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Volumn 69, Issue 4, 2017, Pages 687-699

Review: Immune-Related Adverse Events With Use of Checkpoint Inhibitors for Immunotherapy of Cancer

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOMODULATING AGENT; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; IMMUNOLOGICAL ANTINEOPLASTIC AGENT;

EID: 85014236890     PISSN: 23265191     EISSN: 23265205     Source Type: Journal    
DOI: 10.1002/art.40043     Document Type: Review
Times cited : (103)

References (98)
  • 1
    • 84928774156 scopus 로고    scopus 로고
    • The future of immune checkpoint therapy
    • Sharma P, Allison JP. The future of immune checkpoint therapy. Science 2015;348:56–61.
    • (2015) Science , vol.348 , pp. 56-61
    • Sharma, P.1    Allison, J.P.2
  • 3
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011;144:646–74.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 4
    • 0013979086 scopus 로고
    • Antigenicity of carcinogen-induced and spontaneous tumours in inbred mice
    • Smith HJ. Antigenicity of carcinogen-induced and spontaneous tumours in inbred mice. Br J Cancer 1966;20:831–7.
    • (1966) Br J Cancer , vol.20 , pp. 831-837
    • Smith, H.J.1
  • 5
    • 84960949820 scopus 로고
    • Cancer: a biological approach. Part III. Viruses associated with neoplastic conditions. Part IV. Practical applications
    • Burnet M. Cancer: a biological approach. Part III. Viruses associated with neoplastic conditions. Part IV. Practical applications. Br Med J 1957;1:841–7.
    • (1957) Br Med J , vol.1 , pp. 841-847
    • Burnet, M.1
  • 6
    • 79953151458 scopus 로고    scopus 로고
    • Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion
    • Schreiber RD, Old LJ, Smyth MJ. Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. Science 2011;331:1565–70.
    • (2011) Science , vol.331 , pp. 1565-1570
    • Schreiber, R.D.1    Old, L.J.2    Smyth, M.J.3
  • 7
  • 9
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer 2012;12:252–64.
    • (2012) Nat Rev Cancer , vol.12 , pp. 252-264
    • Pardoll, D.M.1
  • 10
    • 84944472689 scopus 로고    scopus 로고
    • Releasing the brakes on cancer immunotherapy
    • Ribas A. Releasing the brakes on cancer immunotherapy. N Engl J Med 2015;373:1490–2.
    • (2015) N Engl J Med , vol.373 , pp. 1490-1492
    • Ribas, A.1
  • 12
    • 0029947568 scopus 로고    scopus 로고
    • Enhancement of antitumor immunity by CTLA-4 blockade
    • Leach DR, Krummel MF, Allison JP. Enhancement of antitumor immunity by CTLA-4 blockade. Science 1996;271:1734–6.
    • (1996) Science , vol.271 , pp. 1734-1736
    • Leach, D.R.1    Krummel, M.F.2    Allison, J.P.3
  • 13
    • 79952272922 scopus 로고    scopus 로고
    • CTLA-4-blocking immunotherapy with ipilimumab for advanced melanoma
    • Tarhini AA, Kirkwood JM. CTLA-4-blocking immunotherapy with ipilimumab for advanced melanoma. Oncology (Williston Park) 2010;24:1302, 1304.
    • (2010) Oncology (Williston Park) , vol.24 , pp. 1302, 1304
    • Tarhini, A.A.1    Kirkwood, J.M.2
  • 14
    • 84878936788 scopus 로고    scopus 로고
    • Anti-CTLA-4 antibodies of IgG2a isotype enhance antitumor activity through reduction of intratumoral regulatory T cells
    • Selby MJ, Engelhardt JJ, Quigley M, Henning KA, Chen T, Srinivasan M, et al. Anti-CTLA-4 antibodies of IgG2a isotype enhance antitumor activity through reduction of intratumoral regulatory T cells. Cancer Immunol Res 2013;1:32–42.
    • (2013) Cancer Immunol Res , vol.1 , pp. 32-42
    • Selby, M.J.1    Engelhardt, J.J.2    Quigley, M.3    Henning, K.A.4    Chen, T.5    Srinivasan, M.6
  • 16
    • 84857402937 scopus 로고    scopus 로고
    • Therapeutic intervention in cancer and chronic viral infections: antibody mediated manipulation of PD-1/PD-L1 interaction
    • Sakthivel P, Gereke M, Bruder D. Therapeutic intervention in cancer and chronic viral infections: antibody mediated manipulation of PD-1/PD-L1 interaction. Rev Recent Clin Trials 2012;7:10–23.
