica (Cairo) 2013: 857519, 2013
    • (2013) Scientifica (Cairo)
    • Tarhini, A.1
  • 13
    • 85011542577 scopus 로고    scopus 로고
    • Combined nivolumab and ipilimumab versus ipilimumab alone in patients with advanced melanoma: 2-year overall survival outcomes in a multicentre, randomised, controlled, phase 2 trial
    • Hodi FS, Chesney J, Pavlick AC, Robert C, Grossmann KF, McDermott DF, Linette GP, Meyer N, Giguere JK, Agarwala SS, et al: Combined nivolumab and ipilimumab versus ipilimumab alone in patients with advanced melanoma: 2-year overall survival outcomes in a multicentre, randomised, controlled, phase 2 trial. Lancet Oncol 17: 1558-1568, 2016
    • (2016) Lancet Oncol , vol.17 , pp. 1558-1568
    • Hodi, F.S.1    Chesney, J.2    Pavlick, A.C.3    Robert, C.4    Grossmann, K.F.5    McDermott, D.F.6    Linette, G.P.7    Meyer, N.8    Giguere, J.K.9    Agarwala, S.S.10
  • 15
  • 17
    • 84876678621 scopus 로고    scopus 로고
    • MDX010-20 Investigators: Patterns of onset and resolution of immune-related adverse events of special interest with ipilimumab: Detailed safety analysis from a phase 3 trial in patients with advanced melanoma
    • Weber JS, Dummer R, de Pril V, Lebbé C and Hodi FS; MDX010-20 Investigators: Patterns of onset and resolution of immune-related adverse events of special interest with ipilimumab: Detailed safety analysis from a phase 3 trial in patients with advanced melanoma. Cancer 119: 1675-1682, 2013
    • (2013) Cancer , vol.119 , pp. 1675-1682
    • Weber, J.S.1    Dummer, R.2    De Pril, V.3    Lebbé, C.4    Hodi, F.S.5
  • 19
    • 84948171577 scopus 로고    scopus 로고
    • Risk of gastrointestinal complications in cancer patients treated with immune checkpoint inhibitors: A meta-analysis
    • Abdel-Rahman O, ElHalawani H and Fouad M: Risk of gastrointestinal complications in cancer patients treated with immune checkpoint inhibitors: A meta-analysis. Immunotherapy 7: 1213-1227, 2015
    • (2015) Immunotherapy , vol.7 , pp. 1213-1227
    • Abdel-Rahman, O.1    Elhalawani, H.2    Fouad, M.3
  • 20
    • 84927150740 scopus 로고    scopus 로고
    • Immune checkpoint blockade in cancer therapy
    • Postow MA, Callahan MK and Wolchok JD: Immune checkpoint blockade in cancer therapy. J Clin Oncol 33: 1974-1982, 2015
    • (2015) J Clin Oncol , vol.33 , pp. 1974-1982
    • Postow, M.A.1    Callahan, M.K.2    Wolchok, J.D.3
  • 22
    • 84940746759 scopus 로고    scopus 로고
    • Immune related adverse events associated with anti-CTLA-4 antibodies: Systematic review and meta-analysis
    • Bertrand A, Kostine M, Barnetche T, Truchetet ME and Schaeverbeke T: Immune related adverse events associated with anti-CTLA-4 antibodies: Systematic review and meta-analysis. BMC Med 13: 211, 2015
    • (2015) BMC Med , vol.13 , pp. 211
    • Bertrand, A.1    Kostine, M.2    Barnetche, T.3    Truchetet, M.E.4    Schaeverbeke, T.5
  • 25
    • 84908354848 scopus 로고    scopus 로고
    • Anti-p rogrammed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: A randomised dose-comparison cohort of a phase 1 trial
    • Robert C, Ribas A, Wolchok JD, Hodi FS, Hamid O, Kefford R, Weber JS, Joshua AM, Hwu WJ, Gangadhar TC, et al: Anti-p rogrammed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: A randomised dose-comparison cohort of a phase 1 trial. Lancet 384: 1109-1117, 2014
    • (2014) Lancet , vol.384 , pp. 1109-1117
