-
1
-
-
84887066953
-
Right ventricular diastolic impairment in patients with pulmonary arterial hypertension
-
Rain S, Handoko ML, Trip P, Gan CT-J, Westerhof N, Stienen GJ, Paulus WJ, Ottenheijm CAC, Marcus JT, Dorfmüller P, Guignabert C, Humbert M, Macdonald P, Dos Remedios C, Postmus PE, Saripalli C, Hidalgo CG, Granzier HL, Vonk-Noordegraaf A, van der Velden J, de Man FS. Right ventricular diastolic impairment in patients with pulmonary arterial hypertension. Circulation. 2013;128:2016-2025.
-
(2013)
Circulation
, vol.128
, pp. 2016-2025
-
-
Rain, S.1
Handoko, M.L.2
Trip, P.3
Gan, C.T.-J.4
Westerhof, N.5
Stienen, G.J.6
Paulus, W.J.7
Ottenheijm, C.A.C.8
Marcus, J.T.9
Dorfmüller, P.10
Guignabert, C.11
Humbert, M.12
Macdonald, P.13
Dos Remedios, C.14
Postmus, P.E.15
Saripalli, C.16
Hidalgo, C.G.17
Granzier, H.L.18
Vonk-Noordegraaf, A.19
van der Velden, J.20
de Man, F.S.21
more..
-
2
-
-
79955976607
-
The cytoskeleton and the cellular transduction of mechanical strain in the heart: a special issue
-
De Tombe PP, Granzier HL. The cytoskeleton and the cellular transduction of mechanical strain in the heart: a special issue. Pflugers Arch. 2011;462:1-2.
-
(2011)
Pflugers Arch
, vol.462
, pp. 1-2
-
-
De Tombe, P.P.1
Granzier, H.L.2
-
3
-
-
45349086526
-
Physiological functions of the giant elastic protein titin in mammalian striated muscle
-
Fukuda N, Granzier HL, Ishiwata S, Kurihara S. Physiological functions of the giant elastic protein titin in mammalian striated muscle. J Physiol Sci. 2008; 58:151-159.
-
(2008)
J Physiol Sci
, vol.58
, pp. 151-159
-
-
Fukuda, N.1
Granzier, H.L.2
Ishiwata, S.3
Kurihara, S.4
-
4
-
-
84863119104
-
Comprehensive analysis of titin protein isoform and alternative splicing in normal and mutant rats
-
Li S, Guo W, Schmitt BM, Greaser ML. Comprehensive analysis of titin protein isoform and alternative splicing in normal and mutant rats. J Cell Biochem. 2012;113:1265-1273.
-
(2012)
J Cell Biochem
, vol.113
, pp. 1265-1273
-
-
Li, S.1
Guo, W.2
Schmitt, B.M.3
Greaser, M.L.4
-
5
-
-
70349668973
-
PKCA phosphorylation of titin's PEVK element: a novel and conserved pathway for modulating myocardial stiffness
-
17 p following 638
-
Hidalgo C, Hudson B, Bogomolovas J, Zhu Y, Anderson B, Greaser M, Labeit S, Granzier H. PKCA phosphorylation of titin's PEVK element: a novel and conserved pathway for modulating myocardial stiffness. Circ Res. 2009;105:631-638, 17 p following 638.
-
(2009)
Circ Res
, vol.105
, pp. 631-638
-
-
Hidalgo, C.1
Hudson, B.2
Bogomolovas, J.3
Zhu, Y.4
Anderson, B.5
Greaser, M.6
Labeit, S.7
Granzier, H.8
-
6
-
-
0037076791
-
Protein kinase A phosphorylates titin's cardiac-specific N2B domain and reduces passive tension in rat cardiac myocytes
-
Yamasaki R, Wu Y, McNabb M, Greaser M, Labeit S, Granzier H. Protein kinase A phosphorylates titin's cardiac-specific N2B domain and reduces passive tension in rat cardiac myocytes. Circ Res. 2002;90:1181-1188.
