메뉴 건너뛰기




Volumn 58, Issue 9, 2017, Pages 1834-1844

A genome-wide association meta-analysis on lipoprotein (a) concentrations adjusted for apolipoprotein (a) isoforms

(27)  Mack, Salome a   Coassin, Stefan b   Rueedi, Rico c   Yousri, Noha A d   Seppälä, Ilkka f   Gieger, Christian f,u   Schönherr, Sebastian e,w   Forer, Lukas f,t   Erhart, Gertraud h,v   Marques Vidal, Pedro i   Ried, Janina S a   Waeber, Gerard g,i,s   Bergmann, Sven j   Dähnhardt, Doreen k   Stöckl, Andrea k,l   Raitakari, Olli T m   Kähönen, Mika n,x   Peters, Annette o   Meitinger, Thomas a,g   Strauch, Konstantin k   more..


Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; LIPOPROTEIN A; APOLIPOPROTEIN A; ISOPROTEIN;

EID: 85029424122     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M076232     Document Type: Article
Times cited : (110)

References (63)
  • 1
    • 84982764410 scopus 로고    scopus 로고
    • Structure, function, and genetics of lipoprotein (a)
    • Schmidt, K., A. Noureen, F. Kronenberg, and G. Utermann. 2016. Structure, function, and genetics of lipoprotein (a). J. Lipid Res. 57: 1339-1359.
    • (2016) J. Lipid Res. , vol.57 , pp. 1339-1359
    • Schmidt, K.1    Noureen, A.2    Kronenberg, F.3    Utermann, G.4
  • 2
    • 0026667073 scopus 로고
    • Apolipoprotein(a) gene accounts for greater than 90% of the variation in plasma lipoprotein(a) concentrations
    • Boerwinkle, E., C. C. Leffert, J. Lin, C. Lackner, G. Chiesa, and H. H. Hobbs. 1992. Apolipoprotein(a) gene accounts for greater than 90% of the variation in plasma lipoprotein(a) concentrations. J. Clin. Invest. 90: 52-60.
    • (1992) J. Clin. Invest. , vol.90 , pp. 52-60
    • Boerwinkle, E.1    Leffert, C.C.2    Lin, J.3    Lackner, C.4    Chiesa, G.5    Hobbs, H.H.6
  • 3
    • 84871674237 scopus 로고    scopus 로고
    • Lipoprotein(a): Resurrected by genetics
    • Kronenberg, F., and G. Utermann. 2013. Lipoprotein(a): resurrected by genetics. J. Intern. Med. 273: 6-30.
    • (2013) J. Intern. Med. , vol.273 , pp. 6-30
    • Kronenberg, F.1    Utermann, G.2
  • 4
    • 0026526357 scopus 로고
    • The apolipoprotein (a) gene: A transcribed hypervariable locus controlling plasma lipoprotein (a) concentration
    • Kraft, H. G., S. Köchl, H. J. Menzel, C. Sandholzer, and G. Utermann. 1992. The apolipoprotein (a) gene: a transcribed hypervariable locus controlling plasma lipoprotein (a) concentration. Hum. Genet. 90: 220-230.
    • (1992) Hum. Genet. , vol.90 , pp. 220-230
    • Kraft, H.G.1    Köchl, S.2    Menzel, H.J.3    Sandholzer, C.4    Utermann, G.5
  • 5
    • 0026048441 scopus 로고
    • Molecular basis of apolipoprotein (a) isoform size heterogeneity as revealed by pulsed-feld gel electrophoresis
    • Lackner, C., E. Boerwinkle, C. C. Leffert, T. Rahmig, and H. H. Hobbs. 1991. Molecular basis of apolipoprotein (a) isoform size heterogeneity as revealed by pulsed-feld gel electrophoresis. J. Clin. Invest. 87: 2153-2161.
