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Volumn 60, Issue 12, 2015, Pages 755-761

Genome- and exome-wide association study of serum lipoprotein (a) in the Jackson Heart Study

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; LIPOPROTEIN A;

EID: 84951039907     PISSN: 14345161     EISSN: 1435232X     Source Type: Journal    
DOI: 10.1038/jhg.2015.107     Document Type: Article
Times cited : (34)

References (46)
  • 2
    • 67651210632 scopus 로고    scopus 로고
    • Lipoprotein(a) concentration and the risk of coronary heart disease, stroke, and nonvascular mortality
    • Erqou, S., Kaptoge, S., Perry, P. L., Di Angelantonio, E., Thompson, A., White, I. R. et al. Lipoprotein(a) concentration and the risk of coronary heart disease, stroke, and nonvascular mortality. JAMA 302, 412-423 (2009).
    • (2009) JAMA , vol.302 , pp. 412-423
    • Erqou, S.1    Kaptoge, S.2    Perry, P.L.3    Di Angelantonio, E.4    Thompson, A.5    White, I.R.6
  • 3
    • 73549097512 scopus 로고    scopus 로고
    • Genetic variants associated with Lp(a) lipoprotein level and coronary disease
    • Clarke, R., Peden, J. F., Hopewell, J. C., Kyriakou, T., Goel, A., Heath, S. C. et al. Genetic variants associated with Lp(a) lipoprotein level and coronary disease. N. Engl. J. Med. 361, 2518-2528 (2009).
    • (2009) N. Engl. J. Med , vol.361 , pp. 2518-2528
    • Clarke, R.1    Peden, J.F.2    Hopewell, J.C.3    Kyriakou, T.4    Goel, A.5    Heath, S.C.6
  • 4
    • 0027220885 scopus 로고
    • Identification of the cysteine residue in apolipoprotein(a) that mediates extracellular coupling with apolipoprotein B-100
    • Koschinsky, M. L., Cote, G. P., Gabel, B. & van der Hoek, Y. Y. Identification of the cysteine residue in apolipoprotein(a) that mediates extracellular coupling with apolipoprotein B-100. J. Biol. Chem. 268, 19819-19825 (1993).
    • (1993) J. Biol. Chem , vol.268 , pp. 19819-19825
    • Koschinsky, M.L.1    Cote, G.P.2    Gabel, B.3    Van Der Hoek, Y.Y.4
  • 5
    • 0026667073 scopus 로고
    • Apolipoprotein(a) gene accounts for greater than 90% of the variation in plasma lipoprotein(a) concentrations
    • Boerwinkle, E., Leffert, C. C., Lin, J., Lackner, C., Chiesa, G. & Hobbs, H. H. Apolipoprotein(a) gene accounts for greater than 90% of the variation in plasma lipoprotein(a) concentrations. J. Clin. Invest. 90, 52-60 (1992).
    • (1992) J. Clin. Invest , vol.90 , pp. 52-60
    • Boerwinkle, E.1    Leffert, C.C.2    Lin, J.3    Lackner, C.4    Chiesa, G.5    Hobbs, H.H.6
  • 6
    • 0030799057 scopus 로고    scopus 로고
    • The Apo (a) gene is the major determinant of variation in plasma Lp(a) levels in African Americans
    • Mooser, V., Scheer, D., Marcovina, S. M., Wang, J., Guerra, R., Cohen, J. et al. The Apo (a) gene is the major determinant of variation in plasma Lp(a) levels in African Americans. Am. J. Hum. Genet. 61, 402-417 (1997).
    • (1997) Am. J. Hum. Genet , vol.61 , pp. 402-417
    • Mooser, V.1    Scheer, D.2    Marcovina, S.M.3    Wang, J.4    Guerra, R.5    Cohen, J.6
  • 7
    • 67649729589 scopus 로고    scopus 로고
    • Genome-wide association study of plasma lipoprotein(a) levels identifies multiple genes on chromosome 6q
    • Ober, C., Nord, A. S., Thompson, E. E., Pan, L., Tan, Z., Cusanovich, D. et al. Genome-wide association study of plasma lipoprotein(a) levels identifies multiple genes on chromosome 6q. J. Lipid Res. 50, 798-806 (2009).
