Pharmacologic ascorbate induces neuroblastoma cell death by hydrogen peroxide mediated DNA damage and reduction in cancer cell glycolysis

Free Radical Biology and Medicine

Volumn 113, Issue , 2017, Pages 36-47

  Ma, Enlong ^a,b   Chen, Ping ^a   Wilkins, Heather M ^a   Wang, Tao ^a   Swerdlow, Russell H ^a   Chen, Qi ^a  

^a UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Ascorbate; DNA damage; GAPDH; Glycolysis; Neuroblastoma; Poly ADP ribose polymerase

Indexed keywords

ADENOSINE TRIPHOSPHATE; ASCORBIC ACID; HYDROGEN PEROXIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; OLAPARIB; REACTIVE OXYGEN METABOLITE; DNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER INHIBITION; CONTROLLED STUDY; DNA REPAIR; DOUBLE STRANDED DNA BREAK; DRUG CYTOTOXICITY; DRUG MECHANISM; FEMALE; GLYCOLYSIS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NEUROBLASTOMA; NONHUMAN; PRIORITY JOURNAL; SURVIVAL RATE; ANIMAL; CELL DEATH; DNA DAMAGE; DRUG EFFECT; DRUG SCREENING; METABOLISM; OXIDATIVE STRESS; PATHOPHYSIOLOGY;

ANIMALS; ASCORBIC ACID; CELL DEATH; DNA; DNA DAMAGE; DNA REPAIR; HUMANS; HYDROGEN PEROXIDE; MICE; NEUROBLASTOMA; OXIDATIVE STRESS; POLY(ADP-RIBOSE) POLYMERASES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 85029710006     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2017.09.008     Document Type: Article

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