-
1
-
-
0001186007
-
Isolation of a quinone from beef heart mitochondria
-
Crane, F.L., et al. Isolation of a quinone from beef heart mitochondria. Biochim. Biophys. Acta 25 (1957), 220–221.
-
(1957)
Biochim. Biophys. Acta
, vol.25
, pp. 220-221
-
-
Crane, F.L.1
-
2
-
-
33845803442
-
Ubiquinone
-
Morton, R.A., Ubiquinone. Nature 182 (1958), 1764–1767.
-
(1958)
Nature
, vol.182
, pp. 1764-1767
-
-
Morton, R.A.1
-
3
-
-
0003176915
-
Coenzyme Q: a new group of quinones
-
Lester, R.L., et al. Coenzyme Q: a new group of quinones. J. Am. Chem. Soc. 80 (1958), 4751–4752.
-
(1958)
J. Am. Chem. Soc.
, vol.80
, pp. 4751-4752
-
-
Lester, R.L.1
-
4
-
-
33947461714
-
Coenzyme Q. I. Structure Studies on the Coenzyme Q Group
-
Wolf, D.E., Coenzyme Q. I. Structure Studies on the Coenzyme Q Group. J. Am. Chem. Soc., 80, 1958, 4752.
-
(1958)
J. Am. Chem. Soc.
, vol.80
, pp. 4752
-
-
Wolf, D.E.1
-
5
-
-
0016690480
-
Protonmotive redox mechanism of the cytochrome b-c1 complex in the respiratory chain: protonmotive ubiquinone cycle
-
Mitchell, P., Protonmotive redox mechanism of the cytochrome b-c1 complex in the respiratory chain: protonmotive ubiquinone cycle. FEBS Lett. 56 (1975), 1–6.
-
(1975)
FEBS Lett.
, vol.56
, pp. 1-6
-
-
Mitchell, P.1
-
6
-
-
0001553686
-
The natural occurrence of coenzyme Q and related compounds
-
Lester, R.L., Crane, F.L., The natural occurrence of coenzyme Q and related compounds. J. Biol. Chem. 234 (1959), 2169–2175.
-
(1959)
J. Biol. Chem.
, vol.234
, pp. 2169-2175
-
-
Lester, R.L.1
Crane, F.L.2
-
7
-
-
0018823799
-
Pyrimidine nucleotide biosynthesis in animals: genes, enzymes, and regulation of UMP biosynthesis
-
Jones, M.E., Pyrimidine nucleotide biosynthesis in animals: genes, enzymes, and regulation of UMP biosynthesis. Annu. Rev. Biochem. 49 (1980), 253–279.
-
(1980)
Annu. Rev. Biochem.
, vol.49
, pp. 253-279
-
-
Jones, M.E.1
-
8
-
-
0024021560
-
Acyl-CoA dehydrogenases, electron transfer flavoprotein and electron transfer flavoprotein dehydrogenase
-
Frerman, F.E., Acyl-CoA dehydrogenases, electron transfer flavoprotein and electron transfer flavoprotein dehydrogenase. Biochem. Soc. Trans. 16 (1988), 416–418.
-
(1988)
Biochem. Soc. Trans.
, vol.16
, pp. 416-418
-
-
Frerman, F.E.1
-
9
-
-
0034735799
-
Coenzyme Q is an obligatory cofactor for uncoupling protein function
-
Echtay, K.S., et al. Coenzyme Q is an obligatory cofactor for uncoupling protein function. Nature 408 (2000), 609–613.
-
(2000)
Nature
, vol.408
, pp. 609-613
-
-
Echtay, K.S.1
-
10
-
-
0032475979
-
A ubiquinone-binding site regulates the mitochondrial permeability transition pore
-
Fontaine, E., et al. A ubiquinone-binding site regulates the mitochondrial permeability transition pore. J. Biol. Chem. 273 (1998), 25734–25740.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 25734-25740
-
-
Fontaine, E.1
-
11
-
-
0343559188
-
Distribution of coenzyme Q in rat liver cell fractions
-
Sastry, S.P., et al. Distribution of coenzyme Q in rat liver cell fractions. Nature, 189, 1961, 577.
-
(1961)
Nature
, vol.189
, pp. 577
-
-
Sastry, S.P.1
-
12
-
-
0029799910
-
Enhanced sensitivity of ubiquinone-deficient mutants of Saccharomyces cerevisiae to products of autoxidized polyunsaturated fatty acids
-
Do, T.Q., et al. Enhanced sensitivity of ubiquinone-deficient mutants of Saccharomyces cerevisiae to products of autoxidized polyunsaturated fatty acids. Proc. Natl. Acad. Sci. U. S. A. 93 (1996), 7534–7539.
-
(1996)
Proc. Natl. Acad. Sci. U. S. A.
, vol.93
, pp. 7534-7539
-
-
Do, T.Q.1
-
13
-
-
0025979077
-
Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol
-
Stocker, R., et al. Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol. Proc. Natl. Acad. Sci. U. S. A. 88 (1991), 1646–1650.
-
(1991)
Proc. Natl. Acad. Sci. U. S. A.
, vol.88
, pp. 1646-1650
-
-
Stocker, R.1
-
14
-
-
0025327523
-
Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations
-
Frei, B., et al. Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations. Proc. Natl. Acad. Sci. U. S. A. 87 (1990), 4879–4883.
-
(1990)
Proc. Natl. Acad. Sci. U. S. A.
, vol.87
, pp. 4879-4883
-
-
Frei, B.1
-
15
-
-
84896597381
-
Ubiquinone accumulation improves osmotic-stress tolerance in Escherichia coli
-
Sevin, D.C., Sauer, U., Ubiquinone accumulation improves osmotic-stress tolerance in Escherichia coli. Nat. Chem. Biol. 10 (2014), 266–272.
-
(2014)
Nat. Chem. Biol.
, vol.10
, pp. 266-272
-
-
Sevin, D.C.1
Sauer, U.2
-
16
-
-
84899657181
-
A chloroplast retrograde signal regulates nuclear alternative splicing
-
Petrillo, E., et al. A chloroplast retrograde signal regulates nuclear alternative splicing. Science 344 (2014), 427–430.
-
(2014)
Science
, vol.344
, pp. 427-430
-
-
Petrillo, E.1
-
17
-
-
0024401216
-
Age-related changes in the lipid compositions of rat and human tissues
-
Kalen, A., et al. Age-related changes in the lipid compositions of rat and human tissues. Lipids 24 (1989), 579–584.
-
(1989)
Lipids
, vol.24
, pp. 579-584
-
-
Kalen, A.1
-
18
-
-
0029776793
-
Determination of life-span in Caenorhabditis elegans by four clock genes
-
Lakowski, B., Hekimi, S., Determination of life-span in Caenorhabditis elegans by four clock genes. Science 272 (1996), 1010–1013.
-
(1996)
Science
, vol.272
, pp. 1010-1013
-
-
Lakowski, B.1
Hekimi, S.2
-
19
-
-
0031030678
-
Structural and functional conservation of the Caenorhabditis elegans timing gene clk-1
-
Ewbank, J.J., et al. Structural and functional conservation of the Caenorhabditis elegans timing gene clk-1. Science 275 (1997), 980–983.
-
(1997)
Science
, vol.275
, pp. 980-983
-
-
Ewbank, J.J.1
-
20
-
-
0037016442
-
Extension of life-span in Caenorhabditis elegans by a diet lacking coenzyme Q
-
Larsen, P.L., Clarke, C.F., Extension of life-span in Caenorhabditis elegans by a diet lacking coenzyme Q. Science 295 (2002), 120–123.
-
(2002)
Science
, vol.295
, pp. 120-123
-
-
Larsen, P.L.1
Clarke, C.F.2
-
21
-
-
85018249352
-
A single biochemical activity underlies the pleiotropy of the aging-related protein CLK-1
-
Liu, J.-L., et al. A single biochemical activity underlies the pleiotropy of the aging-related protein CLK-1. Sci. Rep., 7, 2017, 859.
-
(2017)
Sci. Rep.
, vol.7
, pp. 859
-
-
Liu, J.-L.1
-
22
-
-
26944501617
-
Evolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice
-
Liu, X., et al. Evolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice. Genes Dev. 19 (2005), 2424–2434.
-
(2005)
Genes Dev.
, vol.19
, pp. 2424-2434
-
-
Liu, X.1
-
23
-
-
84955579916
-
Understanding ubiquinone
-
Wang, Y., Hekimi, S., Understanding ubiquinone. Trends Cell Biol. 26 (2016), 367–378.
-
(2016)
Trends Cell Biol.
, vol.26
, pp. 367-378
-
-
Wang, Y.1
Hekimi, S.2
-
24
-
-
34248188655
-
The uptake and distribution of coenzyme Q10
-
Miles, M.V., The uptake and distribution of coenzyme Q10. Mitochondrion 7 (2007), S72–S77.
-
(2007)
Mitochondrion
, vol.7
, pp. S72-S77
-
-
Miles, M.V.1
-
25
-
-
0015523207
-
3-Polyprenyl-4-hydroxybenzoate synthesis in the inner membrane of mitochondria from p-hydroxybenzoate and isopentenylpyrophosphate. A demonstration of isoprenoid synthesis in rat liver mitochondria
-
Momose, K., Rudney, H., 3-Polyprenyl-4-hydroxybenzoate synthesis in the inner membrane of mitochondria from p-hydroxybenzoate and isopentenylpyrophosphate. A demonstration of isoprenoid synthesis in rat liver mitochondria. J. Biol. Chem. 247 (1972), 3930–3940.
-
(1972)
J. Biol. Chem.
, vol.247
, pp. 3930-3940
-
-
Momose, K.1
Rudney, H.2
-
26
-
-
0025017435
-
Nonaprenyl-4-hydroxybenzoate transferase, an enzyme involved in ubiquinone biosynthesis, in the endoplasmic reticulum-Golgi system of rat liver
-
Kalen, A., et al. Nonaprenyl-4-hydroxybenzoate transferase, an enzyme involved in ubiquinone biosynthesis, in the endoplasmic reticulum-Golgi system of rat liver. J. Biol. Chem. 265 (1990), 1158–1164.
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 1158-1164
-
-
Kalen, A.1
-
27
-
-
0023232221
-
Ubiquinone biosynthesis by the microsomal fraction from rat liver
-
Kalen, A., et al. Ubiquinone biosynthesis by the microsomal fraction from rat liver. Biochim. Biophys. Acta 926 (1987), 70–78.
