-
1
-
-
84928774156
-
The future of immune checkpoint therapy
-
Sharma P, Allison JP. The future of immune checkpoint therapy. Science 2015;348:56–61.
-
(2015)
Science
, vol.348
, pp. 56-61
-
-
Sharma, P.1
Allison, J.P.2
-
3
-
-
79952284127
-
Hallmarks of cancer: the next generation
-
Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011;144:646–74.
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
4
-
-
0013979086
-
Antigenicity of carcinogen-induced and spontaneous tumours in inbred mice
-
Smith HJ. Antigenicity of carcinogen-induced and spontaneous tumours in inbred mice. Br J Cancer 1966;20:831–7.
-
(1966)
Br J Cancer
, vol.20
, pp. 831-837
-
-
Smith, H.J.1
-
5
-
-
84960949820
-
Cancer: a biological approach. Part III. Viruses associated with neoplastic conditions. Part IV. Practical applications
-
Burnet M. Cancer: a biological approach. Part III. Viruses associated with neoplastic conditions. Part IV. Practical applications. Br Med J 1957;1:841–7.
-
(1957)
Br Med J
, vol.1
, pp. 841-847
-
-
Burnet, M.1
-
6
-
-
79953151458
-
Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion
-
Schreiber RD, Old LJ, Smyth MJ. Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. Science 2011;331:1565–70.
-
(2011)
Science
, vol.331
, pp. 1565-1570
-
-
Schreiber, R.D.1
Old, L.J.2
Smyth, M.J.3
-
7
-
-
36849010167
-
Adaptive immunity maintains occult cancer in an equilibrium state
-
Koebel CM, Vermi W, Swann JB, Zerafa N, Rodig SJ, Old LJ, et al. Adaptive immunity maintains occult cancer in an equilibrium state. Nature 2007;450:903–7.
-
(2007)
Nature
, vol.450
, pp. 903-907
-
-
Koebel, C.M.1
Vermi, W.2
Swann, J.B.3
Zerafa, N.4
Rodig, S.J.5
Old, L.J.6
-
8
-
-
84926160709
-
Immune evasion in cancer: mechanistic basis and therapeutic strategies
-
Vinay DS, Ryan EP, Pawelec G, Talib WH, Stagg J, Elkord E, et al. Immune evasion in cancer: mechanistic basis and therapeutic strategies. Semin Cancer Biol 2015;35 Suppl:S185–98.
-
(2015)
Semin Cancer Biol
, vol.35
, pp. S185-S198
-
-
Vinay, D.S.1
Ryan, E.P.2
Pawelec, G.3
Talib, W.H.4
Stagg, J.5
Elkord, E.6
-
9
-
-
84858766182
-
The blockade of immune checkpoints in cancer immunotherapy
-
Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer 2012;12:252–64.
-
(2012)
Nat Rev Cancer
, vol.12
, pp. 252-264
-
-
Pardoll, D.M.1
-
10
-
-
84944472689
-
Releasing the brakes on cancer immunotherapy
-
Ribas A. Releasing the brakes on cancer immunotherapy. N Engl J Med 2015;373:1490–2.
-
(2015)
N Engl J Med
, vol.373
, pp. 1490-1492
-
-
Ribas, A.1
-
11
-
-
0036852170
-
CTLA-4-Ig regulates tryptophan catabolism in vivo
-
Grohmann U, Orabona C, Fallarino F, Vacca C, Calcinaro F, Falorni A, et al. CTLA-4-Ig regulates tryptophan catabolism in vivo. Nat Immunol 2002;3:1097–101.
-
(2002)
Nat Immunol
, vol.3
, pp. 1097-1101
-
-
Grohmann, U.1
Orabona, C.2
Fallarino, F.3
Vacca, C.4
Calcinaro, F.5
Falorni, A.6
-
12
-
-
0029947568
-
Enhancement of antitumor immunity by CTLA-4 blockade
-
Leach DR, Krummel MF, Allison JP. Enhancement of antitumor immunity by CTLA-4 blockade. Science 1996;271:1734–6.
-
(1996)
Science
, vol.271
, pp. 1734-1736
-
-
Leach, D.R.1
Krummel, M.F.2
Allison, J.P.3
-
13
-
-
79952272922
-
CTLA-4-blocking immunotherapy with ipilimumab for advanced melanoma
-
Tarhini AA, Kirkwood JM. CTLA-4-blocking immunotherapy with ipilimumab for advanced melanoma. Oncology (Williston Park) 2010;24:1302, 1304.
-
(2010)
Oncology (Williston Park)
, vol.24
, pp. 1302, 1304
-
-
Tarhini, A.A.1
Kirkwood, J.M.2
-
14
-
-
84878936788
-
Anti-CTLA-4 antibodies of IgG2a isotype enhance antitumor activity through reduction of intratumoral regulatory T cells
-
Selby MJ, Engelhardt JJ, Quigley M, Henning KA, Chen T, Srinivasan M, et al. Anti-CTLA-4 antibodies of IgG2a isotype enhance antitumor activity through reduction of intratumoral regulatory T cells. Cancer Immunol Res 2013;1:32–42.
-
(2013)
Cancer Immunol Res
, vol.1
, pp. 32-42
-
-
Selby, M.J.1
Engelhardt, J.J.2
Quigley, M.3
Henning, K.A.4
Chen, T.5
Srinivasan, M.6
-
16
-
-
84857402937
-
Therapeutic intervention in cancer and chronic viral infections: antibody mediated manipulation of PD-1/PD-L1 interaction
-
Sakthivel P, Gereke M, Bruder D. Therapeutic intervention in cancer and chronic viral infections: antibody mediated manipulation of PD-1/PD-L1 interaction. Rev Recent Clin Trials 2012;7:10–23.
-
(2012)
Rev Recent Clin Trials
, vol.7
, pp. 10-23
-
-
Sakthivel, P.1
Gereke, M.2
Bruder, D.3
-
18
-
-
78449237499
-
Clinical experiences with anti-CD137 and anti-PD1 therapeutic antibodies
-
Ascierto PA, Simeone E, Sznol M, Fu YX, Melero I. Clinical experiences with anti-CD137 and anti-PD1 therapeutic antibodies. Semin Oncol 2010;37:508–16.
