Studies in humans and mice implicate neurocan in the etiology of mania

American Journal of Psychiatry

Volumn 169, Issue 9, 2012, Pages 982-990

  Miró, Xavier ^a,b,c,d,e   Meier, Sandra ^a,b,c,d,e   Dreisow, Marie Luise ^a,b,c,d,e   Frank, Josef ^a,b,c,d,e   Strohmaier, Jana ^a,b,c,d,e   Breuer, René ^a,b,c,d,e   Schmäl, Christine ^a,b,c,d,e   Albayram, Önder ^a,b,c,d,e   Pardo Olmedilla, María Teresa ^a,b,c,d,e   Mühleisen, Thomas W ^a,b,c,d,e   Degenhardt, Franziska A ^a,b,c,d,e   Mattheisen, Manuel ^a,b,c,d,e   Reinhard, Iris ^a,b,c,d,e   Bilkei Gorzo, Andras ^a,b,c,d,e   Cichon, Sven ^a,b,c,d,e   Seidenbecher, Constanze ^a,b,c,d,e   Rietschel, Marcella ^a,b,c,d,e   Nöthen, Markus M ^a,b,c,d,e   Zimmer, Andreas ^a,b,c,d,e  

^a UNIVERSITY OF BONN   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^d FORSCHUNGSZENTRUM JÜLICH   (Germany)

^e LEIBNIZ INSTITUTE FOR NEUROBIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHETAMINE; LITHIUM; NEUROCAN; SACCHARIN;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIPOLAR DISORDER; COMPULSION; CONTROLLED STUDY; DRUG HYPERSENSITIVITY; EMOTION; EXPLORATORY BEHAVIOR; FEMALE; GENE; GENETIC ASSOCIATION; GENETIC RISK; GENOTYPE PHENOTYPE CORRELATION; HUMAN; KNOCKOUT MOUSE; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; MOUSE; NCAN GENE; NONHUMAN; PHENOTYPE; PREPULSE INHIBITION; PRIORITY JOURNAL; SCHIZOPHRENIA; SYMPTOMATOLOGY;

EID: 84865845956     PISSN: 0002953X     EISSN: 15357228     Source Type: Journal    
DOI: 10.1176/appi.ajp.2012.11101585     Document Type: Article

References (38)