-
(1987)
Biochim. Biophys. Acta
, vol.926
, pp. 70-78
-
-
Kalen, A.1
-
28
-
-
84873324400
-
Ubiad1 is an antioxidant enzyme that regulates eNOS activity by CoQ10 synthesis
-
Mugoni, V., et al. Ubiad1 is an antioxidant enzyme that regulates eNOS activity by CoQ10 synthesis. Cell 152 (2013), 504–518.
-
(2013)
Cell
, vol.152
, pp. 504-518
-
-
Mugoni, V.1
-
29
-
-
0033815884
-
New advances in coenzyme Q biosynthesis
-
Clarke, C.F., New advances in coenzyme Q biosynthesis. Protoplasma 213 (2000), 134–147.
-
(2000)
Protoplasma
, vol.213
, pp. 134-147
-
-
Clarke, C.F.1
-
30
-
-
84901842133
-
Biosynthesis and physiology of coenzyme Q in bacteria
-
Aussel, L., et al. Biosynthesis and physiology of coenzyme Q in bacteria. Biochim. Biophys. Acta 1837 (2014), 1004–1011.
-
(2014)
Biochim. Biophys. Acta
, vol.1837
, pp. 1004-1011
-
-
Aussel, L.1
-
31
-
-
9444247197
-
The origin of the benzoquinone ring of coenzyme Q9 in the rat
-
Bentley, R.R., et al. The origin of the benzoquinone ring of coenzyme Q9 in the rat. Biochem. Biophys. Res. Commun. 5 (1961), 443–446.
-
(1961)
Biochem. Biophys. Res. Commun.
, vol.5
, pp. 443-446
-
-
Bentley, R.R.1
-
32
-
-
4244182462
-
Benzoate derivatives as intermediates in the biosynthesis of coenzyme Q in the rat
-
Olson, R.E., et al. Benzoate derivatives as intermediates in the biosynthesis of coenzyme Q in the rat. J. Biol. Chem. 238 (1963), 3146–3148.
-
(1963)
J. Biol. Chem.
, vol.238
, pp. 3146-3148
-
-
Olson, R.E.1
-
33
-
-
0000977593
-
Urinary phenolic acid metabolites of tyrosine
-
Booth, A.N., et al. Urinary phenolic acid metabolites of tyrosine. J. Biol. Chem. 235 (1960), 2649–2652.
-
(1960)
J. Biol. Chem.
, vol.235
, pp. 2649-2652
-
-
Booth, A.N.1
-
34
-
-
84992365080
-
Mechanistic details of early steps in coenzyme Q biosynthesis pathway in yeast
-
Payet, L.A., et al. Mechanistic details of early steps in coenzyme Q biosynthesis pathway in yeast. Cell Chem. Biol. 23 (2016), 1241–1250.
-
(2016)
Cell Chem. Biol.
, vol.23
, pp. 1241-1250
-
-
Payet, L.A.1
-
35
-
-
0013566349
-
The branch point in the biosynthesis of the aromatic amino-acids
-
Gibson, M.I., et al. The branch point in the biosynthesis of the aromatic amino-acids. Nature 195 (1962), 1173–1175.
-
(1962)
Nature
, vol.195
, pp. 1173-1175
-
-
Gibson, M.I.1
-
36
-
-
36949072251
-
Conversion of shikimic acid to aromatic compounds
-
Morgan, P.N., et al. Conversion of shikimic acid to aromatic compounds. Nature 194 (1962), 1239–1241.
-
(1962)
Nature
, vol.194
, pp. 1239-1241
-
-
Morgan, P.N.1
-
37
-
-
48449083807
-
Biosynthesis of vitamin K and ubiquinone. Relation to the shikimic acid pathway in Escherichia coli
-
Cox, G.B., Gibson, F., Biosynthesis of vitamin K and ubiquinone. Relation to the shikimic acid pathway in Escherichia coli. Biochim. Biophys. Acta 93 (1964), 204–206.
-
(1964)
Biochim. Biophys. Acta
, vol.93
, pp. 204-206
-
-
Cox, G.B.1
Gibson, F.2
-
38
-
-
0015954095
-
Biosynthesis of ubiquinone in Escherichia coli K-12: biochemical and genetic characterization of a mutant unable to convert chorismate into 4-hydroxybenzoate
-
Lawrence, J., et al. Biosynthesis of ubiquinone in Escherichia coli K-12: biochemical and genetic characterization of a mutant unable to convert chorismate into 4-hydroxybenzoate. J. Bacteriol. 118 (1974), 41–45.
-
(1974)
J. Bacteriol.
, vol.118
, pp. 41-45
-
-
Lawrence, J.1
-
39
-
-
77956251553
-
para-Aminobenzoic acid is a precursor in coenzyme Q6 biosynthesis in Saccharomyces cerevisiae
-
Marbois, B., et al. para-Aminobenzoic acid is a precursor in coenzyme Q6 biosynthesis in Saccharomyces cerevisiae. J. Biol. Chem. 285 (2010), 27827–27838.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 27827-27838
-
-
Marbois, B.1
-
40
-
-
77954182740
-
Involvement of mitochondrial ferredoxin and para-aminobenzoic acid in yeast coenzyme Q biosynthesis
-
Pierrel, F., et al. Involvement of mitochondrial ferredoxin and para-aminobenzoic acid in yeast coenzyme Q biosynthesis. Chem. Biol. 17 (2010), 449–459.
-
(2010)
Chem. Biol.
, vol.17
, pp. 449-459
-
-
Pierrel, F.1
-
41
-
-
84992435612
-
Hypothesis driven versus hypothesis-free: filling the gaps in CoQ biosynthesis
-
Enriquez, J.A., et al. Hypothesis driven versus hypothesis-free: filling the gaps in CoQ biosynthesis. Cell Metab. 24 (2016), 525–526.
-
(2016)
Cell Metab.
, vol.24
, pp. 525-526
-
-
Enriquez, J.A.1
-
42
-
-
84994896151
-
Mitochondrial protein functions elucidated by multi-omic mass spectrometry profiling
-
Stefely, J.A., et al. Mitochondrial protein functions elucidated by multi-omic mass spectrometry profiling. Nat. Biotechnol. 34 (2016), 1191–1197.
-
(2016)
Nat. Biotechnol.
, vol.34
, pp. 1191-1197
-
-
Stefely, J.A.1
-
43
-
-
33644912080
-
Proteomic analysis of the yeast mitochondrial outer membrane reveals accumulation of a subclass of preproteins
-
Zahedi, R.P., et al. Proteomic analysis of the yeast mitochondrial outer membrane reveals accumulation of a subclass of preproteins. Mol. Biol. Cell 17 (2006), 1436–1450.
-
(2006)
Mol. Biol. Cell
, vol.17
, pp. 1436-1450
-
-
Zahedi, R.P.1
-
44
-
-
49749162582
-
On the biosynthesis of ubiquinone (50)
-
Gloor, U., Wiss, O., On the biosynthesis of ubiquinone (50). Arch. Biochem. Biophys. 83 (1959), 216–222.
-
(1959)
Arch. Biochem. Biophys.
, vol.83
, pp. 216-222
-
-
Gloor, U.1
Wiss, O.2
-
45
-
-
78651171565
-
Studies on coenzyme Q. Pattern of labeling in coenzyme Q9 after administration of isotopic acetate and aromatic amino acids to rats
-
Olson, R.E., et al. Studies on coenzyme Q. Pattern of labeling in coenzyme Q9 after administration of isotopic acetate and aromatic amino acids to rats. J. Biol. Chem. 240 (1965), 514–523.
-
(1965)
J. Biol. Chem.
, vol.240
, pp. 514-523
-
-
Olson, R.E.1
-
46
-
-
0014010953
-
Studies on coenzyme Q. The biosynthesis of coenzyme Q9 in rat tissue slices
-
Gold, P.H., Olson, R.E., Studies on coenzyme Q. The biosynthesis of coenzyme Q9 in rat tissue slices. J. Biol. Chem. 241 (1966), 3507–3516.
-
(1966)
J. Biol. Chem.
, vol.241
, pp. 3507-3516
-
-
Gold, P.H.1
Olson, R.E.2
-
47
-
-
0000135204
-
Phosphorylated intermediates in the synthesis of squalene
-
Chaykin, S., et al. Phosphorylated intermediates in the synthesis of squalene. Proc. Natl. Acad. Sci. U. S. A. 44 (1958), 998–1004.
-
(1958)
Proc. Natl. Acad. Sci. U. S. A.
, vol.44
, pp. 998-1004
-
-
Chaykin, S.1
-
48
-
-
0001016155
-
Farnesyl-pyrophosphat und 3-Methyl-d3-butenyl-1-pyrophosphat, die biologischen vorstufen des squalens
-
Lynen, F.E., et al. Farnesyl-pyrophosphat und 3-Methyl-d3-butenyl-1-pyrophosphat, die biologischen vorstufen des squalens. Angew. Chem. 70 (1958), 738–742.
-
(1958)
Angew. Chem.
, vol.70
, pp. 738-742
-
-
Lynen, F.E.1
-
49
-
-
0001247159
-
g,g-Dimethyl-allyl-pyrophosphat und geranyl-pyrophosphat, biologische vorstufen des squalens
-
Lynen, F.A., et al. g,g-Dimethyl-allyl-pyrophosphat und geranyl-pyrophosphat, biologische vorstufen des squalens. Angew. Chem. 71 (1959), 657–684.
-
(1959)
Angew. Chem.
, vol.71
, pp. 657-684
-
-
Lynen, F.A.1
-
50
-
-
0014685825
-
The incorporation of p-hydroxybenzoic acid and isopentenyl pyrophosphate into ubiquinone precursors by cell-free preparations of rat tissues
-
Winrow, M.J., Rudney, H., The incorporation of p-hydroxybenzoic acid and isopentenyl pyrophosphate into ubiquinone precursors by cell-free preparations of rat tissues. Biochem. Biophys. Res. Commun. 37 (1969), 833–840.
-
(1969)
Biochem. Biophys. Res. Commun.
, vol.37
, pp. 833-840
-
-
Winrow, M.J.1
Rudney, H.2
-
51
-
-
0018175291
-
Formation of 3-hexaprenyl-4-hydroxybenzoate by matrix-free mitochondrial membrane-rich preparations of yeast
-
Casey, J., Threlfall, D.R., Formation of 3-hexaprenyl-4-hydroxybenzoate by matrix-free mitochondrial membrane-rich preparations of yeast. Biochim. Biophys. Acta 530 (1978), 487–502.