    • (2009) J. Lipid Res , vol.50 , pp. 798-806
    • Ober, C.1    Nord, A.S.2    Thompson, E.E.3    Pan, L.4    Tan, Z.5    Cusanovich, D.6
  • 8
    • 0025905304 scopus 로고
    • Effects of the apolipoprotein(a) size polymorphism on the lipoprotein(a) concentration in 7 ethnic groups
    • Sandholzer, C., Hallman, D. M., Saha, N., Sigurdsson, G., Lackner, C., Csaszar, A. et al. Effects of the apolipoprotein(a) size polymorphism on the lipoprotein(a) concentration in 7 ethnic groups. Hum. Genet. 86, 607-614 (1991).
    • (1991) Hum. Genet , vol.86 , pp. 607-614
    • Sandholzer, C.1    Hallman, D.M.2    Saha, N.3    Sigurdsson, G.4    Lackner, C.5    Csaszar, A.6
  • 9
    • 77952487856 scopus 로고    scopus 로고
    • Comprehensive analysis of genomic variation in the LPA locus and its relationship to plasma lipoprotein(a) in South Asians, Chinese, and European Caucasians
    • Lanktree, M. B., Anand, S. S., Yusuf, S. & Hegele, R. A. Comprehensive analysis of genomic variation in the LPA locus and its relationship to plasma lipoprotein(a) in South Asians, Chinese, and European Caucasians. Circ. Cardiovasc. Genet. 3, 39-46 (2010).
    • (2011) Circ. Cardiovasc. Genet , vol.3 , pp. 39-46
    • Lanktree, M.B.1    Anand, S.S.2    Yusuf, S.3    Hegele, R.A.4
  • 10
    • 0030451016 scopus 로고    scopus 로고
    • Differences in Lp[a] concentrations and apo[a] polymorphs between black and white Americans
    • Marcovina, S. M., Albers, J. J., Wijsman, E., Zhang, Z., Chapman, N. H. & Kennedy, H. Differences in Lp[a] concentrations and apo[a] polymorphs between black and white Americans. J. Lipid Res. 37, 2569-2585 (1996).
    • (1996) J. Lipid Res , vol.37 , pp. 2569-2585
    • Marcovina, S.M.1    Albers, J.J.2    Wijsman, E.3    Zhang, Z.4    Chapman, N.H.5    Kennedy, H.6
  • 11
    • 79551551096 scopus 로고    scopus 로고
    • Singlenucleotide polymorphisms in LPA explain most of the ancestry-specific variation in Lp (a) levels in African Americans
    • Deo, R. C., Wilson, J. G., Xing, C., Lawson, K., Kao, W. H., Reich, D. et al. Singlenucleotide polymorphisms in LPA explain most of the ancestry-specific variation in Lp (a) levels in African Americans. PLoS ONE 6, e14581 (2011).
    • (2011) PLoS ONE , vol.6 , pp. e14581
    • Deo, R.C.1    Wilson, J.G.2    Xing, C.3    Lawson, K.4    Kao, W.H.5    Reich, D.6
  • 12
    • 29244442270 scopus 로고    scopus 로고
    • Sociocultural methods in the Jackson Heart Study: Conceptual and descriptive overview
    • Payne, T. J., Wyatt, S. B., Mosley, T. H., Dubbert, P. M., Guiterrez-Mohammed, M. L., Calvin, R. L. et al. Sociocultural methods in the Jackson Heart Study: conceptual and descriptive overview. Ethn Dis. 15, S6-38-48 (2005).
    • (2005) Ethn Dis , vol.15 , Issue.6 , pp. 38-48
    • Payne, T.J.1    Wyatt, S.B.2    Mosley, T.H.3    Dubbert, P.M.4    Guiterrez-Mohammed, M.L.5    Calvin, R.L.6
  • 14
    • 4644314825 scopus 로고    scopus 로고
    • Laboratory, reading center, and coordinating center data management methods in the Jackson Heart Study
    • Carpenter, M. A., Crow, R., Steffes, M., Rock, W., Heilbraun, J., Evans, G. et al. Laboratory, reading center, and coordinating center data management methods in the Jackson Heart Study. Am J Med Sci 328, 131-144 (2004).