    • (1991) J. Clin. Invest. , vol.87 , pp. 2153-2161
    • Lackner, C.1    Boerwinkle, E.2    Leffert, C.C.3    Rahmig, T.4    Hobbs, H.H.5
  • 6
    • 0029916008 scopus 로고    scopus 로고
    • Frequency distributions of apolipoprotein(a) kringle IV repeat alleles and their effects on lipoprotein(a) levels in Caucasian, Asian, and African populations: The distribution of null alleles is non-random
    • Kraft, H. G., A. Lingenhel, R. W. Pang, R. Delport, M. Trommsdorff, H. Vermaak, E. D. Janus, and G. Utermann. 1996. Frequency distributions of apolipoprotein(a) kringle IV repeat alleles and their effects on lipoprotein(a) levels in Caucasian, Asian, and African populations: the distribution of null alleles is non-random. Eur. J. Hum. Genet. 4: 74-87.
    • (1996) Eur. J. Hum. Genet. , vol.4 , pp. 74-87
    • Kraft, H.G.1    Lingenhel, A.2    Pang, R.W.3    Delport, R.4    Trommsdorff, M.5    Vermaak, H.6    Janus, E.D.7    Utermann, G.8
  • 9
    • 79960699966 scopus 로고    scopus 로고
    • Meta analysis of candidate gene variants outside the LPA locus with Lp(a) plasma levels in 14, 500 participants of six White European cohorts
    • Zabaneh, D., M. Kumari, M. Sandhu, N. Wareham, N. Wainwright, T. Papamarkou, J. Hopewell, R. Clarke, K. Li, J. Palmen, et al. 2011. Meta analysis of candidate gene variants outside the LPA locus with Lp(a) plasma levels in 14, 500 participants of six White European cohorts. Atherosclerosis. 217: 447-451.
    • (2011) Atherosclerosis. , vol.217 , pp. 447-451
    • Zabaneh, D.1    Kumari, M.2    Sandhu, M.3    Wareham, N.4    Wainwright, N.5    Papamarkou, T.6    Hopewell, J.7    Clarke, R.8    Li, K.9    Palmen, J.10
  • 11
    • 84863037215 scopus 로고    scopus 로고
    • Genetic variants, plasma lipoprotein(a) levels, and risk of cardiovascular morbidity and mortality among two prospective cohorts of type 2 diabetes
    • Qi, Q., T. Workalemahu, C. Zhang, F. B. Hu, and L. Qi. 2012. Genetic variants, plasma lipoprotein(a) levels, and risk of cardiovascular morbidity and mortality among two prospective cohorts of type 2 diabetes. Eur. Heart J. 33: 325-334.
    • (2012) Eur. Heart J. , vol.33 , pp. 325-334
    • Qi, Q.1    Workalemahu, T.2    Zhang, C.3    Hu, F.B.4    Qi, L.5
  • 16
    • 0023393811 scopus 로고
    • Lp(a) glycoprotein phenotypes. Inheritance and relation to Lp(a)-lipoprotein concentrations in plasma
    • Utermann, G., H. J. Menzel, H. G. Kraft, H. C. Duba, H. G. Kemmler, and C. Seitz. 1987. Lp(a) glycoprotein phenotypes. Inheritance and relation to Lp(a)-lipoprotein concentrations in plasma. J. Clin. Invest. 80: 458-465.
    • (1987) J. Clin. Invest. , vol.80 , pp. 458-465
    • Utermann, G.1    Menzel, H.J.2    Kraft, H.G.3    Duba, H.C.4    Kemmler, H.G.5    Seitz, C.6
  • 17
    • 79955860273 scopus 로고    scopus 로고
    • Random-effects model aimed at discovering associations in meta-analysis of genome-wide association studies
    • Han, B., and E. Eskin. 2011. Random-effects model aimed at discovering associations in meta-analysis of genome-wide association studies. Am. J. Hum. Genet. 88: 586-598.