-
(2010)
Semin Oncol
, vol.37
, pp. 508-516
-
-
Ascierto, P.A.1
Simeone, E.2
Sznol, M.3
Fu, Y.X.4
Melero, I.5
-
19
-
-
84865316603
-
Immunomodulating antibodies in the treatment of metastatic melanoma: the experience with anti-CTLA-4, anti-CD137, and anti-PD1
-
Simeone E, Ascierto PA. Immunomodulating antibodies in the treatment of metastatic melanoma: the experience with anti-CTLA-4, anti-CD137, and anti-PD1. J Immunotoxicol 2012;9:241–7.
-
(2012)
J Immunotoxicol
, vol.9
, pp. 241-247
-
-
Simeone, E.1
Ascierto, P.A.2
-
20
-
-
84862859820
-
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
-
Topalian SL, Hodi FS, Brahmer JR, Gettinger SN, Smith DC, McDermott DF, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med 2012;366:2443–54.
-
(2012)
N Engl J Med
, vol.366
, pp. 2443-2454
-
-
Topalian, S.L.1
Hodi, F.S.2
Brahmer, J.R.3
Gettinger, S.N.4
Smith, D.C.5
McDermott, D.F.6
-
21
-
-
84936147067
-
Combined nivolumab and ipilimumab or monotherapy in untreated melanoma
-
Larkin J, Chiarion-Sileni V, Gonzalez R, Grob JJ, Cowey CL, Lao CD, et al. Combined nivolumab and ipilimumab or monotherapy in untreated melanoma. N Engl J Med 2015;373:23–34.
-
(2015)
N Engl J Med
, vol.373
, pp. 23-34
-
-
Larkin, J.1
Chiarion-Sileni, V.2
Gonzalez, R.3
Grob, J.J.4
Cowey, C.L.5
Lao, C.D.6
-
22
-
-
84929481481
-
Pembrolizumab versus ipilimumab in advanced melanoma
-
Robert C, Schachter J, Long GV, Arance A, Grob JJ, Mortier L, et al. Pembrolizumab versus ipilimumab in advanced melanoma. N Engl J Med 2015;372:2521–32.
-
(2015)
N Engl J Med
, vol.372
, pp. 2521-2532
-
-
Robert, C.1
Schachter, J.2
Long, G.V.3
Arance, A.4
Grob, J.J.5
Mortier, L.6
-
23
-
-
84959577118
-
Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial
-
Rosenberg JE, Hoffman-Censits J, Powles T, van der Heijden MS, Balar AV, Necchi A, et al. Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial. Lancet 2016;387:1909–20.
-
(2016)
Lancet
, vol.387
, pp. 1909-1920
-
-
Rosenberg, J.E.1
Hoffman-Censits, J.2
Powles, T.3
van der Heijden, M.S.4
Balar, A.V.5
Necchi, A.6
-
24
-
-
84947560428
-
Strategies for combining immunotherapy with radiation for anticancer therapy
-
Seyedin SN, Schoenhals JE, Lee DA, Cortez MA, Wang X, Niknam S, et al. Strategies for combining immunotherapy with radiation for anticancer therapy. Immunotherapy 2015;7:967–80.
-
(2015)
Immunotherapy
, vol.7
, pp. 967-980
-
-
Seyedin, S.N.1
Schoenhals, J.E.2
Lee, D.A.3
Cortez, M.A.4
Wang, X.5
Niknam, S.6
-
25
-
-
84927130807
-
Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential
-
Sharma P, Allison JP. Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential. Cell 2015;161:205–14.
-
(2015)
Cell
, vol.161
, pp. 205-214
-
-
Sharma, P.1
Allison, J.P.2
-
26
-
-
84893965118
-
Immune modulation in cancer with antibodies
-
Page DB, Postow MA, Callahan MK, Allison JP, Wolchok JD. Immune modulation in cancer with antibodies. Annu Rev Med 2014;65:185–202.
-
(2014)
Annu Rev Med
, vol.65
, pp. 185-202
-
-
Page, D.B.1
Postow, M.A.2
Callahan, M.K.3
Allison, J.P.4
Wolchok, J.D.5
-
27
-
-
84945472104
-
Review of immune-related adverse events in prostate cancer patients treated with ipilimumab: MD Anderson experience
-
Gao J, He Q, Subudhi S, Aparicio A, Zurita-Saavedra A, Lee DH, et al. Review of immune-related adverse events in prostate cancer patients treated with ipilimumab: MD Anderson experience. Oncogene 2015;34:5411–7.
-
(2015)
Oncogene
, vol.34
, pp. 5411-5417
-
-
Gao, J.1
He, Q.2
Subudhi, S.3
Aparicio, A.4
Zurita-Saavedra, A.5
Lee, D.H.6
-
28
-
-
84941619877
-
A systematic review of immune-related adverse event reporting in clinical trials of immune checkpoint inhibitors
-
Chen TW, Razak AR, Bedard PL, Siu LL, Hansen AR. A systematic review of immune-related adverse event reporting in clinical trials of immune checkpoint inhibitors. Ann Oncol 2015;26:1824–9.
-
(2015)
Ann Oncol
, vol.26
, pp. 1824-1829
-
-
Chen, T.W.1
Razak, A.R.2
Bedard, P.L.3
Siu, L.L.4
Hansen, A.R.5
-
29
-
-
84953309212
-
Immune-related adverse events with immune checkpoint blockade: a comprehensive review
-
Michot JM, Bigenwald C, Champiat S, Collins M, Carbonnel F, Postel-Vinay S, et al. Immune-related adverse events with immune checkpoint blockade: a comprehensive review. Eur J Cancer 2016;54:139–48.
