Both central and peripheral tolerance mechanisms play roles in diabetes prevention in NOD-E transgenic mice

Autoimmunity

Volumn 41, Issue 5, 2008, Pages 383-394

  Mellanby, Richard J ^a   Phillips, Jenny M ^a   Parish, Nicole M ^a   Cooke, Anne ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

CD25; Central tolerance; Diabetes; Foxp3; NOD; NOD E

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2 I E;

ADOPTIVE TRANSFER; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ARTICLE; AUTOIMMUNITY; CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; DIABETES MELLITUS; GENE DELETION; IMMUNOLOGICAL TOLERANCE; LYMPHOCYTE PROLIFERATION; MOLECULAR MECHANICS; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; REGULATORY T LYMPHOCYTE; SCID MOUSE; T CELL DEPLETION; T LYMPHOCYTE ACTIVATION; TRANSGENIC MOUSE;

ADOPTIVE TRANSFER; ANIMALS; ANTIGEN PRESENTATION; CELL PROLIFERATION; CELLS, CULTURED; DENDRITIC CELLS; DIABETES MELLITUS, TYPE 1; FLOW CYTOMETRY; IMMUNE TOLERANCE; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LYMPH NODES; MALE; MICE; MICE, INBRED NOD; MICE, TRANSGENIC; T-LYMPHOCYTES, REGULATORY;

EID: 45949093145     PISSN: 08916934     EISSN: 1607842X     Source Type: Journal    
DOI: 10.1080/08916930801991021     Document Type: Article

References (24)