    • (2011) Am. J. Hum. Genet. , vol.88 , pp. 586-598
    • Han, B.1    Eskin, E.2
  • 18
    • 82355194878 scopus 로고    scopus 로고
    • To stratify or not to stratify: Power considerations for population-based genome-wide association studies of quantitative traits
    • Behrens, G., T. W. Winkler, M. Gorski, M. F. Leitzmann, and I. M. Heid. 2011. To stratify or not to stratify: power considerations for population-based genome-wide association studies of quantitative traits. Genet. Epidemiol. 35: 867-879.
    • (2011) Genet. Epidemiol. , vol.35 , pp. 867-879
    • Behrens, G.1    Winkler, T.W.2    Gorski, M.3    Leitzmann, M.F.4    Heid, I.M.5
  • 19
  • 21
    • 79251484337 scopus 로고    scopus 로고
    • A knowledge-based weighting framework to boost the power of genome-wide association studies
    • Li, M-X., P. C. Sham, S. S. Cherny, and Y-Q. Song. 2010. A knowledge-based weighting framework to boost the power of genome-wide association studies. PLoS One. 5: e14480.
    • (2010) PLoS One. , vol.5 , pp. e14480
    • Li, M.-X.1    Sham, P.C.2    Cherny, S.S.3    Song, Y.-Q.4
  • 22
    • 79952467494 scopus 로고    scopus 로고
    • GATES: A rapid and powerful gene-based association test using extended Simes procedure
    • Li, M-X., H-S. Gui, J. S. H. Kwan, and P. C. Sham. 2011. GATES: a rapid and powerful gene-based association test using extended Simes procedure. Am. J. Hum. Genet. 88: 283-293.
    • (2011) Am. J. Hum. Genet. , vol.88 , pp. 283-293
    • Li, M.-X.1    Gui, H.-S.2    Kwan, J.S.H.3    Sham, P.C.4
  • 27
    • 84929001104 scopus 로고    scopus 로고
    • Human genomics. the Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans
    • GTEx Consortium. 2015. Human genomics. The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans. Science. 348: 648-660.
    • (2015) Science. , vol.348 , pp. 648-660
  • 29
    • 68149165614 scopus 로고    scopus 로고
    • Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm
    • Kumar, P., S. Henikoff, and P. C. Ng. 2009. Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. Nat. Protoc. 4: 1073-1081.
    • (2009) Nat. Protoc. , vol.4 , pp. 1073-1081
    • Kumar, P.1    Henikoff, S.2    Ng, P.C.3
  • 30
    • 0035311403 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms in exons of the apo(a) kringle IV types 6 to 10 domain affect Lp(a) plasma concentrations and have different patterns in Africans and Caucasians
    • Ogorelkova, M., H. G. Kraft, C. Ehnholm, and G. Utermann. 2001. Single nucleotide polymorphisms in exons of the apo(a) kringle IV types 6 to 10 domain affect Lp(a) plasma concentrations and have different patterns in Africans and Caucasians. Hum. Mol. Genet. 10: 815-824.
    • (2001) Hum. Mol. Genet. , vol.10 , pp. 815-824
    • Ogorelkova, M.1    Kraft, H.G.2    Ehnholm, C.3    Utermann, G.4
  • 33
    • 10844258968 scopus 로고    scopus 로고
    • A common nonsense mutation in the repetitive kringle IV-2 domain of human apolipoprotein(a) results in a truncated protein and low plasma Lp(a)
    • Parson, W., H. G. Kraft, H. Niederstätter, A. W. Lingenhel, S. Köchl, F. Fresser, and G. Utermann. 2004. A common nonsense mutation in the repetitive kringle IV-2 domain of human apolipoprotein(a) results in a truncated protein and low plasma Lp(a). Hum. Mutat. 24: 474-480.