    • (2004) Am J Med Sci , vol.328 , pp. 131-144
    • Carpenter, M.A.1    Crow, R.2    Steffes, M.3    Rock, W.4    Heilbraun, J.5    Evans, G.6
  • 15
    • 59249102911 scopus 로고    scopus 로고
    • Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: The Jackson Heart Study
    • Deo, R. C., Reich, D., Tandon, A., Akylbekova, E., Patterson, N., Waliszewska, A. et al. Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: the Jackson Heart Study. PLoS Genet. 5, e1000342 (2009).
    • (2009) PLoS Genet , vol.5 , pp. e1000342
    • Deo, R.C.1    Reich, D.2    Tandon, A.3    Akylbekova, E.4    Patterson, N.5    Waliszewska, A.6
  • 17
    • 34548292504 scopus 로고    scopus 로고
    • PLINK: A tool set for whole-genome association and population-based linkage analyses
    • Purcell, S., Neale, B., Todd-Brown, K., Thomas, L., Ferreira, M. A., Bender, D. et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am. J. Hum. Genet. 81, 559-575 (2007).
    • (2007) Am. J. Hum. Genet , vol.81 , pp. 559-575
    • Purcell, S.1    Neale, B.2    Todd-Brown, K.3    Thomas, L.4    Ferreira, M.A.5    Bender, D.6
  • 18
    • 78649508578 scopus 로고    scopus 로고
    • Mach: Using sequence and genotype data to estimate haplotypes and unobserved genotypes
    • Li, Y., Willer, C. J., Ding, J., Scheet, P. & Abecasis, G. R. MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes. Genet. Epidemiol. 34, 816-834 (2010).
    • (2011) Genet. Epidemiol , vol.34 , pp. 816-834
    • Li, Y.1    Willer, C.J.2    Ding, J.3    Scheet, P.4    Abecasis, G.R.5
  • 19
    • 69749099417 scopus 로고    scopus 로고
    • Fast model-based estimation of ancestry in unrelated individuals
    • Alexander, D. H., Novembre, J. & Lange, K. Fast model-based estimation of ancestry in unrelated individuals. Genome Res. 19, 1655-1664 (2009).
    • (2009) Genome Res , vol.19 , pp. 1655-1664
    • Alexander, D.H.1    Novembre, J.2    Lange, K.3
  • 21
    • 33746512512 scopus 로고    scopus 로고
    • Principal components analysis corrects for stratification in genome-wide association studies
    • Price, A. L., Patterson, N. J., Plenge, R. M., Weinblatt, M. E., Shadick, N. A. & Reich, D. Principal components analysis corrects for stratification in genome-wide association studies. Nat. Genet. 38, 904-909 (2006).
    • (2006) Nat. Genet , vol.38 , pp. 904-909
    • Price, A.L.1    Patterson, N.J.2    Plenge, R.M.3    Weinblatt, M.E.4    Shadick, N.A.5    Reich, D.6
  • 22
    • 84862252240 scopus 로고    scopus 로고
    • Reprioritizing genetic associations in hit regions using LASSO-based resample model averaging
    • Valdar, W., Sabourin, J., Nobel, A. & Holmes, C. C. Reprioritizing genetic associations in hit regions using LASSO-based resample model averaging. Genet. Epidemiol. 36, 451-462 (2012).
    • (2012) Genet. Epidemiol , vol.36 , pp. 451-462
    • Valdar, W.1    Sabourin, J.2    Nobel, A.3    Holmes, C.C.4
  • 23
    • 33644974019 scopus 로고    scopus 로고
    • A fast and flexible statistical model for large-scale population genotype data: Applications to inferring missing genotypes and haplotypic phase
    • Scheet, P. & Stephens, M. A fast and flexible statistical model for large-scale population genotype data: applications to inferring missing genotypes and haplotypic phase. Am. J. Hum. Genet. 78, 629-644 (2006).