-
(2002)
Circ Res
, vol.90
, pp. 1181-1188
-
-
Yamasaki, R.1
Wu, Y.2
McNabb, M.3
Greaser, M.4
Labeit, S.5
Granzier, H.6
-
7
-
-
64249155200
-
Hypophosphorylation of the Stiff N2B titin isoform raises cardiomyocyte resting tension in failing human myocardium
-
Borbély A, Falcao-Pires I, van Heerebeek L, Hamdani N, Edes I, Gavina C, Leite-Moreira AF, Bronzwaer JGF, Papp Z, van der Velden J, Stienen GJM, Paulus WJ. Hypophosphorylation of the Stiff N2B titin isoform raises cardiomyocyte resting tension in failing human myocardium. Circ Res. 2009;104:780-786.
-
(2009)
Circ Res
, vol.104
, pp. 780-786
-
-
Borbély, A.1
Falcao-Pires, I.2
van Heerebeek, L.3
Hamdani, N.4
Edes, I.5
Gavina, C.6
Leite-Moreira, A.F.7
Bronzwaer, J.G.F.8
Papp, Z.9
van der Velden, J.10
Stienen, G.J.M.11
Paulus, W.J.12
-
8
-
-
79551583334
-
Enhanced myofilament responsiveness upon b-adrenergic stimulation in post-infarct remodeled myocardium
-
Boontje NM, Merkus D, Zaremba R, Versteilen A, de Waard MC, Mearini G, de Beer VJ, Carrier L, Walker LA, Niessen HWM, Dobrev D, Stienen GJM, Duncker DJ, van der Velden J. Enhanced myofilament responsiveness upon b-adrenergic stimulation in post-infarct remodeled myocardium. J Mol Cell Cardiol. 2011;50:487-499.
-
(2011)
J Mol Cell Cardiol
, vol.50
, pp. 487-499
-
-
Boontje, N.M.1
Merkus, D.2
Zaremba, R.3
Versteilen, A.4
de Waard, M.C.5
Mearini, G.6
de Beer, V.J.7
Carrier, L.8
Walker, L.A.9
Niessen, H.W.M.10
Dobrev, D.11
Stienen, G.J.M.12
Duncker, D.J.13
van der Velden, J.14
-
9
-
-
82955227502
-
Protein phosphatase 2A affects myofilament contractility in non-failing but not in failing human myocardium
-
Wijnker PJM, Boknik P, Gergs U, Müller FU, Neumann J, dos Remedios C, Schmitz W, Sindermann JR, Stienen GJM, van der Velden J, Kirchhefer U. Protein phosphatase 2A affects myofilament contractility in non-failing but not in failing human myocardium. J Muscle Res Cell Motil. 2011;32:221-233.
-
(2011)
J Muscle Res Cell Motil
, vol.32
, pp. 221-233
-
-
Wijnker, P.J.M.1
Boknik, P.2
Gergs, U.3
Müller, F.U.4
Neumann, J.5
dos Remedios, C.6
Schmitz, W.7
Sindermann, J.R.8
Stienen, G.J.M.9
van der Velden, J.10
Kirchhefer, U.11
-
10
-
-
77951623074
-
Effect of troponin I Ser23/24 phosphorylation on Ca2+-sensitivity in human myocardium depends on the phosphorylation background
-
Kooij V, Saes M, Jaquet K, Zaremba R, Foster DB, Murphy AM, Dos Remedios C, van der Velden J, Stienen GJM. Effect of troponin I Ser23/24 phosphorylation on Ca2+-sensitivity in human myocardium depends on the phosphorylation background. J Mol Cell Cardiol. 2010;48:954-963.
-
(2010)
J Mol Cell Cardiol
, vol.48
, pp. 954-963
-
-
Kooij, V.1
Saes, M.2
Jaquet, K.3
Zaremba, R.4
Foster, D.B.5
Murphy, A.M.6
Dos Remedios, C.7
van der Velden, J.8
Stienen, G.J.M.9
-
11
-
-
0017143827
-
Phosphorylation of troponin I and the inotropic effect of adrenaline in the perfused rabbit heart
-
Solaro RJ, Moir AJ, Perry SV. Phosphorylation of troponin I and the inotropic effect of adrenaline in the perfused rabbit heart. Nature. 1976;262:615-617.