    • (2012) Rev Recent Clin Trials , vol.7 , pp. 10-23
    • Sakthivel, P.1    Gereke, M.2    Bruder, D.3
  • 18
    • 78449237499 scopus 로고    scopus 로고
    • Clinical experiences with anti-CD137 and anti-PD1 therapeutic antibodies
    • Ascierto PA, Simeone E, Sznol M, Fu YX, Melero I. Clinical experiences with anti-CD137 and anti-PD1 therapeutic antibodies. Semin Oncol 2010;37:508–16.
    • (2010) Semin Oncol , vol.37 , pp. 508-516
    • Ascierto, P.A.1    Simeone, E.2    Sznol, M.3    Fu, Y.X.4    Melero, I.5
  • 19
    • 84865316603 scopus 로고    scopus 로고
    • Immunomodulating antibodies in the treatment of metastatic melanoma: the experience with anti-CTLA-4, anti-CD137, and anti-PD1
    • Simeone E, Ascierto PA. Immunomodulating antibodies in the treatment of metastatic melanoma: the experience with anti-CTLA-4, anti-CD137, and anti-PD1. J Immunotoxicol 2012;9:241–7.
    • (2012) J Immunotoxicol , vol.9 , pp. 241-247
    • Simeone, E.1    Ascierto, P.A.2
  • 23
    • 84959577118 scopus 로고    scopus 로고
    • Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial
    • Rosenberg JE, Hoffman-Censits J, Powles T, van der Heijden MS, Balar AV, Necchi A, et al. Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial. Lancet 2016;387:1909–20.
    • (2016) Lancet , vol.387 , pp. 1909-1920
    • Rosenberg, J.E.1    Hoffman-Censits, J.2    Powles, T.3    van der Heijden, M.S.4    Balar, A.V.5    Necchi, A.6
  • 25
    • 84927130807 scopus 로고    scopus 로고
    • Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential
    • Sharma P, Allison JP. Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential. Cell 2015;161:205–14.
    • (2015) Cell , vol.161 , pp. 205-214
    • Sharma, P.1    Allison, J.P.2
  • 27
    • 84945472104 scopus 로고    scopus 로고
    • Review of immune-related adverse events in prostate cancer patients treated with ipilimumab: MD Anderson experience
    • Gao J, He Q, Subudhi S, Aparicio A, Zurita-Saavedra A, Lee DH, et al. Review of immune-related adverse events in prostate cancer patients treated with ipilimumab: MD Anderson experience. Oncogene 2015;34:5411–7.
    • (2015) Oncogene , vol.34 , pp. 5411-5417
    • Gao, J.1    He, Q.2    Subudhi, S.3    Aparicio, A.4    Zurita-Saavedra, A.5    Lee, D.H.6
  • 28
    • 84941619877 scopus 로고    scopus 로고
    • A systematic review of immune-related adverse event reporting in clinical trials of immune checkpoint inhibitors
    • Chen TW, Razak AR, Bedard PL, Siu LL, Hansen AR. A systematic review of immune-related adverse event reporting in clinical trials of immune checkpoint inhibitors. Ann Oncol 2015;26:1824–9.
    • (2015) Ann Oncol , vol.26 , pp. 1824-1829
    • Chen, T.W.1    Razak, A.R.2    Bedard, P.L.3    Siu, L.L.4    Hansen, A.R.5
  • 30
    • 84962286789 scopus 로고    scopus 로고
    • Survivorship in immune therapy: assessing chronic immune toxicities, health outcomes, and functional status among long-term ipilimumab survivors at a single referral center
    • Johnson DB, Friedman DL, Berry EG, Decker I, Ye F, Zhao S, et al. Survivorship in immune therapy: assessing chronic immune toxicities, health outcomes, and functional status among long-term ipilimumab survivors at a single referral center. Cancer Immunol Res 2015;3:464–9.
    • (2015) Cancer Immunol Res , vol.3 , pp. 464-469
    • Johnson, D.B.1    Friedman, D.L.2    Berry, E.G.3    Decker, I.4    Ye, F.5    Zhao, S.6
  • 32
    • 85001610237 scopus 로고    scopus 로고
    • Immune-related adverse effects of cancer immunotherapy: implications for rheumatology
    • Cappelli LC, Shah AA, Bingham CO III. Immune-related adverse effects of cancer immunotherapy: implications for rheumatology. Rheum Dis Clin North Am 2017;43:65–78.
    • (2017) Rheum Dis Clin North Am , vol.43 , pp. 65-78
    • Cappelli, L.C.1    Shah, A.A.2    Bingham, C.O.3
  • 33
    • 85013634537 scopus 로고    scopus 로고
    • Adverse events associated with immune checkpoint blockade in patients with cancer: a systematic review of case reports
    • Abdel-Wahab N, Shah M, Suarez-Almazor ME. Adverse events associated with immune checkpoint blockade in patients with cancer: a systematic review of case reports. PLoS One 2016;11:e0160221.
