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Volumn 7, Issue 1, 2017, Pages

Dysbiosis contributes to chronic constipation development via regulation of serotonin transporter in the intestine

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; SEROTONIN TRANSPORTER;

EID: 85028766330     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/s41598-017-10835-8     Document Type: Article
Times cited : (197)

References (67)
  • 2
    • 80052461147 scopus 로고    scopus 로고
    • Prevalence of, and risk factors for, chronic idiopathic constipation in the community: Systematic review and meta-Analysis
    • quiz 1581, 1592
    • Suares, N. C. & Ford, A. C. Prevalence of, and risk factors for, chronic idiopathic constipation in the community: systematic review and meta-Analysis. Am J Gastroenterol 106, 1582-1591; quiz 1581, 1592 (2011).
    • (2011) Am J Gastroenterol , vol.106 , pp. 1582-1591
    • Suares, N.C.1    Ford, A.C.2
  • 3
    • 84867065456 scopus 로고    scopus 로고
    • Practical treatments for constipation in Korea
    • Park, K. S. et al. Practical treatments for constipation in Korea. Korean J Intern Med 27, 262-270 (2012).
    • (2012) Korean J Intern Med , vol.27 , pp. 262-270
    • Park, K.S.1
  • 4
    • 85017183052 scopus 로고    scopus 로고
    • Potential role of fecal microbiota from patients with slow transit constipation in the regulation of gastrointestinal motility
    • Ge, X. et al. Potential role of fecal microbiota from patients with slow transit constipation in the regulation of gastrointestinal motility. Sci Rep 7, 441 (2017).
    • (2017) Sci Rep , vol.7
    • Ge, X.1
  • 6
    • 84959453587 scopus 로고    scopus 로고
    • Relationship between Microbiota of the Colonic Mucosa vs Feces and Symptoms, Colonic Transit, and Methane Production in Female Patients with Chronic Constipation
    • Parthasarathy, G. et al. Relationship Between Microbiota of the Colonic Mucosa vs Feces and Symptoms, Colonic Transit, and Methane Production in Female Patients With Chronic Constipation. Gastroenterology 150, 367-379.e1 (2016).
    • (2016) Gastroenterology , vol.150 , pp. 367
    • Parthasarathy, G.1
  • 7
    • 77953230588 scopus 로고    scopus 로고
    • Methanogenic flora is associated with altered colonic transit but not stool characteristics in constipation without IBS
    • Attaluri, A., Jackson, M., Valestin, J. & Rao, S. S. Methanogenic flora is associated with altered colonic transit but not stool characteristics in constipation without IBS. Am J Gastroenterol 105, 1407-1411 (2010).
    • (2010) Am J Gastroenterol , vol.105 , pp. 1407-1411
    • Attaluri, A.1    Jackson, M.2    Valestin, J.3    Rao, S.S.4
  • 8
    • 84871120114 scopus 로고    scopus 로고
    • Intestinal microbiota in functional bowel disorders: A Rome foundation report
    • Simrén, M. et al. Intestinal microbiota in functional bowel disorders: A Rome foundation report. Gut 62, 159-176 (2013).
    • (2013) Gut , vol.62 , pp. 159-176
    • Simrén, M.1
  • 9
    • 84858376593 scopus 로고    scopus 로고
    • The impact of the gut microbiota on human health: An integrative view
    • Clemente, J. C., Ursell, L. K., Parfrey, L. W. & Knight, R. The impact of the gut microbiota on human health: An integrative view. Cell 148, 1258-1270 (2012).
    • (2012) Cell , vol.148 , pp. 1258-1270
    • Clemente, J.C.1    Ursell, L.K.2    Parfrey, L.W.3    Knight, R.4
  • 10
    • 84907149871 scopus 로고    scopus 로고
    • Structural changes in the gut microbiome of constipated patients
    • Zhu, L. et al. Structural changes in the gut microbiome of constipated patients. Physiol Genomics 46, 679-686 (2014).
    • (2014) Physiol Genomics , vol.46 , pp. 679-686
    • Zhu, L.1
  • 11
    • 84978795405 scopus 로고    scopus 로고
    • Intestinal microbiota and chronic constipation
    • Zhao, Y. & Yu, Y. B. Intestinal microbiota and chronic constipation. Springerplus 5, 1130 (2016).