-
(1976)
Nature
, vol.262
, pp. 615-617
-
-
Solaro, R.J.1
Moir, A.J.2
Perry, S.V.3
-
12
-
-
40849096222
-
The unique functions of cardiac troponin I in the donor of cardiac muscle contraction and relaxation
-
Solaro RJ, Rosevear P, Kobayashi T. The unique functions of cardiac troponin I in the donor of cardiac muscle contraction and relaxation. Biochem Biophys Res Commun. 2008;369:82-87.
-
(2008)
Biochem Biophys Res Commun
, vol.369
, pp. 82-87
-
-
Solaro, R.J.1
Rosevear, P.2
Kobayashi, T.3
-
13
-
-
84869088602
-
Differential calcium handling in two canine models of right ventricular pressure overload
-
Moon MR, Aziz A, Lee AM, Moon CJ, Okada S, Kanter EM, Yamada KA. Differential calcium handling in two canine models of right ventricular pressure overload. J Surg Res. 2012;178:554-562.
-
(2012)
J Surg Res
, vol.178
, pp. 554-562
-
-
Moon, M.R.1
Aziz, A.2
Lee, A.M.3
Moon, C.J.4
Okada, S.5
Kanter, E.M.6
Yamada, K.A.7
-
14
-
-
84881105043
-
Therapeutic Efficacy of AAV1.SERCA2a in Monocrotaline-Induced Pulmonary Arterial Hypertension
-
Hadri L, Kratlian RG, Benard L, Maron BA, Dorfmüller P, Ladage D, Guignabert C, Ishikawa K, Aguero J, Ibanez B, Turnbull IC, Kohlbrenner E, Liang L, Zsebo K, Humbert M, Hulot J-S, Kawase Y, Hajjar RJ, Leopold JA. Therapeutic Efficacy of AAV1.SERCA2a in Monocrotaline-Induced Pulmonary Arterial Hypertension. Circulation. 2013;128:512-523.
-
(2013)
Circulation
, vol.128
, pp. 512-523
-
-
Hadri, L.1
Kratlian, R.G.2
Benard, L.3
Maron, B.A.4
Dorfmüller, P.5
Ladage, D.6
Guignabert, C.7
Ishikawa, K.8
Aguero, J.9
Ibanez, B.10
Turnbull, I.C.11
Kohlbrenner, E.12
Liang, L.13
Zsebo, K.14
Humbert, M.15
Hulot, J.-S.16
Kawase, Y.17
Hajjar, R.J.18
Leopold, J.A.19
-
15
-
-
35348939588
-
Reduced sarcoplasmic reticulum Ca(2+) load mediates impaired contractile reserve in right ventricular pressure overload
-
Quaile MP, Rossman EI, Berretta RM, Bratinov G, Kubo H, Houser SR, Margulies KB. Reduced sarcoplasmic reticulum Ca(2+) load mediates impaired contractile reserve in right ventricular pressure overload. J Mol Cell Cardiol. 2007;43:552-563.
-
(2007)
J Mol Cell Cardiol
, vol.43
, pp. 552-563
-
-
Quaile, M.P.1
Rossman, E.I.2
Berretta, R.M.3
Bratinov, G.4
Kubo, H.5
Houser, S.R.6
Margulies, K.B.7
-
16
-
-
0036164778
-
Reduced level of serine(16) phosphorylated phospholamban in the failing rat myocardium: a major contributor to reduced SERCA2 activity
-
Sande JB, Sjaastad I, Hoen IB, Bøkenes J, Tønnessen T, Holt E, Lunde PK, Christensen G. Reduced level of serine(16) phosphorylated phospholamban in the failing rat myocardium: a major contributor to reduced SERCA2 activity. Cardiovasc Res. 2002;53:382-391.
