Genetic disruption of ankyrin-G in adult mouse forebrain causes cortical synapse alteration and behavior reminiscent of bipolar disorder

Proceedings of the National Academy of Sciences of the United States of America

Volumn 114, Issue 39, 2017, Pages 10479-10484

  Zhu, Shanshan ^a   Cordner, Zachary A ^a   Xiong, Jiali ^a   Chiu, Chi Tso ^b   Artola, Arabiye ^a   Zuo, Yanning ^a   Nelson, Andrew D ^c   Kim, Tae Yeon ^a   Zaika, Natalya ^a   Woolums, Brian M ^a   Hess, Evan J ^a   Wang, Xiaofang ^a   Chuang, De Maw ^b   Pletnikov, Mikhail M ^a,d   Jenkins, Paul M ^c   Tamashiro, Kellie L ^a   Ross, Christopher A ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^d JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

ANK3; Axon initial segment; Chandelier synapse; Lithium; Mania

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; ANKYRIN; ANKYRIN G; LITHIUM CARBONATE; PROTEIN C FOS; UNCLASSIFIED DRUG; VALPROIC ACID; VOLTAGE GATED POTASSIUM CHANNEL; VOLTAGE GATED SODIUM CHANNEL; ANK3 PROTEIN, MOUSE; LITHIUM; METHYLPHENIDATE; PROTEIN KINASE FYN;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR CHANGE; BIPOLAR DEPRESSION; BIPOLAR DISORDER; CONTROLLED STUDY; FEMALE; FOREBRAIN; GENE DELETION; GENE DISRUPTION; HYPERACTIVITY; LOCOMOTION; MALE; MANIA; MOUSE; MOUSE MODEL; NONHUMAN; OPEN FIELD TEST; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSYCHOSIS; PYRAMIDAL NERVE CELL; SYNAPSE; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; DISEASE MODEL; GENETICS; KNOCKOUT MOUSE; PATHOLOGY; PATHOPHYSIOLOGY;

ANIMALS; ANKYRINS; BIPOLAR DISORDER; DISEASE MODELS, ANIMAL; GABAERGIC NEURONS; LITHIUM; METHYLPHENIDATE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; POTASSIUM CHANNELS, VOLTAGE-GATED; PROSENCEPHALON; PROTO-ONCOGENE PROTEINS C-FYN; SYNAPSES; VALPROIC ACID; VOLTAGE-GATED SODIUM CHANNELS;

EID: 85029849246     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1700689114     Document Type: Article

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