-
(2016)
Eur J Cancer
, vol.54
, pp. 139-148
-
-
Michot, J.M.1
Bigenwald, C.2
Champiat, S.3
Collins, M.4
Carbonnel, F.5
Postel-Vinay, S.6
-
30
-
-
84962286789
-
Survivorship in immune therapy: assessing chronic immune toxicities, health outcomes, and functional status among long-term ipilimumab survivors at a single referral center
-
Johnson DB, Friedman DL, Berry EG, Decker I, Ye F, Zhao S, et al. Survivorship in immune therapy: assessing chronic immune toxicities, health outcomes, and functional status among long-term ipilimumab survivors at a single referral center. Cancer Immunol Res 2015;3:464–9.
-
(2015)
Cancer Immunol Res
, vol.3
, pp. 464-469
-
-
Johnson, D.B.1
Friedman, D.L.2
Berry, E.G.3
Decker, I.4
Ye, F.5
Zhao, S.6
-
31
-
-
84978959070
-
Inflammatory arthritis and sicca syndrome induced by nivolumab and ipilimumab
-
Cappelli LC, Gutierrez AK, Baer AN, Albayda J, Manno RL, Haque U, et al. Inflammatory arthritis and sicca syndrome induced by nivolumab and ipilimumab. Ann Rheum Dis 2017;76:43–50.
-
(2017)
Ann Rheum Dis
, vol.76
, pp. 43-50
-
-
Cappelli, L.C.1
Gutierrez, A.K.2
Baer, A.N.3
Albayda, J.4
Manno, R.L.5
Haque, U.6
-
32
-
-
85001610237
-
Immune-related adverse effects of cancer immunotherapy: implications for rheumatology
-
Cappelli LC, Shah AA, Bingham CO III. Immune-related adverse effects of cancer immunotherapy: implications for rheumatology. Rheum Dis Clin North Am 2017;43:65–78.
-
(2017)
Rheum Dis Clin North Am
, vol.43
, pp. 65-78
-
-
Cappelli, L.C.1
Shah, A.A.2
Bingham, C.O.3
-
33
-
-
85013634537
-
Adverse events associated with immune checkpoint blockade in patients with cancer: a systematic review of case reports
-
Abdel-Wahab N, Shah M, Suarez-Almazor ME. Adverse events associated with immune checkpoint blockade in patients with cancer: a systematic review of case reports. PLoS One 2016;11:e0160221.
-
(2016)
PLoS One
, vol.11
-
-
Abdel-Wahab, N.1
Shah, M.2
Suarez-Almazor, M.E.3
-
34
-
-
84856862354
-
PD-1 blockade augments Th1 and Th17 and suppresses Th2 responses in peripheral blood from patients with prostate and advanced melanoma cancer
-
Dulos J, Carven GJ, van Boxtel SJ, Evers S, Driessen-Engels LJ, Hobo W, et al. PD-1 blockade augments Th1 and Th17 and suppresses Th2 responses in peripheral blood from patients with prostate and advanced melanoma cancer. J Immunother 2012;35:169–78.
-
(2012)
J Immunother
, vol.35
, pp. 169-178
-
-
Dulos, J.1
Carven, G.J.2
van Boxtel, S.J.3
Evers, S.4
Driessen-Engels, L.J.5
Hobo, W.6
-
35
-
-
67649268353
-
CTLA4 blockade increases Th17 cells in patients with metastatic melanoma
-
Von Euw E, Chodon T, Attar N, Jalil J, Koya RC, Comin-Anduix B, et al. CTLA4 blockade increases Th17 cells in patients with metastatic melanoma. J Transl Med 2009;7:35.
-
(2009)
J Transl Med
, vol.7
, pp. 35
-
-
Von Euw, E.1
Chodon, T.2
Attar, N.3
Jalil, J.4
Koya, R.C.5
Comin-Anduix, B.6
-
36
-
-
84896542936
-
Th17 and regulatory T cell balance in autoimmune and inflammatory diseases
-
Noack M, Miossec P. Th17 and regulatory T cell balance in autoimmune and inflammatory diseases. Autoimmun Rev 2014;13:668–77.
-
(2014)
Autoimmun Rev
, vol.13
, pp. 668-677
-
-
Noack, M.1
Miossec, P.2
-
37
-
-
53749094183
-
CTLA-4 control over Foxp3+ regulatory T cell function
-
Wing K, Onishi Y, Prieto-Martin P, Yamaguchi T, Miyara M, Fehervari Z, et al. CTLA-4 control over Foxp3+ regulatory T cell function. Science 2008;322:271–5.
-
(2008)
Science
, vol.322
, pp. 271-275
-
-
Wing, K.1
Onishi, Y.2
Prieto-Martin, P.3
Yamaguchi, T.4
Miyara, M.5
Fehervari, Z.6
-
38
-
-
84856769074
-
Evaluation of serum IL-17 levels during ipilimumab therapy: correlation with colitis [abstract]
-
Callahan MK, Yang A, Tandon S, Xu Y, Subudhi SK, Roman RA, et al. Evaluation of serum IL-17 levels during ipilimumab therapy: correlation with colitis [abstract]. J Clin Oncol 2011;29 Suppl 1:2505.
-
(2011)
J Clin Oncol
, vol.29
, pp. 2505
-
-
Callahan, M.K.1
Yang, A.2
Tandon, S.3
Xu, Y.4
Subudhi, S.K.5
Roman, R.A.6
-
39
-
-
84997771368
-
Baseline circulating IL-17 predicts toxicity while TGF-β1 and IL-10 are prognostic of relapse in ipilimumab neoadjuvant therapy of melanoma
-
Tarhini AA, Zahoor H, Lin Y, Malhotra U, Sander C, Butterfield LH, et al. Baseline circulating IL-17 predicts toxicity while TGF-β1 and IL-10 are prognostic of relapse in ipilimumab neoadjuvant therapy of melanoma. J Immunother Cancer 2015;3:39.
