메뉴 건너뛰기




Volumn 14, Issue 1, 2017, Pages

Preventing HIV infection without targeting the virus: How reducing HIV target cells at the genital tract is a new approach to HIV prevention

Author keywords

Highly exposed seronegative (HESN); HIV; Immune activation; Immune quiescence; Protection

Indexed keywords

ACETYLSALICYLIC ACID; CD4 ANTIGEN; CD69 ANTIGEN; CHEMOKINE RECEPTOR CCR5; HYDROXYCHLOROQUINE; INTERLEUKIN 12; INTERLEUKIN 1ALPHA; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 8; L SELECTIN; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES; VASCULAR CELL ADHESION MOLECULE 1;

EID: 85029222849     PISSN: None     EISSN: 17426405     Source Type: Journal    
DOI: 10.1186/s12981-017-0166-7     Document Type: Review
Times cited : (19)

References (33)
  • 2
    • 84887630069 scopus 로고    scopus 로고
    • Immune quiescence: a model of protection against HIV infection
    • Card CM, Ball TB, Fowke KR. Immune quiescence: a model of protection against HIV infection. Retrovirology. 2013;10:141.
    • (2013) Retrovirology , vol.10 , pp. 141
    • Card, C.M.1    Ball, T.B.2    Fowke, K.R.3
  • 4
    • 58149173412 scopus 로고    scopus 로고
    • Screening for Chlamydia trachomatis and Neisseria gonorrhoeae among adolescents in Family Court, Philadelphia, Pennsylvania
    • Johnson CC, Jones EH, Goldberg M, Asbel LE, Salmon ME, Waller CL. Screening for Chlamydia trachomatis and Neisseria gonorrhoeae among adolescents in Family Court, Philadelphia, Pennsylvania. Sex Transm Dis. 2008;35:S24-7.
    • (2008) Sex Transm Dis , vol.35 , pp. S24-S27
    • Johnson, C.C.1    Jones, E.H.2    Goldberg, M.3    Asbel, L.E.4    Salmon, M.E.5    Waller, C.L.6
  • 5
    • 0031970166 scopus 로고    scopus 로고
    • Heterosexual transmission of human immunodeficiency virus type 1 (HIV): interactions of conventional sexually transmitted diseases, hormonal contraception and HIV-1
    • Plummer FA. Heterosexual transmission of human immunodeficiency virus type 1 (HIV): interactions of conventional sexually transmitted diseases, hormonal contraception and HIV-1. AIDS Res Hum Retrovir. 1998;14(Suppl 1):S5-10.
    • (1998) AIDS Res Hum Retrovir , vol.14 , pp. S5-S10
    • Plummer, F.A.1
  • 6
    • 77951483708 scopus 로고    scopus 로고
    • Critical role of Th17 responses in a murine model of Neisseria gonorrhoeae genital infection
    • Feinen B, Jerse AE, Gaffen SL, Russell MW. Critical role of Th17 responses in a murine model of Neisseria gonorrhoeae genital infection. Mucosal Immunol. 2010;3:312-21.
    • (2010) Mucosal Immunol , vol.3 , pp. 312-321
    • Feinen, B.1    Jerse, A.E.2    Gaffen, S.L.3    Russell, M.W.4
  • 7
    • 79960182157 scopus 로고    scopus 로고
    • New concepts in immunity to Neisseria gonorrhoeae: innate responses and suppression of adaptive immunity favor the pathogen, not the host
    • Liu Y, Feinen B, Russell MW. New concepts in immunity to Neisseria gonorrhoeae: innate responses and suppression of adaptive immunity favor the pathogen, not the host. Front Microbiol. 2011;2:52.
    • (2011) Front Microbiol , vol.2 , pp. 52
    • Liu, Y.1    Feinen, B.2    Russell, M.W.3
  • 8
    • 76949098433 scopus 로고    scopus 로고
    • Th17 cells and HIV infection
    • Elhed A, Unutmaz D. Th17 cells and HIV infection. Curr Opin HIV AIDS. 2010;5:146-50.
