RV Contractile Function and its Coupling to Pulmonary Circulation in Heart Failure With Preserved Ejection Fraction: Stratification of Clinical Phenotypes and Outcomes

JACC: Cardiovascular Imaging

Volumn 10, Issue 10, 2017, Pages 1211-1221

  Guazzi, Marco ^a   Dixon, Debra ^b   Labate, Valentina ^a   Beussink Nelson, Lauren ^b   Bandera, Francesco ^a   Cuttica, Michael J ^b   Shah, Sanijv J ^b  

^a UNIVERSITY OF MILAN   (Italy)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

heart failure with preserved ejection fraction; hemodynamics; pulmonary hypertension; right ventricle

Indexed keywords

ACETYLSALICYLIC ACID; ALDOSTERONE ANTAGONIST; AMINO TERMINAL PRO BRAIN NATRIURETIC PEPTIDE; ANGIOTENSIN RECEPTOR ANTAGONIST; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BRAIN NATRIURETIC PEPTIDE; CALCIUM CHANNEL BLOCKING AGENT; CREATININE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOOP DIURETIC AGENT; NITRATE; SODIUM; THIAZIDE DIURETIC AGENT; WARFARIN;

ADULT; ADVERSE OUTCOME; AEROBIC CAPACITY; AEROBIC EXERCISE; AGED; ARTERY COMPLIANCE; ARTICLE; ATRIAL FIBRILLATION; CARDIAC PATIENT; CARDIOPULMONARY EXERCISE TEST; CARDIOPULMONARY HEMODYNAMICS; CARDIOVASCULAR RISK; CHRONIC KIDNEY FAILURE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL EVALUATION; CLINICAL OUTCOME; COHORT ANALYSIS; COMORBIDITY; CONTROLLED STUDY; CORONARY ARTERY DISEASE; CREATININE BLOOD LEVEL; DIABETES MELLITUS; DIURETIC THERAPY; DOPPLER ECHOCARDIOGRAPHY; ESTIMATED GLOMERULAR FILTRATION RATE; FEMALE; FOLLOW UP; FUNCTIONAL STATUS; HEART CATHETERIZATION; HEART FAILURE WITH PRESERVED EJECTION FRACTION; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE ENDDIASTOLIC VOLUME; HEART LEFT VENTRICLE ENDSYSTOLIC VOLUME; HEART LEFT VENTRICLE MASS; HEART OUTPUT; HEART RIGHT ATRIUM PRESSURE; HEART RIGHT VENTRICLE ENDDIASTOLIC VOLUME; HEART RIGHT VENTRICLE ENDSYSTOLIC VOLUME; HEART RIGHT VENTRICLE FUNCTION; HEART STROKE VOLUME; HEART VENTRICLE CONTRACTILITY; HEART VENTRICLE SIZE; HEART VENTRICLE WALL; HUMAN; HYPERLIPIDEMIA; HYPERTENSION; INDEPENDENT VARIABLE; KIDNEY DYSFUNCTION; LEFT VENTRICULAR DIASTOLIC DYSFUNCTION; LUNG ARTERY PRESSURE; LUNG CIRCULATION; LUNG HEMODYNAMICS; LUNG VASCULAR RESISTANCE; LUNG VENTILATION; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; NEW YORK HEART ASSOCIATION CLASS; OBESITY; PHENOTYPE; PREDICTOR VARIABLE; PREVALENCE; PRIORITY JOURNAL; PROGNOSIS; PROSPECTIVE STUDY; PULMONARY ARTERY; PULMONARY ARTERY DIASTOLIC PRESSURE; PULMONARY ARTERY OCCLUSION PRESSURE; PULMONARY ARTERY SYSTOLIC PRESSURE; REAL TIME ULTRASOUND SCANNER; RIGHT VENTRICULAR CONTRACTILITY; SLEEP DISORDERED BREATHING; SMOKING; SYSTEMIC VASCULAR RESISTANCE; TISSUE DOPPLER IMAGING; TRICUSPID ANNULAR PLANE SYSTOLIC EXCURSION; UREA NITROGEN BLOOD LEVEL; ARTERIAL PRESSURE; CLINICAL TRIAL; HEART CONTRACTION; HEART FAILURE; ILLINOIS; ITALY; MULTICENTER STUDY; PATHOPHYSIOLOGY; PREDICTIVE VALUE; PULMONARY HYPERTENSION; REPRODUCIBILITY; RISK FACTOR; SEVERITY OF ILLNESS INDEX; VALIDATION STUDY; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ARTERIAL PRESSURE; CARDIAC CATHETERIZATION; CHICAGO; COMORBIDITY; ECHOCARDIOGRAPHY, DOPPLER; FEMALE; HEART FAILURE; HUMANS; HYPERTENSION, PULMONARY; ITALY; MALE; MIDDLE AGED; MYOCARDIAL CONTRACTION; PHENOTYPE; PREDICTIVE VALUE OF TESTS; PREVALENCE; PROGNOSIS; PROSPECTIVE STUDIES; PULMONARY ARTERY; PULMONARY CIRCULATION; REPRODUCIBILITY OF RESULTS; RISK FACTORS; SEVERITY OF ILLNESS INDEX; STROKE VOLUME; VENTRICULAR DYSFUNCTION, RIGHT; VENTRICULAR FUNCTION, RIGHT;

EID: 85017435419     PISSN: 1936878X     EISSN: 18767591     Source Type: Journal    
DOI: 10.1016/j.jcmg.2016.12.024     Document Type: Article

References (23)