-
(1978)
Biochim. Biophys. Acta
, vol.530
, pp. 487-502
-
-
Casey, J.1
Threlfall, D.R.2
-
52
-
-
0016686132
-
Assembly of the mitochondrial membrane system. Characterization of nuclear mutants of Saccharomyces cerevisiae with defects in mitochondrial ATPase and respiratory enzymes
-
Tzagoloff, A., et al. Assembly of the mitochondrial membrane system. Characterization of nuclear mutants of Saccharomyces cerevisiae with defects in mitochondrial ATPase and respiratory enzymes. J. Biol. Chem. 250 (1975), 8228–8235.
-
(1975)
J. Biol. Chem.
, vol.250
, pp. 8228-8235
-
-
Tzagoloff, A.1
-
53
-
-
0025145542
-
PET genes of Saccharomyces cerevisiae
-
Tzagoloff, A., Dieckmann, C.L., PET genes of Saccharomyces cerevisiae. Microbiol. Rev. 54 (1990), 211–225.
-
(1990)
Microbiol. Rev.
, vol.54
, pp. 211-225
-
-
Tzagoloff, A.1
Dieckmann, C.L.2
-
54
-
-
0025364138
-
Elucidation of the deficiency in two yeast coenzyme Q mutants. Characterization of the structural gene encoding hexaprenyl pyrophosphate synthetase
-
Ashby, M.N., Edwards, P.A., Elucidation of the deficiency in two yeast coenzyme Q mutants. Characterization of the structural gene encoding hexaprenyl pyrophosphate synthetase. J. Biol. Chem. 265 (1990), 13157–13164.
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 13157-13164
-
-
Ashby, M.N.1
Edwards, P.A.2
-
55
-
-
0026731820
-
COQ2 is a candidate for the structural gene encoding para-hydroxybenzoate:polyprenyltransferase
-
Ashby, M.N., et al. COQ2 is a candidate for the structural gene encoding para-hydroxybenzoate:polyprenyltransferase. J. Biol. Chem. 267 (1992), 4128–4136.
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 4128-4136
-
-
Ashby, M.N.1
-
56
-
-
13244264954
-
Genetic evidence for a multi-subunit complex in coenzyme Q biosynthesis in yeast and the role of the Coq1 hexaprenyl diphosphate synthase
-
Gin, P., Clarke, C.F., Genetic evidence for a multi-subunit complex in coenzyme Q biosynthesis in yeast and the role of the Coq1 hexaprenyl diphosphate synthase. J. Biol. Chem. 280 (2005), 2676–2681.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 2676-2681
-
-
Gin, P.1
Clarke, C.F.2
-
57
-
-
46349103594
-
A mitochondrial protein compendium elucidates complex I disease biology
-
Pagliarini, D.J., et al. A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 (2008), 112–123.
-
(2008)
Cell
, vol.134
, pp. 112-123
-
-
Pagliarini, D.J.1
-
58
-
-
84874956967
-
Proteomic mapping of mitochondria in living cells via spatially restricted enzymatic tagging
-
Rhee, H.W., et al. Proteomic mapping of mitochondria in living cells via spatially restricted enzymatic tagging. Science 339 (2013), 1328–1331.
-
(2013)
Science
, vol.339
, pp. 1328-1331
-
-
Rhee, H.W.1
-
59
-
-
84895725183
-
Coenzyme Q supplementation or over-expression of the yeast Coq8 putative kinase stabilizes multi-subunit Coq polypeptide complexes in yeast coq null mutants
-
He, C.H., et al. Coenzyme Q supplementation or over-expression of the yeast Coq8 putative kinase stabilizes multi-subunit Coq polypeptide complexes in yeast coq null mutants. Biochim. Biophys. Acta 1841 (2014), 630–644.
-
(2014)
Biochim. Biophys. Acta
, vol.1841
, pp. 630-644
-
-
He, C.H.1
-
60
-
-
0030590211
-
Polyprenyl diphosphate synthase essentially defines the length of the side chain of ubiquinone
-
Okada, K., et al. Polyprenyl diphosphate synthase essentially defines the length of the side chain of ubiquinone. Biochim. Biophys. Acta 1302 (1996), 217–223.
-
(1996)
Biochim. Biophys. Acta
, vol.1302
, pp. 217-223
-
-
Okada, K.1
-
61
-
-
84894286780
-
Structural insights into ubiquinone biosynthesis in membranes
-
Cheng, W., Li, W., Structural insights into ubiquinone biosynthesis in membranes. Science 343 (2014), 878–881.
-
(2014)
Science
, vol.343
, pp. 878-881
-
-
Cheng, W.1
Li, W.2
-
62
-
-
0014201703
-
Methionine as the source of methyl groups for ubiquinone and vitamin K: a study using nuclear magnetic resonance and mass spectrometry
-
Jackman, L.M., et al. Methionine as the source of methyl groups for ubiquinone and vitamin K: a study using nuclear magnetic resonance and mass spectrometry. Biochim. Biophys. Acta 141 (1967), 1–7.
-
(1967)
Biochim. Biophys. Acta
, vol.141
, pp. 1-7
-
-
Jackman, L.M.1
-
63
-
-
0018128330
-
Three hydroxylations incorporating molecular oxygen in the aerobic biosynthesis of ubiquinone in Escherichia coli
-
Alexander, K., Young, I.G., Three hydroxylations incorporating molecular oxygen in the aerobic biosynthesis of ubiquinone in Escherichia coli. Biochemistry 17 (1978), 4745–4750.
-
(1978)
Biochemistry
, vol.17
, pp. 4745-4750
-
-
Alexander, K.1
Young, I.G.2
-
64
-
-
84943279587
-
Coq6 is responsible for the C4-deamination reaction in coenzyme Q biosynthesis in Saccharomyces cerevisiae
-
Ozeir, M., et al. Coq6 is responsible for the C4-deamination reaction in coenzyme Q biosynthesis in Saccharomyces cerevisiae. J. Biol. Chem. 290 (2015), 24140–24151.
-
(2015)
J. Biol. Chem.
, vol.290
, pp. 24140-24151
-
-
Ozeir, M.1
-
65
-
-
33947481078
-
2-Decaprenylphenol, biosynthetic precursor of ubiquinone-10
-
Olsen, R.K., et al. 2-Decaprenylphenol, biosynthetic precursor of ubiquinone-10. J. Am. Chem. Soc. 87 (1965), 2298–2300.
-
(1965)
J. Am. Chem. Soc.
, vol.87
, pp. 2298-2300
-
-
Olsen, R.K.1
-
66
-
-
0001264149
-
Complete sequence of biosynthesis from p-hydroxybenzoic acid to ubiquinone
-
Friis, P., et al. Complete sequence of biosynthesis from p-hydroxybenzoic acid to ubiquinone. J. Am. Chem. Soc. 88 (1966), 4754–4756.
-
(1966)
J. Am. Chem. Soc.
, vol.88
, pp. 4754-4756
-
-
Friis, P.1
-
67
-
-
0014023644
-
2-Multiprenylphenols and 2-decaprenyl-6-methoxyphenol, biosynthetic precursors of ubiquinones
-
Olsen, R.K., et al. 2-Multiprenylphenols and 2-decaprenyl-6-methoxyphenol, biosynthetic precursors of ubiquinones. J. Am. Chem. Soc. 88 (1966), 5919–5923.
-
(1966)
J. Am. Chem. Soc.
, vol.88
, pp. 5919-5923
-
-
Olsen, R.K.1
-
68
-
-
0014284876
-
Mutant strains of Escherichia coli K-12 unable to form ubiquinone
-
Cox, G.B., et al. Mutant strains of Escherichia coli K-12 unable to form ubiquinone. J. Bacteriol. 95 (1968), 1591–1598.
-
(1968)
J. Bacteriol.
, vol.95
, pp. 1591-1598
-
-
Cox, G.B.1
-
69
-
-
0015607502
-
Pathway for ubiquinone biosynthesis in Escherichia coli K-12: gene-enzyme relationships and intermediates
-
Young, I.G., et al. Pathway for ubiquinone biosynthesis in Escherichia coli K-12: gene-enzyme relationships and intermediates. J. Bacteriol. 114 (1973), 42–52.
-
(1973)
J. Bacteriol.
, vol.114
, pp. 42-52
-
-
Young, I.G.1
-
70
-
-
0019874682
-
Identification of 3,4-dihydroxy-5-hexaprenylbenzoic acid as an intermediate in the biosynthesis of ubiquinone-6 by Saccharomyces cerevisiae
-
Goewert, R.R., et al. Identification of 3,4-dihydroxy-5-hexaprenylbenzoic acid as an intermediate in the biosynthesis of ubiquinone-6 by Saccharomyces cerevisiae. Biochemistry 20 (1981), 4217–4223.
-
(1981)
Biochemistry
, vol.20
, pp. 4217-4223
-
-
Goewert, R.R.1
-
71
-
-
0019834852
-
Identification of 3-methoxy-4-hydroxy-5-hexaprenylbenzoic acid as a new intermediate in ubiquinone biosynthesis by Saccharomyces cerevisiae
-
Goewert, R.R., et al. Identification of 3-methoxy-4-hydroxy-5-hexaprenylbenzoic acid as a new intermediate in ubiquinone biosynthesis by Saccharomyces cerevisiae. Biochemistry 20 (1981), 5611–5616.
-
(1981)
Biochemistry
, vol.20
, pp. 5611-5616
-
-
Goewert, R.R.1
-
72
-
-
34248195476
-
Endogenous synthesis of coenzyme Q in eukaryotes
-
Tran, U.C., Clarke, C.F., Endogenous synthesis of coenzyme Q in eukaryotes. Mitochondrion 7 (2007), S62–S71.
-
(2007)
Mitochondrion
, vol.7
, pp. S62-S71
-
-
Tran, U.C.1
Clarke, C.F.2
-
73
-
-
0029745317
-
Complementation of coq3 mutant yeast by mitochondrial targeting of the Escherichia coli UbiG polypeptide: evidence that UbiG catalyzes both O-methylation steps in ubiquinone biosynthesis
-
Hsu, A.Y., et al. Complementation of coq3 mutant yeast by mitochondrial targeting of the Escherichia coli UbiG polypeptide: evidence that UbiG catalyzes both O-methylation steps in ubiquinone biosynthesis. Biochemistry 35 (1996), 9797–9806.
