Low-density lipoprotein docosahexaenoic acid nanoparticles induce ferroptotic cell death in hepatocellular carcinoma

Free Radical Biology and Medicine

Volumn 112, Issue , 2017, Pages 597-607

  Ou, Weijun ^a,b   Mulik, Rohit S ^a   Anwar, Arnida ^a   McDonald, Jeffrey G ^c   He, Xiaoshun ^b   Corbin, Ian R ^a,c  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b SUN YAT SEN UNIVERSITY   (China)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Docosahexaenoic acid; Ferroptosis; Glutathione peroxidase; Hepatocellular carcinoma; Low density lipoprotein; Nanoparticle

Indexed keywords

ANTINEOPLASTIC AGENT; APOPTOSIS INHIBITOR; DOCOSAHEXAENOIC ACID; FEROSTATIN 1; GLUTATHIONE; LIPID HYDROPEROXIDE; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN DOCOSAHEXAENOIC ACID NANOPARTICLE; NANOPARTICLE; PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE; UNCLASSIFIED DRUG; GLUTATHIONE PEROXIDASE; GLUTATHIONE PEROXIDASE 4, MOUSE; IRON; LIPID PEROXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; AUTOPHAGY; CELL DEATH; CELL KILLING; CONTROLLED STUDY; DRUG MECHANISM; ENZYME INACTIVATION; FERROPTOSIS; GROWTH INHIBITION; H4-II-E CELL LINE; HEP-G2 CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; LIPID PEROXIDATION; LIVER CELL CARCINOMA; MALE; MOUSE; NECROPTOSIS; NONHUMAN; PLC/PRF/5 CELL LINE; PRIORITY JOURNAL; RAT; TUMOR CELL; TUMOR XENOGRAFT; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; CHEMISTRY; DRUG EFFECT; DRUG SCREENING; GENE EXPRESSION; GENETICS; INTRALESIONAL DRUG ADMINISTRATION; LIVER TUMOR; METABOLISM; PATHOLOGY; SCID MOUSE; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; CARCINOMA, HEPATOCELLULAR; CELL DEATH; CELL LINE, TUMOR; DOCOSAHEXAENOIC ACIDS; GENE EXPRESSION; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HEP G2 CELLS; HUMANS; INJECTIONS, INTRALESIONAL; IRON; LIPID PEROXIDATION; LIPID PEROXIDES; LIPOPROTEINS, LDL; LIVER NEOPLASMS; MALE; MICE; MICE, INBRED BALB C; MICE, SCID; NANOPARTICLES; RATS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 85029426075     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2017.09.002     Document Type: Article

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