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Volumn 37, Issue 3, 2018, Pages 376-384

Interleukin-6 is independently associated with right ventricular function in pulmonary arterial hypertension

Author keywords

biomarkers; inflammation; interleukins; pulmonary hypertension; RV PA coupling

Indexed keywords

AMINO TERMINAL PRO BRAIN NATRIURETIC PEPTIDE; INTERLEUKIN 6;

EID: 85028868595     PISSN: 10532498     EISSN: 15573117     Source Type: Journal    
DOI: 10.1016/j.healun.2017.08.011     Document Type: Article
Times cited : (74)

References (45)
  • 1
    • 84902950876 scopus 로고    scopus 로고
    • Inflammation and immunity in the pathogenesis of pulmonary arterial hypertension
    • Rabinovitch, M., Guignabert, C., Humbert, M., et al. Inflammation and immunity in the pathogenesis of pulmonary arterial hypertension. Circ Res 115 (2014), 165–175.
    • (2014) Circ Res , vol.115 , pp. 165-175
    • Rabinovitch, M.1    Guignabert, C.2    Humbert, M.3
  • 2
    • 0029062419 scopus 로고
    • Increased interleukin-1 and interleukin-6 serum concentrations in severe primary pulmonary hypertension
    • Humbert, M., Monti, G., Brenot, F., et al. Increased interleukin-1 and interleukin-6 serum concentrations in severe primary pulmonary hypertension. Am J Respir Crit Care Med 151 (1995), 1628–1631.
    • (1995) Am J Respir Crit Care Med , vol.151 , pp. 1628-1631
    • Humbert, M.1    Monti, G.2    Brenot, F.3
  • 3
    • 77956390581 scopus 로고    scopus 로고
    • Elevated levels of inflammatory cytokines predict survival in idiopathic and familial pulmonary arterial hypertension
    • Soon, E., Holmes, A.M., Treacy, C.M., et al. Elevated levels of inflammatory cytokines predict survival in idiopathic and familial pulmonary arterial hypertension. Circulation 122 (2010), 920–927.
    • (2010) Circulation , vol.122 , pp. 920-927
    • Soon, E.1    Holmes, A.M.2    Treacy, C.M.3
  • 4
    • 0033157383 scopus 로고    scopus 로고
    • Monocrotaline induces interleukin-6 mRNA expression in rat lungs
    • Bhargava, A., Kumar, A., Yuan, N., et al. Monocrotaline induces interleukin-6 mRNA expression in rat lungs. Heart Dis 1 (1999), 126–132.
    • (1999) Heart Dis , vol.1 , pp. 126-132
    • Bhargava, A.1    Kumar, A.2    Yuan, N.3
  • 5
    • 0028861014 scopus 로고
    • Pulmonary hypertension in rats. 2. Role of interleukin-6
    • Miyata, M., Sakuma, F., Yoshimura, A., et al. Pulmonary hypertension in rats. 2. Role of interleukin-6. Int Arch Allergy Immunol 108 (1995), 287–291.
    • (1995) Int Arch Allergy Immunol , vol.108 , pp. 287-291
    • Miyata, M.1    Sakuma, F.2    Yoshimura, A.3
  • 6
    • 84961287741 scopus 로고    scopus 로고
    • Interleukin-6 and tumor necrosis factor-α are associated with quality of life-related symptoms in pulmonary arterial hypertension
    • Matura, L.A., Ventetuolo, C.E., Palevsky, H.I., et al. Interleukin-6 and tumor necrosis factor-α are associated with quality of life-related symptoms in pulmonary arterial hypertension. Ann Am Thorac Soc 12 (2015), 370–375.
    • (2015) Ann Am Thorac Soc , vol.12 , pp. 370-375
    • Matura, L.A.1    Ventetuolo, C.E.2    Palevsky, H.I.3
  • 7
    • 84895553338 scopus 로고    scopus 로고
    • Plasma interleukin-6 adds prognostic information in pulmonary arterial hypertension
    • Heresi, G.A., Aytekin, M., Hammel, J.P., et al. Plasma interleukin-6 adds prognostic information in pulmonary arterial hypertension. Eur Respir J 43 (2014), 912–914.