    • Robert, C.1    Ribas, A.2    Wolchok, J.D.3    Hodi, F.S.4    Hamid, O.5    Kefford, R.6    Weber, J.S.7    Joshua, A.M.8    Hwu, W.J.9    Gangadhar, T.C.10
  • 27
    • 84954389695 scopus 로고    scopus 로고
    • Immunotherapy and hypophysitis: Clinical presentation, treatment and biologic insights
    • Faje A: Immunotherapy and hypophysitis: Clinical presentation, treatment and biologic insights. Pituitary 19: 82-92, 2016
    • (2016) Pituitary , vol.19 , pp. 82-92
    • Faje, A.1
  • 29
    • 84874994077 scopus 로고    scopus 로고
    • Organizing pneumonia as a side effect of ipilimumab treatment of melanoma
    • Barjaktarevic IZ, Qadir N, Suri A, Santamauro JT and Stover D: Organizing pneumonia as a side effect of ipilimumab treatment of melanoma. Chest 143: 858-861, 2013
    • (2013) Chest , vol.143 , pp. 858-861
    • Barjaktarevic, I.Z.1    Qadir, N.2    Suri, A.3    Santamauro, J.T.4    Stover, D.5
  • 30
    • 84973573023 scopus 로고    scopus 로고
    • Risk of pneumonitis in cancer patients treated with immune checkpoint inhibitors: A meta-analysis
    • Abdel-Rahman O and Fouad M: Risk of pneumonitis in cancer patients treated with immune checkpoint inhibitors: A meta-analysis. Ther Adv Respir Dis 10: 183-193, 2016
    • (2016) Ther Adv Respir Dis , vol.10 , pp. 183-193
    • Abdel-Rahman, O.1    Fouad, M.2
  • 31
    • 84940182635 scopus 로고    scopus 로고
    • Ipilimumab-induced ocular and orbital inflammation-A case series and review of the literature
    • Papavasileiou E, Prasad S, Freitag SK, Sobrin L and Lobo AM: Ipilimumab-induced ocular and orbital inflammation-A case series and review of the literature. Ocul Immunol Inflamm 24: 140-146, 2016
    • (2016) Ocul Immunol Inflamm , vol.24 , pp. 140-146
    • Papavasileiou, E.1    Prasad, S.2    Freitag, S.K.3    Sobrin, L.4    Lobo, A.M.5
  • 32
    • 84879977559 scopus 로고    scopus 로고
    • Neurological immune-related adverse events of ipilimumab
    • Bot I, Blank CU, Boogerd W and Brandsma D: Neurological immune-related adverse events of ipilimumab. Pract Neurol 13: 278-280, 2013
    • (2013) Pract Neurol , vol.13 , pp. 278-280
    • Bot, I.1    Blank, C.U.2    Boogerd, W.3    Brandsma, D.4
  • 33
    • 85001610237 scopus 로고    scopus 로고
    • Immune-related adverse effects of cancer immunotherapy-implications for rheumatology
    • Cappelli LC, Shah AA and Bingham CO III: Immune-related adverse effects of cancer immunotherapy-implications for rheumatology. Rheum Dis Clin North Am 43: 65-78, 2017
    • (2017) Rheum Dis Clin North Am , vol.43 , pp. 65-78
    • Cappelli, L.C.1    Shah, A.A.2    Bingham, C.3
  • 34
    • 84896290367 scopus 로고    scopus 로고
    • Drug-associated polymyalgia rheumatica/giant cell arteritis occurring in two patients after treatment with ipilimumab, an antagonist of ctla-4
    • Goldstein BL, Gedmintas L and Todd DJ: Drug-associated polymyalgia rheumatica/giant cell arteritis occurring in two patients after treatment with ipilimumab, an antagonist of ctla-4. Arthritis Rheumatol 66: 768-769, 2014
    • (2014) Arthritis Rheumatol , vol.66 , pp. 768-769
    • Goldstein, B.L.1    Gedmintas, L.2    Todd, D.J.3
  • 35
    • 67650491041 scopus 로고    scopus 로고
    • Anti-CTLA4 antibody-induced lupus nephritis
    • Fadel F, El Karoui K and Knebelmann B: Anti-CTLA4 antibody-induced lupus nephritis. N Engl J Med 361: 211-212, 2009
    • (2009) N Engl J Med , vol.361 , pp. 211-212