-
(2015)
J Immunother Cancer
, vol.3
, pp. 39
-
-
Tarhini, A.A.1
Zahoor, H.2
Lin, Y.3
Malhotra, U.4
Sander, C.5
Butterfield, L.H.6
-
40
-
-
84899071058
-
Pituitary expression of CTLA-4 mediates hypophysitis secondary to administration of CTLA-4 blocking antibody
-
Iwama S, de Remigis A, Callahan MK, Slovin SF, Wolchok JD, Caturegli P. Pituitary expression of CTLA-4 mediates hypophysitis secondary to administration of CTLA-4 blocking antibody. Sci Transl Med 2014;6:230ra45.
-
(2014)
Sci Transl Med
, vol.6
, pp. 230ra45
-
-
Iwama, S.1
de Remigis, A.2
Callahan, M.K.3
Slovin, S.F.4
Wolchok, J.D.5
Caturegli, P.6
-
41
-
-
84905503399
-
Opportunistic autoimmune disorders potentiated by immune-checkpoint inhibitors anti-CTLA-4 and anti-PD-1
-
Kong YC, Flynn JC. Opportunistic autoimmune disorders potentiated by immune-checkpoint inhibitors anti-CTLA-4 and anti-PD-1. Front Immunol 2014;5:206.
-
(2014)
Front Immunol
, vol.5
, pp. 206
-
-
Kong, Y.C.1
Flynn, J.C.2
-
42
-
-
78650428877
-
Blockade of cytotoxic T-lymphocyte antigen-4 by ipilimumab results in dysregulation of gastrointestinal immunity in patients with advanced melanoma
-
Berman D, Parker SM, Siegel J, Chasalow SD, Weber J, Galbraith S, et al. Blockade of cytotoxic T-lymphocyte antigen-4 by ipilimumab results in dysregulation of gastrointestinal immunity in patients with advanced melanoma. Cancer Immun 2010;10:11.
-
(2010)
Cancer Immun
, vol.10
, pp. 11
-
-
Berman, D.1
Parker, S.M.2
Siegel, J.3
Chasalow, S.D.4
Weber, J.5
Galbraith, S.6
-
45
-
-
78751559991
-
Thyroid autoimmunity and ophthalmopathy related to melanoma biological therapy
-
Min L, Vaidya A, Becker C. Thyroid autoimmunity and ophthalmopathy related to melanoma biological therapy. Eur J Endocrinol 2011;164:303–7.
-
(2011)
Eur J Endocrinol
, vol.164
, pp. 303-307
-
-
Min, L.1
Vaidya, A.2
Becker, C.3
-
46
-
-
84920031180
-
In vitro characterization of the anti-PD-1 antibody nivolumab, BMS-936558, and in vivo toxicology in non-human primates
-
Wang C, Thudium KB, Han M, Wang XT, Huang H, Feingersh D, et al. In vitro characterization of the anti-PD-1 antibody nivolumab, BMS-936558, and in vivo toxicology in non-human primates. Cancer Immunol Res 2014;2:846–56.
-
(2014)
Cancer Immunol Res
, vol.2
, pp. 846-856
-
-
Wang, C.1
Thudium, K.B.2
Han, M.3
Wang, X.T.4
Huang, H.5
Feingersh, D.6
-
47
-
-
73949088551
-
PD-L1 regulates the development, maintenance, and function of induced regulatory T cells
-
Francisco LM, Salinas VH, Brown KE, Vanguri VK, Freeman GJ, Kuchroo VK, et al. PD-L1 regulates the development, maintenance, and function of induced regulatory T cells. J Exp Med 2009;206:3015–29.
-
(2009)
J Exp Med
, vol.206
, pp. 3015-3029
-
-
Francisco, L.M.1
Salinas, V.H.2
Brown, K.E.3
Vanguri, V.K.4
Freeman, G.J.5
Kuchroo, V.K.6
-
48
-
-
45549098562
-
T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR
-
Sauer S, Bruno L, Hertweck A, Finlay D, Leleu M, Spivakov M, et al. T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR. Proc Natl Acad Sci U S A 2008;105:7797–802.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 7797-7802
-
-
Sauer, S.1
Bruno, L.2
Hertweck, A.3
Finlay, D.4
Leleu, M.5
Spivakov, M.6
-
49
-
-
84997637224
-
Acute heart failure due to autoimmune myocarditis under pembrolizumab treatment for metastatic melanoma
-
Laubli H, Balmelli C, Bossard M, Pfister O, Glatz K, Zippelius A. Acute heart failure due to autoimmune myocarditis under pembrolizumab treatment for metastatic melanoma. J Immunother Cancer 2015;3:11.
-
(2015)
J Immunother Cancer
, vol.3
, pp. 11
-
-
Laubli, H.1
Balmelli, C.2
Bossard, M.3
Pfister, O.4
Glatz, K.5
Zippelius, A.6
-
50
-
-
0033180181
-
Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor
-
Nishimura H, Nose M, Hiai H, Minato N, Honjo T. Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity 1999;11:141–51.
-
(1999)
Immunity
, vol.11
, pp. 141-151
-
-
Nishimura, H.1
Nose, M.2
Hiai, H.3
Minato, N.4
Honjo, T.5
-
51
-
-
29144469468
-
Hydronephrosis associated with antiurothelial and antinuclear autoantibodies in BALB/c-Fcgr2b-/-Pdcd1-/- mice
-
Okazaki T, Otaka Y, Wang J, Hiai H, Takai T, Ravetch JV, et al. Hydronephrosis associated with antiurothelial and antinuclear autoantibodies in BALB/c-Fcgr2b-/-Pdcd1-/- mice. J Exp Med 2005;202:1643–8.
-
(2005)
J Exp Med
, vol.202
, pp. 1643-1648
-
-
Okazaki, T.1
Otaka, Y.2
Wang, J.3
Hiai, H.4
Takai, T.5
Ravetch, J.V.6
-
52
-
-
10744220884
-
Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice
-
Okazaki T, Tanaka Y, Nishio R, Mitsuiye T, Mizoguchi A, Wang J, et al. Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice. Nat Med 2003;9:1477–83.