-
(1996)
Biochemistry
, vol.35
, pp. 9797-9806
-
-
Hsu, A.Y.1
-
74
-
-
0035425211
-
Yeast COQ4 encodes a mitochondrial protein required for coenzyme Q synthesis
-
Belogrudov, G.I., et al. Yeast COQ4 encodes a mitochondrial protein required for coenzyme Q synthesis. Arch. Biochem. Biophys. 392 (2001), 48–58.
-
(2001)
Arch. Biochem. Biophys.
, vol.392
, pp. 48-58
-
-
Belogrudov, G.I.1
-
75
-
-
0030988484
-
Characterization of the COQ5 gene from Saccharomyces cerevisiae. Evidence for a C-methyltransferase in ubiquinone biosynthesis
-
Barkovich, R.J., et al. Characterization of the COQ5 gene from Saccharomyces cerevisiae. Evidence for a C-methyltransferase in ubiquinone biosynthesis. J. Biol. Chem. 272 (1997), 9182–9188.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 9182-9188
-
-
Barkovich, R.J.1
-
76
-
-
0030989525
-
The COQ5 gene encodes a yeast mitochondrial protein necessary for ubiquinone biosynthesis and the assembly of the respiratory chain
-
Dibrov, E., et al. The COQ5 gene encodes a yeast mitochondrial protein necessary for ubiquinone biosynthesis and the assembly of the respiratory chain. J. Biol. Chem. 272 (1997), 9175–9181.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 9175-9181
-
-
Dibrov, E.1
-
77
-
-
84907766718
-
Molecular characterization of the human COQ5 C-methyltransferase in coenzyme Q10 biosynthesis
-
Nguyen, T.P., et al. Molecular characterization of the human COQ5 C-methyltransferase in coenzyme Q10 biosynthesis. Biochim. Biophys. Acta 1841 (2014), 1628–1638.
-
(2014)
Biochim. Biophys. Acta
, vol.1841
, pp. 1628-1638
-
-
Nguyen, T.P.1
-
78
-
-
0037816166
-
The Saccharomyces cerevisiae COQ6 gene encodes a mitochondrial flavin-dependent monooxygenase required for coenzyme Q biosynthesis
-
Gin, P., et al. The Saccharomyces cerevisiae COQ6 gene encodes a mitochondrial flavin-dependent monooxygenase required for coenzyme Q biosynthesis. J. Biol. Chem. 278 (2003), 25308–25316.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 25308-25316
-
-
Gin, P.1
-
79
-
-
0032488838
-
Yeast Clk-1 homologue (Coq7/Cat5) is a mitochondrial protein in coenzyme Q synthesis
-
Jonassen, T., et al. Yeast Clk-1 homologue (Coq7/Cat5) is a mitochondrial protein in coenzyme Q synthesis. J. Biol. Chem. 273 (1998), 3351–3357.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 3351-3357
-
-
Jonassen, T.1
-
80
-
-
0035947594
-
A defect in coenzyme Q biosynthesis is responsible for the respiratory deficiency in Saccharomyces cerevisiae abc1 mutants
-
Do, T.Q., et al. A defect in coenzyme Q biosynthesis is responsible for the respiratory deficiency in Saccharomyces cerevisiae abc1 mutants. J. Biol. Chem. 276 (2001), 18161–18168.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 18161-18168
-
-
Do, T.Q.1
-
81
-
-
55349084786
-
Ubiquinone biosynthesis in Saccharomyces cerevisiae: the molecular organization of O-methylase Coq3p depends on Abc1p/Coq8p
-
Tauche, A., et al. Ubiquinone biosynthesis in Saccharomyces cerevisiae: the molecular organization of O-methylase Coq3p depends on Abc1p/Coq8p. FEMS Yeast Res. 8 (2008), 1263–1275.
-
(2008)
FEMS Yeast Res.
, vol.8
, pp. 1263-1275
-
-
Tauche, A.1
-
82
-
-
79953795039
-
Expression of the human atypical kinase ADCK3 rescues coenzyme Q biosynthesis and phosphorylation of Coq polypeptides in yeast coq8 mutants
-
Xie, L.X., et al. Expression of the human atypical kinase ADCK3 rescues coenzyme Q biosynthesis and phosphorylation of Coq polypeptides in yeast coq8 mutants. Biochim. Biophys. Acta 1811 (2011), 348–360.
-
(2011)
Biochim. Biophys. Acta
, vol.1811
, pp. 348-360
-
-
Xie, L.X.1
-
83
-
-
24744460063
-
COQ9, a new gene required for the biosynthesis of coenzyme Q in Saccharomyces cerevisiae
-
Johnson, A., et al. COQ9, a new gene required for the biosynthesis of coenzyme Q in Saccharomyces cerevisiae. J. Biol. Chem. 280 (2005), 31397–31404.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 31397-31404
-
-
Johnson, A.1
-
84
-
-
34249945844
-
Saccharomyces cerevisiae Coq9 polypeptide is a subunit of the mitochondrial coenzyme Q biosynthetic complex
-
Hsieh, E.J., et al. Saccharomyces cerevisiae Coq9 polypeptide is a subunit of the mitochondrial coenzyme Q biosynthetic complex. Arch. Biochem. Biophys. 463 (2007), 19–26.
-
(2007)
Arch. Biochem. Biophys.
, vol.463
, pp. 19-26
-
-
Hsieh, E.J.1
-
85
-
-
84907930226
-
A Gly-zipper motif mediates homodimerization of the transmembrane domain of the mitochondrial kinase ADCK3
-
Khadria, A.S., et al. A Gly-zipper motif mediates homodimerization of the transmembrane domain of the mitochondrial kinase ADCK3. J. Am. Chem. Soc. 136 (2014), 14068–14077.
-
(2014)
J. Am. Chem. Soc.
, vol.136
, pp. 14068-14077
-
-
Khadria, A.S.1
-
86
-
-
84920625908
-
Mitochondrial ADCK3 employs an atypical protein kinase-like fold to enable coenzyme Q biosynthesis
-
Stefely, J.A., et al. Mitochondrial ADCK3 employs an atypical protein kinase-like fold to enable coenzyme Q biosynthesis. Mol. Cell 57 (2015), 83–94.
-
(2015)
Mol. Cell
, vol.57
, pp. 83-94
-
-
Stefely, J.A.1
-
87
-
-
84992702854
-
Cerebellar ataxia and coenzyme Q deficiency through loss of unorthodox kinase activity
-
Stefely, J.A., et al. Cerebellar ataxia and coenzyme Q deficiency through loss of unorthodox kinase activity. Mol. Cell 63 (2016), 608–620.
-
(2016)
Mol. Cell
, vol.63
, pp. 608-620
-
-
Stefely, J.A.1
-
88
-
-
84930181548
-
A nuclear role for the respiratory enzyme CLK-1 in regulating mitochondrial stress responses and longevity
-
Monaghan, R.M., et al. A nuclear role for the respiratory enzyme CLK-1 in regulating mitochondrial stress responses and longevity. Nat. Cell Biol. 17 (2015), 782–792.
-
(2015)
Nat. Cell Biol.
, vol.17
, pp. 782-792
-
-
Monaghan, R.M.1
-
89
-
-
80053160231
-
Coenzyme Q biosynthesis: Coq6 is required for the C5-hydroxylation reaction and substrate analogs rescue Coq6 deficiency
-
Ozeir, M., et al. Coenzyme Q biosynthesis: Coq6 is required for the C5-hydroxylation reaction and substrate analogs rescue Coq6 deficiency. Chem. Biol. 18 (2011), 1134–1142.
-
(2011)
Chem. Biol.
, vol.18
, pp. 1134-1142
-
-
Ozeir, M.1
-
90
-
-
84880079427
-
ubiI, a new gene in Escherichia coli coenzyme Q biosynthesis, is involved in aerobic C5-hydroxylation
-
Hajj Chehade, M., et al. ubiI, a new gene in Escherichia coli coenzyme Q biosynthesis, is involved in aerobic C5-hydroxylation. J. Biol. Chem. 288 (2013), 20085–20092.
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 20085-20092
-
-
Hajj Chehade, M.1
-
91
-
-
0026095839
-
Ubiquinone biosynthesis in Saccharomyces cerevisiae. Isolation and sequence of COQ3, the 3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase gene
-
Clarke, C.F., et al. Ubiquinone biosynthesis in Saccharomyces cerevisiae. Isolation and sequence of COQ3, the 3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase gene. J. Biol. Chem. 266 (1991), 16636–16644.
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 16636-16644
-
-
Clarke, C.F.1
-
92
-
-
0034724885
-
Isolation and functional expression of human COQ3, a gene encoding a methyltransferase required for ubiquinone biosynthesis
-
Jonassen, T., Clarke, C.F., Isolation and functional expression of human COQ3, a gene encoding a methyltransferase required for ubiquinone biosynthesis. J. Biol. Chem. 275 (2000), 12381–12387.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 12381-12387
-
-
Jonassen, T.1
Clarke, C.F.2
-
93
-
-
0015253065
-
Mutants of Escherichia coli K-12 blocked in the final reaction of ubiquinone biosynthesis: characterization and genetic analysis
-
Stroobant, P., et al. Mutants of Escherichia coli K-12 blocked in the final reaction of ubiquinone biosynthesis: characterization and genetic analysis. J. Bacteriol. 109 (1972), 134–139.
-
(1972)
J. Bacteriol.
, vol.109
, pp. 134-139
-
-
Stroobant, P.1
-
94
-
-
0017276084
-
Membrane-associated reactions in ubiquinone biosynthesis. 2-Octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase
-
Leppik, R.A., et al. Membrane-associated reactions in ubiquinone biosynthesis. 2-Octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase. Biochim. Biophys. Acta 428 (1976), 146–156.
-
(1976)
Biochim. Biophys. Acta
, vol.428
, pp. 146-156
-
-
Leppik, R.A.1
-
95
-
-
0033618376
-
Yeast and rat Coq3 and Escherichia coli UbiG polypeptides catalyze both O-methyltransferase steps in coenzyme Q biosynthesis
-
Poon, W.W., et al. Yeast and rat Coq3 and Escherichia coli UbiG polypeptides catalyze both O-methyltransferase steps in coenzyme Q biosynthesis. J. Biol. Chem. 274 (1999), 21665–21672.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 21665-21672
-
-
Poon, W.W.1
-
96
-
-
0014558891
-
Biosynthesis of ubiquinone in Escherichia coli K-12: location of genes affecting the metabolism of 3-octaprenyl-4-hydroxybenzoic acid and 2-octaprenylphenol
-
Cox, G.B., et al. Biosynthesis of ubiquinone in Escherichia coli K-12: location of genes affecting the metabolism of 3-octaprenyl-4-hydroxybenzoic acid and 2-octaprenylphenol. J. Bacteriol. 99 (1969), 450–458.