    • (2010) Curr Opin HIV AIDS , vol.5 , pp. 146-150
    • Elhed, A.1    Unutmaz, D.2
  • 9
    • 84911409001 scopus 로고    scopus 로고
    • Defining genital tract cytokine signatures of sexually transmitted infections and bacterial vaginosis in women at high risk of HIV infection: a cross-sectional study
    • Masson L, Mlisana K, Little F, Werner L, Mkhize NN, Ronacher K, et al. Defining genital tract cytokine signatures of sexually transmitted infections and bacterial vaginosis in women at high risk of HIV infection: a cross-sectional study. Sex Transm Infect. 2014;90:580-7.
    • (2014) Sex Transm Infect , vol.90 , pp. 580-587
    • Masson, L.1    Mlisana, K.2    Little, F.3    Werner, L.4    Mkhize, N.N.5    Ronacher, K.6
  • 10
    • 33847219957 scopus 로고    scopus 로고
    • Negative mucosal synergy between Herpes simplex type 2 and HIV in the female genital tract
    • Rebbapragada A, Wachihi C, Pettengell C, Sunderji S, Huibner S, Jaoko W, et al. Negative mucosal synergy between Herpes simplex type 2 and HIV in the female genital tract. AIDS. 2007;21:589-98.
    • (2007) AIDS , vol.21 , pp. 589-598
    • Rebbapragada, A.1    Wachihi, C.2    Pettengell, C.3    Sunderji, S.4    Huibner, S.5    Jaoko, W.6
  • 11
    • 0034974386 scopus 로고    scopus 로고
    • Evaluation of a low-dose nonoxynol-9 gel for the prevention of sexually transmitted diseases: a randomized clinical trial
    • Richardson BA, Lavreys L, Martin HL, Stevens CE, Ngugi E, Mandaliya K, et al. Evaluation of a low-dose nonoxynol-9 gel for the prevention of sexually transmitted diseases: a randomized clinical trial. Sex Transm Dis. 2001;28:394-400.
    • (2001) Sex Transm Dis , vol.28 , pp. 394-400
    • Richardson, B.A.1    Lavreys, L.2    Martin, H.L.3    Stevens, C.E.4    Ngugi, E.5    Mandaliya, K.6
  • 12
    • 84876382684 scopus 로고    scopus 로고
    • Decreased cervical epithelial sensitivity to nonoxynol-9 (N-9) after four daily applications in a murine model of topical vaginal microbicide safety
    • Lozenski K, Ownbey R, Wigdahl B, Kish-Catalone T, Krebs FC. Decreased cervical epithelial sensitivity to nonoxynol-9 (N-9) after four daily applications in a murine model of topical vaginal microbicide safety. BMC Pharmacol Toxicol. 2012;13:9.
    • (2012) BMC Pharmacol Toxicol , vol.13 , pp. 9
    • Lozenski, K.1    Ownbey, R.2    Wigdahl, B.3    Kish-Catalone, T.4    Krebs, F.C.5
  • 13
    • 84861172621 scopus 로고    scopus 로고
    • L-selectin and P-selectin are novel biomarkers of cervicovaginal inflammation for preclinical mucosal safety assessment of anti-HIV-1 microbicide
    • Zhong M, He B, Yang J, Bao R, Zhang Y, Zhou D, et al. L-selectin and P-selectin are novel biomarkers of cervicovaginal inflammation for preclinical mucosal safety assessment of anti-HIV-1 microbicide. Antimicrob Agents Chemother. 2012;56:3121-32.
    • (2012) Antimicrob Agents Chemother , vol.56 , pp. 3121-3132
    • Zhong, M.1    He, B.2    Yang, J.3    Bao, R.4    Zhang, Y.5    Zhou, D.6
  • 14
    • 0035882332 scopus 로고    scopus 로고
    • The molecular basis of nonoxynol-9-induced vaginal inflammation and its possible relevance to human immunodeficiency virus type 1 transmission
    • Fichorova RN, Tucker LD, Anderson DJ. The molecular basis of nonoxynol-9-induced vaginal inflammation and its possible relevance to human immunodeficiency virus type 1 transmission. J Infect Dis. 2001;184:418-28.