    • (2016) Springerplus , vol.5
    • Zhao, Y.1    Yu, Y.B.2
  • 12
    • 84876734170 scopus 로고    scopus 로고
    • Is serotonin in enteric nerves required for distension-evoked peristalsis and propulsion of content in Guinea-pig distal colon
    • Sia, T. C. et al. Is serotonin in enteric nerves required for distension-evoked peristalsis and propulsion of content in guinea-pig distal colon. Neuroscience 240, 325-335 (2013).
    • (2013) Neuroscience , vol.240 , pp. 325-335
    • Sia, T.C.1
  • 13
    • 80054878220 scopus 로고    scopus 로고
    • The effect of tegaserod on symptoms and quality of life in Korean women with irritable bowel syndrome with constipation
    • Kim, Y. S. et al. The effect of tegaserod on symptoms and quality of life in korean women with irritable bowel syndrome with constipation. J Neurogastroenterol Motil 16, 61-70 (2010).
    • (2010) J Neurogastroenterol Motil , vol.16 , pp. 61-70
    • Kim, Y.S.1
  • 14
    • 85012992087 scopus 로고    scopus 로고
    • The TNF-α antagonist etanercept reverses age-related decreases in colonic SERT expression and faecal output in mice
    • Patel, B. A. et al. The TNF-α antagonist etanercept reverses age-related decreases in colonic SERT expression and faecal output in mice. Sci Rep 7, 42754 (2017).
    • (2017) Sci Rep , vol.7
    • Patel, B.A.1
  • 15
    • 2942525747 scopus 로고    scopus 로고
    • Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome
    • Coates, M. D. et al. Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome. Gastroenterology 126, 1657-1664 (2004).
    • (2004) Gastroenterology , vol.126 , pp. 1657-1664
    • Coates, M.D.1
  • 16
    • 84991080572 scopus 로고    scopus 로고
    • M. Regulation of the serotonin transporter in the pathogenesis of irritable bowel syndrome
    • Jin, D. C. et al. M. Regulation of the serotonin transporter in the pathogenesis of irritable bowel syndrome. World J Gastroenterol 22, 8137-8148 (2016).
    • (2016) World J Gastroenterol , vol.22 , pp. 8137-8148
    • Jin, D.C.1
  • 17
    • 85021704165 scopus 로고    scopus 로고
    • Human-derived gut microbiota modulates colonic secretion in mice by regulating 5-HT3 receptor expression via acetate production
    • Bhattarai, Y. et al. Human-derived gut microbiota modulates colonic secretion in mice by regulating 5-HT3 receptor expression via acetate production. Am J Physiol Gastrointest Liver Physiol 313, G80-80G87 (2017).
    • (2017) Am J Physiol Gastrointest Liver Physiol , vol.313 , pp. G80-80G87
    • Bhattarai, Y.1
  • 18
    • 84927131694 scopus 로고    scopus 로고
    • Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis
    • Yano, J. M. et al. Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis. Cell 161, 264-276 (2015).
    • (2015) Cell , vol.161 , pp. 264-276
    • Yano, J.M.1
  • 19
    • 84948671061 scopus 로고    scopus 로고
    • Escherichia coli Nissle 1917 enhances bioavailability of serotonin in gut tissues through modulation of synthesis and clearance
    • Nzakizwanayo, J. et al. Escherichia coli Nissle 1917 enhances bioavailability of serotonin in gut tissues through modulation of synthesis and clearance. Sci Rep 5, 17324 (2015).
    • (2015) Sci Rep , vol.5
    • Nzakizwanayo, J.1
  • 20
    • 84982804411 scopus 로고    scopus 로고
    • Listeria monocytogenes Inhibits Serotonin Transporter in Human Intestinal Caco-2 Cells
    • Latorre, E. et al. Listeria monocytogenes Inhibits Serotonin Transporter in Human Intestinal Caco-2 Cells. Microb Ecol 72, 730-739 (2016).
    • (2016) Microb Ecol , vol.72 , pp. 730-739
    • Latorre, E.1
  • 21
    • 84881479285 scopus 로고    scopus 로고
    • Serotonin signalling in the gut-functions, dysfunctions and therapeutic targets
    • Mawe, G. M. & Hoffman, J. M. Serotonin signalling in the gut-functions, dysfunctions and therapeutic targets. Nat Rev Gastroenterol Hepatol 10, 473-486 (2013).