    • (2006) Am. J. Hum. Genet , vol.78 , pp. 629-644
    • Scheet, P.1    Stephens, M.2
  • 24
    • 0034017850 scopus 로고    scopus 로고
    • GOLD-graphical overview of linkage disequilibrium
    • Abecasis, G. R. & Cookson, W. O. GOLD-graphical overview of linkage disequilibrium. Bioinformatics 16, 182-183 (2000).
    • (2000) Bioinformatics , vol.16 , pp. 182-183
    • Abecasis, G.R.1    Cookson, W.O.2
  • 25
    • 13444269543 scopus 로고    scopus 로고
    • Haploview: Analysis and visualization of LD and haplotype maps
    • Barrett, J. C., Fry, B., Maller, J. & Daly, M. J. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21, 263-265 (2005).
    • (2005) Bioinformatics , vol.21 , pp. 263-265
    • Barrett, J.C.1    Fry, B.2    Maller, J.3    Daly, M.J.4
  • 26
    • 33644830588 scopus 로고    scopus 로고
    • Power and sample size for testing associations of haplotypes with complex traits
    • Schaid, D. J. Power and sample size for testing associations of haplotypes with complex traits. Ann. Hum. Genet. 70, 116-130 (2006).
    • (2006) Ann. Hum. Genet , vol.70 , pp. 116-130
    • Schaid . D, J.1
  • 27
    • 61449168010 scopus 로고    scopus 로고
    • A groupwise association test for rare mutations using a weighted sum statistic
    • Madsen, B. E. & Browning, S. R. A groupwise association test for rare mutations using a weighted sum statistic. PLoS Genet. 5, e1000384 (2009).
    • (2009) PLoS Genet , vol.5 , pp. e1000384
    • Madsen, B.E.1    Browning, S.R.2
  • 28
    • 84864953892 scopus 로고    scopus 로고
    • Optimal tests for rare variant effects in sequencing association studies
    • Lee, S., Wu, M. C. & Lin, X. Optimal tests for rare variant effects in sequencing association studies. Biostatistics (Oxford, England) 13, 762-775 (2012).
    • (2012) Biostatistics (Oxford, England , vol.13 , pp. 762-775
    • Lee, S.1    Wu, M.C.2    Lin, X.3
  • 29
    • 80051499915 scopus 로고    scopus 로고
    • Rare-variant association testing for sequencing data with the sequence kernel association test
    • Wu, M. C., Lee, S., Cai, T., Li, Y., Boehnke, M. & Lin, X. Rare-variant association testing for sequencing data with the sequence kernel association test. Am. J. Hum. Genet. 89, 82-93 (2011).
    • (2011) Am. J. Hum. Genet , vol.89 , pp. 82-93
    • Wu, M.C.1    Lee, S.2    Cai, T.3    Li, Y.4    Boehnke, M.5    Lin, X.6
  • 30
    • 84878799611 scopus 로고    scopus 로고
    • Predicting functional effect of human missense mutations using PolyPhen-2
    • Chapter 7, Unit 7.20
    • Adzhubei, I., Jordan, D. M. & Sunyaev, S. R. Predicting functional effect of human missense mutations using PolyPhen-2. Curr. Protoc. Hum. Genet. Chapter 7, Unit 7.20; doi: 10.1002/0471142905.hg0720s76 (2013).
    • (2013) Curr. Protoc. Hum. Genet
    • Adzhubei, I.1    Jordan, D.M.2    Sunyaev, S.R.3
  • 31
    • 0043122919 scopus 로고    scopus 로고
    • SIFT: Predicting amino acid changes that affect protein function
    • Ng, P. C. & Henikoff, S. SIFT: Predicting amino acid changes that affect protein function. Nucleic Acids Res. 31, 3812-3814 (2003).
    • (2003) Nucleic Acids Res , vol.31 , pp. 3812-3814
    • Ng, P.C.1    Henikoff, S.2
  • 32
    • 0028172990 scopus 로고
    • The role of lecithin: Cholesterol acyltransferase for lipoprotein (a) assembly Structural integrity of low density lipoproteins is a prerequisite for Lp(a) formation in human plasma
    • Steyrer, E., Durovic, S., Frank, S., Giessauf, W., Burger, A., Dieplinger, H. et al. The role of lecithin: cholesterol acyltransferase for lipoprotein (a) assembly. Structural integrity of low density lipoproteins is a prerequisite for Lp(a) formation in human plasma. J. Clin. Invest. 94, 2330-2340 (1994).