-
(1969)
J. Bacteriol.
, vol.99
, pp. 450-458
-
-
Cox, G.B.1
-
97
-
-
77954185299
-
The conversion of p-hydroxybenzaldehyde to the benzoquinone ring of ubiquinone in Rhodospirillum rubrum
-
Rudney, H., Parson, W.W., The conversion of p-hydroxybenzaldehyde to the benzoquinone ring of ubiquinone in Rhodospirillum rubrum. J. Biol. Chem. 238 (1963), 3137–3138.
-
(1963)
J. Biol. Chem.
, vol.238
, pp. 3137-3138
-
-
Rudney, H.1
Parson, W.W.2
-
98
-
-
35748939100
-
The role of UbiX in Escherichia coli coenzyme Q biosynthesis
-
Gulmezian, M., et al. The role of UbiX in Escherichia coli coenzyme Q biosynthesis. Arch. Biochem. Biophys. 467 (2007), 144–153.
-
(2007)
Arch. Biochem. Biophys.
, vol.467
, pp. 144-153
-
-
Gulmezian, M.1
-
99
-
-
84933056649
-
UbiX is a flavin prenyltransferase required for bacterial ubiquinone biosynthesis
-
White, M.D., et al. UbiX is a flavin prenyltransferase required for bacterial ubiquinone biosynthesis. Nature 522 (2015), 502–506.
-
(2015)
Nature
, vol.522
, pp. 502-506
-
-
White, M.D.1
-
100
-
-
84933073520
-
New cofactor supports alpha,beta-unsaturated acid decarboxylation via 1,3-dipolar cycloaddition
-
Payne, K.A., et al. New cofactor supports alpha,beta-unsaturated acid decarboxylation via 1,3-dipolar cycloaddition. Nature 522 (2015), 497–501.
-
(2015)
Nature
, vol.522
, pp. 497-501
-
-
Payne, K.A.1
-
101
-
-
84933039515
-
Biochemistry: unexpected role for vitamin B2
-
Clarke, C.F., Allan, C.M., Biochemistry: unexpected role for vitamin B2. Nature 522 (2015), 427–428.
-
(2015)
Nature
, vol.522
, pp. 427-428
-
-
Clarke, C.F.1
Allan, C.M.2
-
102
-
-
84973402378
-
Disruption of the human COQ5-containing protein complex is associated with diminished coenzyme Q10 levels under two different conditions of mitochondrial energy deficiency
-
Yen, H.C., et al. Disruption of the human COQ5-containing protein complex is associated with diminished coenzyme Q10 levels under two different conditions of mitochondrial energy deficiency. Biochim. Biophys. Acta 1860 (2016), 1864–1876.
-
(2016)
Biochim. Biophys. Acta
, vol.1860
, pp. 1864-1876
-
-
Yen, H.C.1
-
103
-
-
0015027020
-
Characterization and genetic analysis of mutant strains of Escherichia coli K-12 accumulating the ubiquinone precursors 2-octaprenyl-6-methoxy-1,4-benzoquinone and 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone
-
Young, I.G.M., et al. Characterization and genetic analysis of mutant strains of Escherichia coli K-12 accumulating the ubiquinone precursors 2-octaprenyl-6-methoxy-1,4-benzoquinone and 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone. J. Bacteriol. 105 (1971), 769–778.
-
(1971)
J. Bacteriol.
, vol.105
, pp. 769-778
-
-
Young, I.G.M.1
-
104
-
-
0031038898
-
A C-methyltransferase involved in both ubiquinone and menaquinone biosynthesis: isolation and identification of the Escherichia coli ubiE gene
-
Lee, P.T., et al. A C-methyltransferase involved in both ubiquinone and menaquinone biosynthesis: isolation and identification of the Escherichia coli ubiE gene. J. Bacteriol. 179 (1997), 1748–1754.
-
(1997)
J. Bacteriol.
, vol.179
, pp. 1748-1754
-
-
Lee, P.T.1
-
105
-
-
84905457499
-
Crystal structures and catalytic mechanism of the C-methyltransferase Coq5 provide insights into a key step of the yeast coenzyme Q synthesis pathway
-
Dai, Y.N., et al. Crystal structures and catalytic mechanism of the C-methyltransferase Coq5 provide insights into a key step of the yeast coenzyme Q synthesis pathway. Acta Crystallogr. D Biol. Crystallogr. 70 (2014), 2085–2092.
-
(2014)
Acta Crystallogr. D Biol. Crystallogr.
, vol.70
, pp. 2085-2092
-
-
Dai, Y.N.1
-
106
-
-
0030063759
-
The COQ7 gene encodes a protein in Saccharomyces cerevisiae necessary for ubiquinone biosynthesis
-
Marbois, B.N., Clarke, C.F., The COQ7 gene encodes a protein in Saccharomyces cerevisiae necessary for ubiquinone biosynthesis. J. Biol. Chem. 271 (1996), 2995–3004.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 2995-3004
-
-
Marbois, B.N.1
Clarke, C.F.2
-
107
-
-
0035823556
-
A new member of the family of di-iron carboxylate proteins. Coq7 (clk-1), a membrane-bound hydroxylase involved in ubiquinone biosynthesis
-
Stenmark, P., et al. A new member of the family of di-iron carboxylate proteins. Coq7 (clk-1), a membrane-bound hydroxylase involved in ubiquinone biosynthesis. J. Biol. Chem. 276 (2001), 33297–33300.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 33297-33300
-
-
Stenmark, P.1
-
108
-
-
78149457379
-
The aging-associated enzyme CLK-1 is a member of the carboxylate-bridged diiron family of proteins
-
Behan, R.K., Lippard, S.J., The aging-associated enzyme CLK-1 is a member of the carboxylate-bridged diiron family of proteins. Biochemistry 49 (2010), 9679–9681.
-
(2010)
Biochemistry
, vol.49
, pp. 9679-9681
-
-
Behan, R.K.1
Lippard, S.J.2
-
109
-
-
84875798430
-
Aging-associated enzyme human clock-1: substrate-mediated reduction of the diiron center for 5-demethoxyubiquinone hydroxylation
-
Lu, T.T., et al. Aging-associated enzyme human clock-1: substrate-mediated reduction of the diiron center for 5-demethoxyubiquinone hydroxylation. Biochemistry 52 (2013), 2236–2244.
-
(2013)
Biochemistry
, vol.52
, pp. 2236-2244
-
-
Lu, T.T.1
-
110
-
-
85024395052
-
Evolution of ubiquinone biosynthesis: multiple proteobacterial enzymes with various regioselectivities to catalyze three contiguous aromatic hydroxylation reactions
-
e00091-16
-
Pelosi, L., et al. Evolution of ubiquinone biosynthesis: multiple proteobacterial enzymes with various regioselectivities to catalyze three contiguous aromatic hydroxylation reactions. mSystems, 1, 2016 e00091-16.
-
(2016)
mSystems
, vol.1
-
-
Pelosi, L.1
-
111
-
-
84863624059
-
Overexpression of the Coq8 kinase in Saccharomyces cerevisiae coq null mutants allows for accumulation of diagnostic intermediates of the coenzyme Q6 biosynthetic pathway
-
Xie, L.X., et al. Overexpression of the Coq8 kinase in Saccharomyces cerevisiae coq null mutants allows for accumulation of diagnostic intermediates of the coenzyme Q6 biosynthetic pathway. J. Biol. Chem. 287 (2012), 23571–23581.
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 23571-23581
-
-
Xie, L.X.1
-
112
-
-
0029016724
-
3-Hexaprenyl-4-hydroxybenzoic acid forms a predominant intermediate pool in ubiquinone biosynthesis in Saccharomyces cerevisiae
-
Poon, W.W., et al. 3-Hexaprenyl-4-hydroxybenzoic acid forms a predominant intermediate pool in ubiquinone biosynthesis in Saccharomyces cerevisiae. Arch. Biochem. Biophys. 320 (1995), 305–314.
-
(1995)
Arch. Biochem. Biophys.
, vol.320
, pp. 305-314
-
-
Poon, W.W.1
-
113
-
-
20144363128
-
Coq3 and Coq4 define a polypeptide complex in yeast mitochondria for the biosynthesis of coenzyme Q
-
Marbois, B., et al. Coq3 and Coq4 define a polypeptide complex in yeast mitochondria for the biosynthesis of coenzyme Q. J. Biol. Chem. 280 (2005), 20231–20238.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 20231-20238
-
-
Marbois, B.1
-
114
-
-
33745205101
-
Complementation of Saccharomyces cerevisiae coq7 mutants by mitochondrial targeting of the Escherichia coli UbiF polypeptide: two functions of yeast Coq7 polypeptide in coenzyme Q biosynthesis
-
Tran, U.C., et al. Complementation of Saccharomyces cerevisiae coq7 mutants by mitochondrial targeting of the Escherichia coli UbiF polypeptide: two functions of yeast Coq7 polypeptide in coenzyme Q biosynthesis. J. Biol. Chem. 281 (2006), 16401–16409.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 16401-16409
-
-
Tran, U.C.1
-
115
-
-
84925308729
-
Identification of Coq11, a new coenzyme Q biosynthetic protein in the CoQ-synthome in Saccharomyces cerevisiae
-
Allan, C.M., et al. Identification of Coq11, a new coenzyme Q biosynthetic protein in the CoQ-synthome in Saccharomyces cerevisiae. J. Biol. Chem. 290 (2015), 7517–7534.
-
(2015)
J. Biol. Chem.
, vol.290
, pp. 7517-7534
-
-
Allan, C.M.1
-
116
-
-
84914689325
-
Mitochondrial COQ9 is a lipid-binding protein that associates with COQ7 to enable coenzyme Q biosynthesis
-
Lohman, D.C., et al. Mitochondrial COQ9 is a lipid-binding protein that associates with COQ7 to enable coenzyme Q biosynthesis. Proc. Natl. Acad. Sci. U. S. A. 111 (2014), E4697–E4705.