    • (2004) Hum. Mutat. , vol.24 , pp. 474-480
    • Parson, W.1    Kraft, H.G.2    Niederstätter, H.3    Lingenhel, A.W.4    Köchl, S.5    Fresser, F.6    Utermann, G.7
  • 34
    • 84926320277 scopus 로고    scopus 로고
    • Sequence variation within the KIV-2 copy number polymorphism of the human LPA gene in African, Asian, and European populations
    • Noureen, A., F. Fresser, G. Utermann, and K. Schmidt. 2015. Sequence variation within the KIV-2 copy number polymorphism of the human LPA gene in African, Asian, and European populations. PLoS One. 10: e0121582.
    • (2015) PLoS One. , vol.10 , pp. e0121582
    • Noureen, A.1    Fresser, F.2    Utermann, G.3    Schmidt, K.4
  • 35
    • 84905718180 scopus 로고    scopus 로고
    • Genetic determination of lipoprotein(a) and its association with cardiovascular disease: Convenient does not always mean better
    • Kronenberg, F. 2014. Genetic determination of lipoprotein(a) and its association with cardiovascular disease: convenient does not always mean better. J. Intern. Med. 276: 243-247.
    • (2014) J. Intern. Med. , vol.276 , pp. 243-247
    • Kronenberg, F.1
  • 36
    • 77950020917 scopus 로고    scopus 로고
    • The I4399M variant of apolipoprotein(a) is associated with increased oxidized phos-pholipids on apolipoprotein B-100 particles
    • Arai, K., M. M. Luke, M. L. Koschinsky, E. R. Miller, C. R. Pullinger, J. L. Witztum, J. P. Kane, and S. Tsimikas. 2010. The I4399M variant of apolipoprotein(a) is associated with increased oxidized phos-pholipids on apolipoprotein B-100 particles. Atherosclerosis. 209: 498-503.
    • (2010) Atherosclerosis. , vol.209 , pp. 498-503
    • Arai, K.1    Luke, M.M.2    Koschinsky, M.L.3    Miller, E.R.4    Pullinger, C.R.5    Witztum, J.L.6    Kane, J.P.7    Tsimikas, S.8
  • 38
    • 0032837868 scopus 로고    scopus 로고
    • Molecular basis of congenital lp(a) defciency: A frequent apo(a) "null" mutation in Caucasians
    • Ogorelkova, M., A. Gruber, and G. Utermann. 1999. Molecular basis of congenital lp(a) defciency: a frequent apo(a) "null" mutation in Caucasians. Hum. Mol. Genet. 8: 2087-2096.
    • (1999) Hum. Mol. Genet. , vol.8 , pp. 2087-2096
    • Ogorelkova, M.1    Gruber, A.2    Utermann, G.3
  • 40
    • 84963837739 scopus 로고    scopus 로고
    • Meta-analysis of 49, 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels
    • van Leeuwen, E. M., A. Sabo, J. C. Bis, J. E. Huffman, A. Manichaikul, A. V Smith, M. F. Feitosa, S. Demissie, P. K. Joshi, Q. Duan, et al. 2016. Meta-analysis of 49, 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels. J. Med. Genet. 53: 441-449.
    • (2016) J. Med. Genet. , vol.53 , pp. 441-449
    • Van Leeuwen, E.M.1    Sabo, A.2    Bis, J.C.3    Huffman, J.E.4    Manichaikul, A.5    Smith, A.V.6    Feitosa, M.F.7    Demissie, S.8    Joshi, P.K.9    Duan, Q.10
  • 41
    • 79960646130 scopus 로고    scopus 로고
    • Lipoprotein(a)-cholesterol: A signifcant component of serum cholesterol
    • Kinpara, K., H. Okada, A. Yoneyama, M. Okubo, and T. Murase. 2011. Lipoprotein(a)-cholesterol: a signifcant component of serum cholesterol. Clin. Chim. Acta. 412: 1783-1787.
