The association of cytotoxic T-lymphocyte antigen-4 + 49A/G and CT60 polymorphisms with type 1 diabetes and latent autoimmune diabetes in Chinese adults

Journal of Endocrinological Investigation

Volumn 38, Issue 2, 2015, Pages 149-154

  Jin, P ^a,b   Xiang, B ^a   Huang, G ^a   Zhou, Z ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b THE THIRD XIANGYA HOSPITAL OF CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Autoantibodies; Cytotoxic T lymphocyte antigen 4; Glutamic acid decarboxylase; Latent autoimmune diabetes in adults; Polymorphism; Type 1 diabetes

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GLUTAMATE DECARBOXYLASE ANTIBODY; CTLA4 PROTEIN, HUMAN;

ADULT; ARTICLE; AUTOIMMUNE DISEASE; CHINESE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4 GENE; FEMALE; GENE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC DIFFERENCE; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; LATENT AUTOIMMUNE DIABETES IN ADULTS; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; NON INSULIN DEPENDENT DIABETES MELLITUS; POLYMERASE CHAIN REACTION; RADIOASSAY; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; YOUNG ADULT; ASIAN CONTINENTAL ANCESTRY GROUP; BLOOD; DIABETES MELLITUS, TYPE 1; GENETIC ASSOCIATION STUDY; GENETICS; PROCEDURES;

ADULT; ASIAN CONTINENTAL ANCESTRY GROUP; CTLA-4 ANTIGEN; DIABETES MELLITUS, TYPE 1; FEMALE; GENETIC ASSOCIATION STUDIES; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84921717634     PISSN: 03914097     EISSN: 17208386     Source Type: Journal    
DOI: 10.1007/s40618-014-0162-x     Document Type: Article

References (30)