    • (2013) Nat Rev Gastroenterol Hepatol , vol.10 , pp. 473-486
    • Mawe, G.M.1    Hoffman, J.M.2
  • 22
    • 84907466503 scopus 로고    scopus 로고
    • Stomach antral endocrine cells in patients with irritable bowel syndrome
    • El-Salhy, M., Gilja, O. H., Hatlebakk, J. G. & Hausken, T. Stomach antral endocrine cells in patients with irritable bowel syndrome. Int J Mol Med 34, 967-974 (2014).
    • (2014) Int J Mol Med , vol.34 , pp. 967-974
    • El-Salhy, M.1    Gilja, O.H.2    Hatlebakk, J.G.3    Hausken, T.4
  • 23
    • 84993995685 scopus 로고    scopus 로고
    • Modulation of serotonin transporter function by kappa-opioid receptor ligands
    • Sundaramurthy, S. et al. Modulation of serotonin transporter function by kappa-opioid receptor ligands. Neuropharmacology 113, 281-292 (2016).
    • (2016) Neuropharmacology , vol.113 , pp. 281-292
    • Sundaramurthy, S.1
  • 24
    • 70649088930 scopus 로고    scopus 로고
    • Enteropathogenic Escherichia coli infection inhibits intestinal serotonin transporter function and expression
    • Esmaili, A. et al. Enteropathogenic Escherichia coli infection inhibits intestinal serotonin transporter function and expression. Gastroenterology 137, 2074-2083 (2009).
    • (2009) Gastroenterology , vol.137 , pp. 2074-2083
    • Esmaili, A.1
  • 25
    • 79955926831 scopus 로고    scopus 로고
    • Progesterone receptors and serotonin levels in colon epithelial cells from females with slow transit constipation
    • Guarino, M. et al. Progesterone receptors and serotonin levels in colon epithelial cells from females with slow transit constipation. Neurogastroenterol Motil 23, 575-575e210 (2011).
    • (2011) Neurogastroenterol Motil , vol.23 , pp. 575-575e210
    • Guarino, M.1
  • 26
    • 84896912045 scopus 로고    scopus 로고
    • Transgelins, cytoskeletal proteins implicated in different aspects of cancer development
    • Dvorakova, M., Nenutil, R. & Bouchal, P. Transgelins, cytoskeletal proteins implicated in different aspects of cancer development. Expert Rev Proteomics 11, 149-165 (2014).
    • (2014) Expert Rev Proteomics , vol.11 , pp. 149-165
    • Dvorakova, M.1    Nenutil, R.2    Bouchal, P.3
  • 27
    • 84921424406 scopus 로고    scopus 로고
    • Microbiota controls the homeostasis of glial cells in the gut lamina propria
    • Kabouridis, P. S. et al. Microbiota controls the homeostasis of glial cells in the gut lamina propria. Neuron 85, 289-295 (2015).
    • (2015) Neuron , vol.85 , pp. 289-295
    • Kabouridis, P.S.1
  • 28
    • 84937394501 scopus 로고    scopus 로고
    • Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells
    • Reigstad, C. S. et al. Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells. FASEB J 29, 1395-1403 (2015).
    • (2015) FASEB J , vol.29 , pp. 1395-1403
    • Reigstad, C.S.1
  • 29
    • 84959489486 scopus 로고    scopus 로고
    • Constipation and the Microbiome: Lumen Versus Mucosa
    • Quigley, E. M. & Spiller, R. C. Constipation and the Microbiome: Lumen Versus Mucosa. Gastroenterology 150, 300-303 (2016).
    • (2016) Gastroenterology , vol.150 , pp. 300-303
    • Quigley, E.M.1    Spiller, R.C.2
  • 30
    • 84920278098 scopus 로고    scopus 로고
    • Change of Fecal Flora and Effectiveness of the Short-Term VSL#3 Probiotic Treatment in Patients with Functional Constipation
    • Kim, S. E. et al. Change of Fecal Flora and Effectiveness of the Short-Term VSL#3 Probiotic Treatment in Patients With Functional Constipation. J Neurogastroenterol Motil 21, 111-120 (2015).
    • (2015) J Neurogastroenterol Motil , vol.21 , pp. 111-120
    • Kim, S.E.1
  • 31
    • 85005965070 scopus 로고    scopus 로고
    • The human intestinal microbiome in health and disease
    • Lynch, S. V. & Pedersen, O. The Human Intestinal Microbiome in Health and Disease. N Engl J Med 375, 2369-2379 (2016).