1. Shah, S.J., Kitzman, D.W., Borlaug, B.A., et al. Phenotype-specific treatment of heart failure with preserved ejection fraction: a multiorgan roadmap. Circulation 134 (2016), 73–90.
2. Shah, S.J., Katz, D.H., Selvaraj, S., et al. Phenomapping for novel classification of heart failure with preserved ejection fraction. Circulation 131 (2015), 269–279.
3. Kawaguchi, M., Hay, I., Fetics, B., Kass, D.A., Combined ventricular systolic and arterial stiffening in patients with heart failure and preserved ejection fraction: implications for systolic and diastolic reserve limitations. Circulation 107 (2003), 714–720.
4. Guazzi, M., Pulmonary hypertension in heart failure preserved ejection fraction: prevalence, pathophysiology, and clinical perspectives. Circ Heart Fail 7 (2014), 367–377.
5. Lam, C.S., Roger, V.L., Rodeheffer, R.J., Borlaug, B.A., Enders, F.T., Redfield, M.M., Pulmonary hypertension in heart failure with preserved ejection fraction: a community-based study. J Am Coll Cardiol 53 (2009), 1119–1126.
6. Mohammed, S.F., Hussain, I., AbouEzzeddine, O.F., et al. Right ventricular function in heart failure with preserved ejection fraction: a community-based study. Circulation 130 (2014), 2310–2320.
7. Guazzi, M., Bandera, F., Pelissero, G., et al. Tricuspid annular plane systolic excursion and pulmonary arterial systolic pressure relationship in heart failure: an index of right ventricular contractile function and prognosis. Am J Physiol Heart Circ Physiol 305 (2013), H1373–H1381.
8. Burke, M.A., Katz, D.H., Beussink, L., et al. Prognostic importance of pathophysiologic markers in patients with heart failure and preserved ejection fraction. Circ Heart Fail 7 (2014), 288–299.
9. Damy, T., Kallvikbacka-Bennett, A., Goode, K., et al. Prevalence of, associations with, and prognostic value of tricuspid annular plane systolic excursion (TAPSE) among out-patients referred for the evaluation of heart failure. J Card Fail 18 (2012), 216–225.
10. Hussain, I., Mohammed, S.F., Forfia, P.R., et al. Impaired right ventricular-pulmonary arterial coupling and effect of sildenafil in heart failure with preserved ejection fraction: an ancillary analysis from the phosphodiesterase-5 inhibition to improve clinical status and exercise capacity in diastolic heart failure (relax) trial. Circ Heart Fail, 9, 2016, e002729.
11. McKee, P.A., Castelli, W.P., McNamara, P.M., Kannel, W.B., The natural history of congestive heart failure: the Framingham study. N Engl J Med 285 (1971), 1441–1446.
12. Paulus, W.J., Tschope, C., Sanderson, J.E., et al. How to diagnose diastolic heart failure: a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the heart failure and echocardiography associations of the European Society of Cardiology. Eur Heart J 28 (2007), 2539–2550.
13. Nagueh, S.F., Appleton, C.P., Gillebert, T.C., et al. Recommendations for the evaluation of left ventricular diastolic function by echocardiography. J Am Soc Echocardiogr 22 (2009), 107–133.
14. Rudski, L.G., Lai, W.W., Afilalo, J., et al. Guidelines for the echocardiographic assessment of the right heart in adults: a report from the American Society of Echocardiography endorsed by the European Association of Echocardiography, a registered branch of the European Society of Cardiology, and the Canadian Society of Echocardiography. J Am Soc Echocardiogr 23 (2010), 685–713 quiz 786–688.
15. Nagueh, S.F., Middleton, K.J., Kopelen, H.A., Zoghbi, W.A., Quinones, M.A., Doppler tissue imaging: a noninvasive technique for evaluation of left ventricular relaxation and estimation of filling pressures. J Am Coll Cardiol 30 (1997), 1527–1533.
16. Redfield, M.M., Jacobsen, S.J., Burnett, J.C. Jr., Mahoney, D.W., Bailey, K.R., Rodeheffer, R.J., Burden of systolic and diastolic ventricular dysfunction in the community: appreciating the scope of the heart failure epidemic. JAMA 289 (2003), 194–202.
17. Gerges, M., Gerges, C., Pistritto, A.M., et al. Pulmonary hypertension in heart failure. Epidemiology, right ventricular function, and survival. Am J Respir Crit Care Med 192 (2015), 1234–1246.
18. Guazzi, M., Adams, V., Conraads, V., et al. EACPR/AHA scientific statement. Clinical recommendations for cardiopulmonary exercise testing data assessment in specific patient populations. Circulation 126 (2012), 2261–2274.
19. Klotz, S., Dickstein, M.L., Burkhoff, D., A computational method of prediction of the end-diastolic pressure-volume relationship by single beat. Nat Protoc 2 (2007), 2152–2158.
20. Melenovsky, V., Hwang, S.J., Lin, G., Redfield, M.M., Borlaug, B.A., Right heart dysfunction in heart failure with preserved ejection fraction. Eur Heart J 35 (2014), 3452–3462.
21. Melenovsky, V., Kotrc, M., Borlaug, B.A., et al. Relationships between right ventricular function, body composition, and prognosis in advanced heart failure. J Am Coll Cardiol 62 (2013), 1660–1670.
22. Zotter-Tufaro, C., Duca, F., Kammerlander, A.A., et al. Diastolic pressure gradient predicts outcome in patients with heart failure and preserved ejection fraction. J Am Coll Cardiol 66 (2015), 1308–1310.
23. Ghio, S., Guazzi, M., Scardovi, A.B., et al. Different correlates but similar prognostic implications for right ventricular dysfunction in heart failure patients with reduced or preserved ejection fraction. Eur J Heart Fail 19 (2017), 873–879.