    • (2016) PLoS One , vol.11
    • Abdel-Wahab, N.1    Shah, M.2    Suarez-Almazor, M.E.3
  • 34
    • 84856862354 scopus 로고    scopus 로고
    • PD-1 blockade augments Th1 and Th17 and suppresses Th2 responses in peripheral blood from patients with prostate and advanced melanoma cancer
    • Dulos J, Carven GJ, van Boxtel SJ, Evers S, Driessen-Engels LJ, Hobo W, et al. PD-1 blockade augments Th1 and Th17 and suppresses Th2 responses in peripheral blood from patients with prostate and advanced melanoma cancer. J Immunother 2012;35:169–78.
    • (2012) J Immunother , vol.35 , pp. 169-178
    • Dulos, J.1    Carven, G.J.2    van Boxtel, S.J.3    Evers, S.4    Driessen-Engels, L.J.5    Hobo, W.6
  • 36
    • 84896542936 scopus 로고    scopus 로고
    • Th17 and regulatory T cell balance in autoimmune and inflammatory diseases
    • Noack M, Miossec P. Th17 and regulatory T cell balance in autoimmune and inflammatory diseases. Autoimmun Rev 2014;13:668–77.
    • (2014) Autoimmun Rev , vol.13 , pp. 668-677
    • Noack, M.1    Miossec, P.2
  • 38
    • 84856769074 scopus 로고    scopus 로고
    • Evaluation of serum IL-17 levels during ipilimumab therapy: correlation with colitis [abstract]
    • Callahan MK, Yang A, Tandon S, Xu Y, Subudhi SK, Roman RA, et al. Evaluation of serum IL-17 levels during ipilimumab therapy: correlation with colitis [abstract]. J Clin Oncol 2011;29 Suppl 1:2505.
    • (2011) J Clin Oncol , vol.29 , pp. 2505
    • Callahan, M.K.1    Yang, A.2    Tandon, S.3    Xu, Y.4    Subudhi, S.K.5    Roman, R.A.6
  • 39
    • 84997771368 scopus 로고    scopus 로고
    • Baseline circulating IL-17 predicts toxicity while TGF-β1 and IL-10 are prognostic of relapse in ipilimumab neoadjuvant therapy of melanoma
    • Tarhini AA, Zahoor H, Lin Y, Malhotra U, Sander C, Butterfield LH, et al. Baseline circulating IL-17 predicts toxicity while TGF-β1 and IL-10 are prognostic of relapse in ipilimumab neoadjuvant therapy of melanoma. J Immunother Cancer 2015;3:39.
    • (2015) J Immunother Cancer , vol.3 , pp. 39
    • Tarhini, A.A.1    Zahoor, H.2    Lin, Y.3    Malhotra, U.4    Sander, C.5    Butterfield, L.H.6
  • 40
    • 84899071058 scopus 로고    scopus 로고
    • Pituitary expression of CTLA-4 mediates hypophysitis secondary to administration of CTLA-4 blocking antibody
    • Iwama S, de Remigis A, Callahan MK, Slovin SF, Wolchok JD, Caturegli P. Pituitary expression of CTLA-4 mediates hypophysitis secondary to administration of CTLA-4 blocking antibody. Sci Transl Med 2014;6:230ra45.
    • (2014) Sci Transl Med , vol.6 , pp. 230ra45
    • Iwama, S.1    de Remigis, A.2    Callahan, M.K.3    Slovin, S.F.4    Wolchok, J.D.5    Caturegli, P.6
  • 41
    • 84905503399 scopus 로고    scopus 로고
    • Opportunistic autoimmune disorders potentiated by immune-checkpoint inhibitors anti-CTLA-4 and anti-PD-1
    • Kong YC, Flynn JC. Opportunistic autoimmune disorders potentiated by immune-checkpoint inhibitors anti-CTLA-4 and anti-PD-1. Front Immunol 2014;5:206.
    • (2014) Front Immunol , vol.5 , pp. 206
    • Kong, Y.C.1    Flynn, J.C.2
  • 42
    • 78650428877 scopus 로고    scopus 로고
    • Blockade of cytotoxic T-lymphocyte antigen-4 by ipilimumab results in dysregulation of gastrointestinal immunity in patients with advanced melanoma
    • Berman D, Parker SM, Siegel J, Chasalow SD, Weber J, Galbraith S, et al. Blockade of cytotoxic T-lymphocyte antigen-4 by ipilimumab results in dysregulation of gastrointestinal immunity in patients with advanced melanoma. Cancer Immun 2010;10:11.
    • (2010) Cancer Immun , vol.10 , pp. 11
    • Berman, D.1    Parker, S.M.2    Siegel, J.3    Chasalow, S.D.4    Weber, J.5    Galbraith, S.6
  • 43
    • 67650491041 scopus 로고    scopus 로고
    • Anti-CTLA4 antibody-induced lupus nephritis
    • Fadel F, El Karoui K, Knebelmann B. Anti-CTLA4 antibody-induced lupus nephritis. N Engl J Med 2009;361:211–2.