    • (2001) J Infect Dis , vol.184 , pp. 418-428
    • Fichorova, R.N.1    Tucker, L.D.2    Anderson, D.J.3
  • 15
    • 77955930318 scopus 로고    scopus 로고
    • Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women
    • Abdool Karim Q, Abdool Karim SS, Frohlich JA, Grobler AC, Baxter C, Mansoor LE, et al. Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women. Science. 2010;329:1168-74.
    • (2010) Science , vol.329 , pp. 1168-1174
    • Abdool Karim, Q.1    Abdool Karim, S.S.2    Frohlich, J.A.3    Grobler, A.C.4    Baxter, C.5    Mansoor, L.E.6
  • 16
    • 84866137168 scopus 로고    scopus 로고
    • Innate immune activation enhances hiv acquisition in women, diminishing the effectiveness of tenofovir microbicide gel
    • Naranbhai V, Abdool Karim SS, Altfeld M, Samsunder N, Durgiah R, Sibeko S, et al. Innate immune activation enhances hiv acquisition in women, diminishing the effectiveness of tenofovir microbicide gel. J Infect Dis. 2012;206:993-1001.
    • (2012) J Infect Dis , vol.206 , pp. 993-1001
    • Naranbhai, V.1    Abdool Karim, S.S.2    Altfeld, M.3    Samsunder, N.4    Durgiah, R.5    Sibeko, S.6
  • 17
    • 84957432102 scopus 로고    scopus 로고
    • Genital inflammation, immune activation and risk of sexual HIV acquisition
    • Passmore J-AS, Jaspan HB, Masson L. Genital inflammation, immune activation and risk of sexual HIV acquisition. Curr Opin HIV AIDS. 2016;11:156-62.
    • (2016) Curr Opin HIV AIDS , vol.11 , pp. 156-162
    • Passmore, J.-A.1    Jaspan, H.B.2    Masson, L.3
  • 18
    • 84862904805 scopus 로고    scopus 로고
    • Extended follow-up confirms early vaccine-enhanced risk of HIV acquisition and demonstrates waning effect over time among participants in a randomized trial of recombinant adenovirus HIV vaccine (Step Study)
    • Duerr A, Huang Y, Buchbinder S, Coombs RW, Sanchez J, del Rio C, et al. Extended follow-up confirms early vaccine-enhanced risk of HIV acquisition and demonstrates waning effect over time among participants in a randomized trial of recombinant adenovirus HIV vaccine (Step Study). J Infect Dis. 2012;206:258-66.
    • (2012) J Infect Dis , vol.206 , pp. 258-266
    • Duerr, A.1    Huang, Y.2    Buchbinder, S.3    Coombs, R.W.4    Sanchez, J.5    Rio, C.6
  • 19
    • 84934343721 scopus 로고    scopus 로고
    • Immune-correlates analysis of an HIV-1 vaccine efficacy trial reveals an association of nonspecific interferon-γ secretion with increased HIV-1 infection risk: a cohort-based modeling study
    • Huang Y, Duerr A, Frahm N, Zhang L, Moodie Z, De Rosa S, et al. Immune-correlates analysis of an HIV-1 vaccine efficacy trial reveals an association of nonspecific interferon-γ secretion with increased HIV-1 infection risk: a cohort-based modeling study. PLoS ONE. 2014;9:e108631-11.
    • (2014) PLoS ONE. , vol.9
    • Huang, Y.1    Duerr, A.2    Frahm, N.3    Zhang, L.4    Moodie, Z.5    Rosa, S.6
  • 20
    • 44649098153 scopus 로고    scopus 로고
    • Not just sheer luck! Immune correlates of protection against HIV-1 infection
    • Piacentini L, Fenizia C, Naddeo V, Clerici M. Not just sheer luck! Immune correlates of protection against HIV-1 infection. Vaccine. 2008;26:3002-7.
    • (2008) Vaccine , vol.26 , pp. 3002-3007
    • Piacentini, L.1    Fenizia, C.2    Naddeo, V.3    Clerici, M.4
  • 21
    • 78049423723 scopus 로고    scopus 로고
    • Cohorts for the study of HIV-1-exposed but uninfected individuals: benefits and limitations
    • Horton RE, McLaren PJ, Fowke K, Kimani J, Ball TB. Cohorts for the study of HIV-1-exposed but uninfected individuals: benefits and limitations. J Infect Dis. 2010;202(Suppl 3):S377-81.
