Differences in immunoregulatory cytokine expression patterns in the systemic and genital tract compartments of HIV-1-infected commercial sex workers in Benin

Mucosal Immunology

Volumn 1, Issue 4, 2008, Pages 309-316

  Lajoie, J ^a,b   Poudrier, J ^a,b   Massinga Loembe, M ^c,d   Guedou F ^d   Agossa Gbenafa, C ^e   Labbe A C ^b,f   Alary, M ^d   Roger, M ^a,b  

^a CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

^c INSTITUTE OF TROPICAL MEDICINE   (Belgium)

^d UNIVERSITÉ LAVAL   (Canada)

^e Centre de Santé de la Commune de Cotonou 1   (Belgium)

^f MAISONNEUVE ROSEMONT HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE COURSE; FEMALE; FEMALE GENITAL SYSTEM; GENE EXPRESSION PROFILING; GENITAL TRACT INFECTION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; HUMAN TISSUE; IMMUNOREGULATION; INFECTION SENSITIVITY; MAJOR CLINICAL STUDY; MUCOSAL IMMUNITY; NONHUMAN; PRIORITY JOURNAL; PROSTITUTION; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SEXUAL BEHAVIOR; UTERINE CERVIX CYTOLOGY; VAGINA MUCOSA;

EID: 45449098302     PISSN: 19330219     EISSN: None     Source Type: Journal    
DOI: 10.1038/mi.2008.18     Document Type: Article

References (33)