-
(2002)
Cardiovasc Res
, vol.53
, pp. 382-391
-
-
Sande, J.B.1
Sjaastad, I.2
Hoen, I.B.3
Bøkenes, J.4
Tønnessen, T.5
Holt, E.6
Lunde, P.K.7
Christensen, G.8
-
17
-
-
0035947592
-
Na+-Ca2+ exchanger remodeling in pressure overload cardiac hypertrophy
-
Wang Z, Nolan B, Kutschke W, Hill JA. Na+-Ca2+ exchanger remodeling in pressure overload cardiac hypertrophy. J Biol Chem. 2001;276:17706-17711.
-
(2001)
J Biol Chem
, vol.276
, pp. 17706-17711
-
-
Wang, Z.1
Nolan, B.2
Kutschke, W.3
Hill, J.A.4
-
18
-
-
1242281665
-
Developmental donor of titin isoform expression and passive stiffness in fetal and neonatal myocardium
-
Lahmers S, Wu Y, Call DR, Labeit S, Granzier H. Developmental donor of titin isoform expression and passive stiffness in fetal and neonatal myocardium. Circ Res. 2004;94:505-513.
-
(2004)
Circ Res
, vol.94
, pp. 505-513
-
-
Lahmers, S.1
Wu, Y.2
Call, D.R.3
Labeit, S.4
Granzier, H.5
-
19
-
-
0034027364
-
Effect of protein kinase A on calcium sensitivity of force and its sarcomere length dependence in human cardiomyocytes
-
Van der Velden J, de Jong JW, Owen VJ, Burton PB, Stienen GJ. Effect of protein kinase A on calcium sensitivity of force and its sarcomere length dependence in human cardiomyocytes. Cardiovasc Res. 2000;46:487-495.
-
(2000)
Cardiovasc Res
, vol.46
, pp. 487-495
-
-
Van der Velden, J.1
de Jong, J.W.2
Owen, V.J.3
Burton, P.B.4
Stienen, G.J.5
-
20
-
-
68749095276
-
Distinct myocardial effects of beta-blocker therapy in heart failure with normal and reduced left ventricular ejection fraction
-
Hamdani N, Paulus WJ, van Heerebeek L, Borbély A, Boontje NM, Zuidwijk MJ, Bronzwaer JGF, Simonides WS, Niessen HWM, Stienen GJM, van der Velden J. Distinct myocardial effects of beta-blocker therapy in heart failure with normal and reduced left ventricular ejection fraction. Eur Heart J. 2009;30:1863-1872.
-
(2009)
Eur Heart J
, vol.30
, pp. 1863-1872
-
-
Hamdani, N.1
Paulus, W.J.2
van Heerebeek, L.3
Borbély, A.4
Boontje, N.M.5
Zuidwijk, M.J.6
Bronzwaer, J.G.F.7
Simonides, W.S.8
Niessen, H.W.M.9
Stienen, G.J.M.10
van der Velden, J.11
-
21
-
-
84871383473
-
The multifunctional Ca(2+)/calmodulindependent protein kinase II delta (CaMKIId) phosphorylates cardiac titin's spring elements
-
Hidalgo CG, Chung CS, Saripalli C, Methawasin M, Hutchinson KR, Tsaprailis G, Labeit S, Mattiazzi A, Granzier HL. The multifunctional Ca(2+)/calmodulindependent protein kinase II delta (CaMKIId) phosphorylates cardiac titin's spring elements. J Mol Cell Cardiol. 2013;54:90-97.
-
(2013)
J Mol Cell Cardiol
, vol.54
, pp. 90-97
-
-
Hidalgo, C.G.1
Chung, C.S.2
Saripalli, C.3
Methawasin, M.4
Hutchinson, K.R.5
Tsaprailis, G.6
Labeit, S.7
Mattiazzi, A.8
Granzier, H.L.9
-
22
-
-
80053573173
-
Hyperphosphorylation of mouse cardiac titin contributes to transverse aortic constriction-induced diastolic dysfunction
-
Hudson B, Hidalgo C, Saripalli C, Granzier H. Hyperphosphorylation of mouse cardiac titin contributes to transverse aortic constriction-induced diastolic dysfunction. Circ Res. 2011;109:858-866.