-
(2003)
Nat Med
, vol.9
, pp. 1477-1483
-
-
Okazaki, T.1
Tanaka, Y.2
Nishio, R.3
Mitsuiye, T.4
Mizoguchi, A.5
Wang, J.6
-
53
-
-
77954019731
-
PD-1 deficiency results in the development of fatal myocarditis in MRL mice
-
Wang J, Okazaki IM, Yoshida T, Chikuma S, Kato Y, Nakaki F, et al. PD-1 deficiency results in the development of fatal myocarditis in MRL mice. Int Immunol 2010;22:443–52.
-
(2010)
Int Immunol
, vol.22
, pp. 443-452
-
-
Wang, J.1
Okazaki, I.M.2
Yoshida, T.3
Chikuma, S.4
Kato, Y.5
Nakaki, F.6
-
54
-
-
84959916365
-
Idiopathic thrombocytopenic purpura induced by nivolumab in a metastatic melanoma patient with elevated PD-1 expression on B cells
-
Kanameishi S, Otsuka A, Nonomura Y, Fujisawa A, Endo Y, Kabashima K. Idiopathic thrombocytopenic purpura induced by nivolumab in a metastatic melanoma patient with elevated PD-1 expression on B cells. Ann Oncol 2016;27:546–7.
-
(2016)
Ann Oncol
, vol.27
, pp. 546-547
-
-
Kanameishi, S.1
Otsuka, A.2
Nonomura, Y.3
Fujisawa, A.4
Endo, Y.5
Kabashima, K.6
-
55
-
-
84957565779
-
Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis
-
Dubin K, Callahan MK, Ren B, Khanin R, Viale A, Ling L, et al. Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis. Nat Commun 2016;7:10391.
-
(2016)
Nat Commun
, vol.7
, pp. 10391
-
-
Dubin, K.1
Callahan, M.K.2
Ren, B.3
Khanin, R.4
Viale, A.5
Ling, L.6
-
56
-
-
84994144982
-
Fulminant myocarditis with combination immune checkpoint blockade
-
Johnson DB, Balko JM, Compton ML, Chalkias S, Gorham J, Xu Y, et al. Fulminant myocarditis with combination immune checkpoint blockade. N Engl J Med 2016;375:1749–55.
-
(2016)
N Engl J Med
, vol.375
, pp. 1749-1755
-
-
Johnson, D.B.1
Balko, J.M.2
Compton, M.L.3
Chalkias, S.4
Gorham, J.5
Xu, Y.6
-
57
-
-
84905664930
-
Th17 cells in cancer: the ultimate identity crisis
-
Bailey SR, Nelson MH, Himes RA, Li Z, Mehrotra S, Paulos CM. Th17 cells in cancer: the ultimate identity crisis. Front Immunol 2014;5:276.
-
(2014)
Front Immunol
, vol.5
, pp. 276
-
-
Bailey, S.R.1
Nelson, M.H.2
Himes, R.A.3
Li, Z.4
Mehrotra, S.5
Paulos, C.M.6
-
58
-
-
77950196277
-
H 17 cells in tumour immunity and immunotherapy
-
H 17 cells in tumour immunity and immunotherapy. Nat Rev Immunol 2010;10:248–56.
-
(2010)
Nat Rev Immunol
, vol.10
, pp. 248-256
-
-
Zou, W.1
Restifo, N.P.2
-
59
-
-
84969535050
-
Managing adverse events with immune checkpoint agents
-
Dadu R, Zobniw C, Diab A. Managing adverse events with immune checkpoint agents. Cancer J 2016;22:121–9.
-
(2016)
Cancer J
, vol.22
, pp. 121-129
-
-
Dadu, R.1
Zobniw, C.2
Diab, A.3
-
60
-
-
84964573640
-
Management of immune checkpoint blockade dysimmune toxicities: a collaborative position paper
-
Champiat S, Lambotte O, Barreau E, Belkhir R, Berdelou A, Carbonnel F, et al. Management of immune checkpoint blockade dysimmune toxicities: a collaborative position paper. Ann Oncol 2016;27:559–74.
-
(2016)
Ann Oncol
, vol.27
, pp. 559-574
-
-
Champiat, S.1
Lambotte, O.2
Barreau, E.3
Belkhir, R.4
Berdelou, A.5
Carbonnel, F.6
-
61
-
-
84865692521
-
Risk of malignancies in patients with rheumatoid arthritis treated with biologic therapy: a meta-analysis
-
Lopez-Olivo MA, Tayar JH, Martinez-Lopez JA, Pollono EN, Cueto JP, Gonzales-Crespo MR, et al. Risk of malignancies in patients with rheumatoid arthritis treated with biologic therapy: a meta-analysis. JAMA 2012;308:898–908.
-
(2012)
JAMA
, vol.308
, pp. 898-908
-
-
Lopez-Olivo, M.A.1
Tayar, J.H.2
Martinez-Lopez, J.A.3
Pollono, E.N.4
Cueto, J.P.5
Gonzales-Crespo, M.R.6
-
62
-
-
79959833640
-
Does cancer that occurs during or after anti–tumor necrosis factor therapy have a worse prognosis? A national assessment of overall and site-specific cancer survival in rheumatoid arthritis patients treated with biologic agents
-
Raaschou P, Simard JF, Neovius M, Askling J, for the Anti-Rheumatic Therapy in Sweden Study Group. Does cancer that occurs during or after anti–tumor necrosis factor therapy have a worse prognosis? A national assessment of overall and site-specific cancer survival in rheumatoid arthritis patients treated with biologic agents. Arthritis Rheum 2011;63:1812–22.
-
(2011)
Arthritis Rheum
, vol.63
, pp. 1812-1822
-
-
Raaschou, P.1
Simard, J.F.2
Neovius, M.3
Askling, J.4
-
63
-
-
84954380570
-
TNF inhibitor therapy and risk of breast cancer recurrence in patients with rheumatoid arthritis: a nationwide cohort study
-
Raaschou P, Frisell T, Askling J, for the ARTIS Study Group. TNF inhibitor therapy and risk of breast cancer recurrence in patients with rheumatoid arthritis: a nationwide cohort study. Ann Rheum Dis 2015;74:2137–43.