-
(2014)
Proc. Natl. Acad. Sci. U. S. A.
, vol.111
, pp. E4697-E4705
-
-
Lohman, D.C.1
-
117
-
-
84992735863
-
Mitochondrial protein interaction mapping identifies regulators of respiratory chain function
-
Floyd, B.J., et al. Mitochondrial protein interaction mapping identifies regulators of respiratory chain function. Mol. Cell 63 (2016), 621–632.
-
(2016)
Mol. Cell
, vol.63
, pp. 621-632
-
-
Floyd, B.J.1
-
118
-
-
84890038202
-
ADCK4 mutations promote steroid-resistant nephrotic syndrome through CoQ10 biosynthesis disruption
-
Ashraf, S., et al. ADCK4 mutations promote steroid-resistant nephrotic syndrome through CoQ10 biosynthesis disruption. J. Clin. Invest. 123 (2013), 5179–5189.
-
(2013)
J. Clin. Invest.
, vol.123
, pp. 5179-5189
-
-
Ashraf, S.1
-
120
-
-
0022515187
-
Organization of citric acid cycle enzymes into a multienzyme cluster
-
Barnes, S.J., Weitzman, P.D., Organization of citric acid cycle enzymes into a multienzyme cluster. FEBS Lett. 201 (1986), 267–270.
-
(1986)
FEBS Lett.
, vol.201
, pp. 267-270
-
-
Barnes, S.J.1
Weitzman, P.D.2
-
121
-
-
85005975973
-
A new view into the regulation of purine metabolism: the purinosome
-
Pedley, A.M., Benkovic, S.J., A new view into the regulation of purine metabolism: the purinosome. Trends Biochem. Sci. 42 (2017), 141–154.
-
(2017)
Trends Biochem. Sci.
, vol.42
, pp. 141-154
-
-
Pedley, A.M.1
Benkovic, S.J.2
-
122
-
-
84995900407
-
Characterization of a dynamic metabolon producing the defense compound dhurrin in sorghum
-
Laursen, T., et al. Characterization of a dynamic metabolon producing the defense compound dhurrin in sorghum. Science 354 (2016), 890–893.
-
(2016)
Science
, vol.354
, pp. 890-893
-
-
Laursen, T.1
-
123
-
-
84982262288
-
Adrenal mitochondria and steroidogenesis: from individual proteins to functional protein assemblies
-
Midzak, A., Papadopoulos, V., Adrenal mitochondria and steroidogenesis: from individual proteins to functional protein assemblies. Front. Endocrinol. (Lausanne), 7, 2016, 106.
-
(2016)
Front. Endocrinol. (Lausanne)
, vol.7
, pp. 106
-
-
Midzak, A.1
Papadopoulos, V.2
-
124
-
-
77956090193
-
Mitochondrial protein import: from proteomics to functional mechanisms
-
Schmidt, O., et al. Mitochondrial protein import: from proteomics to functional mechanisms. Nat. Rev. Mol. Cell Biol. 11 (2010), 655–667.
-
(2010)
Nat. Rev. Mol. Cell Biol.
, vol.11
, pp. 655-667
-
-
Schmidt, O.1
-
125
-
-
84903940006
-
The regulation of coenzyme q biosynthesis in eukaryotic cells: all that yeast can tell us
-
Gonzalez-Mariscal, I., et al. The regulation of coenzyme q biosynthesis in eukaryotic cells: all that yeast can tell us. Mol. Syndromol. 5 (2014), 107–118.
-
(2014)
Mol. Syndromol.
, vol.5
, pp. 107-118
-
-
Gonzalez-Mariscal, I.1
-
126
-
-
85031755642
-
Post-transcriptional control of coenzyme Q biosynthesis revealed by transomic analysis of the RNA-binding protein Puf3p
-
Lapointe, C.P., et al. Post-transcriptional control of coenzyme Q biosynthesis revealed by transomic analysis of the RNA-binding protein Puf3p. bioRxiv, 2017, 146985.
-
(2017)
bioRxiv
, pp. 146985
-
-
Lapointe, C.P.1
-
127
-
-
0033198845
-
Different import pathways through the mitochondrial intermembrane space for inner membrane proteins
-
Leuenberger, D., et al. Different import pathways through the mitochondrial intermembrane space for inner membrane proteins. EMBO J. 18 (1999), 4816–4822.
-
(1999)
EMBO J.
, vol.18
, pp. 4816-4822
-
-
Leuenberger, D.1
-
128
-
-
0035800788
-
Mouse CLK-1 is imported into mitochondria by an unusual process that requires a leader sequence but no membrane potential
-
Jiang, N., et al. Mouse CLK-1 is imported into mitochondria by an unusual process that requires a leader sequence but no membrane potential. J. Biol. Chem. 276 (2001), 29218–29225.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 29218-29225
-
-
Jiang, N.1
-
129
-
-
0021816512
-
Location and mobility of ubiquinones of different chain lengths in artificial membrane vesicles
-
Ulrich, E.L., et al. Location and mobility of ubiquinones of different chain lengths in artificial membrane vesicles. Biochemistry 24 (1985), 2501–2508.
-
(1985)
Biochemistry
, vol.24
, pp. 2501-2508
-
-
Ulrich, E.L.1
-
130
-
-
0000388160
-
NMR studies of ubiquinone location in oriented model membranes: evidence for a single motionally-averaged population
-
Metz, G.H., et al. NMR studies of ubiquinone location in oriented model membranes: evidence for a single motionally-averaged population. J. Am. Chem. Soc. 117 (1995), 564–565.
-
(1995)
J. Am. Chem. Soc.
, vol.117
, pp. 564-565
-
-
Metz, G.H.1
-
131
-
-
65549119172
-
Genetic evidence for the requirement of the endocytic pathway in the uptake of coenzyme Q6 in Saccharomyces cerevisiae
-
Padilla-Lopez, S., et al. Genetic evidence for the requirement of the endocytic pathway in the uptake of coenzyme Q6 in Saccharomyces cerevisiae. Biochim. Biophys. Acta 1788 (2009), 1238–1248.
-
(2009)
Biochim. Biophys. Acta
, vol.1788
, pp. 1238-1248
-
-
Padilla-Lopez, S.1
-
132
-
-
21844465110
-
Coenzyme Q. distribution in HL-60 human cells depends on the endomembrane system
-
Fernandez-Ayala, D.J., et al. Coenzyme Q. distribution in HL-60 human cells depends on the endomembrane system. Biochim. Biophys. Acta 1713 (2005), 129–137.
-
(2005)
Biochim. Biophys. Acta
, vol.1713
, pp. 129-137
-
-
Fernandez-Ayala, D.J.1
-
133
-
-
57649178662
-
The yeast Coq4 polypeptide organizes a mitochondrial protein complex essential for coenzyme Q biosynthesis
-
Marbois, B., et al. The yeast Coq4 polypeptide organizes a mitochondrial protein complex essential for coenzyme Q biosynthesis. Biochim. Biophys. Acta 1791 (2009), 69–75.
-
(2009)
Biochim. Biophys. Acta
, vol.1791
, pp. 69-75
-
-
Marbois, B.1
-
134
-
-
0031722706
-
Novel families of putative protein kinases in bacteria and archaea: evolution of the “eukaryotic” protein kinase superfamily
-
Leonard, C.J., et al. Novel families of putative protein kinases in bacteria and archaea: evolution of the “eukaryotic” protein kinase superfamily. Genome Res. 8 (1998), 1038–1047.
-
(1998)
Genome Res.
, vol.8
, pp. 1038-1047
-
-
Leonard, C.J.1
-
135
-
-
0033820931
-
Identification of Escherichia coli ubiB, a gene required for the first monooxygenase step in ubiquinone biosynthesis
-
Poon, W.W., et al. Identification of Escherichia coli ubiB, a gene required for the first monooxygenase step in ubiquinone biosynthesis. J. Bacteriol. 182 (2000), 5139–5146.
-
(2000)
J. Bacteriol.
, vol.182
, pp. 5139-5146
-
-
Poon, W.W.1
-
136
-
-
41149121580
-
ADCK3, an ancestral kinase, is mutated in a form of recessive ataxia associated with coenzyme Q10 deficiency
-
Lagier-Tourenne, C., et al. ADCK3, an ancestral kinase, is mutated in a form of recessive ataxia associated with coenzyme Q10 deficiency. Am. J. Hum. Genet. 82 (2008), 661–672.
-
(2008)
Am. J. Hum. Genet.
, vol.82
, pp. 661-672
-
-
Lagier-Tourenne, C.1
-
137
-
-
33947226782
-
Structural and functional diversity of the microbial kinome
-
Kannan, N., et al. Structural and functional diversity of the microbial kinome. PLoS Biol., 5, 2007, e17.
-
(2007)
PLoS Biol.
, vol.5
, pp. e17
-
-
Kannan, N.1
-
138
-
-
85031744861
-
Conserved lipid and small molecule modulation of COQ8 reveals regulation of the ancient UbiB family
-
Reidenbach, A., et al. Conserved lipid and small molecule modulation of COQ8 reveals regulation of the ancient UbiB family. bioRxiv, 2017, 149823.
-
(2017)
bioRxiv
, pp. 149823
-
-
Reidenbach, A.1
-
139
-
-
84874507385
-
Dysfunctional Coq9 protein causes predominant encephalomyopathy associated with CoQ deficiency
-
Garcia-Corzo, L., et al. Dysfunctional Coq9 protein causes predominant encephalomyopathy associated with CoQ deficiency. Hum. Mol. Genet. 22 (2013), 1233–1248.
-
(2013)
Hum. Mol. Genet.
, vol.22
, pp. 1233-1248
-
-
Garcia-Corzo, L.1
-
140
-
-
84935836805
-
Yeast Coq9 controls deamination of coenzyme Q intermediates that derive from para-aminobenzoic acid
-
He, C.H., et al. Yeast Coq9 controls deamination of coenzyme Q intermediates that derive from para-aminobenzoic acid. Biochim. Biophys. Acta 1851 (2015), 1227–1239.