    • (2014) Eur Respir J , vol.43 , pp. 912-914
    • Heresi, G.A.1    Aytekin, M.2    Hammel, J.P.3
  • 8
    • 59849118025 scopus 로고    scopus 로고
    • Interleukin-6 overexpression induces pulmonary hypertension
    • Steiner, M.K., Syrkina, O.L., Kolliputi, N., et al. Interleukin-6 overexpression induces pulmonary hypertension. Circ Res 104 (2009), 236–244.
    • (2009) Circ Res , vol.104 , pp. 236-244
    • Steiner, M.K.1    Syrkina, O.L.2    Kolliputi, N.3
  • 9
    • 61549104663 scopus 로고    scopus 로고
    • Impact of interleukin-6 on hypoxia-induced pulmonary hypertension and lung inflammation in mice
    • Savale, L., Tu, L., Rideau, D., et al. Impact of interleukin-6 on hypoxia-induced pulmonary hypertension and lung inflammation in mice. Respir Res, 10, 2009, 6.
    • (2009) Respir Res , vol.10 , pp. 6
    • Savale, L.1    Tu, L.2    Rideau, D.3
  • 10
    • 34447534205 scopus 로고    scopus 로고
    • Interaction of interleukin-6 and the BMP pathway in pulmonary smooth muscle
    • Hagen, M., Fagan, K., Steudel, W., et al. Interaction of interleukin-6 and the BMP pathway in pulmonary smooth muscle. Am J Physiol Lung Cell Mol Physiol 292 (2007), L1473–L1479.
    • (2007) Am J Physiol Lung Cell Mol Physiol , vol.292 , pp. L1473-L1479
    • Hagen, M.1    Fagan, K.2    Steudel, W.3
  • 11
    • 66949118228 scopus 로고    scopus 로고
    • Interleukin-6 modulates the expression of the bone morphogenic protein receptor type II through a novel STAT3-microRNA cluster 17/92 pathway
    • Brock, M., Trenkmann, M., Gay, R.E., et al. Interleukin-6 modulates the expression of the bone morphogenic protein receptor type II through a novel STAT3-microRNA cluster 17/92 pathway. Circ Res 104 (2009), 1184–1191.
    • (2009) Circ Res , vol.104 , pp. 1184-1191
    • Brock, M.1    Trenkmann, M.2    Gay, R.E.3
  • 12
    • 0026735208 scopus 로고
    • Negative inotropic effects of cytokines on the heart mediated by nitric oxide
    • Finkel, M.S., Oddis, C.V., Jacob, T.D., et al. Negative inotropic effects of cytokines on the heart mediated by nitric oxide. Science 257 (1992), 387–389.
    • (1992) Science , vol.257 , pp. 387-389
    • Finkel, M.S.1    Oddis, C.V.2    Jacob, T.D.3
  • 13
    • 0028276951 scopus 로고
    • Nitric oxide-mediated effects of interleukin-6 on [Ca2+]i and cell contraction in cultured chick ventricular myocytes
    • Kinugawa, K., Takahashi, T., Kohmoto, O., et al. Nitric oxide-mediated effects of interleukin-6 on [Ca2+]i and cell contraction in cultured chick ventricular myocytes. Circ Res 75 (1994), 285–295.
    • (1994) Circ Res , vol.75 , pp. 285-295
    • Kinugawa, K.1    Takahashi, T.2    Kohmoto, O.3
  • 14
    • 0034055146 scopus 로고    scopus 로고
    • Leukemia inhibitory factor and interleukin-6 downregulate sarcoplasmic reticulum Ca2+ ATPase (SERCA2) in cardiac myocytes
    • Villegas, S., Villarreal, F.J., Dillmann, W.H., Leukemia inhibitory factor and interleukin-6 downregulate sarcoplasmic reticulum Ca2+ ATPase (SERCA2) in cardiac myocytes. Basic Res Cardiol 95 (2000), 47–54.
    • (2000) Basic Res Cardiol , vol.95 , pp. 47-54
    • Villegas, S.1    Villarreal, F.J.2    Dillmann, W.H.3
  • 15
    • 84973922837 scopus 로고    scopus 로고
    • Deletion of interleukin-6 attenuates pressure overload-induced left ventricular hypertrophy and dysfunction
    • Zhao, L., Cheng, G., Jin, R., et al. Deletion of interleukin-6 attenuates pressure overload-induced left ventricular hypertrophy and dysfunction. Circ Res 118 (2016), 1918–1929.