    • (1994) J. Clin. Invest , vol.94 , pp. 2330-2340
    • Steyrer, E.1    Durovic, S.2    Frank, S.3    Giessauf, W.4    Burger, A.5    Dieplinger, H.6
  • 33
    • 78449274394 scopus 로고    scopus 로고
    • Interrogating local population structure for fine mapping in genome-wide association studies
    • Qin, H., Morris, N., Kang, S. J., Li, M., Tayo, B., Lyon, H. et al. Interrogating local population structure for fine mapping in genome-wide association studies. Bioinformatics 26, 2961-2968 (2010).
    • (2011) Bioinformatics , vol.26 , pp. 2961-2968
    • Qin, H.1    Morris, N.2    Kang, S.J.3    Li, M.4    Tayo, B.5    Lyon, H.6
  • 34
    • 79951997040 scopus 로고    scopus 로고
    • Adjustment for local ancestry in genetic association analysis of admixed populations
    • Wang, X., Zhu, X., Qin, H., Cooper, R. S., Ewens, W. J., Li, C. et al. Adjustment for local ancestry in genetic association analysis of admixed populations. Bioinformatics 27, 670-677 (2011).
    • (2011) Bioinformatics , vol.27 , pp. 670-677
    • Wang, X.1    Zhu, X.2    Qin, H.3    Cooper, R.S.4    Ewens, W.J.5    Li, C.6
  • 35
    • 0029038023 scopus 로고
    • Lack of association of apolipoprotein e polymorphism with plasma Lp(a) levels in the Chinese
    • Heng, C. K., Saha, N. & Tay, J. S. Lack of association of apolipoprotein E polymorphism with plasma Lp(a) levels in the Chinese. Clin. Genet. 48, 113-119 (1995).
    • (1995) Clin. Genet , vol.48 , pp. 113-119
    • Heng, C.K.1    Saha, N.2    Tay, J.S.3
  • 36
    • 0343832920 scopus 로고    scopus 로고
    • Apolipoprotein e polymorphism influence on lipids, apolipoproteins and Lp(a) in a Spanish population underexpressing apo E4
    • Muros, M. & Rodriguez-Ferrer, C. Apolipoprotein E polymorphism influence on lipids, apolipoproteins and Lp(a) in a Spanish population underexpressing apo E4. Atherosclerosis 121, 13-21 (1996).
    • (1996) Atherosclerosis , vol.121 , pp. 13-21
    • Muros, M.1    Rodriguez-Ferrer, C.2
  • 37
    • 0027717601 scopus 로고
    • The effects of weight loss and apolipoprotein e polymorphism on serum lipids, apolipoproteins A-I and B, and lipoprotein(a)
    • Muls, E., Kempen, K., Vansant, G., Cobbaert, C. & Saris, W. The effects of weight loss and apolipoprotein E polymorphism on serum lipids, apolipoproteins A-I and B, and lipoprotein(a). Int. J. Obes. Relat. Metab. Disord. 17, 711-716 (1993).
    • (1993) Int. J. Obes. Relat. Metab. Disord , vol.17 , pp. 711-716
    • Muls, E.1    Kempen, K.2    Vansant, G.3    Cobbaert, C.4    Saris, W.5
  • 39
    • 0028919186 scopus 로고
    • Lipoprotein(a) in childhood: Relation with other atherosclerosis risk factors and family history of atherosclerosis
    • Bailleul, S., Couderc, R., Rossignol, C., Fermanian, J., Boutouchent, F., Farnier, M. A. et al. Lipoprotein(a) in childhood: relation with other atherosclerosis risk factors and family history of atherosclerosis. Clin. Chem. 41, 241-245 (1995).
