Hepatic Arterial Infusion of Low-Density Lipoprotein Docosahexaenoic Acid Nanoparticles Selectively Disrupts Redox Balance in Hepatoma Cells and Reduces Growth of Orthotopic Liver Tumors in Rats

Gastroenterology

Volumn 150, Issue 2, 2016, Pages 488-498

  Wen, Xiaodong ^a   Reynolds, Lacy ^a   Mulik, Rohit S ^a   Kim, Soo Young ^a   Van Treuren, Tim ^a   Nguyen, Liem H ^a   Zhu, Hao ^a   Corbin, Ian R ^a  

^a UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

Lipid Peroxidation; Liver Cancer; Nanomedicine; Omega 3 Fatty Acids

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ASPARTATE AMINOTRANSFERASE; CASPASE 3; CYTOCHROME P450; DOCOSAHEXAENOIC ACID; FREE RADICAL; GLUTATHIONE; GLUTATHIONE DISULFIDE; KI 67 ANTIGEN; LIPOXYGENASE; LOW DENSITY LIPOPROTEIN; NANOPARTICLE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE; PROSTAGLANDIN SYNTHASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TRIOLEIN; ANTINEOPLASTIC AGENT; ANTIOXIDANT; DRUG CARRIER;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOCHEMISTRY; CANCER INHIBITION; CANCER SIZE; CELL PROLIFERATION; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; INTRAHEPATIC DRUG ADMINISTRATION; LIPID PEROXIDATION; LIPOSOMAL DELIVERY; LIVER CELL CARCINOMA; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OXIDATION REDUCTION POTENTIAL; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RAT; REDOX STRESS; SINGLE DRUG DOSE; SURFACE CHARGE; TRANSMISSION ELECTRON MICROSCOPY; TUMOR NECROSIS; WESTERN BLOTTING; ANIMAL; CARCINOMA, HEPATOCELLULAR; DRUG EFFECTS; HEPATIC ARTERY; INTRAARTERIAL DRUG ADMINISTRATION; LIVER NEOPLASMS; METABOLISM; NECROSIS; PATHOLOGY; TIME FACTOR; TUMOR CELL LINE; TUMOR VOLUME; VASCULARIZATION;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL PROLIFERATION; DOCOSAHEXAENOIC ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG CARRIERS; HEPATIC ARTERY; INFUSIONS, INTRA-ARTERIAL; LIPID PEROXIDATION; LIPOPROTEINS, LDL; LIVER NEOPLASMS; NANOPARTICLES; NECROSIS; OXIDATION-REDUCTION; OXIDATIVE STRESS; RATS; REACTIVE OXYGEN SPECIES; TIME FACTORS; TUMOR BURDEN;

EID: 84959532243     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2015.10.008     Document Type: Article

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