    • (2016) Circ Res , vol.118 , pp. 1918-1929
    • Zhao, L.1    Cheng, G.2    Jin, R.3
  • 16
    • 84960977368 scopus 로고    scopus 로고
    • Deletion of interleukin-6 alleviated interstitial fibrosis in streptozotocin-induced diabetic cardiomyopathy of mice through affecting TGFβ1 and miR-29 pathways
    • Zhang, Y., Wang, J.H., Zhang, Y.Y., et al. Deletion of interleukin-6 alleviated interstitial fibrosis in streptozotocin-induced diabetic cardiomyopathy of mice through affecting TGFβ1 and miR-29 pathways. Sci Rep, 6, 2016, 23010.
    • (2016) Sci Rep , vol.6 , pp. 23010
    • Zhang, Y.1    Wang, J.H.2    Zhang, Y.Y.3
  • 17
    • 77950462113 scopus 로고    scopus 로고
    • Relationship of interleukin-6 with regional and global left-ventricular function in asymptomatic individuals without clinical cardiovascular disease: insights from the Multi-Ethnic Study of Atherosclerosis
    • Yan, A.T., Yan, R.T., Cushman, M., et al. Relationship of interleukin-6 with regional and global left-ventricular function in asymptomatic individuals without clinical cardiovascular disease: insights from the Multi-Ethnic Study of Atherosclerosis. Eur Heart J 31 (2010), 875–882.
    • (2010) Eur Heart J , vol.31 , pp. 875-882
    • Yan, A.T.1    Yan, R.T.2    Cushman, M.3
  • 18
    • 0029871896 scopus 로고    scopus 로고
    • Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: a report from the Studies of Left Ventricular Dysfunction (SOLVD)
    • Torre-Amione, G., Kapadia, S., Benedict, C., et al. Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: a report from the Studies of Left Ventricular Dysfunction (SOLVD). J Am Coll Cardiol 27 (1996), 1201–1206.
    • (1996) J Am Coll Cardiol , vol.27 , pp. 1201-1206
    • Torre-Amione, G.1    Kapadia, S.2    Benedict, C.3
  • 19
    • 0034883243 scopus 로고    scopus 로고
    • Activation of the cardiac interleukin-6 system in advanced heart failure
    • Plenz, G., Song, Z.F., Tjan, T.D., et al. Activation of the cardiac interleukin-6 system in advanced heart failure. Eur J Heart Fail 3 (2001), 415–421.
    • (2001) Eur J Heart Fail , vol.3 , pp. 415-421
    • Plenz, G.1    Song, Z.F.2    Tjan, T.D.3
  • 20
    • 84886283330 scopus 로고    scopus 로고
    • Relationship of CRP, IL-6, and fibrinogen with right ventricular structure and function: the MESA-Right Ventricle Study
    • Harhay, M.O., Tracy, R.P., Bagiella, E., et al. Relationship of CRP, IL-6, and fibrinogen with right ventricular structure and function: the MESA-Right Ventricle Study. Int J Cardiol 168 (2013), 3818–3824.
    • (2013) Int J Cardiol , vol.168 , pp. 3818-3824
    • Harhay, M.O.1    Tracy, R.P.2    Bagiella, E.3
  • 21
    • 77951961897 scopus 로고    scopus 로고
    • Survival in pulmonary arterial hypertension: a reappraisal of the NIH risk stratification equation
    • Thenappan, T., Shah, S.J., Rich, S., et al. Survival in pulmonary arterial hypertension: a reappraisal of the NIH risk stratification equation. Eur Respir J 35 (2010), 1079–1087.
    • (2010) Eur Respir J , vol.35 , pp. 1079-1087
    • Thenappan, T.1    Shah, S.J.2    Rich, S.3
  • 22
    • 33646269035 scopus 로고    scopus 로고
    • Pulmonary arterial hypertension in France: results from a national registry
    • Humbert, M., Sitbon, O., Chaouat, A., et al. Pulmonary arterial hypertension in France: results from a national registry. Am J Respir Crit Care Med 173 (2006), 1023–1030.