-
(2015)
Ann Rheum Dis
, vol.74
, pp. 2137-2143
-
-
Raaschou, P.1
Frisell, T.2
Askling, J.3
-
64
-
-
85016385438
-
-
Yervoy. Medication guide
-
Yervoy. URLUS Food and Drug Administration. Medication guide: : http://www.fda.gov/downloads/Drugs/DrugSafety/UCM249168.pdf.
-
URLUS Food and Drug Administration
-
-
-
65
-
-
84984663113
-
Checkpoint immunotherapy: good for cancer therapy, bad for rheumatic diseases
-
Calabrese L, Velcheti V. Checkpoint immunotherapy: good for cancer therapy, bad for rheumatic diseases. Ann Rheum Dis 2017;76:1–3.
-
(2017)
Ann Rheum Dis
, vol.76
, pp. 1-3
-
-
Calabrese, L.1
Velcheti, V.2
-
66
-
-
47249153181
-
CTLA-4: a key regulatory point in the control of autoimmune disease
-
Scalapino KJ, Daikh DI. CTLA-4: a key regulatory point in the control of autoimmune disease. Immunol Rev 2008;223:143–55.
-
(2008)
Immunol Rev
, vol.223
, pp. 143-155
-
-
Scalapino, K.J.1
Daikh, D.I.2
-
68
-
-
84910101471
-
The effect of CTLA-4 A49G polymorphism on rheumatoid arthritis risk: a meta-analysis
-
Li G, Shi F, Liu J, Li Y. The effect of CTLA-4 A49G polymorphism on rheumatoid arthritis risk: a meta-analysis. Diagn Pathol 2014;9:157.
-
(2014)
Diagn Pathol
, vol.9
, pp. 157
-
-
Li, G.1
Shi, F.2
Liu, J.3
Li, Y.4
-
69
-
-
4444354041
-
Evidence for CTLA4 as a susceptibility gene for systemic lupus erythematosus
-
Barreto M, Santos E, Ferreira R, Fesel C, Fontes MF, Pereira C, et al. Evidence for CTLA4 as a susceptibility gene for systemic lupus erythematosus. Eur J Hum Genet 2004;12:620–6.
-
(2004)
Eur J Hum Genet
, vol.12
, pp. 620-626
-
-
Barreto, M.1
Santos, E.2
Ferreira, R.3
Fesel, C.4
Fontes, M.F.5
Pereira, C.6
-
70
-
-
85016356887
-
The association between CTLA-4 (+49 A/G) polymorphism and susceptibility to ankylosing spondylitis: a meta-analysis
-
E-pub ahead of print
-
Wu J, Zhang L, Zhou Y. The association between CTLA-4 (+49 A/G) polymorphism and susceptibility to ankylosing spondylitis: a meta-analysis. Int J Rheum Dis 2015. E-pub ahead of print.
-
(2015)
Int J Rheum Dis
-
-
Wu, J.1
Zhang, L.2
Zhou, Y.3
-
71
-
-
84896548089
-
CTLA-4 polymorphisms and susceptibility to inflammatory bowel disease: a meta-analysis
-
Lee YH, Kim JH, Seo YH, Choi SJ, Ji JD, Song GG. CTLA-4 polymorphisms and susceptibility to inflammatory bowel disease: a meta-analysis. Hum Immunol 2014;75:414–21.
-
(2014)
Hum Immunol
, vol.75
, pp. 414-421
-
-
Lee, Y.H.1
Kim, J.H.2
Seo, Y.H.3
Choi, S.J.4
Ji, J.D.5
Song, G.G.6
-
72
-
-
84939892080
-
Meta-analysis of genetic polymorphisms in programmed cell death 1: associations with rheumatoid arthritis, ankylosing spondylitis, and type 1 diabetes susceptibility
-
Lee YH, Bae SC, Kim JH, Song GG. Meta-analysis of genetic polymorphisms in programmed cell death 1: associations with rheumatoid arthritis, ankylosing spondylitis, and type 1 diabetes susceptibility. Z Rheumatol 2015;74:230–9.
-
(2015)
Z Rheumatol
, vol.74
, pp. 230-239
-
-
Lee, Y.H.1
Bae, S.C.2
Kim, J.H.3
Song, G.G.4
-
73
-
-
62149115181
-
Association between the PD1.3A/G polymorphism of the PDCD1 gene and systemic lupus erythematosus in European populations: a meta-analysis
-
Liu JL, Zhang FY, Liang YH, Xiao FL, Zhang SQ, Cheng YL, et al. Association between the PD1.3A/G polymorphism of the PDCD1 gene and systemic lupus erythematosus in European populations: a meta-analysis. J Eur Acad Dermatol Venereol 2009;23:425–32.
-
(2009)
J Eur Acad Dermatol Venereol
, vol.23
, pp. 425-432
-
-
Liu, J.L.1
Zhang, F.Y.2
Liang, Y.H.3
Xiao, F.L.4
Zhang, S.Q.5
Cheng, Y.L.6
-
74
-
-
62749182367
-
Association of programmed cell death 1 polymorphisms and systemic lupus erythematosus: a meta-analysis
-
Lee YH, Woo JH, Choi SJ, Ji JD, Song GG. Association of programmed cell death 1 polymorphisms and systemic lupus erythematosus: a meta-analysis. Lupus 2009;18:9–15.
-
(2009)
Lupus
, vol.18
, pp. 9-15
-
-
Lee, Y.H.1
Woo, J.H.2
Choi, S.J.3
Ji, J.D.4
Song, G.G.5
-
76
-
-
84904553412
-
Kidney injuries related to ipilimumab
-
Izzedine H, Gueutin V, Gharbi C, Mateus C, Robert C, Routier E, et al. Kidney injuries related to ipilimumab. Invest New Drugs 2014;32:769–73.