-
(2015)
Biochim. Biophys. Acta
, vol.1851
, pp. 1227-1239
-
-
He, C.H.1
-
141
-
-
30044432823
-
The Saccharomyces cerevisiae COQ10 gene encodes a START domain protein required for function of coenzyme Q in respiration
-
Barros, M.H., et al. The Saccharomyces cerevisiae COQ10 gene encodes a START domain protein required for function of coenzyme Q in respiration. J. Biol. Chem. 280 (2005), 42627–42635.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 42627-42635
-
-
Barros, M.H.1
-
142
-
-
84873435551
-
A conserved START domain coenzyme Q-binding polypeptide is required for efficient Q biosynthesis, respiratory electron transport, and antioxidant function in Saccharomyces cerevisiae
-
Allan, C.M., et al. A conserved START domain coenzyme Q-binding polypeptide is required for efficient Q biosynthesis, respiratory electron transport, and antioxidant function in Saccharomyces cerevisiae. Biochim. Biophys. Acta 1831 (2013), 776–791.
-
(2013)
Biochim. Biophys. Acta
, vol.1831
, pp. 776-791
-
-
Allan, C.M.1
-
143
-
-
85024365170
-
The UbiK protein is an accessory factor necessary for bacterial ubiquinone (UQ) biosynthesis and forms a complex with the UQ biogenesis factor UbiJ
-
Published online May 30, 2017
-
Loiseau, L., et al. The UbiK protein is an accessory factor necessary for bacterial ubiquinone (UQ) biosynthesis and forms a complex with the UQ biogenesis factor UbiJ. J. Biol. Chem., 2017, 10.1074/jbc.M117.789164 Published online May 30, 2017.
-
(2017)
J. Biol. Chem.
-
-
Loiseau, L.1
-
144
-
-
84890291473
-
ubiJ, a new gene required for aerobic growth and proliferation in macrophage, is involved in coenzyme Q biosynthesis in Escherichia coli and Salmonella enterica serovar Typhimurium
-
Aussel, L., et al. ubiJ, a new gene required for aerobic growth and proliferation in macrophage, is involved in coenzyme Q biosynthesis in Escherichia coli and Salmonella enterica serovar Typhimurium. J. Bacteriol. 196 (2014), 70–79.
-
(2014)
J. Bacteriol.
, vol.196
, pp. 70-79
-
-
Aussel, L.1
-
145
-
-
31544480133
-
A mutation in para-hydroxybenzoate-polyprenyl transferase (COQ2) causes primary coenzyme Q10 deficiency
-
Quinzii, C., et al. A mutation in para-hydroxybenzoate-polyprenyl transferase (COQ2) causes primary coenzyme Q10 deficiency. Am. J. Hum. Genet. 78 (2006), 345–349.
-
(2006)
Am. J. Hum. Genet.
, vol.78
, pp. 345-349
-
-
Quinzii, C.1
-
146
-
-
84875476544
-
A novel mutation in COQ2 leading to fatal infantile multisystem disease
-
Jakobs, B.S., et al. A novel mutation in COQ2 leading to fatal infantile multisystem disease. J. Neurol. Sci. 326 (2013), 24–28.
-
(2013)
J. Neurol. Sci.
, vol.326
, pp. 24-28
-
-
Jakobs, B.S.1
-
147
-
-
34250668197
-
COQ2 nephropathy: a newly described inherited mitochondriopathy with primary renal involvement
-
Diomedi-Camassei, F., et al. COQ2 nephropathy: a newly described inherited mitochondriopathy with primary renal involvement. J. Am. Soc. Nephrol. 18 (2007), 2773–2780.
-
(2007)
J. Am. Soc. Nephrol.
, vol.18
, pp. 2773-2780
-
-
Diomedi-Camassei, F.1
-
148
-
-
84939266277
-
Primary coenzyme Q10 deficiency presenting as fatal neonatal multiorgan failure
-
Desbats, M.A., et al. Primary coenzyme Q10 deficiency presenting as fatal neonatal multiorgan failure. Eur. J. Hum. Genet. 23 (2015), 1254–1258.
-
(2015)
Eur. J. Hum. Genet.
, vol.23
, pp. 1254-1258
-
-
Desbats, M.A.1
-
149
-
-
84860277256
-
Haploinsufficiency of COQ4 causes coenzyme Q10 deficiency
-
Salviati, L., et al. Haploinsufficiency of COQ4 causes coenzyme Q10 deficiency. J. Med. Genet. 49 (2012), 187–191.
-
(2012)
J. Med. Genet.
, vol.49
, pp. 187-191
-
-
Salviati, L.1
-
150
-
-
84924942443
-
COQ4 mutations cause a broad spectrum of mitochondrial disorders associated with CoQ10 deficiency
-
Brea-Calvo, G., et al. COQ4 mutations cause a broad spectrum of mitochondrial disorders associated with CoQ10 deficiency. Am. J. Hum. Genet. 96 (2015), 309–317.
-
(2015)
Am. J. Hum. Genet.
, vol.96
, pp. 309-317
-
-
Brea-Calvo, G.1
-
151
-
-
79955520308
-
COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness
-
Heeringa, S.F., et al. COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness. J. Clin. Invest. 121 (2011), 2013–2024.
-
(2011)
J. Clin. Invest.
, vol.121
, pp. 2013-2024
-
-
Heeringa, S.F.1
-
152
-
-
84887709796
-
Effect of vanillic acid on COQ6 mutants identified in patients with coenzyme Q10 deficiency
-
Doimo, M., et al. Effect of vanillic acid on COQ6 mutants identified in patients with coenzyme Q10 deficiency. Biochim. Biophys. Acta 1842 (2014), 1–6.
-
(2014)
Biochim. Biophys. Acta
, vol.1842
, pp. 1-6
-
-
Doimo, M.1
-
153
-
-
84954361939
-
Rescue of primary ubiquinone deficiency due to a novel COQ7 defect using 2,4-dihydroxybensoic acid
-
Freyer, C., et al. Rescue of primary ubiquinone deficiency due to a novel COQ7 defect using 2,4-dihydroxybensoic acid. J. Med. Genet. 52 (2015), 779–783.
-
(2015)
J. Med. Genet.
, vol.52
, pp. 779-783
-
-
Freyer, C.1
-
154
-
-
41149134880
-
CABC1 gene mutations cause ubiquinone deficiency with cerebellar ataxia and seizures
-
Mollet, J., et al. CABC1 gene mutations cause ubiquinone deficiency with cerebellar ataxia and seizures. Am. J. Hum. Genet. 82 (2008), 623–630.
-
(2008)
Am. J. Hum. Genet.
, vol.82
, pp. 623-630
-
-
Mollet, J.1
-
155
-
-
84898869310
-
Autosomal-recessive cerebellar ataxia caused by a novel ADCK3 mutation that elongates the protein: clinical, genetic and biochemical characterisation
-
Liu, Y.T., et al. Autosomal-recessive cerebellar ataxia caused by a novel ADCK3 mutation that elongates the protein: clinical, genetic and biochemical characterisation. J. Neurol. Neurosurg. Psychiatry 85 (2014), 493–498.
-
(2014)
J. Neurol. Neurosurg. Psychiatry
, vol.85
, pp. 493-498
-
-
Liu, Y.T.1
-
156
-
-
84922101913
-
Heterozygous mutations in the ADCK3 gene in siblings with cerebellar atrophy and extreme phenotypic variability
-
Blumkin, L., et al. Heterozygous mutations in the ADCK3 gene in siblings with cerebellar atrophy and extreme phenotypic variability. JIMD Rep. 12 (2014), 103–107.
-
(2014)
JIMD Rep.
, vol.12
, pp. 103-107
-
-
Blumkin, L.1
-
157
-
-
77955424107
-
Nonsense mutations in CABC1/ADCK3 cause progressive cerebellar ataxia and atrophy
-
Gerards, M., et al. Nonsense mutations in CABC1/ADCK3 cause progressive cerebellar ataxia and atrophy. Mitochondrion 10 (2010), 510–515.
-
(2010)
Mitochondrion
, vol.10
, pp. 510-515
-
-
Gerards, M.1
-
158
-
-
84855616355
-
Adult-onset cerebellar ataxia due to mutations in CABC1/ADCK3
-
Horvath, R., et al. Adult-onset cerebellar ataxia due to mutations in CABC1/ADCK3. J. Neurol. Neurosurg. Psychiatry 83 (2012), 174–178.
-
(2012)
J. Neurol. Neurosurg. Psychiatry
, vol.83
, pp. 174-178
-
-
Horvath, R.1
-
159
-
-
84954451992
-
ADCK4-associated glomerulopathy causes adolescence-onset FSGS
-
Korkmaz, E., et al. ADCK4-associated glomerulopathy causes adolescence-onset FSGS. J. Am. Soc. Nephrol. 27 (2015), 63–68.
-
(2015)
J. Am. Soc. Nephrol.
, vol.27
, pp. 63-68
-
-
Korkmaz, E.1
-
160
-
-
65549087610
-
A nonsense mutation in COQ9 causes autosomal-recessive neonatal-onset primary coenzyme Q10 deficiency: a potentially treatable form of mitochondrial disease
-
Duncan, A.J., et al. A nonsense mutation in COQ9 causes autosomal-recessive neonatal-onset primary coenzyme Q10 deficiency: a potentially treatable form of mitochondrial disease. Am. J. Hum. Genet. 84 (2009), 558–566.
-
(2009)
Am. J. Hum. Genet.
, vol.84
, pp. 558-566
-
-
Duncan, A.J.1
-
161
-
-
84958105102
-
Fatal neonatal encephalopathy and lactic acidosis caused by a homozygous loss-of-function variant in COQ9
-
Danhauser, K., et al. Fatal neonatal encephalopathy and lactic acidosis caused by a homozygous loss-of-function variant in COQ9. Eur. J. Hum. Genet. 24 (2015), 450–454.
-
(2015)
Eur. J. Hum. Genet.
, vol.24
, pp. 450-454
-
-
Danhauser, K.1
-
162
-
-
33847347629
-
Prenyldiphosphate synthase, subunit 1 (PDSS1) and OH-benzoate polyprenyltransferase (COQ2) mutations in ubiquinone deficiency and oxidative phosphorylation disorders
-
Mollet, J., et al. Prenyldiphosphate synthase, subunit 1 (PDSS1) and OH-benzoate polyprenyltransferase (COQ2) mutations in ubiquinone deficiency and oxidative phosphorylation disorders. J. Clin. Invest. 117 (2007), 765–772.
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 765-772
-
-
Mollet, J.1
-
163
-
-
33845232634
-
Leigh syndrome with nephropathy and CoQ10 deficiency due to decaprenyl diphosphate synthase subunit 2 (PDSS2) mutations
-
Lopez, L.C., et al. Leigh syndrome with nephropathy and CoQ10 deficiency due to decaprenyl diphosphate synthase subunit 2 (PDSS2) mutations. Am. J. Hum. Genet. 79 (2006), 1125–1129.