1. Nöthen MM, Nieratschker V, Cichon S, Rietschel M: New findings in the genetics of major psychoses. Dialogues Clin Neurosci 2010; 12:85-93
2. Cichon S, Mühleisen TW, Degenhardt FA, Mattheisen M, Miró X, Strohmaier J, Steffens M, Meesters C, Herms S, Weingarten M, Priebe L, Haenisch B, Alexander M, Vollmer J, Breuer R, Schmäl C, Tessmann P, Moebus S, Wichmann HE, Schreiber S, Müller-Myhsok B, Lucae S, Jamain S, Leboyer M, Bellivier F, Etain B, Henry C, Kahn JP, Heath S, Hamshere M, O'Donovan MC, Owen MJ, Craddock N, Schwarz M, Vedder H, Kammerer-Ciernioch J, Reif A, Sasse J, Bauer M, Hautzinger M, Wright A, Mitchell PB, Schofield PR, Montgomery GW, Medland SE, Gordon SD, Martin NG, Gustafsson O, Andreassen O, Djurovic S, Sigurdsson E, Steinberg S, Stefansson H, Stefansson K, Kapur-Pojskic L, Oruc L, Rivas F, Mayoral F, Chuchalin A, Babadjanova G, Tiganov AS, Pantelejeva G, Abramova LI, Grigoroiu-Serbanescu M, Diaconu CC, Czerski PM, Hauser J, Zimmer A, Lathrop M, Schulze TG, Wienker TF, Schumacher J, Maier W, Propping P, Rietschel M, Nöthen MM; Bipolar Disorder Genome Study (BiGS) Consortium: Genome-wide association study identifies genetic variation in neurocan as a susceptibility factor for bipolar disorder. Am J Hum Genet 2011; 88:372-381
3. Ferreira MA, O'Donovan MC, Meng YA, Jones IR, Ruderfer DM, Jones L, Fan J, Kirov G, Perlis RH, Green EK, Smoller JW, Grozeva D, Stone J, Nikolov I, Chambert K, Hamshere ML, Nimgaonkar VL, Moskvina V, Thase ME, Caesar S, Sachs GS, Franklin J, Gordon-Smith K, Ardlie KG, Gabriel SB, Fraser C, Blumenstiel B, Defelice M, Breen G, Gill M, Morris DW, Elkin A, Muir WJ, McGhee KA, Williamson R, MacIntyre DJ, MacLean AW, St CD, Robinson M, Van Beck M, Pereira AC, Kandaswamy R, McQuillin A, Collier DA, Bass NJ, Young AH, Lawrence J, Ferrier IN, Anjorin A, Farmer A, Curtis D, Scolnick EM, McGuffin P, Daly MJ, Corvin AP, Holmans PA, Blackwood DH, Gurling HM, Owen MJ, Purcell SM, Sklar P, Craddock N; Wellcome Trust Case Control Consortium: Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nat Genet 2008; 40:1056-1058
4. Sklar P, Ripke S, Scott LJ, Andreassen OA, Cichon S, Craddock N, et al (Psychiatric GWAS Consortium Bipolar Disorder Working Group): Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nat Genet 2011; 43:977-983
5. Purcell SM, Wray NR, Stone JL, Visscher PM, O'Donovan MC, Sullivan PF, Sklar P; International Schizophrenia Consortium: Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 2009; 460:748-752
6. Schulze TG, McMahon FJ: Defining the phenotype in human genetic studies: forward genetics and reverse phenotyping. Hum Hered 2004; 58:131-138 (Pubitemid 40754344)
7. Malkesman O, Austin DR, Chen G, Manji HK: Reverse translational strategies for developing animal models of bipolar disorder. Dis Model Mech 2009; 2:238-245
8. Moskvina V, Craddock N, Holmans P, Nikolov I, Pahwa JS, Green E, Owen MJ, O'Donovan MC; Wellcome Trust Case Control Consortium: Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk. Mol Psychiatry 2009; 14:252-260
9. Lichtenstein P, Yip BH, Björk C, Pawitan Y, Cannon TD, Sullivan PF, Hultman CM: Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study. Lancet 2009; 373:234-239
10. First MB, Spitzer RL, Gibbon M, Williams JBW: Structured Clinical Interview for DSM-IV Axis I Disorders. Washington, DC, American Psychiatric Press, 1998
11. McGuffin P, Farmer A, Harvey I: A polydiagnostic application of operational criteria in studies of psychotic illness. Development and reliability of the OPCRIT system. Arch Gen Psychiatry 1991; 48:764-770
12. Rietschel M, Mattheisen M, Frank J, Treutlein J, Degenhardt F, Breuer R, Steffens M, Mier D, Esslinger C, Walter H, Kirsch P, Erk S, Schnell K, Herms S, Wichmann HE, Schreiber S, Jöckel KH, Strohmaier J, Roeske D, Haenisch B, Gross M, Hoefels S, Lucae S, Binder EB, Wienker TF, Schulze TG, Schmäl C, Zimmer A, Juraeva D, Brors B, Bettecken T, Meyer-Lindenberg A, Müller-Myhsok B, Maier W, Nöthen MM, Cichon S: Genome-wide association-, replication-, and neuroimaging study implicates HOMER1 in the etiology of major depression. Biol Psychiatry 2010; 68:578-585
13. Rietschel M, Mattheisen M, Degenhardt F, Kahn RS, Linszen DH, Os JV, et al: Association between genetic variation in a region on chromosome 11 and schizophrenia in large samples from Europe. Mol Psychiatry 2011; 10.1038/mp.2011.80
14. Cattell RB: The scree test for the number of factors. Multivariate Behav Res 1966; 1:254-276
15. Tabachnick BG, Fidell LS: Using Multivariate Statistics. New York, HarperCollins College, 1996