    • (2009) N Engl J Med , vol.361 , pp. 211-212
    • Fadel, F.1    El Karoui, K.2    Knebelmann, B.3
  • 44
    • 80455173518 scopus 로고    scopus 로고
    • Hemophilia A induced by ipilimumab
    • Delyon J, Mateus C, Lambert T. Hemophilia A induced by ipilimumab. N Engl J Med 2011;365:1747–8.
    • (2011) N Engl J Med , vol.365 , pp. 1747-1748
    • Delyon, J.1    Mateus, C.2    Lambert, T.3
  • 45
    • 78751559991 scopus 로고    scopus 로고
    • Thyroid autoimmunity and ophthalmopathy related to melanoma biological therapy
    • Min L, Vaidya A, Becker C. Thyroid autoimmunity and ophthalmopathy related to melanoma biological therapy. Eur J Endocrinol 2011;164:303–7.
    • (2011) Eur J Endocrinol , vol.164 , pp. 303-307
    • Min, L.1    Vaidya, A.2    Becker, C.3
  • 46
    • 84920031180 scopus 로고    scopus 로고
    • In vitro characterization of the anti-PD-1 antibody nivolumab, BMS-936558, and in vivo toxicology in non-human primates
    • Wang C, Thudium KB, Han M, Wang XT, Huang H, Feingersh D, et al. In vitro characterization of the anti-PD-1 antibody nivolumab, BMS-936558, and in vivo toxicology in non-human primates. Cancer Immunol Res 2014;2:846–56.
    • (2014) Cancer Immunol Res , vol.2 , pp. 846-856
    • Wang, C.1    Thudium, K.B.2    Han, M.3    Wang, X.T.4    Huang, H.5    Feingersh, D.6
  • 49
    • 84997637224 scopus 로고    scopus 로고
    • Acute heart failure due to autoimmune myocarditis under pembrolizumab treatment for metastatic melanoma
    • Laubli H, Balmelli C, Bossard M, Pfister O, Glatz K, Zippelius A. Acute heart failure due to autoimmune myocarditis under pembrolizumab treatment for metastatic melanoma. J Immunother Cancer 2015;3:11.
    • (2015) J Immunother Cancer , vol.3 , pp. 11
    • Laubli, H.1    Balmelli, C.2    Bossard, M.3    Pfister, O.4    Glatz, K.5    Zippelius, A.6
  • 50
    • 0033180181 scopus 로고    scopus 로고
    • Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor
    • Nishimura H, Nose M, Hiai H, Minato N, Honjo T. Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity 1999;11:141–51.
    • (1999) Immunity , vol.11 , pp. 141-151
    • Nishimura, H.1    Nose, M.2    Hiai, H.3    Minato, N.4    Honjo, T.5
  • 51
    • 29144469468 scopus 로고    scopus 로고
    • Hydronephrosis associated with antiurothelial and antinuclear autoantibodies in BALB/c-Fcgr2b-/-Pdcd1-/- mice
    • Okazaki T, Otaka Y, Wang J, Hiai H, Takai T, Ravetch JV, et al. Hydronephrosis associated with antiurothelial and antinuclear autoantibodies in BALB/c-Fcgr2b-/-Pdcd1-/- mice. J Exp Med 2005;202:1643–8.
    • (2005) J Exp Med , vol.202 , pp. 1643-1648
    • Okazaki, T.1    Otaka, Y.2    Wang, J.3    Hiai, H.4    Takai, T.5    Ravetch, J.V.6
  • 52
    • 10744220884 scopus 로고    scopus 로고
    • Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice
    • Okazaki T, Tanaka Y, Nishio R, Mitsuiye T, Mizoguchi A, Wang J, et al. Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice. Nat Med 2003;9:1477–83.
    • (2003) Nat Med , vol.9 , pp. 1477-1483
    • Okazaki, T.1    Tanaka, Y.2    Nishio, R.3    Mitsuiye, T.4    Mizoguchi, A.5    Wang, J.6
  • 53
    • 77954019731 scopus 로고    scopus 로고
    • PD-1 deficiency results in the development of fatal myocarditis in MRL mice
    • Wang J, Okazaki IM, Yoshida T, Chikuma S, Kato Y, Nakaki F, et al. PD-1 deficiency results in the development of fatal myocarditis in MRL mice. Int Immunol 2010;22:443–52.
    • (2010) Int Immunol , vol.22 , pp. 443-452
    • Wang, J.1    Okazaki, I.M.2    Yoshida, T.3    Chikuma, S.4    Kato, Y.5    Nakaki, F.6
  • 54
    • 84959916365 scopus 로고    scopus 로고
    • Idiopathic thrombocytopenic purpura induced by nivolumab in a metastatic melanoma patient with elevated PD-1 expression on B cells
    • Kanameishi S, Otsuka A, Nonomura Y, Fujisawa A, Endo Y, Kabashima K. Idiopathic thrombocytopenic purpura induced by nivolumab in a metastatic melanoma patient with elevated PD-1 expression on B cells. Ann Oncol 2016;27:546–7.