1. http://www.unaids.org/en/KnowledgeCentre/HIVData/EpiUpdate/EpiUpdArchive/ 2007default.asp.
2. Cohen, J. Did Mark's failed HIV vaccine cause harm? Science 318 1048-1049 (2007).
3. Cone, R.A., Hoen, T., Wong, X., Abusuwwa, R., Anderson, D.J. & Moench, T.R. Vaginal microbicides: Detecting toxicities in vivo that paradoxically increase pathogen transmission. BMC Infect. Dis. 6, 90-103 (2006).
4. Lederman, M.M., Offord, R.E. & Hartley, O. Microbicides and other topical strategies to prevent vaginal transmission of HIV. Nat. Rev. Immunol. 6, 371-382 (2006).
5. Cohen, B. & Trussell, J. Preventing and Mitigating AIDS in Sub-Saharan Africa: Research and Data Priorities for the Social and Behavioural Sciences. pp 105-154 (National Academy Press, NW, Washington DC, 1996).
6. Prohaska, T.R., Albrecht, G., Levy, J.A., Sugrue, N. & Kim, J.H. Determinants of self-perceived risk for AIDS. J. Health Soc. Behav. 31, 384-394 (1990).
7. Ahlburg, D.A., Jensen, E.R. & Perez, A.E. Determinants of extramarital sex in the Philippines. Health Transit. Rev. 7 (supplement), 467-479 (1997).
8. McClelland, R.S., Lavreys, L., Hassan, W.M., Mandaliya, K., Ndinya-Achoia, J.O. & Baeten, J.M. Vaginal washing and increased risk of HIV-1 acquisition among African women: A 10 years prospective study. AIDS 20, 269-273 (2006).
9. Lajoie, J., Hargrove, J., Zijenah, L.S., Humphrey, J., Ward, B.J. & Roger, M. Genetic variants in nonclassical major histocompatibility complex class I human leukocyte antigen (HLA)-E and HLA-G molecules are associated with susceptibility to heterosexual Acquisition of HIV-1. J. Infect. Dis. 193, 298-301 (2006).
10. Kaslow, R.A., Dorak, T. & Tang, J.J. Influence of Host genetic variation on susceptibility to HIV type 1 infection. J. Infect. Dis. 191 S68-S77 (2005).
11. Freeman, E.E., Weiss, H.A., Glynn, J.R., Cross, P.L., Whitworth, J.A. & Hayes, R.J. Herpes simplex virus 2 infection increases HIV acquisition in men and women: Systematic review and meta-analysis of longitudinal studies. AIDS 20, 73-83 (2006).
12. Rebbapragada, A. et al. Negative mucosall synergy between Herpes simplex type 2 and HIV in the female genital tract. AIDS 21, 589-898 (2007).
13. Haynes, B.F. Gut microbes out of control in HIV infection. Nat. Med. 33, 915-933 (2006).
14. Wira, C.R., Fahey, J.V., Sentman, C.L., Pioli, P.A. & Shen, L. Innate and adaptive immunity in female genital tract: Cellular responses and interactions. Immunol. Rev. 206, 306-335 (2005).
15. Sugaya, M., Loré, K., Koup, R.A., Douek, D.C. & Blauvelt, A. HVI-infected Langerhans cells preferentially transmit virus to proliferating autologous CD4+ memory T cells located within Langerhens cell-T cell cluters. J. Immunol. 172, 2219-2224 (2004).
16. Fowke, K.R. et al. Resistance to HIV-1 infection among persistently seronegative prostitutes in Nairobi, Kenya. Lancet 348, 1347-1351 (1996).
17. Fowke, K.R. et al. HIV-1 specific cellular immune responses among HIV-1 resistant sex workers. Immunol. Cell Biol 78, 586-895 (2000).
18. Kaul, R. et al. HIV-1 specific mucosal CD8+ lymphocyte responses in the cervix of HIV-1 resistant prostitutes in Nairobi. J. Immunol. 164, 1602-1611 (2000).
19. Kaul, R. et al. HIV-1 specific mucosal IgA in a cohort of HIV-1 resistant Kenyan sex worker. AIDS 13, 23-29 (1999).
20. Devito, C. et al. Cross-Clade HIV-1 specific neutralizing IgA in mucosal and systemic compartments of HIV-1 exposed persistently seronegative subjects. J. Acquir. Immune. Defic. Syndr. 30, 413-420 (2002).
21. Broliden, K. et al. Functional HIV-1 specific IgA antibodies in HIV-1 exposed persistently IgGi seronegative female sex workers. Immunol. Lett. 79, 29-36 (2001).
22. Iqbal, S.M. et al. Elevated T cell counts and Rantes expression in the genital mucosa of HIV-1-resistant Kenyan commercial sex workers. J. Infec. Dis. 192, 728-738 (2005).
23. Kannanganat, S. et al. Human Immunodeficiency virus type 1 controllers but not noncontrollers maintain CD4T cells coexpressing three cytokines. J. Virol. 81, 12071-12075 (2007).
24. Sankaran, S. et al. Rapid onset of intestinal epithelial barrier dysfunction in primary HIV infection is driven by imbalance between immune response and mucosal repair and regeneration. J. Virol. 82, 538-545 (2008).
25. Abel, K., Rocke, D.M., Chohan, B., Fritts, L. & Miller, C.J. Temporal and anatomic relationship between virus replication and cytokine gene expression after vaginal simian immunodeficiency virus infection. J. Virol. 79, 12164-12172 (2005).
26. Musey, L., Hu, Y., Eckert, L., Christensen, M., Karchmer, T. & McElrath, M.J. HFV-1 induces cytotoxic; T lymphocytes in the cervix of infected women. J. Exp. Med. 185, 293-303 (1997).
27. Kaul, R. et al. The genital tract immune milieu: An important determinant of HIV-1 susceptibility and secondary transmission. J. Reprod. Immunol. 77, 32-40 (2008).
28. Brenchley, J.M., Price, D.A. & Douek, D.C. HIV disease: Fallout from a mucosal catastrophe? Nat. immunol. 7, 235-239 (2006).
29. Brenchley, J.M. & Douek, D.C. HIV infection and gastrointestinal immune system. Mucosal. Immunol. 1, 23-30 (2008).
30. Cohen, C.R. et al. Increased interleukin-10 in the endocervical secretions of women with non-ulcerative sexually transmitted diseases: A mechanism for enhanced HIV-1 transmission? AIDS 13, 327-332 (1999).
31. Yasodhara, P., Raghunath, M., Sreeramulu, D., Venu, L., Hemalatha, R. & Krishna, T.P. Local immunity in Indian women with bacterial vaginosis. J. Reprod. Immunol. 70, 133-141 (2006).
32. Boulton, I.C. &, Gray-Owen, S.D. Neisserial binding to CEACAM-1 arrests the activation and proliferation of CD4+ T lymphocytes. Nat. Immunol. 3, 229-236 (2002).
33. Fichorova, R.N., Desai, P.J., Gibson, F.C. III & Genco, C.A. Distinct proinflammatory host responses to Neisseria gonorrhoeae infection in immortalized human cervical and vaginal epithelial cells. Infect. Immun. 69, 5840-5848 (2001).