-
(2011)
Circ Res
, vol.109
, pp. 858-866
-
-
Hudson, B.1
Hidalgo, C.2
Saripalli, C.3
Granzier, H.4
-
23
-
-
84883221659
-
Differential changes in titin domain phosphorylation increase myofilament stiffness in failing human hearts
-
Kötter S, Gout L, Von Frieling-Salewsky M, Müller AE, Helling S, Marcus K, Dos Remedios C, Linke WA, Krüger M. Differential changes in titin domain phosphorylation increase myofilament stiffness in failing human hearts. Cardiovasc Res. 2013;99:648-656.
-
(2013)
Cardiovasc Res
, vol.99
, pp. 648-656
-
-
Kötter, S.1
Gout, L.2
Von Frieling-Salewsky, M.3
Müller, A.E.4
Helling, S.5
Marcus, K.6
Dos Remedios, C.7
Linke, W.A.8
Krüger, M.9
-
24
-
-
59649084739
-
Protein kinase G modulates human myocardial passive stiffness by phosphorylation of the titin springs
-
Krüger M, Kötter S, Grützner A, Lang P, Andresen C, Redfield MM, Butt E, dos Remedios CG, Linke WA. Protein kinase G modulates human myocardial passive stiffness by phosphorylation of the titin springs. Circ Res. 2009; 104:87-94.
-
(2009)
Circ Res
, vol.104
, pp. 87-94
-
-
Krüger, M.1
Kötter, S.2
Grützner, A.3
Lang, P.4
Andresen, C.5
Redfield, M.M.6
Butt, E.7
dos Remedios, C.G.8
Linke, W.A.9
-
25
-
-
84865495526
-
A novel mechanism involving four-and-a-half LIM domain protein-1 and extracellular signal-regulated kinase-2 regulates titin phosphorylation and mechanics
-
Raskin A, Lange S, Banares K, Lyon RC, Zieseniss A, Lee LK, Yamazaki KG, Granzier HL, Gregorio CC, McCulloch AD, Omens JH, Sheikh F. A novel mechanism involving four-and-a-half LIM domain protein-1 and extracellular signal-regulated kinase-2 regulates titin phosphorylation and mechanics. J Biol Chem. 2012;287:29273-29284.
-
(2012)
J Biol Chem
, vol.287
, pp. 29273-29284
-
-
Raskin, A.1
Lange, S.2
Banares, K.3
Lyon, R.C.4
Zieseniss, A.5
Lee, L.K.6
Yamazaki, K.G.7
Granzier, H.L.8
Gregorio, C.C.9
McCulloch, A.D.10
Omens, J.H.11
Sheikh, F.12
-
26
-
-
84874256463
-
Crucial role for Ca2(+)/calmodulin-dependent protein kinase-II in regulating diastolic stress of normal and failing hearts via titin phosphorylation
-
Hamdani N, Krysiak J, Kreusser MM, Neef S, Dos Remedios CG, Maier LS, Krüger M, Backs J, Linke WA. Crucial role for Ca2(+)/calmodulin-dependent protein kinase-II in regulating diastolic stress of normal and failing hearts via titin phosphorylation. Circ Res. 2013;112:664-674.
-
(2013)
Circ Res
, vol.112
, pp. 664-674
-
-
Hamdani, N.1
Krysiak, J.2
Kreusser, M.M.3
Neef, S.4
Dos Remedios, C.G.5
Maier, L.S.6
Krüger, M.7
Backs, J.8
Linke, W.A.9
-
27
-
-
84878871182
-
Tuning the molecular giant titin through phosphorylation: role in health and disease
-
Hidalgo C, Granzier H. Tuning the molecular giant titin through phosphorylation: role in health and disease. Trends Cardiovasc Med. 2013;23:165-171.
-
(2013)
Trends Cardiovasc Med
, vol.23
, pp. 165-171
-
-
Hidalgo, C.1
Granzier, H.2
-
28
-
-
79958822121
-
Diastolic myofilament dysfunction in the failing human heart
-
Van der Velden J. Diastolic myofilament dysfunction in the failing human heart. Pflugers Arch. 2011;462:155-163.
-
(2011)
Pflugers Arch
, vol.462
, pp. 155-163
-
-
Van der Velden, J.1
-
29
-
-
0037049977
-
Cardiac excitation-contraction coupling
-
Bers DM. Cardiac excitation-contraction coupling. Nature. 2002;415:198-205.