    • (2016) Ann Oncol , vol.27 , pp. 546-547
    • Kanameishi, S.1    Otsuka, A.2    Nonomura, Y.3    Fujisawa, A.4    Endo, Y.5    Kabashima, K.6
  • 55
    • 84957565779 scopus 로고    scopus 로고
    • Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis
    • Dubin K, Callahan MK, Ren B, Khanin R, Viale A, Ling L, et al. Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis. Nat Commun 2016;7:10391.
    • (2016) Nat Commun , vol.7 , pp. 10391
    • Dubin, K.1    Callahan, M.K.2    Ren, B.3    Khanin, R.4    Viale, A.5    Ling, L.6
  • 58
    • 77950196277 scopus 로고    scopus 로고
    • H 17 cells in tumour immunity and immunotherapy
    • H 17 cells in tumour immunity and immunotherapy. Nat Rev Immunol 2010;10:248–56.
    • (2010) Nat Rev Immunol , vol.10 , pp. 248-256
    • Zou, W.1    Restifo, N.P.2
  • 59
    • 84969535050 scopus 로고    scopus 로고
    • Managing adverse events with immune checkpoint agents
    • Dadu R, Zobniw C, Diab A. Managing adverse events with immune checkpoint agents. Cancer J 2016;22:121–9.
    • (2016) Cancer J , vol.22 , pp. 121-129
    • Dadu, R.1    Zobniw, C.2    Diab, A.3
  • 60
    • 84964573640 scopus 로고    scopus 로고
    • Management of immune checkpoint blockade dysimmune toxicities: a collaborative position paper
    • Champiat S, Lambotte O, Barreau E, Belkhir R, Berdelou A, Carbonnel F, et al. Management of immune checkpoint blockade dysimmune toxicities: a collaborative position paper. Ann Oncol 2016;27:559–74.
    • (2016) Ann Oncol , vol.27 , pp. 559-574
    • Champiat, S.1    Lambotte, O.2    Barreau, E.3    Belkhir, R.4    Berdelou, A.5    Carbonnel, F.6
  • 62
    • 79959833640 scopus 로고    scopus 로고
    • Does cancer that occurs during or after anti–tumor necrosis factor therapy have a worse prognosis? A national assessment of overall and site-specific cancer survival in rheumatoid arthritis patients treated with biologic agents
    • Raaschou P, Simard JF, Neovius M, Askling J, for the Anti-Rheumatic Therapy in Sweden Study Group. Does cancer that occurs during or after anti–tumor necrosis factor therapy have a worse prognosis? A national assessment of overall and site-specific cancer survival in rheumatoid arthritis patients treated with biologic agents. Arthritis Rheum 2011;63:1812–22.
    • (2011) Arthritis Rheum , vol.63 , pp. 1812-1822
    • Raaschou, P.1    Simard, J.F.2    Neovius, M.3    Askling, J.4
  • 63
    • 84954380570 scopus 로고    scopus 로고
    • TNF inhibitor therapy and risk of breast cancer recurrence in patients with rheumatoid arthritis: a nationwide cohort study
    • Raaschou P, Frisell T, Askling J, for the ARTIS Study Group. TNF inhibitor therapy and risk of breast cancer recurrence in patients with rheumatoid arthritis: a nationwide cohort study. Ann Rheum Dis 2015;74:2137–43.
    • (2015) Ann Rheum Dis , vol.74 , pp. 2137-2143
    • Raaschou, P.1    Frisell, T.2    Askling, J.3
  • 64
    • 85016385438 scopus 로고    scopus 로고
    • Yervoy. Medication guide
    • Yervoy. URLUS Food and Drug Administration. Medication guide: : http://www.fda.gov/downloads/Drugs/DrugSafety/UCM249168.pdf.
    • URLUS Food and Drug Administration
  • 65
    • 84984663113 scopus 로고    scopus 로고
    • Checkpoint immunotherapy: good for cancer therapy, bad for rheumatic diseases
    • Calabrese L, Velcheti V. Checkpoint immunotherapy: good for cancer therapy, bad for rheumatic diseases. Ann Rheum Dis 2017;76:1–3.
    • (2017) Ann Rheum Dis , vol.76 , pp. 1-3
    • Calabrese, L.1    Velcheti, V.2
  • 66
    • 47249153181 scopus 로고    scopus 로고
    • CTLA-4: a key regulatory point in the control of autoimmune disease
    • Scalapino KJ, Daikh DI. CTLA-4: a key regulatory point in the control of autoimmune disease. Immunol Rev 2008;223:143–55.
