Protective major histocompatibility complex allele prevents type 1 diabetes by shaping the intestinal microbiota early in ontogeny

Proceedings of the National Academy of Sciences of the United States of America

Volumn 114, Issue 36, 2017, Pages 9671-9676

  Silverman, Michael ^a,b,e,h   Kua, Lindsay ^a   Tanca, Alessandro ^c   Pala, Mauro ^d   Palomba, Antonio ^c   Tanes, Ceylan ^e   Bittinger, Kyle ^e   Uzzau, Sergio ^c,f   Benoist, Christophe ^a,g   Mathis, Diane ^a,g  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c Porto Conte Ricerche Srl   (Italy)

^d Milan Unit   (Italy)

^e CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^f UNIVERSITY OF SASSARI   (Italy)

^g BRIGHAM AND WOMEN S HOSPITAL   (United States)

^h UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Autoimmune disease; Microbiome; Neonatal; NOD mice; Type 1 diabetes

Indexed keywords

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; CECUM; CONTROLLED STUDY; GENE EXPRESSION; GENOMICS; INSULIN DEPENDENT DIABETES MELLITUS; INSULITIS; INTESTINE FLORA; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; ONTOGENY; PRIORITY JOURNAL; PROTEOMICS; TRANSGENE; ANIMAL; DRUG EFFECT; FEMALE; FETOMATERNAL TRANSFUSION; GENETICS; HUMAN; IMMUNOLOGY; MALE; MICROBIOLOGY; NEWBORN; PANCREAS ISLET; PATHOLOGY; PREGNANCY; TRANSGENIC MOUSE;

ANTIINFECTIVE AGENT; HLA ANTIGEN CLASS 2;

ALLELES; ANIMALS; ANTI-BACTERIAL AGENTS; AUTOIMMUNITY; DIABETES MELLITUS, TYPE 1; FEMALE; GASTROINTESTINAL MICROBIOME; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; INFANT, NEWBORN; ISLETS OF LANGERHANS; MALE; MATERNAL-FETAL EXCHANGE; MICE; MICE, INBRED NOD; MICE, TRANSGENIC; PREGNANCY;

EID: 85029218782     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1712280114     Document Type: Article

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