    • (2011) Clin. Chim. Acta. , vol.412 , pp. 1783-1787
    • Kinpara, K.1    Okada, H.2    Yoneyama, A.3    Okubo, M.4    Murase, T.5
  • 42
    • 0030785295 scopus 로고    scopus 로고
    • Characterization of multiple enhancer regions upstream of the apolipoprotein(a) gene
    • Wade, D. P., L. H. Puckey, B. L. Knight, F. Acquati, A. Mihalich, and R. Taramelli. 1997. Characterization of multiple enhancer regions upstream of the apolipoprotein(a) gene. J. Biol. Chem. 272: 30387-30399.
    • (1997) J. Biol. Chem. , vol.272 , pp. 30387-30399
    • Wade, D.P.1    Puckey, L.H.2    Knight, B.L.3    Acquati, F.4    Mihalich, A.5    Taramelli, R.6
  • 43
    • 0037212134 scopus 로고    scopus 로고
    • Sequence and functional changes in a putative enhancer region upstream of the apolipoprotein(a) gene
    • Puckey, L. H., and B. L. Knight. 2003. Sequence and functional changes in a putative enhancer region upstream of the apolipoprotein(a) gene. Atherosclerosis. 166: 119-127.
    • (2003) Atherosclerosis. , vol.166 , pp. 119-127
    • Puckey, L.H.1    Knight, B.L.2
  • 45
    • 77952487856 scopus 로고    scopus 로고
    • Comprehensive analysis of genomic variation in the LPA locus and its relationship to plasma lipoprotein(a) in South Asians, Chinese, and European Caucasians
    • Lanktree, M. B., S. S. Anand, S. Yusuf, and R. A. Hegele; SHARE Investigators. 2010. Comprehensive analysis of genomic variation in the LPA locus and its relationship to plasma lipoprotein(a) in South Asians, Chinese, and European Caucasians. Circ. Cardiovasc. Genet. 3: 39-46.
    • (2010) Circ. Cardiovasc. Genet. , vol.3 , pp. 39-46
    • Lanktree, M.B.1    Anand, S.S.2    Yusuf, S.3    Hegele, R.A.4    Investigators, S.5
  • 46
    • 0032723934 scopus 로고    scopus 로고
    • The identifcation of polymorphisms in the coding region of the apoli-poprotein (a) gene-association with earlier identifed polymorphic sites and infuence on the lipoprotein (a) concentration
    • Prins, J., F. R. Leus, B. N. Bouma, and H. J. van Rijn. 1999. The identifcation of polymorphisms in the coding region of the apoli-poprotein (a) gene-association with earlier identifed polymorphic sites and infuence on the lipoprotein (a) concentration. Thromb. Haemost. 82: 1709-1717.
    • (1999) Thromb. Haemost. , vol.82 , pp. 1709-1717
    • Prins, J.1    Leus, F.R.2    Bouma, B.N.3    Van Rijn, H.J.4
  • 51
    • 84924405717 scopus 로고    scopus 로고
    • Apolipoprotein E isoforms and lipoprotein metabolism
    • Phillips, M. C. 2014. Apolipoprotein E isoforms and lipoprotein metabolism. IUBMB Life. 66: 616-623.
    • (2014) IUBMB Life. , vol.66 , pp. 616-623
    • Phillips, M.C.1
  • 52
    • 0028153877 scopus 로고
    • Post-prandial Lp(a): Identifcation of a triglyceride-rich particle containing apo E
    • Scanu, A. M., D. Pfaffnger, and C. Edelstein. 1994. Post-prandial Lp(a): identifcation of a triglyceride-rich particle containing apo E. Chem. Phys. Lipids. 67-68: 193-198.
    • (1994) Chem. Phys. Lipids. , vol.67-68 , pp. 193-198
    • Scanu, A.M.1    Pfaffnger, D.2    Edelstein, C.3
  • 54
    • 0017773790 scopus 로고
    • Polymorphism of apolipoprotein E and occurrence of dysbetalipoproteinaemia in man
    • Utermann, G., M. Hees, and A. Steinmetz. 1977. Polymorphism of apolipoprotein E and occurrence of dysbetalipoproteinaemia in man. Nature. 269: 604-607.