    • (2016) N Engl J Med , vol.375 , pp. 2369-2379
    • Lynch, S.V.1    Pedersen, O.2
  • 32
    • 84996538070 scopus 로고    scopus 로고
    • Role of oxidative stress in oxaliplatin-induced enteric neuropathy and colonic dysmotility in mice
    • McQuade, R. M. et al. Role of oxidative stress in oxaliplatin-induced enteric neuropathy and colonic dysmotility in mice. Br J Pharmacol 173, 3502-3521 (2016).
    • (2016) Br J Pharmacol , vol.173 , pp. 3502-3521
    • McQuade, R.M.1
  • 33
    • 85028759751 scopus 로고    scopus 로고
    • Assessment of the Asian Neurogastroenterology and Motility Association Chronic Constipation Criteria: An Asian Multicenter Cross-sectional Study
    • Gwee, K. A. et al. Assessment of the Asian Neurogastroenterology and Motility Association Chronic Constipation Criteria: An Asian Multicenter Cross-sectional Study. J Neurogastroenterol Motil (2016).
    • (2016) J Neurogastroenterol Motil
    • Gwee, K.A.1
  • 34
    • 84961935840 scopus 로고    scopus 로고
    • Olanzapine May Inhibit Colonic Motility Associated with the 5-HT Receptor and Myosin Light Chain Kinase
    • Zhang, J. et al. Olanzapine May Inhibit Colonic Motility Associated with the 5-HT Receptor and Myosin Light Chain Kinase. Psychiatry Investig 13, 232-238 (2016).
    • (2016) Psychiatry Investig , vol.13 , pp. 232-238
    • Zhang, J.1
  • 35
    • 84992108029 scopus 로고    scopus 로고
    • Characterization of Microbiota in Children with Chronic Functional Constipation
    • e0164731 27760208 5070844
    • de Meij, T. G. et al. Characterization of Microbiota in Children with Chronic Functional Constipation. PLoS One 11, e0164731 (2016).
    • (2016) PLoS One , vol.11
    • De Meij, T.G.1
  • 36
    • 33644878279 scopus 로고    scopus 로고
    • Alterations in the colonic flora and intestinal permeability and evidence of immune activation in chronic constipation
    • Khalif, I. L., Quigley, E. M., Konovitch, E. A. & Maximova, I. D. Alterations in the colonic flora and intestinal permeability and evidence of immune activation in chronic constipation. Dig Liver Dis 37, 838-849 (2005).
    • (2005) Dig Liver Dis , vol.37 , pp. 838-849
    • Khalif, I.L.1    Quigley, E.M.2    Konovitch, E.A.3    Maximova, I.D.4
  • 37
    • 80955180995 scopus 로고    scopus 로고
    • Intestinal microbiota in human health and disease: The impact of probiotics
    • Gerritsen, J., Smidt, H., Rijkers, G. T. & de Vos, W. M. Intestinal microbiota in human health and disease: The impact of probiotics. Genes Nutr 6, 209-240 (2011).
    • (2011) Genes Nutr , vol.6 , pp. 209-240
    • Gerritsen, J.1    Smidt, H.2    Rijkers, G.T.3    De Vos, W.M.4
  • 38
    • 85028748236 scopus 로고    scopus 로고
    • A randomised, double-blind, placebo-controlled clinical study: The effects of a synbiotic, Lepicol, in adults with chronic, functional constipation
    • Cudmore, S., Doolan, A., Lacey, S. & Shanahan, F. A randomised, double-blind, placebo-controlled clinical study: The effects of a synbiotic, Lepicol, in adults with chronic, functional constipation. Int J Food Sci Nutr 1-12 (2016).
    • (2016) Int J Food Sci Nutr , pp. 1-12
    • Cudmore, S.1    Doolan, A.2    Lacey, S.3    Shanahan, F.4
  • 39
    • 85016650297 scopus 로고    scopus 로고
    • Prevention and management of constipation in adults
    • Collins, B. R. & O'Brien, L. Prevention and management of constipation in adults. Nurs Stand 29, 49-58 (2015).
    • (2015) Nurs Stand , vol.29 , pp. 49-58
    • Collins, B.R.1    O'Brien, L.2
  • 40
    • 85018179114 scopus 로고    scopus 로고
    • Constipation in children: Fibre and probiotics
    • Tabbers, M. M. & Benninga, M. A. Constipation in children: fibre and probiotics. BMJ Clin Evid 2015 (2015).