    • (2006) Am J Respir Crit Care Med , vol.173 , pp. 1023-1030
    • Humbert, M.1    Sitbon, O.2    Chaouat, A.3
  • 23
    • 77954759389 scopus 로고    scopus 로고
    • Predicting survival in pulmonary arterial hypertension: insights from the Registry to Evaluate Early and Long-Term Pulmonary Arterial Hypertension Disease Management (REVEAL)
    • Benza, R.L., Miller, D.P., Gomberg-Maitland, M., et al. Predicting survival in pulmonary arterial hypertension: insights from the Registry to Evaluate Early and Long-Term Pulmonary Arterial Hypertension Disease Management (REVEAL). Circulation 122 (2010), 164–172.
    • (2010) Circulation , vol.122 , pp. 164-172
    • Benza, R.L.1    Miller, D.P.2    Gomberg-Maitland, M.3
  • 24
    • 33750579180 scopus 로고    scopus 로고
    • Tricuspid annular displacement predicts survival in pulmonary hypertension
    • Forfia, P.R., Fisher, M.R., Mathai, S.C., et al. Tricuspid annular displacement predicts survival in pulmonary hypertension. Am J Respir Crit Care Med 174 (2006), 1034–1041.
    • (2006) Am J Respir Crit Care Med , vol.174 , pp. 1034-1041
    • Forfia, P.R.1    Fisher, M.R.2    Mathai, S.C.3
  • 25
    • 82455203954 scopus 로고    scopus 로고
    • Progressive right ventricular dysfunction in patients with pulmonary arterial hypertension responding to therapy
    • van de Veerdonk, M.C., Kind, T., Marcus, J.T., et al. Progressive right ventricular dysfunction in patients with pulmonary arterial hypertension responding to therapy. J Am Coll Cardiol 58 (2011), 2511–2519.
    • (2011) J Am Coll Cardiol , vol.58 , pp. 2511-2519
    • van de Veerdonk, M.C.1    Kind, T.2    Marcus, J.T.3
  • 26
    • 85006409830 scopus 로고    scopus 로고
    • Pulmonary pulse wave transit time is associated with right ventricular-pulmonary artery coupling in pulmonary arterial hypertension
    • Prins, K.W., Weir, E.K., Archer, S.L., et al. Pulmonary pulse wave transit time is associated with right ventricular-pulmonary artery coupling in pulmonary arterial hypertension. Pulm Circ 6 (2016), 576–585.
    • (2016) Pulm Circ , vol.6 , pp. 576-585
    • Prins, K.W.1    Weir, E.K.2    Archer, S.L.3
  • 27
    • 85047675269 scopus 로고
    • The estimation of oxygen consumption
    • LaFarge, C.G., Miettinen, O.S., The estimation of oxygen consumption. Cardiovasc Res 4 (1970), 23–30.
    • (1970) Cardiovasc Res , vol.4 , pp. 23-30
    • LaFarge, C.G.1    Miettinen, O.S.2
  • 28
    • 32644435423 scopus 로고    scopus 로고
    • Relationship of pulmonary arterial capacitance and mortality in idiopathic pulmonary arterial hypertension
    • Mahapatra, S., Nishimura, R.A., Sorajja, P., et al. Relationship of pulmonary arterial capacitance and mortality in idiopathic pulmonary arterial hypertension. J Am Coll Cardiol 47 (2006), 799–803.
    • (2006) J Am Coll Cardiol , vol.47 , pp. 799-803
    • Mahapatra, S.1    Nishimura, R.A.2    Sorajja, P.3
  • 29
    • 84925515752 scopus 로고    scopus 로고
    • Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging
    • e14
    • Lang, R.M., Badano, L.P., Mor-Avi, V., et al. Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr 28 (2015), 1–39 e14.
    • (2015) J Am Soc Echocardiogr , vol.28 , pp. 1-39
    • Lang, R.M.1    Badano, L.P.2    Mor-Avi, V.3
  • 30
    • 84925238954 scopus 로고    scopus 로고
    • Echocardiographic predictors of mortality in patients with pulmonary hypertension and cardiopulmonary comorbidities
    • Steiner, J., Wu, W.C., Jankowich, M., et al. Echocardiographic predictors of mortality in patients with pulmonary hypertension and cardiopulmonary comorbidities. PLoS One, 10, 2015, e0119277.