    • (1995) Clin. Chem , vol.41 , pp. 241-245
    • Bailleul, S.1    Couderc, R.2    Rossignol, C.3    Fermanian, J.4    Boutouchent, F.5    Farnier, M.A.6
  • 41
    • 0029912148 scopus 로고    scopus 로고
    • Effects of prospective, randomized cholesterol-lowering dietary intervention and apolipoprotein e phenotype on serum lipoprotein(a) concentrations of infants aged 7-24 mo
    • Routi, T., Ronnemaa, T., Salo, P., Seppanen, R., Marniemi, J., Viikari, J. et al. Effects of prospective, randomized cholesterol-lowering dietary intervention and apolipoprotein E phenotype on serum lipoprotein(a) concentrations of infants aged 7-24 mo. Am. J. Clin. Nutr. 63, 386-391 (1996).
    • (1996) Am. J. Clin. Nutr , vol.63 , pp. 386-391
    • Routi, T.1    Ronnemaa, T.2    Salo, P.3    Seppanen, R.4    Marniemi, J.5    Viikari, J.6
  • 42
    • 0029840492 scopus 로고    scopus 로고
    • Effects of apoE gene polymorphism on Lp(a) concentrations depend on the size of apo (a): A study of 466 white men
    • Klausen, I. C., Gerdes, L. U., Hansen, P. S., Lemming, L., Gerdes, C. & Faergeman, O. Effects of apoE gene polymorphism on Lp(a) concentrations depend on the size of apo (a): a study of 466 white men. J. Mol. Med. 74, 685-690 (1996).
    • (1996) J. Mol. Med , vol.74 , pp. 685-690
    • Klausen, I.C.1    Gerdes, L.U.2    Hansen, P.S.3    Lemming, L.4    Gerdes, C.5    Faergeman, O.6
  • 43
    • 0028355331 scopus 로고
    • Effects of apolipoprotein e polymorphism on plasma lipoprotein(a) levels
    • Horita, K., Eto, M., Saito, M., Nakata, H., Iwashima, Y., Ito, H. et al. Effects of apolipoprotein E polymorphism on plasma lipoprotein(a) levels. Artery 20, 324-336 (1993).
    • (1993) Artery , vol.20 , pp. 324-336
    • Horita, K.1    Eto, M.2    Saito, M.3    Nakata, H.4    Iwashima, Y.5    Ito, H.6
  • 44
    • 0033748494 scopus 로고    scopus 로고
    • Context-dependent and invariant associations between lipids, lipoproteins, and apolipoproteins and apolipoprotein e genotype
    • Frikke-Schmidt, R., Nordestgaard, B. G., Agerholm-Larsen, B., Schnohr, P. & Tybjaerg-Hansen, A. Context-dependent and invariant associations between lipids, lipoproteins, and apolipoproteins and apolipoprotein E genotype. J. Lipid Res. 41, 1812-1822 (2000).
    • (2000) J. Lipid Res , vol.41 , pp. 1812-1822
    • Frikke-Schmidt, R.1    Nordestgaard, B.G.2    Agerholm-Larsen, B.3    Schnohr, P.4    Tybjaerg-Hansen, A.5
  • 45
    • 0028067167 scopus 로고
    • Apolipoprotein e phenotype and lipoprotein(a) in familial hypercholesterolaemia: Implication for lipoprotein(a) metabolism
    • Lindahl, G., Mailly, F., Humphries, S. & Seed, M. Apolipoprotein E phenotype and lipoprotein(a) in familial hypercholesterolaemia: implication for lipoprotein(a) metabolism. Clin. Invest. 72, 631-638 (1994).
    • (1994) Clin. Invest , vol.72 , pp. 631-638
    • Lindahl, G.1    Mailly, F.2    Humphries, S.3    Seed, M.4
  • 46
    • 33947113858 scopus 로고    scopus 로고
    • ApoE genotype affects allele-specific apo[a] levels for large apo[a] sizes in African Americans: The Harlem-Basset Study
    • Anuurad, E., Lu, G., Rubin, J., Pearson, T. A. & Berglund, L. ApoE genotype affects allele-specific apo[a] levels for large apo[a] sizes in African Americans: the Harlem-Basset Study. J. Lipid Res. 48, 693-698 (2007).
    • (2007) J. Lipid Res , vol.48 , pp. 693-698
    • Anuurad, E.1    Lu, G.2    Rubin, J.3    Pearson, T.A.4    Berglund, L.5


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