Do long telomeres affect cellular fitness?

Current Genetics

Volumn 64, Issue 1, 2018, Pages 173-176

  Harari, Yaniv ^a   Kupiec, Martin ^a  

^a TEL AVIV UNIVERSITY   (Israel)

Author keywords

Aging; Ethanol; Fitness; Telomeres; Yeast

Indexed keywords

AGING; ANEUPLOIDY; CELL AGING; CELL DIVISION; CELL FUNCTION; CELL GROWTH; DNA DAMAGE; DNA REPLICATION; FITNESS; GENE MUTATION; GENOMIC INSTABILITY; HUMAN; LIFESPAN; MAMMAL CELL; MEIOSIS; MITOSIS; NONHUMAN; PRIORITY JOURNAL; REVIEW; SACCHAROMYCES CEREVISIAE; TELOMERE LENGTH; TELOMERE SHORTENING; YEAST CELL; ANIMAL; CELL SURVIVAL; GENETICS; METABOLISM; PHYSIOLOGICAL STRESS; REPRODUCTIVE FITNESS; TELOMERE; TELOMERE HOMEOSTASIS; YEAST;

ANIMALS; CELL SURVIVAL; CELLULAR SENESCENCE; GENETIC FITNESS; HUMANS; STRESS, PHYSIOLOGICAL; TELOMERE; TELOMERE HOMEOSTASIS; YEASTS;

EID: 85028988118     PISSN: 01728083     EISSN: 14320983     Source Type: Journal    
DOI: 10.1007/s00294-017-0746-z     Document Type: Review

References (27)

1. Askree SH, Yehuda T, Smolikov S, Gurevich R, Hawk J, Coker C, Krauskopf A, Kupiec M, McEachern MJ (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci USA 101:8658–8663. doi:10.1073/pnas.0401263101
2. Avilion AA, Piatyszek MA, Gupta J, Shay JW, Bacchetti S, Greider CW (1996) Human telomerase RNA and telomerase activity in immortal cell lines and tumor tissues. Cancer Res 56:645–650
3. Bakaysa SL, Mucci LA, Slagboom PE, Boomsma DI, McClearn GE, Johansson B, Pedersen NL (2007) Telomere length predicts survival independent of genetic influences. Aging Cell 6:769–774. doi:10.1111/j.1474-9726.2007.00340.x
4. Blasco MA (2005) Telomeres and human disease: ageing, cancer and beyond. Nat Rev Genet 6:611–622. doi:10.1038/nrg1656
5. Cowell JK, Miller OJ (1983) Occurrence and evolution of homogeneously staining regions may be due to breakage-fusion-bridge cycles following telomere loss. Chromosoma 88:216–221
6. de Lange T (2009) How telomeres solve the end-protection problem. Science 326:948–952. doi:10.1126/science.1170633
7. Gatbonton T, Imbesi M, Nelson M, Akey JM, Ruderfer DM, Kruglyak L, Simon JA, Bedalov A (2006) Telomere length as a quantitative trait: genome-wide survey and genetic mapping of telomere length-control genes in yeast. PLoS Genet 2:e35. doi:10.1371/journal.pgen.0020035
8. Harari Y, Kupiec M (2017) Long telomeres do not affect cellular fitness in yeast. mBio. doi:10.1128/mBio.01314-1710
9. Harley CB, Futcher AB, Greider CW (1990) Telomeres shorten during ageing of human fibroblasts. Nature 345:458–460
10. Hayflick L (1965) The limited in vitro lifetime of human diploid cell strains. Exp Cell Res 37:614–636
11. Jaskelioff M, Muller FL, Paik JH, Thomas E, Jiang S, Adams AC, Sahin E, Kost-Alimova M, Protopopov A, Cadinanos J, Horner JW, Maratos-Flier E, Depinho RA (2011) Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice. Nature 469:102–106. doi:10.1038/nature09603
12. Lazzerini Denchi E, Celli G, de Lange T (2006) Hepatocytes with extensive telomere deprotection and fusion remain viable and regenerate liver mass through endoreduplication. Genes Dev 20:2648–2653. doi:10.1101/gad.1453606
13. Levy MZ, Allsopp RC, Futcher AB, Greider CW, Harley CB (1992) Telomere end-replication problem and cell aging. J Mol Biol 225:951–960
14. Li B, Lustig AJ (1996) A novel mechanism for telomere size control in Saccharomyces cerevisiae. Genes Dev 10:1310–1326
15. Matsuda T, Fujimura S, Suda H, Matsufuji Y, Nakagawa J (2011) Alteration of ethanol tolerance caused by the deficiency in the genes associated with histone deacetylase complex in budding yeast. Biosci Biotechnol Biochem 75:1829–1831. doi:10.1271/bbb.110232
16. Niida H, Matsumoto T, Satoh H, Shiwa M, Tokutake Y, Furuichi Y, Shinkai Y (1998) Severe growth defect in mouse cells lacking the telomerase RNA component. Nat Genet 19:203–206
17. Olovnikov AM (1973) A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon. J Theor Biol 41:181–190
18. Pickett HA, Cesare AJ, Johnston RL, Neumann AA, Reddel RR (2009) Control of telomere length by a trimming mechanism that involves generation of t-circles. EMBO J 28:799–809. doi:10.1038/emboj.2009.42
19. Romano GH, Harari Y, Yehuda T, Podhorzer A, Rubinstein L, Shamir R, Gottlieb A, Silberberg Y, Pe’er D, Ruppin E, Sharan R, Kupiec M (2013) Environmental stresses disrupt telomere length homeostasis. PLoS Genet 9:e1003721. doi:10.1371/journal.pgen.1003721
20. Satoh T, Nakatsuka D, Watanabe Y, Nagata I, Kikuchi H, Namura S (2000) Neuroprotection by MAPK/ERK kinase inhibition with U0126 against oxidative stress in a mouse neuronal cell line and rat primary cultured cortical neurons. Neurosci lett 288:163–166
21. Shachar R, Ungar L, Kupiec M, Ruppin E, Sharan R (2008) A systems-level approach to mapping the telomere length maintenance gene circuitry. Mol Syst Biol 4:172. doi:10.1038/msb.2008.13
22. Smogorzewska A, de Lange T (2004) Regulation of telomerase by telomeric proteins. Annu Rev Biochem 73:177–208
23. Stanley SE, Armanios M (2015) The short and long telomere syndromes: paired paradigms for molecular medicine. Curr Opin Genet Dev 33:1–9. doi:10.1016/j.gde.2015.06.004
24. Ungar L, Yosef N, Sela Y, Sharan R, Ruppin E, Kupiec M (2009) A genome-wide screen for essential yeast genes that affect telomere length maintenance. Nucleic Acids Res 37:3840–3849. doi:10.1093/nar/gkp259
25. Yamamoto Y, Izawa S (2013) Adaptive response in stress granule formation and bulk translational repression upon a combined stress of mild heat shock and mild ethanol stress in yeast. Genes Cells 18:974–984. doi:10.1111/gtc.12090
26. Yona AH, Manor YS, Herbst RH, Romano GH, Mitchell A, Kupiec M, Pilpel Y, Dahan O (2012) Chromosomal duplication is a transient evolutionary solution to stress. Proc Natl Acad Sci USA 109:21010–21015. doi:10.1073/pnas.1211150109
27. Yosef N, Kupiec M, Ruppin E, Sharan R (2009) A complex-centric view of protein network evolution. Nucleic Acids Res 37:e88. doi:10.1093/nar/gkp414