    • (2015) BMJ Clin Evid , vol.2015
    • Tabbers, M.M.1    Benninga, M.A.2
  • 41
    • 5444248493 scopus 로고    scopus 로고
    • Akkermansia muciniphila gen. Nov., Sp. Nov., a human intestinal mucin-degrading bacterium
    • Derrien, M., Vaughan, E. E., Plugge, C. M. & de Vos, W. M. Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium. Int J Syst Evol Microbiol 54, 1469-1476 (2004).
    • (2004) Int J Syst Evol Microbiol , vol.54 , pp. 1469-1476
    • Derrien, M.1    Vaughan, E.E.2    Plugge, C.M.3    De Vos, W.M.4
  • 42
    • 84973541347 scopus 로고    scopus 로고
    • Caffeic acid ameliorates colitis in association with increased Akkermansia population in the gut microbiota of mice
    • Zhang, Z. et al. Caffeic acid ameliorates colitis in association with increased Akkermansia population in the gut microbiota of mice. Oncotarget 7, 31790-31799 (2016).
    • (2016) Oncotarget , vol.7 , pp. 31790-31799
    • Zhang, Z.1
  • 43
    • 84897960120 scopus 로고    scopus 로고
    • An increase in the Akkermansia spp. Population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice
    • Shin, N. R. W. et al. An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice. Gut 63, 727-735 (2014).
    • (2014) Gut , vol.63 , pp. 727-735
    • Shin, N.R.W.1
  • 44
    • 84886286566 scopus 로고    scopus 로고
    • Extracellular vesicles derived from gut microbiota, especially Akkermansia muciniphila, protect the progression of dextran sulfate sodium-induced colitis
    • e76520 2013PLoSO.876520K 1:CAS:528:DC%2BC3sXhslSjs7zE 24204633 3811976
    • Kang, C. S. et al. Extracellular vesicles derived from gut microbiota, especially Akkermansia muciniphila, protect the progression of dextran sulfate sodium-induced colitis. PLoS One 8, e76520 (2013).
    • (2013) PLoS One , vol.8
    • Kang, C.S.1
  • 45
    • 84878465280 scopus 로고    scopus 로고
    • Cross-Talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity
    • Everard, A. et al. Cross-Talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Proc Natl Acad Sci USA 110, 9066-9071 (2013).
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 9066-9071
    • Everard, A.1
  • 46
    • 84984551811 scopus 로고    scopus 로고
    • Akkermansia muciniphila and Helicobacter typhlonius modulate intestinal tumor development in mice
    • Dingemanse, C. et al. Akkermansia muciniphila and Helicobacter typhlonius modulate intestinal tumor development in mice. Carcinogenesis 36, 1388-1396 (2015).
    • (2015) Carcinogenesis , vol.36 , pp. 1388-1396
    • Dingemanse, C.1
  • 47
    • 84881501418 scopus 로고    scopus 로고
    • Obesity impairs lymphatic fluid transport and dendritic cell migration to lymph nodes
    • e70703 2013PLoSO.870703W 1:CAS:528:DC%2BC3sXhtlamsLfI 23950984 3741281
    • Weitman, E. S. et al. Obesity impairs lymphatic fluid transport and dendritic cell migration to lymph nodes. PLoS One 8, e70703 (2013).
    • (2013) PLoS One , vol.8
    • Weitman, E.S.1
  • 48
    • 62949247401 scopus 로고    scopus 로고
    • K. Localized release of serotonin (5-hydroxytryptamine) by a fecal pellet regulates migrating motor complexes in murine colon
    • Heredia, D. J. et al. K. Localized release of serotonin (5-hydroxytryptamine) by a fecal pellet regulates migrating motor complexes in murine colon. Gastroenterology 136, 1328-1338 (2009).
    • (2009) Gastroenterology , vol.136 , pp. 1328-1338
    • Heredia, D.J.1
  • 49
    • 75649107842 scopus 로고    scopus 로고
    • Calcium activity in different classes of myenteric neurons underlying the migrating motor complex in the murine colon
    • Bayguinov, P. O., Hennig, G. W. & Smith, T. K. Calcium activity in different classes of myenteric neurons underlying the migrating motor complex in the murine colon. J Physiol 588, 399-421 (2010).
    • (2010) J Physiol , vol.588 , pp. 399-421
    • Bayguinov, P.O.1    Hennig, G.W.2    Smith, T.K.3
  • 50
    • 84871926401 scopus 로고    scopus 로고
    • 5-Hydroxytryptamine (serotonin) in the gastrointestinal tract
    • Gershon, M. D. 5-Hydroxytryptamine (serotonin) in the gastrointestinal tract. Curr Opin Endocrinol Diabetes Obes 20, 14-21 (2013).