-
(2002)
Nature
, vol.415
, pp. 198-205
-
-
Bers, D.M.1
-
30
-
-
84872001689
-
Neurohormonal axis in patients with pulmonary arterial hypertension: friend or foe?
-
De Man FS, Handoko ML, Guignabert C, Bogaard HJ, Vonk-Noordegraaf A. Neurohormonal axis in patients with pulmonary arterial hypertension: friend or foe? Am J Respir Crit Care Med. 2013;187:14-19.
-
(2013)
Am J Respir Crit Care Med
, vol.187
, pp. 14-19
-
-
De Man, F.S.1
Handoko, M.L.2
Guignabert, C.3
Bogaard, H.J.4
Vonk-Noordegraaf, A.5
-
31
-
-
0022980843
-
Beta 1-and beta 2-adrenergic-receptor subpopulations in nonfailing and failing human ventricular myocardium: coupling of both receptor subtypes to muscle contraction and selective beta 1-receptor down-regulation in heart failure
-
Bristow MR, Ginsburg R, Umans V, Fowler M, Minobe W, Rasmussen R, Zera P, Menlove R, Shah P, Jamieson S. Beta 1-and beta 2-adrenergic-receptor subpopulations in nonfailing and failing human ventricular myocardium: coupling of both receptor subtypes to muscle contraction and selective beta 1-receptor down-regulation in heart failure. Circ Res. 1986;59:297-309.
-
(1986)
Circ Res
, vol.59
, pp. 297-309
-
-
Bristow, M.R.1
Ginsburg, R.2
Umans, V.3
Fowler, M.4
Minobe, W.5
Rasmussen, R.6
Zera, P.7
Menlove, R.8
Shah, P.9
Jamieson, S.10
-
32
-
-
84859628413
-
Bisoprolol delays progression towards right heart failure in experimental pulmonary hypertension
-
De Man FS, Handoko ML, van Ballegoij JJM, Schalij I, Bogaards SJP, Postmus PE, van der Velden J, Westerhof N, Paulus WJ, Vonk-Noordegraaf A. Bisoprolol delays progression towards right heart failure in experimental pulmonary hypertension. Circ Heart Fail. 2012;5:97-105.
-
(2012)
Circ Heart Fail
, vol.5
, pp. 97-105
-
-
De Man, F.S.1
Handoko, M.L.2
van Ballegoij, J.J.M.3
Schalij, I.4
Bogaards, S.J.P.5
Postmus, P.E.6
van der Velden, J.7
Westerhof, N.8
Paulus, W.J.9
Vonk-Noordegraaf, A.10
-
33
-
-
77957694135
-
Adrenergic receptor blockade reverses right heart remodeling and dysfunction in pulmonary hypertensive rats
-
Bogaard HJ, Natarajan R, Mizuno S, Abbate A, Chang PJ, Chau VQ, Hoke NN, Kraskauskas D, Kasper M, Salloum FN, Voelkel NF. Adrenergic receptor blockade reverses right heart remodeling and dysfunction in pulmonary hypertensive rats. Am J Respir Crit Care Med. 2010;182:652-660.
-
(2010)
Am J Respir Crit Care Med
, vol.182
, pp. 652-660
-
-
Bogaard, H.J.1
Natarajan, R.2
Mizuno, S.3
Abbate, A.4
Chang, P.J.5
Chau, V.Q.6
Hoke, N.N.7
Kraskauskas, D.8
Kasper, M.9
Salloum, F.N.10
Voelkel, N.F.11
-
34
-
-
85027956045
-
Mechanotransduction: the role of mechanical stress, myocyte shape, and cytoskeletal architecture on cardiac function
-
McCain ML, Parker KK. Mechanotransduction: the role of mechanical stress, myocyte shape, and cytoskeletal architecture on cardiac function. Pflugers Arch. 2011;462:89-104.
-
(2011)
Pflugers Arch
, vol.462
, pp. 89-104
-
-
McCain, M.L.1
Parker, K.K.2
|