1. Tuomi T, Groop LC, Zimmet PZ et al (1993) Antibodies to glutamic acid decarboxylase reveal latent autoimmune diabetes mellitus in adults with a non-insulin-dependent onset of disease. Diabetes 42(2):359-362
2. Naik RG, Brooks-Worrell BM, Palmer JP (2009) Latent autoimmune diabetes in adults. J Clin Endocrinol Metab 94(12):4635-4644. Doi: 10.1210/jc.2009-1120
3. Turner R, Stratton I, Horton V et al (1997) UKPDS 25: autoantibodies to islet-cell cytoplasm and glutamic acid decarboxylase for prediction of insulin requirement in type 2 diabetes. UK prospective diabetes study group. Lancet 350(9087):1288-1293
4. Buzzetti R, Di Pietro S, Giaccari A et al (2007) High titer of autoantibodies to GAD identifies a specific phenotype of adult-onset autoimmune diabetes. Diabetes Care 30(4):932-938. Doi: 10.2337/dc06-1696
5. Borg H, Gottsater A, Landin-Olsson M et al (2001) High levels of antigen-specific islet antibodies predict future beta-cell failure in patients with onset of diabetes in adult age. J Clin Endocrinol Metab 86(7):3032-3038. Doi: 10.1210/jcem.86.7.7658
6. Zhou Z, Xiang Y, Ji L et al (2013) Frequency, immunogenetics, and clinical characteristics of latent autoimmune diabetes in China (LADA China study): a nationwide, multicenter, clinic-based cross-sectional study. Diabetes 62(2):543-550. Doi: 10.2337/db12-0207
7. Fourlanos S, Dotta F, Greenbaum CJ et al (2005) Latent autoimmune diabetes in adults (LADA) should be less latent. Diabetologia 48(11):2206-2212. Doi: 10.1007/s00125-005-1960-7
8. Cervin C, Lyssenko V, Bakhtadze E et al (2008) Genetic similarities between latent autoimmune diabetes in adults, type 1 diabetes, and type 2 diabetes. Diabetes 57(5):1433-1437. Doi: 10.2337/db07-0299
9. Andersen MK, Lundgren V, Turunen JA et al (2010) Latent autoimmune diabetes in adults differs genetically from classical type 1 diabetes diagnosed after the age of 35 years. Diabetes Care 33(9):2062-2064. Doi: 10.2337/dc09-2188
10. Ueda H, Howson JM, Esposito L et al (2003) Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature 423(6939):506-511. Doi: 10.1038/nature01621
11. Chen Z, Fei M, Fu D et al (2013) Association between cytotoxic T lymphocyte antigen-4 polymorphism and type 1 diabetes: a meta-analysis. Gene 516(2):263-270. Doi: 10.1016/j.gene.2012.12.030
12. Nie W, Chen J, Xiu Q (2012) Cytotoxic T-lymphocyte associated antigen 4 polymorphisms and asthma risk: a meta-analysis. PLoS One 7(7):e42062. Doi: 10.1371/journal.pone.0042062
13. Ikegami H, Awata T, Kawasaki E et al (2006) The association of CTLA4 polymorphism with type 1 diabetes is concentrated in patients complicated with autoimmune thyroid disease: a multicenter collaborative study in Japan. J Clin Endocrinol Metab 91(3):1087-1092. Doi: 10.1210/jc.2005-1407
14. Douroudis K, Laine AP, Heinonen M et al (2009) Association of CTLA4 but not ICOS polymorphisms with type 1 diabetes in two populations with different disease rates. Hum Immunol 70(7):536-539. Doi: 10.1016/j.humimm.2009.04.023
15. Howson JM, Dunger DB, Nutland S et al (2007) A type 1 diabetes subgroup with a female bias is characterised by failure in tolerance to thyroid peroxidase at an early age and a strong association with the cytotoxic T-lymphocyte-associated antigen-4 gene. Diabetologia 50(4):741-746. Doi: 10.1007/s00125-007-0603-6
16. Song GG, Kim JH, Kim YH et al (2013) Association between CTLA-4 polymorphisms and susceptibility to Celiac disease: a meta-analysis. Hum Immunol 74(9):1214-1218. Doi: 10.1016/j.humimm.2013.05.014
17. Cosentino A, Gambelunghe G, Tortoioli C et al (2002) CTLA-4 gene polymorphism contributes to the genetic risk for latent autoimmune diabetes in adults. Ann NY Acad Sci 958:337-340
18. Caputo M, Cerrone GE, Lopez AP et al (2005) Cytotoxic T lymphocyte antigen 4 heterozygous codon 49 A/G dimorphism is associated to latent autoimmune diabetes in adults (LADA). Autoimmunity 38(4):277-281
19. Haller K, Kisand K, Pisarev H et al (2007) Insulin gene VNTR, CTLA-4 +49A/G and HLA-DQB1 alleles distinguish latent autoimmune diabetes in adults from type 1 diabetes and from type 2 diabetes group. Tissue Antigens 69(2):121-127. Doi: 10.1111/j.1399-0039.2006.00745.x
20. Douroudis K, Prans E, Kisand K et al (2009) Cytotoxic T-lymphocyte antigen 4 gene polymorphisms are associated with latent autoimmune diabetes in adults. Clin Chim Acta 403(1-2):226-228. Doi: 10.1016/j.cca.2009.03.036
21. Kisand K, Uibo R (2012) LADA and T1D in Estonian population - two different genetic risk profiles. Gene 497(2):285-291. Doi: 10.1016/j.gene.2012.01.089
22. Jin P, Huang G, Lin J et al (2011) Epitope analysis of GAD65 autoantibodies in adult-onset type 1 diabetes and latent autoimmune diabetes in adults with thyroid autoimmunity. Acta Diabetol 48(2):149-155. Doi: 10.1007/s00592-010-0250-0
23. Jin P, Huang G, Lin J et al (2011) High titre of antiglutamic acid decarboxylase autoantibody is a strong predictor of the development of thyroid autoimmunity in patients with type 1 diabetes and latent autoimmune diabetes in adults. Clin Endocrinol Oxf 74(5):587-592. Doi: 10.1111/j.1365-2265.2011.03976.x
24. Si X, Zhang X, Luo Y et al (2012) Association between the CTLA-4 +49A/G polymorphism and type 1 diabetes: a meta-analysis. Genet Test Mol Biomark 16(11):1336-1342. Doi: 10.1089/gtmb.2012.0169
25. Kouki T, Sawai Y, Gardine CA et al (2000) CTLA-4 gene polymorphism at position 49 in exon 1 reduces the inhibitory function of CTLA-4 and contributes to the pathogenesis of Graves' disease. J Immunol 165(11):6606-6611
26. Maurer M, Loserth S, Kolb-Maurer A et al (2002) A polymorphism in the human cytotoxic T-lymphocyte antigen 4 (CTLA4) gene (exon 1 +49) alters T-cell activation. Immunogenetics 54(1):1-8. Doi: 10.1007/s00251-002-0429-9
27. Li X, Zhang C, Zhang J et al (2012) Polymorphisms in the CTLA-4 gene and rheumatoid arthritis susceptibility: a meta-analysis. J Clin Immunol 32(3):530-539. Doi: 10.1007/s10875-012-9650-y
28. Lei C, Dongqing Z, Yeqing S et al (2005) Association of the CTLA-4 gene with rheumatoid arthritis in Chinese Han population. Eur J Hum Genet 13(7):823-828. Doi: 10.1038/sj.ejhg.5201423
29. Pettersen E, Skorpen F, Kvaloy K et al (2010) Genetic heterogeneity in latent autoimmune diabetes is linked to various degrees of autoimmune activity: results from the Nord-Trondelag Health Study. Diabetes 59(1):302-310. Doi: 10.2337/db09-0923
30. Lin J, Zhou ZG, Wang JP et al (2008) From Type 1, through LADA, to type 2 diabetes: a continuous spectrum? Ann NY Acad Sci 1150:99-102. Doi: 10.1196/annals.1447.036