-
(2006)
Am. J. Hum. Genet.
, vol.79
, pp. 1125-1129
-
-
Lopez, L.C.1
-
164
-
-
84885632958
-
Focal segmental glomerulosclerosis is associated with a PDSS2 haplotype and, independently, with a decreased content of coenzyme Q10
-
Gasser, D.L., et al. Focal segmental glomerulosclerosis is associated with a PDSS2 haplotype and, independently, with a decreased content of coenzyme Q10. Am. J. Physiol. Renal Physiol. 305 (2013), F1228–F1238.
-
(2013)
Am. J. Physiol. Renal Physiol.
, vol.305
, pp. F1228-F1238
-
-
Gasser, D.L.1
-
165
-
-
34248171499
-
The myopathic form of coenzyme Q10 deficiency is caused by mutations in the electron-transferring-flavoprotein dehydrogenase (ETFDH) gene
-
Gempel, K., et al. The myopathic form of coenzyme Q10 deficiency is caused by mutations in the electron-transferring-flavoprotein dehydrogenase (ETFDH) gene. Brain 130 (2007), 2037–2044.
-
(2007)
Brain
, vol.130
, pp. 2037-2044
-
-
Gempel, K.1
-
166
-
-
69449083834
-
Coenzyme Q(10) is decreased in fibroblasts of patients with methylmalonic aciduria but not in mevalonic aciduria
-
Haas, D., et al. Coenzyme Q(10) is decreased in fibroblasts of patients with methylmalonic aciduria but not in mevalonic aciduria. J. Inherit. Metab. Dis. 32 (2009), 570–575.
-
(2009)
J. Inherit. Metab. Dis.
, vol.32
, pp. 570-575
-
-
Haas, D.1
-
167
-
-
13244277454
-
Coenzyme Q deficiency and cerebellar ataxia associated with an aprataxin mutation
-
Quinzii, C.M., et al. Coenzyme Q deficiency and cerebellar ataxia associated with an aprataxin mutation. Neurology 64 (2005), 539–541.
-
(2005)
Neurology
, vol.64
, pp. 539-541
-
-
Quinzii, C.M.1
-
168
-
-
35448950741
-
Cardiofaciocutaneous (CFC) syndrome associated with muscular coenzyme Q10 deficiency
-
Aeby, A., et al. Cardiofaciocutaneous (CFC) syndrome associated with muscular coenzyme Q10 deficiency. J. Inherit. Metab. Dis., 30, 2007, 827.
-
(2007)
J. Inherit. Metab. Dis.
, vol.30
, pp. 827
-
-
Aeby, A.1
-
169
-
-
34249826635
-
The role of coenzyme Q10 in statin-associated myopathy: a systematic review
-
Marcoff, L., Thompson, P.D., The role of coenzyme Q10 in statin-associated myopathy: a systematic review. J. Am. Coll. Cardiol. 49 (2007), 2231–2237.
-
(2007)
J. Am. Coll. Cardiol.
, vol.49
, pp. 2231-2237
-
-
Marcoff, L.1
Thompson, P.D.2
-
170
-
-
84920199403
-
Myopathy during treatment with the antianginal drug ranolazine
-
Kassardjian, C.D., et al. Myopathy during treatment with the antianginal drug ranolazine. J. Neurol. Sci. 347 (2014), 380–382.
-
(2014)
J. Neurol. Sci.
, vol.347
, pp. 380-382
-
-
Kassardjian, C.D.1
-
171
-
-
84865622739
-
Heterogeneity of coenzyme Q10 deficiency: patient study and literature review
-
Emmanuele, V., et al. Heterogeneity of coenzyme Q10 deficiency: patient study and literature review. Arch. Neurol. 69 (2012), 978–983.
-
(2012)
Arch. Neurol.
, vol.69
, pp. 978-983
-
-
Emmanuele, V.1
-
172
-
-
84869051280
-
Mitochondrial disorders as windows into an ancient organelle
-
Vafai, S.B., Mootha, V.K., Mitochondrial disorders as windows into an ancient organelle. Nature 491 (2012), 374–383.
-
(2012)
Nature
, vol.491
, pp. 374-383
-
-
Vafai, S.B.1
Mootha, V.K.2
-
173
-
-
45949099527
-
Early coenzyme Q10 supplementation in primary coenzyme Q10 deficiency
-
Montini, G., et al. Early coenzyme Q10 supplementation in primary coenzyme Q10 deficiency. N. Engl. J. Med. 358 (2008), 2849–2850.
-
(2008)
N. Engl. J. Med.
, vol.358
, pp. 2849-2850
-
-
Montini, G.1
-
174
-
-
84887565727
-
Mitochondrial respiration without ubiquinone biosynthesis
-
Wang, Y., Hekimi, S., Mitochondrial respiration without ubiquinone biosynthesis. Hum. Mol. Genet. 22 (2013), 4768–4783.
-
(2013)
Hum. Mol. Genet.
, vol.22
, pp. 4768-4783
-
-
Wang, Y.1
Hekimi, S.2
-
176
-
-
84940892038
-
Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging
-
Ben-Meir, A., et al. Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging. Aging Cell 14 (2015), 887–895.
-
(2015)
Aging Cell
, vol.14
, pp. 887-895
-
-
Ben-Meir, A.1
-
177
-
-
84922805752
-
Dependence of brown adipose tissue function on CD36-mediated coenzyme Q uptake
-
Anderson, C.M., et al. Dependence of brown adipose tissue function on CD36-mediated coenzyme Q uptake. Cell Rep. 10 (2015), 505–515.
-
(2015)
Cell Rep.
, vol.10
, pp. 505-515
-
-
Anderson, C.M.1
-
178
-
-
0037373280
-
Distribution and breakdown of labeled coenzyme Q10 in rat
-
Bentinger, M., et al. Distribution and breakdown of labeled coenzyme Q10 in rat. Free Radic. Biol. Med. 34 (2003), 563–575.
-
(2003)
Free Radic. Biol. Med.
, vol.34
, pp. 563-575
-
-
Bentinger, M.1
-
179
-
-
0037192846
-
Uptake of exogenous coenzyme Q and transport to mitochondria is required for bc1 complex stability in yeast coq mutants
-
Santos-Ocana, C., et al. Uptake of exogenous coenzyme Q and transport to mitochondria is required for bc1 complex stability in yeast coq mutants. J. Biol. Chem. 277 (2002), 10973–10981.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 10973-10981
-
-
Santos-Ocana, C.1
-
180
-
-
84897371083
-
Ubiquinol-10 ameliorates mitochondrial encephalopathy associated with CoQ deficiency
-
Garcia-Corzo, L., et al. Ubiquinol-10 ameliorates mitochondrial encephalopathy associated with CoQ deficiency. Biochim. Biophys. Acta 1842 (2014), 893–901.
-
(2014)
Biochim. Biophys. Acta
, vol.1842
, pp. 893-901
-
-
Garcia-Corzo, L.1
-
181
-
-
84924560078
-
Mitochondrial function and lifespan of mice with controlled ubiquinone biosynthesis
-
Wang, Y., et al. Mitochondrial function and lifespan of mice with controlled ubiquinone biosynthesis. Nat. Commun., 6, 2015, 6393.
-
(2015)
Nat. Commun.
, vol.6
, pp. 6393
-
-
Wang, Y.1
-
182
-
-
84928989367
-
The clinical heterogeneity of coenzyme Q10 deficiency results from genotypic differences in the Coq9 gene
-
Luna-Sanchez, M., et al. The clinical heterogeneity of coenzyme Q10 deficiency results from genotypic differences in the Coq9 gene. EMBO Mol. Med. 7 (2015), 670–687.
-
(2015)
EMBO Mol. Med.
, vol.7
, pp. 670-687
-
-
Luna-Sanchez, M.1
-
183
-
-
84886408132
-
Practice patterns of mitochondrial disease physicians in North America Part 2: treatment, care and management
-
Parikh, S., et al. Practice patterns of mitochondrial disease physicians in North America Part 2: treatment, care and management. Mitochondrion 13 (2013), 681–687.
-
(2013)
Mitochondrion
, vol.13
, pp. 681-687
-
-
Parikh, S.1
-
184
-
-
70350136445
-
A modern approach to the treatment of mitochondrial disease
-
Parikh, S., et al. A modern approach to the treatment of mitochondrial disease. Curr. Treat. Options Neurol. 11 (2009), 414–430.
-
(2009)
Curr. Treat. Options Neurol.
, vol.11
, pp. 414-430
-
-
Parikh, S.1
-
185
-
-
84875679362
-
Mitochondria targeted therapeutic approaches in Parkinson's and Huntington's diseases
-
Chaturvedi, R.K., Beal, M.F., Mitochondria targeted therapeutic approaches in Parkinson's and Huntington's diseases. Mol. Cell. Neurosci. 55 (2013), 101–114.
-
(2013)
Mol. Cell. Neurosci.
, vol.55
, pp. 101-114
-
-
Chaturvedi, R.K.1
Beal, M.F.2
-
186
-
-
80155191237
-
Coenzyme Q10 decreases amyloid pathology and improves behavior in a transgenic mouse model of Alzheimer's disease
-
Dumont, M., et al. Coenzyme Q10 decreases amyloid pathology and improves behavior in a transgenic mouse model of Alzheimer's disease. J. Alzheimers Dis. 27 (2011), 211–223.
-
(2011)
J. Alzheimers Dis.
, vol.27
, pp. 211-223
-
-
Dumont, M.1
-
187
-
-
84975156981
-
Systems proteomics of liver mitochondria function
-
Williams, E.G., et al. Systems proteomics of liver mitochondria function. Science, 352, 2016, aad0189.
-
(2016)
Science
, vol.352
, pp. aad0189
-
-
Williams, E.G.1
-
188
-
-
0015321309
-
Biochemical and genetic studies on ubiquinone biosynthesis in Escherichia coli K-12:4-hydroxybenzoate octaprenyltransferase
-
Young, I.G., et al. Biochemical and genetic studies on ubiquinone biosynthesis in Escherichia coli K-12:4-hydroxybenzoate octaprenyltransferase. J. Bacteriol. 110 (1972), 18–25.
-
(1972)
J. Bacteriol.
, vol.110
, pp. 18-25
-
-
Young, I.G.1
|