    • (2008) Immunol Rev , vol.223 , pp. 143-155
    • Scalapino, K.J.1    Daikh, D.I.2
  • 67
  • 68
    • 84910101471 scopus 로고    scopus 로고
    • The effect of CTLA-4 A49G polymorphism on rheumatoid arthritis risk: a meta-analysis
    • Li G, Shi F, Liu J, Li Y. The effect of CTLA-4 A49G polymorphism on rheumatoid arthritis risk: a meta-analysis. Diagn Pathol 2014;9:157.
    • (2014) Diagn Pathol , vol.9 , pp. 157
    • Li, G.1    Shi, F.2    Liu, J.3    Li, Y.4
  • 70
    • 85016356887 scopus 로고    scopus 로고
    • The association between CTLA-4 (+49 A/G) polymorphism and susceptibility to ankylosing spondylitis: a meta-analysis
    • E-pub ahead of print
    • Wu J, Zhang L, Zhou Y. The association between CTLA-4 (+49 A/G) polymorphism and susceptibility to ankylosing spondylitis: a meta-analysis. Int J Rheum Dis 2015. E-pub ahead of print.
    • (2015) Int J Rheum Dis
    • Wu, J.1    Zhang, L.2    Zhou, Y.3
  • 71
    • 84896548089 scopus 로고    scopus 로고
    • CTLA-4 polymorphisms and susceptibility to inflammatory bowel disease: a meta-analysis
    • Lee YH, Kim JH, Seo YH, Choi SJ, Ji JD, Song GG. CTLA-4 polymorphisms and susceptibility to inflammatory bowel disease: a meta-analysis. Hum Immunol 2014;75:414–21.
    • (2014) Hum Immunol , vol.75 , pp. 414-421
    • Lee, Y.H.1    Kim, J.H.2    Seo, Y.H.3    Choi, S.J.4    Ji, J.D.5    Song, G.G.6
  • 72
    • 84939892080 scopus 로고    scopus 로고
    • Meta-analysis of genetic polymorphisms in programmed cell death 1: associations with rheumatoid arthritis, ankylosing spondylitis, and type 1 diabetes susceptibility
    • Lee YH, Bae SC, Kim JH, Song GG. Meta-analysis of genetic polymorphisms in programmed cell death 1: associations with rheumatoid arthritis, ankylosing spondylitis, and type 1 diabetes susceptibility. Z Rheumatol 2015;74:230–9.
    • (2015) Z Rheumatol , vol.74 , pp. 230-239
    • Lee, Y.H.1    Bae, S.C.2    Kim, J.H.3    Song, G.G.4
  • 73
    • 62149115181 scopus 로고    scopus 로고
    • Association between the PD1.3A/G polymorphism of the PDCD1 gene and systemic lupus erythematosus in European populations: a meta-analysis
    • Liu JL, Zhang FY, Liang YH, Xiao FL, Zhang SQ, Cheng YL, et al. Association between the PD1.3A/G polymorphism of the PDCD1 gene and systemic lupus erythematosus in European populations: a meta-analysis. J Eur Acad Dermatol Venereol 2009;23:425–32.
    • (2009) J Eur Acad Dermatol Venereol , vol.23 , pp. 425-432
    • Liu, J.L.1    Zhang, F.Y.2    Liang, Y.H.3    Xiao, F.L.4    Zhang, S.Q.5    Cheng, Y.L.6
  • 74
    • 62749182367 scopus 로고    scopus 로고
    • Association of programmed cell death 1 polymorphisms and systemic lupus erythematosus: a meta-analysis
    • Lee YH, Woo JH, Choi SJ, Ji JD, Song GG. Association of programmed cell death 1 polymorphisms and systemic lupus erythematosus: a meta-analysis. Lupus 2009;18:9–15.
    • (2009) Lupus , vol.18 , pp. 9-15
    • Lee, Y.H.1    Woo, J.H.2    Choi, S.J.3    Ji, J.D.4    Song, G.G.5
  • 77
    • 84997610273 scopus 로고    scopus 로고
    • Rapid complete response of metastatic melanoma in a patient undergoing ipilimumab immunotherapy in the setting of active ulcerative colitis
    • Bostwick AD, Salama AK, Hanks BA. Rapid complete response of metastatic melanoma in a patient undergoing ipilimumab immunotherapy in the setting of active ulcerative colitis. J Immunother Cancer 2015;3:19.
    • (2015) J Immunother Cancer , vol.3 , pp. 19
    • Bostwick, A.D.1    Salama, A.K.2    Hanks, B.A.3
  • 78
    • 85015837474 scopus 로고    scopus 로고
    • Ipilimumab-induced colitis in a patient with ulcerative colitis and lung cancer
    • Kamil F, Cohen M, Kumta N, Wan D. Ipilimumab-induced colitis in a patient with ulcerative colitis and lung cancer. Am J Gastroenterol 2013;108:S404.