-
(2014)
Invest New Drugs
, vol.32
, pp. 769-773
-
-
Izzedine, H.1
Gueutin, V.2
Gharbi, C.3
Mateus, C.4
Robert, C.5
Routier, E.6
-
77
-
-
84997610273
-
Rapid complete response of metastatic melanoma in a patient undergoing ipilimumab immunotherapy in the setting of active ulcerative colitis
-
Bostwick AD, Salama AK, Hanks BA. Rapid complete response of metastatic melanoma in a patient undergoing ipilimumab immunotherapy in the setting of active ulcerative colitis. J Immunother Cancer 2015;3:19.
-
(2015)
J Immunother Cancer
, vol.3
, pp. 19
-
-
Bostwick, A.D.1
Salama, A.K.2
Hanks, B.A.3
-
78
-
-
85015837474
-
Ipilimumab-induced colitis in a patient with ulcerative colitis and lung cancer
-
Kamil F, Cohen M, Kumta N, Wan D. Ipilimumab-induced colitis in a patient with ulcerative colitis and lung cancer. Am J Gastroenterol 2013;108:S404.
-
(2013)
Am J Gastroenterol
, vol.108
, pp. S404
-
-
Kamil, F.1
Cohen, M.2
Kumta, N.3
Wan, D.4
-
79
-
-
84916205029
-
Successful treatment with ipilimumab and interleukin-2 in two patients with metastatic melanoma and systemic autoimmune disease
-
Pedersen M, Andersen R, Norgaard P, Jacobsen S, Thielsen P, Thor Straten P, et al. Successful treatment with ipilimumab and interleukin-2 in two patients with metastatic melanoma and systemic autoimmune disease. Cancer Immunol Immunother 2014;63:1341–6.
-
(2014)
Cancer Immunol Immunother
, vol.63
, pp. 1341-1346
-
-
Pedersen, M.1
Andersen, R.2
Norgaard, P.3
Jacobsen, S.4
Thielsen, P.5
Thor Straten, P.6
-
80
-
-
85016348948
-
Induction of muscular sarcoidosis in a metastastic melanoma patient treated with ipilimumab
-
Plachouri KM, Mohr M, Sunderkotter C, Weishaupt C. Induction of muscular sarcoidosis in a metastastic melanoma patient treated with ipilimumab. J Dtsch Dermatol Ges 2012;10:861.
-
(2012)
J Dtsch Dermatol Ges
, vol.10
, pp. 861
-
-
Plachouri, K.M.1
Mohr, M.2
Sunderkotter, C.3
Weishaupt, C.4
-
81
-
-
85016355628
-
Muscular sarcoidosis in a metastatic melanoma patient treated with ipilimumab
-
Weishaupt C, Mohr M, Sunderkotter C. Muscular sarcoidosis in a metastatic melanoma patient treated with ipilimumab. J Dtsch Dermatol Ges 2012;10:683.
-
(2012)
J Dtsch Dermatol Ges
, vol.10
, pp. 683
-
-
Weishaupt, C.1
Mohr, M.2
Sunderkotter, C.3
-
82
-
-
84971324112
-
Severe psoriasis flare after anti-programmed death ligand 1 (PD-L1) therapy for metastatic non-small cell lung cancer (NSCLC)
-
Chia PL, John T. Severe psoriasis flare after anti-programmed death ligand 1 (PD-L1) therapy for metastatic non-small cell lung cancer (NSCLC). J Immunother 2016;39:202–4.
-
(2016)
J Immunother
, vol.39
, pp. 202-204
-
-
Chia, P.L.1
John, T.2
-
83
-
-
84962198249
-
Precipitation of autoimmune diabetes with anti-PD-1 immunotherapy
-
Hughes J, Vudattu N, Sznol M, Gettinger S, Kluger H, Lupsa B, et al. Precipitation of autoimmune diabetes with anti-PD-1 immunotherapy. Diabetes Care 2015;38:e55–7.
-
(2015)
Diabetes Care
, vol.38
, pp. e55-e57
-
-
Hughes, J.1
Vudattu, N.2
Sznol, M.3
Gettinger, S.4
Kluger, H.5
Lupsa, B.6
-
84
-
-
84954554294
-
Exacerbation of psoriasis during nivolumab therapy for metastatic melanoma
-
Matsumura N, Ohtsuka M, Kikuchi N, Yamamoto T. Exacerbation of psoriasis during nivolumab therapy for metastatic melanoma. Acta Derm Venereol 2016;96:259–60.
-
(2016)
Acta Derm Venereol
, vol.96
, pp. 259-260
-
-
Matsumura, N.1
Ohtsuka, M.2
Kikuchi, N.3
Yamamoto, T.4
-
86
-
-
84961942697
-
Successful anti-PD-1 antibody treatment in a metastatic melanoma patient with known severe autoimmune disease
-
Maul LV, Weichenthal M, Kahler KC, Hauschild A. Successful anti-PD-1 antibody treatment in a metastatic melanoma patient with known severe autoimmune disease. J Immunother 2016;39:188–90.
-
(2016)
J Immunother
, vol.39
, pp. 188-190
-
-
Maul, L.V.1
Weichenthal, M.2
Kahler, K.C.3
Hauschild, A.4
-
87
-
-
84952785505
-
Severe relapse in a multiple sclerosis patient associated with ipilimumab treatment of melanoma
-
Gettings EJ, Hackett CT, Scott TF. Severe relapse in a multiple sclerosis patient associated with ipilimumab treatment of melanoma. Mult Scler 2015;21:670.
-
(2015)
Mult Scler
, vol.21
, pp. 670
-
-
Gettings, E.J.1
Hackett, C.T.2
Scott, T.F.3
-
88
-
-
85015914196
-
A case of myasthenia gravis exacerbation in a patient with melanoma treated with pembrolizumab [poster]
-
Lau KH, Kumar A, Yang I, Nowak R. A case of myasthenia gravis exacerbation in a patient with melanoma treated with pembrolizumab [poster]. Neurology 2016;86 Suppl P3.138.
