Blue mussel (Mytilus edulis) protein hydrolysate promotes mouse mesenchymal stem cell differentiation into osteoblasts through up-regulation of bone morphogenetic protein

Food Chemistry

Volumn 242, Issue , 2018, Pages 156-161

  Hyung, Jun Ho ^a   Ahn, Chang Bum ^b   Je, Jae Young ^a  

^a Pukyong National University   (South Korea)

^b Chonnam National University   (South Korea)

Author keywords

Blue mussel; Bone morphogenetic protein; Enzymatic hydrolysis; Noggin; Osteoblast

Indexed keywords

BONE; ENZYMATIC HYDROLYSIS; FLOWCHARTING; MOLLUSCS; OSTEOBLASTS; PHOSPHATASES; STEM CELLS; TRANSCRIPTION; TRANSCRIPTION FACTORS;

ALKALINE PHOSPHATASE; BLUE MUSSELS; BONE MORPHOGENETIC PROTEIN-2; BONE MORPHOGENETIC PROTEINS; MESENCHYMAL STEM CELL; MITOGEN ACTIVATED PROTEIN KINASE; NOGGIN; OSTEOBLAST DIFFERENTIATION;

CELL CULTURE;

ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 2; CALCIUM; COLLAGEN TYPE 1; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NATURAL PRODUCT; NOGGIN; OSTEOCALCIN; PROTEIN HYDROLYSATE; SMAD1 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; STRESS ACTIVATED PROTEIN KINASE 1; TRANSCRIPTION FACTOR DLX5; TRANSCRIPTION FACTOR OSTERIX; TRANSCRIPTION FACTOR RUNX2;

ANIMAL CELL; ARTICLE; BONE DEVELOPMENT; BONE MINERALIZATION; CELL DIFFERENTIATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HYDROLYSIS; MAPK SIGNALING; MESENCHYMAL STEM CELL; MOUSE; MYTILUS EDULIS; NONHUMAN; OSSIFICATION; OSTEOBLAST; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; CYTOLOGY; DRUG EFFECT; MESENCHYMAL STROMA CELL; METABOLISM;

ANIMALS; BONE MORPHOGENETIC PROTEINS; CELL DIFFERENTIATION; MESENCHYMAL STROMAL CELLS; MICE; MYTILUS EDULIS; OSTEOBLASTS; PROTEIN HYDROLYSATES; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 85029388320     PISSN: 03088146     EISSN: 18737072     Source Type: Journal    
DOI: 10.1016/j.foodchem.2017.09.043     Document Type: Article

References (30)