    • (2015) PLoS One , vol.10 , pp. e0119277
    • Steiner, J.1    Wu, W.C.2    Jankowich, M.3
  • 31
    • 84903772161 scopus 로고    scopus 로고
    • Right heart dysfunction in heart failure with preserved ejection fraction
    • Melenovsky, V., Hwang, S.J., Lin, G., et al. Right heart dysfunction in heart failure with preserved ejection fraction. Eur Heart J 35 (2014), 3452–3462.
    • (2014) Eur Heart J , vol.35 , pp. 3452-3462
    • Melenovsky, V.1    Hwang, S.J.2    Lin, G.3
  • 32
    • 84938545364 scopus 로고    scopus 로고
    • Enhanced pulmonary vasodilator reserve and abnormal right ventricular: pulmonary artery coupling in heart failure with preserved ejection fraction
    • Andersen, M.J., Hwang, S.J., Kane, G.C., et al. Enhanced pulmonary vasodilator reserve and abnormal right ventricular: pulmonary artery coupling in heart failure with preserved ejection fraction. Circ Heart Fail 8 (2015), 542–550.
    • (2015) Circ Heart Fail , vol.8 , pp. 542-550
    • Andersen, M.J.1    Hwang, S.J.2    Kane, G.C.3
  • 33
    • 84886995370 scopus 로고    scopus 로고
    • Tricuspid annular plane systolic excursion and pulmonary arterial systolic pressure relationship in heart failure: an index of right ventricular contractile function and prognosis
    • Guazzi, M., Bandera, F., Pelissero, G., et al. Tricuspid annular plane systolic excursion and pulmonary arterial systolic pressure relationship in heart failure: an index of right ventricular contractile function and prognosis. Am J Physiol Heart Circ Physiol 305 (2013), H1373–H1381.
    • (2013) Am J Physiol Heart Circ Physiol , vol.305 , pp. H1373-H1381
    • Guazzi, M.1    Bandera, F.2    Pelissero, G.3
  • 34
    • 84937541986 scopus 로고    scopus 로고
    • Echocardiography of right ventriculoarterial coupling combined with cardiopulmonary exercise testing to predict outcome in heart failure
    • Guazzi, M., Naeije, R., Arena, R., et al. Echocardiography of right ventriculoarterial coupling combined with cardiopulmonary exercise testing to predict outcome in heart failure. Chest 148 (2015), 226–234.
    • (2015) Chest , vol.148 , pp. 226-234
    • Guazzi, M.1    Naeije, R.2    Arena, R.3
  • 35
    • 85017435419 scopus 로고    scopus 로고
    • RV contractile function and its coupling to pulmonary circulation in heart failure with preserved ejection fraction: stratification of clinical phenotypes and outcomes
    • Guazzi, M., Dixon, D., Labate, V., et al. RV contractile function and its coupling to pulmonary circulation in heart failure with preserved ejection fraction: stratification of clinical phenotypes and outcomes. JACC Cardiovasc Imaging 10 (2017), 1211–1221.
    • (2017) JACC Cardiovasc Imaging , vol.10 , pp. 1211-1221
    • Guazzi, M.1    Dixon, D.2    Labate, V.3
  • 36
    • 77954910405 scopus 로고    scopus 로고
    • Prognostic relevance of the echocardiographic assessment of right ventricular function in patients with idiopathic pulmonary arterial hypertension
    • Ghio, S., Klersy, C., Magrini, G., et al. Prognostic relevance of the echocardiographic assessment of right ventricular function in patients with idiopathic pulmonary arterial hypertension. Int J Cardiol 140 (2010), 272–278.
    • (2010) Int J Cardiol , vol.140 , pp. 272-278
    • Ghio, S.1    Klersy, C.2    Magrini, G.3
  • 37
    • 34547611337 scopus 로고    scopus 로고
    • Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility
    • Nagendran, J., Archer, S.L., Soliman, D., et al. Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility. Circulation 116 (2007), 238–248.