    • (2010) J Infect Dis , vol.202 , pp. S377-S381
    • Horton, R.E.1    McLaren, P.J.2    Fowke, K.3    Kimani, J.4    Ball, T.B.5
  • 22
    • 84866943598 scopus 로고    scopus 로고
    • Quantifying ongoing HIV-1 exposure in HIV-1-serodiscordant couples to identify individuals with potential host resistance to HIV-1
    • Mackelprang RD, Baeten JM, Donnell D, Celum C, Farquhar C, de Bruyn G, et al. Quantifying ongoing HIV-1 exposure in HIV-1-serodiscordant couples to identify individuals with potential host resistance to HIV-1. J Infect Dis. 2012;206:1299-308.
    • (2012) J Infect Dis , vol.206 , pp. 1299-1308
    • Mackelprang, R.D.1    Baeten, J.M.2    Donnell, D.3    Celum, C.4    Farquhar, C.5    Bruyn, G.6
  • 23
    • 0030590749 scopus 로고    scopus 로고
    • Resistance to HIV-1 infection among persistently seronegative prostitutes in Nairobi, Kenya
    • Fowke KR, Nagelkerke NJ, Kimani J, Simonsen JN, Anzala AO, Bwayo JJ, et al. Resistance to HIV-1 infection among persistently seronegative prostitutes in Nairobi, Kenya. Lancet. 1996;348:1347-51.
    • (1996) Lancet , vol.348 , pp. 1347-1351
    • Fowke, K.R.1    Nagelkerke, N.J.2    Kimani, J.3    Simonsen, J.N.4    Anzala, A.O.5    Bwayo, J.J.6
  • 24
    • 84944511131 scopus 로고    scopus 로고
    • Risk factors for HIV acquisition in a prospective Nairobi-based female sex worker cohort
    • McKinnon LR, Izulla P, Nagelkerke N, Munyao J, Wanjiru T, Shaw SY, et al. Risk factors for HIV acquisition in a prospective Nairobi-based female sex worker cohort. AIDS Behav. 2015;19:2204-13.
    • (2015) AIDS Behav , vol.19 , pp. 2204-2213
    • McKinnon, L.R.1    Izulla, P.2    Nagelkerke, N.3    Munyao, J.4    Wanjiru, T.5    Shaw, S.Y.6
  • 25
    • 78049448608 scopus 로고    scopus 로고
    • HIV-exposed seronegative commercial sex workers show a quiescent phenotype in the CD4+ T cell compartment and reduced expression of HIV-dependent host factors
    • McLaren PJ, Ball TB, Wachihi C, Jaoko W, Kelvin DJ, Danesh A, et al. HIV-exposed seronegative commercial sex workers show a quiescent phenotype in the CD4+ T cell compartment and reduced expression of HIV-dependent host factors. J Infect Dis. 2010;202:S339-44.
    • (2010) J Infect Dis , vol.202 , pp. S339-S344
    • McLaren, P.J.1    Ball, T.B.2    Wachihi, C.3    Jaoko, W.4    Kelvin, D.J.5    Danesh, A.6
  • 26
    • 84856255109 scopus 로고    scopus 로고
    • Microarray analysis of HIV resistant female sex workers reveal a gene expression signature pattern reminiscent of a lowered immune activation state
    • Songok EM, Luo M, Liang B, Mclaren P, Kaefer N, Apidi W, et al. Microarray analysis of HIV resistant female sex workers reveal a gene expression signature pattern reminiscent of a lowered immune activation state. PLoS ONE. 2012;7:e30048.
    • (2012) PLoS ONE , vol.7
    • Songok, E.M.1    Luo, M.2    Liang, B.3    Mclaren, P.4    Kaefer, N.5    Apidi, W.6
  • 27
    • 65649106139 scopus 로고    scopus 로고
    • Decreased immune activation in resistance to HIV-1 infection is associated with an elevated frequency of CD4(+)CD25(+)FOXP3(+) regulatory T cells
    • Card CM, McLaren PJ, Wachihi C, Kimani J, Plummer FA, Fowke KR. Decreased immune activation in resistance to HIV-1 infection is associated with an elevated frequency of CD4(+)CD25(+)FOXP3(+) regulatory T cells. J Infect Dis. 2009;199:1318-22.