1. Chalamaiah, M., Dinesh Kumar, B., Hemalatha, R., Jyothirmayi, T., Fish protein hydrolysates: Proximate composition, amino acid composition, antioxidant activities and applications: A review. Food Chemistry 135:4 (2012), 3020–3038.
2. Ghassem, M., Fern, S.S., Said, M., Ali, Z.M., Ibrahim, S., Babji, A.S., Kinetic characterization of Channa striatus muscle sarcoplasmic and myofibrillar protein hydrolysates. Journal of Food Science and Technology 51:3 (2014), 467–475.
3. Gu, Q., Chen, C., Zhang, Z., Wu, Z., Fan, X., Zhang, Z., Shi, L., Ginkgo biloba extract promotes osteogenic differentiation of human bone marrow mesenchymal stem cells in a pathway involving Wnt/beta-catenin signaling. Pharmacological Research 97 (2015), 70–78.
4. Guicheux, J., Lemonnier, J., Ghayor, C., Suzuki, A., Palmer, G., Caverzasio, J., Activation of p38 mitogen-activated protein kinase and c-Jun-NH2-terminal kinase by BMP-2 and their implication in the stimulation of osteoblastic cell differentiation. Journal of Bone and Mineral Research 18:11 (2003), 2060–2068.
5. Hu, Y., Chan, E., Wang, S.X., Li, B., Activation of p38 mitogen-activated protein kinase is required for osteoblast differentiation. Endocrinology 144:5 (2003), 2068–2074.
6. Huang, R.L., Yuan, Y., Tu, J., Zou, G.M., Li, Q., Opposing TNF-alpha/IL-1beta- and BMP-2-activated MAPK signaling pathways converge on Runx2 to regulate BMP-2-induced osteoblastic differentiation. Cell Death and Disease, 5, 2014, e1187.
7. Hyung, J.H., Ahn, C.B., Je, J.Y., Osteoblastogenic activity of ark shell protein hydrolysates with low molecular weight in mouse mesenchymal stem cells. RSC Advances 6 (2016), 29365–29370.
8. Jakab, L., Bone tissue: Rebuilding and inflammation. Orvosi Hetilap 155:40 (2014), 1575–1583.
9. Je, J.Y., Park, S.Y., Hwang, J.Y., Ahn, C.B., Amino acid composition and in vitro antioxidant and cytoprotective activity of abalone viscera hydrolysate. Journal of Functional Foods 16 (2015), 94–103.
10. Johnson, G.L., Lapadat, R., Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 298:5600 (2002), 1911–1912.
11. Kim, B.S., Kang, H.J., Park, J.Y., Lee, J., Fucoidan promotes osteoblast differentiation via JNK- and ERK-dependent BMP2-Smad 1/5/8 signaling in human mesenchymal stem cells. Experimental and Molecular Medicine, 47, 2015, e128.
12. Kim, J.M., Lee, J.E., Ryu, S.H., Suh, P.G., Chlormadinone acetate promotes osteoblast differentiation of human mesenchymal stem cells through the ERK signaling pathway. European Journal of Pharmacology 726 (2014), 1–8.
13. Kimira, Y., Ogura, K., Taniuchi, Y., Kataoka, A., Inoue, N., Sugihara, F., Mano, H., Collagen-derived dipeptide prolyl-hydroxyproline promotes differentiation of MC3T3-E1 osteoblastic cells. Biochemican and Biophysical Research Communication 453:3 (2014), 498–501.
14. Liu, H., Liu, Y., Viggeswarapu, M., Zheng, Z., Titus, L., Boden, S.D., Activation of c-Jun NH(2)-terminal kinase 1 increases cellular responsiveness to BMP-2 and decreases binding of inhibitory Smad6 to the type 1 BMP receptor. Journal of Bone and Mineral Research 26:5 (2011), 1122–1132.
15. Matsuo, K., Irie, N., Osteoclast-osteoblast communication. Archives of Biochemistry and Biophysics 473:2 (2008), 201–209.
16. Nguyen, M.H.T., Qian, Z.J., Nguyen, V.T., Choi, I.W., Heo, S.J., Oh, C.H., Jung, W.K., Tetrameic peptide purified from hydrolysates of biodiesel byproducts of Nannochloropsis oculata induces osteoblastic differentiation through MAPK and Smad pathway on MG-63 and D1 cells. Process Biochemistry 48 (2013), 1387–1394.
17. Nohe, A., Keating, E., Knaus, P., Petersen, N.O., Signal transduction of bone morphogenetic protein receptors. Cellular Signalling 16:3 (2004), 291–299.
18. Panetta, N.J., Gupta, D.M., Longaker, M.T., Bone regeneration and repair. Current Stem Cell Research and Therapy 5:2 (2010), 122–128.
19. Park, S.Y., Ahn, C.B., Je, J.Y., Antioxidant and anti-inflammatory activities of protein hydrolysates from Mytilus edulis and ultrafiltration membrane fractions. Journal of Food Biochemistry 38 (2014), 460–468.
20. Park, S.Y., Kim, Y.S., Ahn, C.B., Je, J.Y., Partial purification and identification of three antioxidant peptides with hepatoprotective effects from blue mussel (Mytilus edulis) hydrolysate by peptic hydrolysis. Journal of Functional Foods 20 (2016), 88–95.
21. Parris, N., Moreau, R.A., Johnston, D.B., Dickey, L.C., Aluko, R.E., Angiotensin I converting enzyme-inhibitory peptides from commercial wet- and dry-milled corn germ. Journal of Agricultural and Food Chemistry 56:8 (2008), 2620–2623.
22. Raggatt, L.J., Partridge, N.C., Cellular and molecular mechanisms of bone remodeling. Journal of Biological Chemistry 285:33 (2010), 25103–25108.
23. Rodan, G.A., Martin, T.J., Therapeutic approaches to bone diseases. Science 289:5484 (2000), 1508–1514.
24. Sarmadi, B.H., Ismail, A., Antioxidative peptides from food proteins: A review. Peptides 31:10 (2010), 1949–1956.
25. Udenigwe, C.C., Aluko, R.E., Food protein-derived bioactive peptides: Production, processing, and potential health benefits. Journal of Food Science 77:1 (2012), R11–24.
26. Wan, M., Cao, X., BMP signaling in skeletal development. Biochemican and Biophysical Research Communication 328:3 (2005), 651–657.
27. Wang, B., Li, L., Chi, C.F., Ma, J.H., Luo, H.Y., Xu, Y.F., Purification and characterisation of a novel antioxidant peptide derived from blue mussel (Mytilus edulis) protein hydrolysate. Food Chemistry 138:2–3 (2013), 1713–1719.
28. Wu, C.J., Lu, H.K., Smad signal pathway in BMP-2-induced osteogenesis-a mini review. Journal of Dental Sciences 3 (2008), 13–21.
29. Yamaguchi, A., Komori, T., Suda, T., Regulation of osteoblast differentiation mediated by bone morphogenetic proteins, hedgehogs, and Cbfa1. Endocrine Reviews 21:4 (2000), 393–411.
30. Yu, S.F., Yang, T.S., Chiu, W.C., Hsu, C.Y., Chou, C.L., Su, Y.J., Cheng, T.T., Non-adherence to anti-osteoporotic medications in Taiwan: Physician specialty makes a difference. Journal of Bone and Mineral Research 31:3 (2013), 351–359.