-
(2016)
Neurology
, vol.86
, pp. 138
-
-
Lau, K.H.1
Kumar, A.2
Yang, I.3
Nowak, R.4
-
89
-
-
84958985225
-
Immune thrombocytopenia exacerbated by nivolumab in a patient with non-small-cell lung cancer
-
Bagley SJ, Kosteva JA, Evans TL, Langer CJ. Immune thrombocytopenia exacerbated by nivolumab in a patient with non-small-cell lung cancer. Cancer Treat Commun 2016;6:20–3.
-
(2016)
Cancer Treat Commun
, vol.6
, pp. 20-23
-
-
Bagley, S.J.1
Kosteva, J.A.2
Evans, T.L.3
Langer, C.J.4
-
90
-
-
85015907153
-
Hyperthyroidism followed by worsening primary hypothyroidism in a patient treated with ipilimumab and pembrolizumab
-
Batacchi Z, Alarcon-Casas Wright L. Hyperthyroidism followed by worsening primary hypothyroidism in a patient treated with ipilimumab and pembrolizumab. Thyroid 2015;25:A215.
-
(2015)
Thyroid
, vol.25
, pp. A215
-
-
Batacchi, Z.1
Alarcon-Casas Wright, L.2
-
91
-
-
84956840392
-
Serological aggravation of autoimmune thyroid disease in two cases receiving nivolumab
-
Narita T, Oiso N, Taketomo Y, Okahashi K, Yamauchi K, Sato M, et al. Serological aggravation of autoimmune thyroid disease in two cases receiving nivolumab. J Dermatol 2016;43:210–4.
-
(2016)
J Dermatol
, vol.43
, pp. 210-214
-
-
Narita, T.1
Oiso, N.2
Taketomo, Y.3
Okahashi, K.4
Yamauchi, K.5
Sato, M.6
-
92
-
-
85016342140
-
Anti-CTLA-4 antibody therapy causing autoimmune hypophysitis in a patient with a longstanding history of Hashimotos's thyroiditis
-
Zmeili O, Samantray J. Anti-CTLA-4 antibody therapy causing autoimmune hypophysitis in a patient with a longstanding history of Hashimotos's thyroiditis. Endocr Rev 2013;1.
-
(2013)
Endocr Rev
, pp. 1
-
-
Zmeili, O.1
Samantray, J.2
-
93
-
-
85003054266
-
Ipilimumab therapy in patients with advanced melanoma and preexisting autoimmune disorders
-
Johnson DB, Sullivan RJ, Ott PA, Carlino MS, Khushalani NI, Ye F, et al. Ipilimumab therapy in patients with advanced melanoma and preexisting autoimmune disorders. JAMA Oncol 2016;2:234–40.
-
(2016)
JAMA Oncol
, vol.2
, pp. 234-240
-
-
Johnson, D.B.1
Sullivan, R.J.2
Ott, P.A.3
Carlino, M.S.4
Khushalani, N.I.5
Ye, F.6
-
94
-
-
84974824082
-
The use of ipilimumab in patients with rheumatoid arthritis and metastatic melanoma
-
Lee B, Wong A, Kee D, Neeson P, Shackleton M, McArthur G, et al. The use of ipilimumab in patients with rheumatoid arthritis and metastatic melanoma. Ann Oncol 2016;27:1174–7.
-
(2016)
Ann Oncol
, vol.27
, pp. 1174-1177
-
-
Lee, B.1
Wong, A.2
Kee, D.3
Neeson, P.4
Shackleton, M.5
McArthur, G.6
-
95
-
-
85006200692
-
Anti-PD-1 therapy in patients with advanced melanoma and preexisting autoimmune disorders or major toxicity with ipilimumab
-
E-Pub ahead of print
-
Menzies AM, Johnson DB, Ramanujam S, Atkinson VG, Wong AN, Park JJ, et al. Anti-PD-1 therapy in patients with advanced melanoma and preexisting autoimmune disorders or major toxicity with ipilimumab. Ann Oncol 2016. E-Pub ahead of print.
-
(2016)
Ann Oncol
-
-
Menzies, A.M.1
Johnson, D.B.2
Ramanujam, S.3
Atkinson, V.G.4
Wong, A.N.5
Park, J.J.6
-
96
-
-
84940746759
-
Immune related adverse events associated with anti-CTLA-4 antibodies: systematic review and meta-analysis
-
Bertrand A, Kostine M, Barnetche T, Truchetet ME, Schaeverbeke T. Immune related adverse events associated with anti-CTLA-4 antibodies: systematic review and meta-analysis. BMC Med 2015;13:211.
-
(2015)
BMC Med
, vol.13
, pp. 211
-
-
Bertrand, A.1
Kostine, M.2
Barnetche, T.3
Truchetet, M.E.4
Schaeverbeke, T.5
-
97
-
-
77954801079
-
Improved survival with ipilimumab in patients with metastatic melanoma
-
Hodi FS, O'Day SJ, McDermott DF, Weber RW, Sosman JA, Haanen JB, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 2010;363:711–23.
-
(2010)
N Engl J Med
, vol.363
, pp. 711-723
-
-
Hodi, F.S.1
O'Day, S.J.2
McDermott, D.F.3
Weber, R.W.4
Sosman, J.A.5
Haanen, J.B.6
-
98
-
-
84965032301
-
Safety profiles of anti-CTLA-4 and anti-PD-1 antibodies alone and in combination
-
Boutros C, Tarhini A, Routier E, Lambotte O, Ladurie FL, Carbonnel F, et al. Safety profiles of anti-CTLA-4 and anti-PD-1 antibodies alone and in combination. Nat Rev Clin Oncol 2016;13:473–86.
-
(2016)
Nat Rev Clin Oncol
, vol.13
, pp. 473-486
-
-
Boutros, C.1
Tarhini, A.2
Routier, E.3
Lambotte, O.4
Ladurie, F.L.5
Carbonnel, F.6
|