    • (2013) Am J Gastroenterol , vol.108 , pp. S404
    • Kamil, F.1    Cohen, M.2    Kumta, N.3    Wan, D.4
  • 79
    • 84916205029 scopus 로고    scopus 로고
    • Successful treatment with ipilimumab and interleukin-2 in two patients with metastatic melanoma and systemic autoimmune disease
    • Pedersen M, Andersen R, Norgaard P, Jacobsen S, Thielsen P, Thor Straten P, et al. Successful treatment with ipilimumab and interleukin-2 in two patients with metastatic melanoma and systemic autoimmune disease. Cancer Immunol Immunother 2014;63:1341–6.
    • (2014) Cancer Immunol Immunother , vol.63 , pp. 1341-1346
    • Pedersen, M.1    Andersen, R.2    Norgaard, P.3    Jacobsen, S.4    Thielsen, P.5    Thor Straten, P.6
  • 80
    • 85016348948 scopus 로고    scopus 로고
    • Induction of muscular sarcoidosis in a metastastic melanoma patient treated with ipilimumab
    • Plachouri KM, Mohr M, Sunderkotter C, Weishaupt C. Induction of muscular sarcoidosis in a metastastic melanoma patient treated with ipilimumab. J Dtsch Dermatol Ges 2012;10:861.
    • (2012) J Dtsch Dermatol Ges , vol.10 , pp. 861
    • Plachouri, K.M.1    Mohr, M.2    Sunderkotter, C.3    Weishaupt, C.4
  • 81
    • 85016355628 scopus 로고    scopus 로고
    • Muscular sarcoidosis in a metastatic melanoma patient treated with ipilimumab
    • Weishaupt C, Mohr M, Sunderkotter C. Muscular sarcoidosis in a metastatic melanoma patient treated with ipilimumab. J Dtsch Dermatol Ges 2012;10:683.
    • (2012) J Dtsch Dermatol Ges , vol.10 , pp. 683
    • Weishaupt, C.1    Mohr, M.2    Sunderkotter, C.3
  • 82
    • 84971324112 scopus 로고    scopus 로고
    • Severe psoriasis flare after anti-programmed death ligand 1 (PD-L1) therapy for metastatic non-small cell lung cancer (NSCLC)
    • Chia PL, John T. Severe psoriasis flare after anti-programmed death ligand 1 (PD-L1) therapy for metastatic non-small cell lung cancer (NSCLC). J Immunother 2016;39:202–4.
    • (2016) J Immunother , vol.39 , pp. 202-204
    • Chia, P.L.1    John, T.2
  • 84
    • 84954554294 scopus 로고    scopus 로고
    • Exacerbation of psoriasis during nivolumab therapy for metastatic melanoma
    • Matsumura N, Ohtsuka M, Kikuchi N, Yamamoto T. Exacerbation of psoriasis during nivolumab therapy for metastatic melanoma. Acta Derm Venereol 2016;96:259–60.
    • (2016) Acta Derm Venereol , vol.96 , pp. 259-260
    • Matsumura, N.1    Ohtsuka, M.2    Kikuchi, N.3    Yamamoto, T.4
  • 86
    • 84961942697 scopus 로고    scopus 로고
    • Successful anti-PD-1 antibody treatment in a metastatic melanoma patient with known severe autoimmune disease
    • Maul LV, Weichenthal M, Kahler KC, Hauschild A. Successful anti-PD-1 antibody treatment in a metastatic melanoma patient with known severe autoimmune disease. J Immunother 2016;39:188–90.
    • (2016) J Immunother , vol.39 , pp. 188-190
    • Maul, L.V.1    Weichenthal, M.2    Kahler, K.C.3    Hauschild, A.4
  • 87
    • 84952785505 scopus 로고    scopus 로고
    • Severe relapse in a multiple sclerosis patient associated with ipilimumab treatment of melanoma
    • Gettings EJ, Hackett CT, Scott TF. Severe relapse in a multiple sclerosis patient associated with ipilimumab treatment of melanoma. Mult Scler 2015;21:670.
    • (2015) Mult Scler , vol.21 , pp. 670
    • Gettings, E.J.1    Hackett, C.T.2    Scott, T.F.3
  • 88
    • 85015914196 scopus 로고    scopus 로고
    • A case of myasthenia gravis exacerbation in a patient with melanoma treated with pembrolizumab [poster]
    • Lau KH, Kumar A, Yang I, Nowak R. A case of myasthenia gravis exacerbation in a patient with melanoma treated with pembrolizumab [poster]. Neurology 2016;86 Suppl P3.138.