    • Fadel, F.1    El Karoui, K.2    Knebelmann, B.3
  • 36
    • 84867760126 scopus 로고    scopus 로고
    • Ipilimumab-induced immune-related renal failure--a case report
    • Forde PM, Rock K, Wilson G and O'Byrne KJ: Ipilimumab-induced immune-related renal failure--a case report. Anticancer Res 32: 4607-4608, 2012
    • (2012) Anticancer Res , vol.32 , pp. 4607-4608
    • Forde, P.M.1    Rock, K.2    Wilson, G.3    O'byrne, K.J.4
  • 37
    • 67349240111 scopus 로고    scopus 로고
    • Immune-mediated red cell aplasia after anti-CTLA-4 immunotherapy for metastatic melanoma
    • Gordon IO, Wade T, Chin K, Dickstein J and Gajewski TF: Immune-mediated red cell aplasia after anti-CTLA-4 immunotherapy for metastatic melanoma. Cancer Immunol Immunother 58: 1351-1353, 2009
    • (2009) Cancer Immunol Immunother , vol.58 , pp. 1351-1353
    • Gordon, I.O.1    Wade, T.2    Chin, K.3    Dickstein, J.4    Gajewski, T.F.5
  • 38
    • 84941266893 scopus 로고    scopus 로고
    • Novel immune check-point regulators in tolerance maintenance
    • Guo Y and Wang AY: Novel immune check-point regulators in tolerance maintenance. Fron Immunol 6: 421, 2015
    • (2015) Fron Immunol , vol.6 , pp. 421
    • Guo, Y.1    Wang, A.Y.2
  • 40
    • 84921717634 scopus 로고    scopus 로고
    • The association of cytotoxic T-lymphocyte antigen-4 + 49A/G and CT60 polymorphisms with type 1 diabetes and latent autoimmune diabetes in Chinese adults
    • Jin P, Xiang B, Huang G and Zhou Z: The association of cytotoxic T-lymphocyte antigen-4 + 49A/G and CT60 polymorphisms with type 1 diabetes and latent autoimmune diabetes in Chinese adults. J Endocrinol Invest 38: 149-154, 2015
    • (2015) J Endocrinol Invest , vol.38 , pp. 149-154
    • Jin, P.1    Xiang, B.2    Huang, G.3    Zhou, Z.4
  • 41
    • 78449256966 scopus 로고    scopus 로고
    • Update on immunologic therapy with anti-CTLA-4 antibodies in melanoma: Identification of clinical and biological response patterns, immune-related adverse events, and their management
    • Kaehler KC, Piel S, Livingstone E, Schilling B, Hauschild A and Schadendorf D: Update on immunologic therapy with anti-CTLA-4 antibodies in melanoma: Identification of clinical and biological response patterns, immune-related adverse events, and their management. Semin Oncol 37: 485-498, 2010
    • (2010) Semin Oncol , vol.37 , pp. 485-498
    • Kaehler, K.C.1    Piel, S.2    Livingstone, E.3    Schilling, B.4    Hauschild, A.5    Schadendorf, D.6
  • 42
    • 78650428877 scopus 로고    scopus 로고
    • Blockade of cytotoxic T-lymphocyte antigen-4 by ipilimumab results in dysregulation of gastrointestinal immunity in patients with advanced melanoma
    • Berman D, Parker SM, Siegel J, Chasalow SD, Weber J, Galbraith S, Targan SR and Wang HL: Blockade of cytotoxic T-lymphocyte antigen-4 by ipilimumab results in dysregulation of gastrointestinal immunity in patients with advanced melanoma. Cancer Immun 10: 11, 2010
    • (2010) Cancer Immun , vol.10 , pp. 11
    • Berman, D.1    Parker, S.M.2    Siegel, J.3    Chasalow, S.D.4    Weber, J.5    Galbraith, S.6    Targan, S.R.7    Wang, H.L.8
  • 43
    • 84863987094 scopus 로고    scopus 로고
    • Blockade of cytotoxic T-lymphocyte antigen-4 by ipilimumab is associated with a profound long-lasting depletion of Foxp3+ regulatory T cells: A mechanistic explanation for ipilimumab-induced severe enterocolitis?