16. Ng WX, Lau IY, Graham S, Sim K: Neurobiological evidence for thalamic, hippocampal and related glutamatergic abnormalities in bipolar disorder: a review and synthesis. Neurosci Biobehav Rev 2009; 33:336-354
17. Nestler EJ, Hyman SE: Animal models of neuropsychiatric disorders. Nat Neurosci 2010; 13:1161-1169
18. Tondo L, Baldessarini RJ, Hennen J, Floris G: Lithium maintenance treatment of depression and mania in bipolar I and bipolar II disorders. Am J Psychiatry 1998; 155:638-645 (Pubitemid 28225404)
19. Gelenberg AJ, Kane JM, Keller MB, Lavori P, Rosenbaum JF, Cole K, Lavelle J: Comparison of standard and low serum levels of lithium for maintenance treatment of bipolar disorder. N Engl J Med 1989; 321:1489-1493 (Pubitemid 20015538)
20. Roybal K, Theobold D, Graham A, DiNieri JA, Russo SJ, Krishnan V, Chakravarty S, Peevey J, Oehrlein N, Birnbaum S, Vitaterna MH, Orsulak P, Takahashi JS, Nestler EJ, Carlezon WA Jr, McClung CA: Mania-like behavior induced by disruption of CLOCK. Proc Natl Acad Sci USA 2007; 104:6406-6411 (Pubitemid 47186107)
21. Lien R, Flaisher-Grinberg S, Cleary C, Hejny M, Einat H: Behavioral effects of Bcl-2 deficiency: implications for affective disorders. Pharmacol Rep 2008; 60:490-498
22. Shaltiel G, Maeng S, Malkesman O, Pearson B, Schloesser RJ, Tragon T, Rogawski M, Gasior M, Luckenbaugh D, Chen G, Manji HK: Evidence for the involvement of the kainate receptor subunit GluR6 (GRIK2) in mediating behavioral displays related to behavioral symptoms of mania. Mol Psychiatry 2008; 13:858-872
23. O'Donovan MC, Craddock NJ, Owen MJ: Genetics of psychosis; insights from views across the genome. Hum Genet 2009; 126:3-12
24. Hollander E, Pallanti S, Allen A, Sood E, Baldini Rossi N: Does sustained-release lithium reduce impulsive gambling and affective instability versus placebo in pathological gamblers with bipolar spectrum disorders? Am J Psychiatry 2005; 162:137-145 (Pubitemid 40095683)
25. Porsolt RD, Bertin A, Jalfre M: Behavioral despair in mice: a primary screening test for antidepressants. Arch Int Pharmacodyn Ther 1977; 229:327-336 (Pubitemid 8225714)
26. Flaisher-Grinberg S, Einat H: A possible utilization of the mice forced swim test for modeling manic-like increase in vigor and goal-directed behavior. J Pharmacol Toxicol Methods 2009; 59:141-145
27. Thomas A, Burant A, Bui N, Graham D, Yuva-Paylor LA, Paylor R: Marble burying reflects a repetitive and perseverative behavior more than novelty-induced anxiety. Psychopharmacology (Berl) 2009; 204:361-373
28. Flaisher-Grinberg S, Overgaard S, Einat H: Attenuation of high sweet solution preference by mood stabilizers: a possible mouse model for the increased reward-seeking domain of mania. J Neurosci Methods 2009; 177:44-50
29. Powell CM, Miyakawa T: Schizophrenia-relevant behavioral testing in rodent models: a uniquely human disorder? Biol Psychiatry 2006; 59:1198-1207
30. Anand A, Verhoeff P, Seneca N, Zoghbi SS, Seibyl JP, Charney DS, Innis RB: Brain SPECT imaging of amphetamine-induced dopamine release in euthymic bipolar disorder patients. Am J Psychiatry 2000; 157:1108-1114 (Pubitemid 30432492)
31. Perry W, Minassian A, Feifel D, Braff DL: Sensorimotor gating deficits in bipolar disorder patients with acute psychotic mania. Biol Psychiatry 2001; 50:418-424 (Pubitemid 32885591)
32. Geyer MA, McIlwain KL, Paylor R: Mouse genetic models for prepulse inhibition: an early review. Mol Psychiatry 2002; 7:1039-1053 (Pubitemid 36044262)
33. Engel SR, Creson TK, Hao Y, Shen Y, Maeng S, Nekrasova T, Landreth GE, Manji HK, Chen G: The extracellular signal-regulated kinase pathway contributes to the control of behavioral excitement. Mol Psychiatry 2009; 14:448-461
34. Prickaerts J, Moechars D, Cryns K, Lenaerts I, van Craenendonck H, Goris I, Daneels G, Bouwknecht JA, Steckler T: Transgenic mice overexpressing glycogen synthase kinase 3beta: a putative model of hyperactivity and mania. J Neurosci 2006; 26:9022-9029 (Pubitemid 44319393)
35. Järveläinen H, Sainio A, Koulu M, Wight TN, Penttinen R: Extracellular matrix molecules: potential targets in pharmacotherapy. Pharmacol Rev 2009; 61:198-223
36. Friedlander DR, Milev P, Karthikeyan L, Margolis RK, Margolis RU, Grumet M: The neuronal chondroitin sulfate proteoglycan neurocan binds to the neural cell adhesion molecules Ng-CAM/L1/NILE and N-CAM, and inhibits neuronal adhesion and neurite outgrowth. J Cell Biol 1994; 125:669-680 (Pubitemid 24149848)
37. BrainSpan: Atlas of the Developing Human Brain [Internet]. http://www.brainspan.org/rnaseq/search?type5rnaseq&query5NCAN
38. Adler CM, DelBello MP, Strakowski SM: Brain network dysfunction in bipolar disorder. CNS Spectr 2006; 11:312-320