A nuclear role for the respiratory enzyme CLK-1 in regulating mitochondrial stress responses and longevity

Nature Cell Biology

Volumn 17, Issue 6, 2015, Pages 782-792

  Monaghan, Richard M ^a   Barnes, Robert G ^a   Fisher, Kate ^a   Andreou, Tereza ^a   Rooney, Nicholas ^a,b   Poulin, Gino B ^a,c   Whitmarsh, Alan J ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF LEEDS   (United Kingdom)

^c BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MONOOXYGENASE CLK 1; MUTANT PROTEIN; PROTEIN COQ7; REACTIVE OXYGEN METABOLITE; SERINE PROTEINASE OMI; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE; CAENORHABDITIS ELEGANS PROTEIN; CHROMATIN; CLK DUAL-SPECIFICITY KINASES; CLK-1 PROTEIN, C ELEGANS; PROTEIN BINDING; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE KINASE;

ADULT; AEROBIC METABOLISM; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BIOSYNTHESIS; CAENORHABDITIS ELEGANS; CELL NUCLEUS; CELL RESPIRATION; CELL SURVIVAL; CELLULAR DISTRIBUTION; CELLULAR STRESS RESPONSE; CHROMATIN; CONTROLLED STUDY; ENZYME LOCALIZATION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; LONGEVITY; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; UNFOLDED PROTEIN RESPONSE; WILD TYPE; YOUNG ADULT; AGING; ANIMAL; CELL PROLIFERATION; CHLOROCEBUS AETHIOPS; COS 1 CELL LINE; GENETICS; HEK293 CELL LINE; HELA CELL LINE; METABOLISM; OXIDATIVE STRESS; PHYSIOLOGICAL STRESS; SIGNAL TRANSDUCTION; TRANSGENIC ANIMAL; TUMOR CELL LINE;

CAENORHABDITIS ELEGANS;

AGING; ANIMALS; ANIMALS, GENETICALLY MODIFIED; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL RESPIRATION; CELL SURVIVAL; CERCOPITHECUS AETHIOPS; CHROMATIN; COS CELLS; HEK293 CELLS; HELA CELLS; HUMANS; LONGEVITY; MITOCHONDRIA; OXIDATIVE STRESS; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; STRESS, PHYSIOLOGICAL; UNFOLDED PROTEIN RESPONSE;

EID: 84930181548     PISSN: 14657392     EISSN: 14764679     Source Type: Journal    
DOI: 10.1038/ncb3170     Document Type: Article

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