    • Nancey S, Boschetti G, Cotte E, Ruel K, Almeras T, Chauvenet M, Stroeymeyt K, Moussata D, Kaiserlian D and Flourié B: Blockade of cytotoxic T-lymphocyte antigen-4 by ipilimumab is associated with a profound long-lasting depletion of Foxp3+ regulatory T cells: A mechanistic explanation for ipilimumab-induced severe enterocolitis? Inflamm Bowel Dis 18: E1598-E1600, 2012
    • (2012) Inflamm Bowel Dis , vol.18 , pp. E1598-E1600
    • Nancey, S.1    Boschetti, G.2    Cotte, E.3    Ruel, K.4    Almeras, T.5    Chauvenet, M.6    Stroeymeyt, K.7    Moussata, D.8    Kaiserlian, D.9    Flourié, B.10
  • 46
    • 79953653271 scopus 로고    scopus 로고
    • Treatment and side effect management of CTLA-4 antibody therapy in metastatic melanoma
    • (In English, German)
    • Kähler KC and Hauschild A: Treatment and side effect management of CTLA-4 antibody therapy in metastatic melanoma. J Dtsch Dermatol Ges 9: 277-286, 2011 (In English, German)
    • (2011) J Dtsch Dermatol Ges , vol.9 , pp. 277-286
    • Kähler, K.C.1    Hauschild, A.2
  • 48
    • 69949095926 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled, phase II study comparing the tolerability and efficacy of ipilimumab administered with or without prophylactic budesonide in patients with unresectable stage III or IV melanoma
    • Weber J, Thompson JA, Hamid O, Minor D, Amin A, Ron I, Ridolfi R, Assi H, Maraveyas A, Berman D, et al: A randomized, double-blind, placebo-controlled, phase II study comparing the tolerability and efficacy of ipilimumab administered with or without prophylactic budesonide in patients with unresectable stage III or IV melanoma. Clin Cancer Res 15: 5591-5598, 2009
    • (2009) Clin Cancer Res , vol.15 , pp. 5591-5598
    • Weber, J.1    Thompson, J.A.2    Hamid, O.3    Minor, D.4    Amin, A.5    Ron, I.6    Ridolfi, R.7    Assi, H.8    Maraveyas, A.9    Berman, D.10
  • 49
    • 84864052441 scopus 로고    scopus 로고
    • Management of immune-related adverse events and kinetics of response with ipilimumab
    • Weber JS, Kähler KC and Hauschild A: Management of immune-related adverse events and kinetics of response with ipilimumab. J Clin Oncol 30: 2691-2697, 2012
    • (2012) J Clin Oncol , vol.30 , pp. 2691-2697
    • Weber, J.S.1    Kähler, K.C.2    Hauschild, A.3
  • 50
    • 84958181736 scopus 로고    scopus 로고
    • Immune checkpoint inhibitors in clinical practice: Update on management of immune-related toxicities
    • Villadolid J and Amin A: Immune checkpoint inhibitors in clinical practice: Update on management of immune-related toxicities. Transl Lung Cancer Res 4: 560-575, 2015
    • (2015) Transl Lung Cancer Res , vol.4 , pp. 560-575
    • Villadolid, J.1    Amin, A.2
  • 51
    • 55949094210 scopus 로고    scopus 로고
    • Safety and efficacy of ipilimumab with or without prophylactic budesonide in treatment-naive and previously treated patients with advanced melanoma
    • Weber JS, Berman D, Siegel J, Minor D, Amin A, Thompson JA, Ron I, Ridolfi R, Assi H and Hamid O: Safety and efficacy of ipilimumab with or without prophylactic budesonide in treatment-naive and previously treated patients with advanced melanoma. J Clin Oncol, 2008
    • (2008) J Clin Oncol
    • Weber, J.S.1    Berman, D.2    Siegel, J.3    Minor, D.4    Amin, A.5    Thompson, J.A.6    Ron, I.7    Ridolfi, R.8    Assi, H.9    Hamid, O.10
  • 52
    • 84975728236 scopus 로고    scopus 로고
    • Management of toxicities of immune checkpoint inhibitors
    • Spain L, Diem S and Larkin J: Management of toxicities of immune checkpoint inhibitors. Cancer Treat Rev 44: 51-60, 2016
    • (2016) Cancer Treat Rev , vol.44 , pp. 51-60
    • Spain, L.1    Diem, S.2    Larkin, J.3
  • 53
    • 85013762676 scopus 로고    scopus 로고
    • Treatment of the immune-related adverse effects of immune checkpoint inhibitors: A review
    • Friedman CF, Proverbs-Singh TA and Postow MA: Treatment of the immune-related adverse effects of immune checkpoint inhibitors: A review. JAMA Oncol 2: 1346-1353, 2016
    • (2016) JAMA Oncol , vol.2 , pp. 1346-1353
    • Friedman, C.F.1    Proverbs-Singh, T.A.2    Postow, M.A.3
  • 55
    • 84996551335 scopus 로고    scopus 로고
    • Management of dermatologic toxicities
    • Lacouture ME: Management of dermatologic toxicities. J Natl Compr Canc Netw 13 (5 Suppl): S686-S689, 2015