1. Adorini, L., Gregori, S. and Harrison, LC (2002) Understanding autoimmune diabetes: Insights from mouse models. Trends Mol Med, 8, pp. 31-38.
2. Uno, M., Miyazaki, T., Uehira, M., Nishimoto, H., Kimoto, M., Miyazaki, J. and Yamamura, K. (1992) Complete prevention of diabetes in transgenic NOD mice expressing I-E molecules. Immunol Lett, 31, pp. 47-52.
3. Nishimoto, H., Kikutani, H., Yamamura, K. and Kishimoto, T. (1987) Prevention of autoimmune insulitis by expression of I-E molecules in NOD mice. Nature, 328, pp. 432-434.
4. Lund, T., O'Reilly, L., Hutchings, P., Kanagawa, O., Simpson, E., Gravely, R., Chandler, P., Dyson, J., Picard, JK Edwards, A. et al. (1990) Prevention of insulin-dependent diabetes mellitus in non-obese diabetic mice by transgenes encoding modified I-A beta-chain or normal I-E alpha-chain. Nature, 345, pp. 727-729.
5. Bohme, J., Schuhbaur, B., Kanagawa, O., Benoist, C. and Mathis, D. (1990) MHC-linked protection from diabetes dissociated from clonal deletion of T cells. Science, 249, pp. 293-295.
6. O'Shea, H., Yousaf, N., Altmann, D., Fehervari, Z., Tonks, P., Hetherington, C., Harach, S., Bland, C., Cooke, A. and Lund, T. (2006) Effect of X- and Y-box deletions on the development of diabetes in H-2Ealpha-chain transgenic nonobese diabetic mice. Scand J Immunol, 63, pp. 17-25.
7. Trembleau, S., Gregori, S., Penna, G., Gorny, I. and Adorini, L. (2001) IL-12 administration reveals diabetogenic T cells in genetically resistant I-Ealpha-transgenic nonobese diabetic mice: Resistance to autoimmune diabetes is associated with binding of Ealpha-derived peptides to the I-A(g7) molecule. J Immunol, 167, pp. 4104-4114.
8. Reich, EP, Sherwin, RS, Kanagawa, O. and Janeway Jr, CA (1989) An explanation for the protective effect of the MHC class II I-E molecule in murine diabetes. Nature, 341, pp. 326-328.
9. Kappler, JW, Roehm, N. and Marrack, P. (1987) T cell tolerance by clonal elimination in the thymus. Cell, 49, pp. 273-280.
10. Nakano, N., Kikutani, H., Nishimoto, H. and Kishimoto, T. (1991) T cell receptor V gene usage of islet beta cell-reactive T cells is not restricted in non-obese diabetic mice. J Exp Med, 173, pp. 1091-1097.
11. Tomonari, K. (1990) Linkage between Tcrb-V and a gene responsible for deletion of Tcrb-V11+T cells. Immunogenetics, 32, pp. 60-62.
12. Schmidt, D., Verdaguer, J., Averill, N. and Santamaria, P. (1997) A mechanism for the major histocompatibility complex-linked resistance to autoimmunity. J Exp Med, 186, pp. 1059-1075.
13. Schmidt, D., Amrani, A., Verdaguer, J., Bou, S. and Santamaria, P. (1999) Autoantigen-independent deletion of diabetogenic CD4+ thymocytes by protective MHC class II molecules. J Immunol, 162, pp. 4627-4636.
14. Parish, NM, Chandler, P., Quartey-Papafio, R., Simpson, E. and Cooke, A. (1993) The effect of bone marrow and thymus chimerism between non-obese diabetic (NOD) and NOD-E transgenic mice, on the expression and prevention of diabetes. Eur J Immunol, 23, pp. 2667-2675.
15. Hanson, MS, Cetkovic-Cvrlje, M., Ramiya, VK, Atkinson, MA, Maclaren, NK, Singh, B., Elliott, JF, Serreze, DV and Leiter, EH (1996) Quantitative thresholds of MHC class II I-E expressed on hemopoietically derived antigen-presenting cells in transgenic NOD/Lt mice determine level of diabetes resistance and indicate mechanism of protection. J Immunol, 157, pp. 1279-1287.
16. Brenden, N. and Bohme, J. (1998) Disease-protected major histocompatibility complex Ea-transgenic non-obese diabetic (NOD) mice show interleukin-4 production not seen in susceptible Ea-transgenic and non-transgenic NOD mice. Immunology, 95, pp. 1-7.
17. Johnson, EA, Silveira, P., Chapman, HD, Leiter, EH and Serreze, DV (2001) Inhibition of autoimmune diabetes in nonobese diabetic mice by transgenic restoration of H2-E MHC class II expression: Additive, but unequal, involvement of multiple APC subtypes. J Immunol, 167, pp. 2404-2410.
18. Deng, H., Apple, R., Clare-Salzler, M., Trembleau, S., Mathis, D., Adorini, L. and Sercarz, E. (1993) Determinant capture as a possible mechanism of protection afforded by major histocompatibility complex class II molecules in autoimmune disease. J Exp Med, 178, pp. 1675-1680.
19. Gregori, S., Trembleau, S., Penna, G., Gallazzi, F., Hammer, J., Papadopoulos, GK and Adorini, L. (1999) A peptide binding motif for I-Eg7, the MHC class II molecule that protects E alpha-transgenic nonobese diabetic mice from autoimmune diabetes. J Immunol, 162, pp. 6630-6640.
20. Nepom, GT (1990) A unified hypothesis for the complex genetics of HLA associations with IDDM. Diabetes, 39, pp. 1153-1157.
21. Roberts, SA, Barbour, G., Matarrese, MR, Mason, DL, Leiter, EH, Haskins, K. and Hanson, MS (2003) Adoptive transfer of islet antigen-autoreactive T cell clones to transgenic NOD.Ea(d)mice induces diabetes indicating a lack of I-E mediated protection against activated effector T cells. J Autoimmun, 21, pp. 139-147.
22. Forsyth, IA, Hutchings, A. and Butcher, GW (2000) A panel of monoclonal antibodies to ovine placental lactogen. J Endocrinol, 165, pp. 435-442.
23. Judkowski, V., Pinilla, C., Schroder, K., Tucker, L., Sarvetnick, N. and Wilson, DB (2001) Identification of MHC class II-restricted peptide ligands, including a glutamic acid decarboxylase 65 sequence, that stimulate diabetogenic T cells from transgenic BDC2.5 nonobese diabetic mice. J Immunol, 166, pp. 908-917.
24. Mellanby, RJ, Thomas, D., Phillips, JM and Cooke, A. (2007) Diabetes in non-obese diabetic mice is not associated with quantitative changes in CD4(+) CD25(+) Foxp3(+) regulatory T cells. Immunology, 121, pp. 15-28.