    • (2007) Circulation , vol.116 , pp. 238-248
    • Nagendran, J.1    Archer, S.L.2    Soliman, D.3
  • 38
    • 84930396691 scopus 로고    scopus 로고
    • Protein changes contributing to right ventricular cardiomyocyte diastolic dysfunction in pulmonary arterial hypertension
    • Rain, S., Bos Dda, S., Handoko, M.L., et al. Protein changes contributing to right ventricular cardiomyocyte diastolic dysfunction in pulmonary arterial hypertension. J Am Heart Assoc, 3, 2014, e000716.
    • (2014) J Am Heart Assoc , vol.3 , pp. e000716
    • Rain, S.1    Bos Dda, S.2    Handoko, M.L.3
  • 39
    • 84869088602 scopus 로고    scopus 로고
    • Differential calcium handling in two canine models of right ventricular pressure overload
    • Moon, M.R., Aziz, A., Lee, A.M., et al. Differential calcium handling in two canine models of right ventricular pressure overload. J Surg Res 178 (2012), 554–562.
    • (2012) J Surg Res , vol.178 , pp. 554-562
    • Moon, M.R.1    Aziz, A.2    Lee, A.M.3
  • 40
    • 0042526001 scopus 로고    scopus 로고
    • Mechanical load-dependent regulation of gene expression in monocrotaline-induced right ventricular hypertrophy in the rat
    • Kögler, H., Hartmann, O., Leineweber, K., et al. Mechanical load-dependent regulation of gene expression in monocrotaline-induced right ventricular hypertrophy in the rat. Circ Res 93 (2003), 230–237.
    • (2003) Circ Res , vol.93 , pp. 230-237
    • Kögler, H.1    Hartmann, O.2    Leineweber, K.3
  • 41
    • 84856240643 scopus 로고    scopus 로고
    • Sildenafil prevents and reverses transverse-tubule remodeling and Ca(2+) handling dysfunction in right ventricle failure induced by pulmonary artery hypertension
    • Xie, Y.P., Chen, B., Sanders, P., et al. Sildenafil prevents and reverses transverse-tubule remodeling and Ca(2+) handling dysfunction in right ventricle failure induced by pulmonary artery hypertension. Hypertension 59 (2012), 355–362.
    • (2012) Hypertension , vol.59 , pp. 355-362
    • Xie, Y.P.1    Chen, B.2    Sanders, P.3
  • 42
    • 77949540909 scopus 로고    scopus 로고
    • Plasma interleukin-6 is independently associated with mortality in both hemodialysis and pre-dialysis patients with chronic kidney disease
    • Barreto, D.V., Barreto, F.C., Liabeuf, S., et al. Plasma interleukin-6 is independently associated with mortality in both hemodialysis and pre-dialysis patients with chronic kidney disease. Kidney Int 77 (2010), 550–556.
    • (2010) Kidney Int , vol.77 , pp. 550-556
    • Barreto, D.V.1    Barreto, F.C.2    Liabeuf, S.3
  • 43
    • 0036569317 scopus 로고    scopus 로고
    • The interleukin-6/interleukin-6-receptor system is activated in donor hearts
    • Plenz, G., Eschert, H., Erren, M., et al. The interleukin-6/interleukin-6-receptor system is activated in donor hearts. J Am Coll Cardiol 39 (2002), 1508–1512.
    • (2002) J Am Coll Cardiol , vol.39 , pp. 1508-1512
    • Plenz, G.1    Eschert, H.2    Erren, M.3
  • 44
    • 0028909730 scopus 로고
    • Hypoxic stress induces cardiac myocyte-derived interleukin-6
    • Yamauchi-Takihara, K., Ihara, Y., Ogata, A., et al. Hypoxic stress induces cardiac myocyte-derived interleukin-6. Circulation 91 (1995), 1520–1524.
    • (1995) Circulation , vol.91 , pp. 1520-1524
    • Yamauchi-Takihara, K.1    Ihara, Y.2    Ogata, A.3
  • 45
    • 2342486700 scopus 로고    scopus 로고
    • Pulmonary hypertension in transgenic mice expressing a dominant-negative BMPRII gene in smooth muscle
    • West, J., Fagan, K., Steudel, W., et al. Pulmonary hypertension in transgenic mice expressing a dominant-negative BMPRII gene in smooth muscle. Circ Res 94 (2004), 1109–1114.
    • (2004) Circ Res , vol.94 , pp. 1109-1114
    • West, J.1    Fagan, K.2    Steudel, W.3


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