    • (2016) Neurology , vol.86 , pp. 138
    • Lau, K.H.1    Kumar, A.2    Yang, I.3    Nowak, R.4
  • 89
    • 84958985225 scopus 로고    scopus 로고
    • Immune thrombocytopenia exacerbated by nivolumab in a patient with non-small-cell lung cancer
    • Bagley SJ, Kosteva JA, Evans TL, Langer CJ. Immune thrombocytopenia exacerbated by nivolumab in a patient with non-small-cell lung cancer. Cancer Treat Commun 2016;6:20–3.
    • (2016) Cancer Treat Commun , vol.6 , pp. 20-23
    • Bagley, S.J.1    Kosteva, J.A.2    Evans, T.L.3    Langer, C.J.4
  • 90
    • 85015907153 scopus 로고    scopus 로고
    • Hyperthyroidism followed by worsening primary hypothyroidism in a patient treated with ipilimumab and pembrolizumab
    • Batacchi Z, Alarcon-Casas Wright L. Hyperthyroidism followed by worsening primary hypothyroidism in a patient treated with ipilimumab and pembrolizumab. Thyroid 2015;25:A215.
    • (2015) Thyroid , vol.25 , pp. A215
    • Batacchi, Z.1    Alarcon-Casas Wright, L.2
  • 91
    • 84956840392 scopus 로고    scopus 로고
    • Serological aggravation of autoimmune thyroid disease in two cases receiving nivolumab
    • Narita T, Oiso N, Taketomo Y, Okahashi K, Yamauchi K, Sato M, et al. Serological aggravation of autoimmune thyroid disease in two cases receiving nivolumab. J Dermatol 2016;43:210–4.
    • (2016) J Dermatol , vol.43 , pp. 210-214
    • Narita, T.1    Oiso, N.2    Taketomo, Y.3    Okahashi, K.4    Yamauchi, K.5    Sato, M.6
  • 92
    • 85016342140 scopus 로고    scopus 로고
    • Anti-CTLA-4 antibody therapy causing autoimmune hypophysitis in a patient with a longstanding history of Hashimotos's thyroiditis
    • Zmeili O, Samantray J. Anti-CTLA-4 antibody therapy causing autoimmune hypophysitis in a patient with a longstanding history of Hashimotos's thyroiditis. Endocr Rev 2013;1.
    • (2013) Endocr Rev , pp. 1
    • Zmeili, O.1    Samantray, J.2
  • 93
    • 85003054266 scopus 로고    scopus 로고
    • Ipilimumab therapy in patients with advanced melanoma and preexisting autoimmune disorders
    • Johnson DB, Sullivan RJ, Ott PA, Carlino MS, Khushalani NI, Ye F, et al. Ipilimumab therapy in patients with advanced melanoma and preexisting autoimmune disorders. JAMA Oncol 2016;2:234–40.
    • (2016) JAMA Oncol , vol.2 , pp. 234-240
    • Johnson, D.B.1    Sullivan, R.J.2    Ott, P.A.3    Carlino, M.S.4    Khushalani, N.I.5    Ye, F.6
  • 94
    • 84974824082 scopus 로고    scopus 로고
    • The use of ipilimumab in patients with rheumatoid arthritis and metastatic melanoma
    • Lee B, Wong A, Kee D, Neeson P, Shackleton M, McArthur G, et al. The use of ipilimumab in patients with rheumatoid arthritis and metastatic melanoma. Ann Oncol 2016;27:1174–7.
    • (2016) Ann Oncol , vol.27 , pp. 1174-1177
    • Lee, B.1    Wong, A.2    Kee, D.3    Neeson, P.4    Shackleton, M.5    McArthur, G.6
  • 95
    • 85006200692 scopus 로고    scopus 로고
    • Anti-PD-1 therapy in patients with advanced melanoma and preexisting autoimmune disorders or major toxicity with ipilimumab
    • E-Pub ahead of print
    • Menzies AM, Johnson DB, Ramanujam S, Atkinson VG, Wong AN, Park JJ, et al. Anti-PD-1 therapy in patients with advanced melanoma and preexisting autoimmune disorders or major toxicity with ipilimumab. Ann Oncol 2016. E-Pub ahead of print.
    • (2016) Ann Oncol
    • Menzies, A.M.1    Johnson, D.B.2    Ramanujam, S.3    Atkinson, V.G.4    Wong, A.N.5    Park, J.J.6
  • 96
    • 84940746759 scopus 로고    scopus 로고
    • Immune related adverse events associated with anti-CTLA-4 antibodies: systematic review and meta-analysis
    • Bertrand A, Kostine M, Barnetche T, Truchetet ME, Schaeverbeke T. Immune related adverse events associated with anti-CTLA-4 antibodies: systematic review and meta-analysis. BMC Med 2015;13:211.
    • (2015) BMC Med , vol.13 , pp. 211
    • Bertrand, A.1    Kostine, M.2    Barnetche, T.3    Truchetet, M.E.4    Schaeverbeke, T.5


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