    • (1977) Nature. , vol.269 , pp. 604-607
    • Utermann, G.1    Hees, M.2    Steinmetz, A.3
  • 55
    • 0028067167 scopus 로고
    • Apolipoprotein E phenotype and lipoprotein(a) in familial hyper-cholesterolaemia: Implication for lipoprotein(a) metabolism
    • Lindahl, G., F. Mailly, S. Humphries, and M. Seed. 1994. Apolipoprotein E phenotype and lipoprotein(a) in familial hyper-cholesterolaemia: implication for lipoprotein(a) metabolism. Clin. Investig. 72: 631-638.
    • (1994) Clin. Investig. , vol.72 , pp. 631-638
    • Lindahl, G.1    Mailly, F.2    Humphries, S.3    Seed, M.4
  • 56
    • 0027475419 scopus 로고
    • Variation in lipoprotein(a) concentrations among individuals with the same apolipoprotein (a) isoform is determined by the rate of lipoprotein(a) production
    • Rader, D. J., W. Cain, L. A. Zech, D. Usher, and H. B. Brewer. 1993. Variation in lipoprotein(a) concentrations among individuals with the same apolipoprotein (a) isoform is determined by the rate of lipoprotein(a) production. J. Clin. Invest. 91: 443-447.
    • (1993) J. Clin. Invest. , vol.91 , pp. 443-447
    • Rader, D.J.1    Cain, W.2    Zech, L.A.3    Usher, D.4    Brewer, H.B.5
  • 58
    • 84891755468 scopus 로고    scopus 로고
    • TLR2 and TLR4 in autoimmune diseases: A comprehensive review
    • Liu, Y., H. Yin, M. Zhao, and Q. Lu. 2014. TLR2 and TLR4 in autoimmune diseases: a comprehensive review. Clin. Rev. Allergy Immunol. 47: 136-147.
    • (2014) Clin. Rev. Allergy Immunol. , vol.47 , pp. 136-147
    • Liu, Y.1    Yin, H.2    Zhao, M.3    Lu, Q.4
  • 60
    • 67049167090 scopus 로고    scopus 로고
    • Genetically elevated lipoprotein(a) and increased risk of myocardial infarction
    • Kamstrup, P. R., A. Tybjaerg-Hansen, R. Steffensen, and B. G. Nordestgaard. 2009. Genetically elevated lipoprotein(a) and increased risk of myocardial infarction. JAMA. 301: 2331-2339.
    • (2009) JAMA. , vol.301 , pp. 2331-2339
    • Kamstrup, P.R.1    Tybjaerg-Hansen, A.2    Steffensen, R.3    Nordestgaard, B.G.4
  • 63
    • 84994607113 scopus 로고    scopus 로고
    • Antisense oligonucleotides targeting apolipoprotein(a) in people with raised lipoprotein(a): Two randomised, double-blind, placebo-controlled, dose-ranging trials
    • Viney, N. J., J. C. van Capelleveen, R. S. Geary, S. Xia, J. A. Tami, R. Z. Yu, S. M. Marcovina, S. G. Hughes, M. J. Graham, R. M. Crooke, et al. 2016. Antisense oligonucleotides targeting apolipoprotein(a) in people with raised lipoprotein(a): two randomised, double-blind, placebo-controlled, dose-ranging trials. Lancet. 388: 2239-2253.
    • (2016) Lancet. , vol.388 , pp. 2239-2253
    • Viney, N.J.1    Van Capelleveen, J.C.2    Geary, R.S.3    Xia, S.4    Tami, J.A.5    Yu, R.Z.6    Marcovina, S.M.7    Hughes, S.G.8    Graham, M.J.9    Crooke, R.M.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.