    • (2009) J Infect Dis , vol.199 , pp. 1318-1322
    • Card, C.M.1    McLaren, P.J.2    Wachihi, C.3    Kimani, J.4    Plummer, F.A.5    Fowke, K.R.6
  • 28
    • 84859824979 scopus 로고    scopus 로고
    • A distinct cytokine and chemokine profile at the genital mucosa is associated with HIV-1 protection among HIV-exposed seronegative commercial sex workers
    • Lajoie J, Juno J, Burgener A, Rahman S, Mogk K, Wachihi C, et al. A distinct cytokine and chemokine profile at the genital mucosa is associated with HIV-1 protection among HIV-exposed seronegative commercial sex workers. Mucosal Immunol. 2012;5:277-87.
    • (2012) Mucosal Immunol , vol.5 , pp. 277-287
    • Lajoie, J.1    Juno, J.2    Burgener, A.3    Rahman, S.4    Mogk, K.5    Wachihi, C.6
  • 29
    • 80655129298 scopus 로고    scopus 로고
    • Comprehensive proteomic study identifies serpin and cystatin antiproteases as novel correlates of HIV-1 resistance in the cervicovaginal mucosa of female sex workers
    • Burgener A, Rahman S, Ahmad R, Lajoie J, Ramdahin S, Mesa C, et al. Comprehensive proteomic study identifies serpin and cystatin antiproteases as novel correlates of HIV-1 resistance in the cervicovaginal mucosa of female sex workers. J Proteome Res. 2011;10:5139-49.
    • (2011) J Proteome Res , vol.10 , pp. 5139-5149
    • Burgener, A.1    Rahman, S.2    Ahmad, R.3    Lajoie, J.4    Ramdahin, S.5    Mesa, C.6
  • 30
    • 27144528202 scopus 로고    scopus 로고
    • Low-level CD4+ T cell activation is associated with low susceptibility to HIV-1 infection
    • Koning FA, Otto SA, Hazenberg MD, Dekker L, Prins M, Miedema F, et al. Low-level CD4+ T cell activation is associated with low susceptibility to HIV-1 infection. J Immunol. 2005;175:6117-22.
    • (2005) J Immunol , vol.175 , pp. 6117-6122
    • Koning, F.A.1    Otto, S.A.2    Hazenberg, M.D.3    Dekker, L.4    Prins, M.5    Miedema, F.6
  • 32
    • 85014799903 scopus 로고    scopus 로고
    • Highly-exposed HIV-1 seronegative female commercial sex workers sustain in their genital mucosa increased frequencies of tolerogenic myeloid and regulatory T-cells
    • Thibodeau V, Fourcade L, Labbé A-C, Alary M, Guédou F, Poudrier J, et al. Highly-exposed HIV-1 seronegative female commercial sex workers sustain in their genital mucosa increased frequencies of tolerogenic myeloid and regulatory T-cells. Sci Rep. 2017;7:43857.
    • (2017) Sci Rep , vol.7 , pp. 43857
    • Thibodeau, V.1    Fourcade, L.2    Labbé, A.-C.3    Alary, M.4    Guédou, F.5    Poudrier, J.6
  • 33
    • 45449098302 scopus 로고    scopus 로고
    • Differences in immunoregulatory cytokine expression patterns in the systemic and genital tract compartments of HIV-1-infected commercial sex workers in Benin
    • Lajoie J, Poudrier J, Massinga-Loembe M, Guédou F, Agossa-Gbenafa C, Labbé A-C, et al. Differences in immunoregulatory cytokine expression patterns in the systemic and genital tract compartments of HIV-1-infected commercial sex workers in Benin. Mucosal Immunol. 2008;1:309-16.
    • (2008) Mucosal Immunol , vol.1 , pp. 309-316
    • Lajoie, J.1    Poudrier, J.2    Massinga-Loembe, M.3    Guédou, F.4    Agossa-Gbenafa, C.5    Labbé, A.-C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.