    • (2015) J Natl Compr Canc Netw , vol.13 , Issue.5 , pp. S686-S689
    • Lacouture, M.E.1
  • 56
    • 85027510221 scopus 로고    scopus 로고
    • Incidence of pneumonitis with use of PD-1 and PD-L1 inhibitors in non-small cell lung cancer: A systematic review and meta-analysis of trials
    • Khunger M, Rakshit S, Pasupuleti V, Hernandez AV, Mazzone P, Stevenson J, Pennell NA and Velcheti V: Incidence of pneumonitis with use of PD-1 and PD-L1 inhibitors in non-small cell lung cancer: A systematic review and meta-analysis of trials. Chest 152: 271-281, 2017
    • (2017) Chest , vol.152 , pp. 271-281
    • Khunger, M.1    Rakshit, S.2    Pasupuleti, V.3    Hernandez, A.V.4    Mazzone, P.5    Stevenson, J.6    Pennell, N.A.7    Velcheti, V.8
  • 59
    • 77949274549 scopus 로고    scopus 로고
    • Anti-CTLA-4 antibody therapy associated autoimmune hypophysitis: Serious immune related adverse events across a spectrum of cancer subtypes
    • Dillard T, Yedinak CG, Alumkal J and Fleseriu M: Anti-CTLA-4 antibody therapy associated autoimmune hypophysitis: Serious immune related adverse events across a spectrum of cancer subtypes. Pituitary 13: 29-38, 2010
    • (2010) Pituitary , vol.13 , pp. 29-38
    • Dillard, T.1    Yedinak, C.G.2    Alumkal, J.3    Fleseriu, M.4
  • 61
    • 84978523049 scopus 로고    scopus 로고
    • Spanish Group for Cancer Immuno-Biotherapy (GETICA): Immune checkpoint inhibitors: Review and management of endocrine adverse events
    • González-Rodríguez E and Rodríguez-Abreu D; Spanish Group for Cancer Immuno-Biotherapy (GETICA): Immune checkpoint inhibitors: Review and management of endocrine adverse events. Oncologist 21: 804-816, 2016
    • (2016) Oncologist , vol.21 , pp. 804-816
    • González-Rodríguez, E.1    Rodríguez-Abreu, D.2
  • 62
    • 84929347192 scopus 로고    scopus 로고
    • Induction of painless thyroiditis in patients receiving programmed death 1 receptor immunotherapy for metastatic malignancies
    • Orlov S, Salari F, Kashat L and Walfish PG: Induction of painless thyroiditis in patients receiving programmed death 1 receptor immunotherapy for metastatic malignancies. J Clin Endocrinol Metab 100: 1738-1741, 2015
    • (2015) J Clin Endocrinol Metab , vol.100 , pp. 1738-1741
    • Orlov, S.1    Salari, F.2    Kashat, L.3    Walfish, P.G.4
  • 63
    • 78449237338 scopus 로고    scopus 로고
    • Evaluation of the effect of systemic corticosteroids for the treatment of immune-related adverse events (IrAEs) on the development or maintenance of ipilimumab clinical activity
    • Amin A, DePril V, Hamid O, Wolchock J, Maio M, Neyns B, Chin K, Ibrahim R, Hoos A and O'Day S: Evaluation of the effect of systemic corticosteroids for the treatment of immune-related adverse events (irAEs) on the development or maintenance of ipilimumab clinical activity. J Clin Oncol 27, 2009
    • (2009) J Clin Oncol , pp. 27
    • Amin, A.1    Depril, V.2    Hamid, O.3    Wolchock, J.4    Maio, M.5    Neyns, B.6    Chin, K.7    Ibrahim, R.8    Hoos, A.9    O'day, S.10
  • 64
    • 85014236890 scopus 로고    scopus 로고
    • Review: Immune-related adverse events with use of checkpoint inhibitors for immunotherapy of cancer
    • Suarez-Almazor ME, Kim ST, Abdel-Wahab N and Diab A: Review: Immune-related adverse events with use of checkpoint inhibitors for immunotherapy of cancer. Arthritis Rheumatol 69: 687-699, 2017
    • (2017) Arthritis Rheumatol , vol.69 , pp. 687-699
    • Suarez-Almazor, M.E.1    Kim, S.T.2    Abdel-Wahab, N.3    Diab, A.4
  • 66
    • 34548202165 scopus 로고    scopus 로고
    • Vitamin D signalling pathways in cancer: Potential for anticancer therapeutics
    • Deeb KK, Trump DL and Johnson CS: Vitamin D signalling pathways in cancer: Potential for anticancer therapeutics. Nat Rev Cancer 7: 684-700, 2007
    • (2007) Nat Rev Cancer , vol.7 , pp. 684-700
    • Deeb, K.K.1    Trump, D.L.2    Johnson, C.S.3
  • 67
    • 85015671867 scopus 로고    scopus 로고
    • Microbiota: A key orchestrator of cancer therapy
    • Roy S and Trinchieri G: Microbiota: A key orchestrator of cancer therapy. Nat Rev Cancer 17: 271-285, 2017
    • (2017) Nat Rev Cancer , vol.17 , pp. 271-285
    • Roy, S.1    Trinchieri, G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.