    • (2013) Curr Opin Endocrinol Diabetes Obes , vol.20 , pp. 14-21
    • Gershon, M.D.1
  • 51
    • 84904891545 scopus 로고    scopus 로고
    • J. Control of intrinsic pacemaker frequency and velocity of colonic migrating motor complexes in mouse
    • Barnes, K. J. et al. J. Control of intrinsic pacemaker frequency and velocity of colonic migrating motor complexes in mouse. Front Neurosci 8, 96 (2014).
    • (2014) Front Neurosci , vol.8
    • Barnes, K.J.1
  • 52
    • 33646201266 scopus 로고    scopus 로고
    • The functional gastrointestinal disorders and the Rome III process
    • Drossman, D. A. The functional gastrointestinal disorders and the Rome III process. Gastroenterology 130, 1377-1390 (2006).
    • (2006) Gastroenterology , vol.130 , pp. 1377-1390
    • Drossman, D.A.1
  • 53
    • 84902115707 scopus 로고    scopus 로고
    • Prucalopride improves bowel function and colonic transit time in patients with chronic constipation: An integrated analysis
    • Emmanuel, A., Cools, M., Vandeplassche, L. & Kerstens, R. Prucalopride improves bowel function and colonic transit time in patients with chronic constipation: An integrated analysis. Am J Gastroenterol 109, 887-894 (2014).
    • (2014) Am J Gastroenterol , vol.109 , pp. 887-894
    • Emmanuel, A.1    Cools, M.2    Vandeplassche, L.3    Kerstens, R.4
  • 54
    • 84963547235 scopus 로고    scopus 로고
    • Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host's metabolism
    • Zheng, P. et al. Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host's metabolism. Mol Psychiatry 21, 786-796 (2016).
    • (2016) Mol Psychiatry , vol.21 , pp. 786-796
    • Zheng, P.1
  • 55
    • 84928175356 scopus 로고    scopus 로고
    • Distinct Commensals Induce Interleukin-1β via NLRP3 Inflammasome in Inflammatory Monocytes to Promote Intestinal Inflammation in Response to Injury
    • Seo, S. U. et al. Distinct Commensals Induce Interleukin-1β via NLRP3 Inflammasome in Inflammatory Monocytes to Promote Intestinal Inflammation in Response to Injury. Immunity 42, 744-755 (2015).
    • (2015) Immunity , vol.42 , pp. 744-755
    • Seo, S.U.1
  • 56
    • 84896713690 scopus 로고    scopus 로고
    • Colonization of the human gut by E. Coli and colorectal cancer risk
    • Bonnet, M. et al. Colonization of the human gut by E. coli and colorectal cancer risk. Clin Cancer Res 20, 859-867 (2014).
    • (2014) Clin Cancer Res , vol.20 , pp. 859-867
    • Bonnet, M.1
  • 57
    • 84884414277 scopus 로고    scopus 로고
    • Intestinal microbiota determines development of non-Alcoholic fatty liver disease in mice
    • Le, R. T. et al. Intestinal microbiota determines development of non-Alcoholic fatty liver disease in mice. Gut 62, 1787-1794 (2013).
    • (2013) Gut , vol.62 , pp. 1787-1794
    • Le, R.T.1
  • 58
    • 35948958955 scopus 로고    scopus 로고
    • TLR4 enhances TGF-beta signaling and hepatic fibrosis
    • Seki, E. et al. TLR4 enhances TGF-beta signaling and hepatic fibrosis. Nat Med 13, 1324-1332 (2007).
    • (2007) Nat Med , vol.13 , pp. 1324-1332
    • Seki, E.1
  • 59
    • 84859853683 scopus 로고    scopus 로고
    • Effects of ethanol and acetaldehyde on tight junction integrity: In vitro study in a three dimensional intestinal epithelial cell culture model
    • e35008 2012PLoSO.735008E 1:CAS:528:DC%2BC38XmsFKjtLc%3D 22563376 3339854
    • Elamin, E. et al. Effects of ethanol and acetaldehyde on tight junction integrity: in vitro study in a three dimensional intestinal epithelial cell culture model. PLoS One 7, e35008 (2012).
    • (2012) PLoS One , vol.7
    • Elamin, E.1
  • 60
    • 84871304988 scopus 로고    scopus 로고
    • The receptor TGR5 mediates the prokinetic actions of intestinal bile acids and is required for normal defecation in mice
    • Alemi, F. et al. The receptor TGR5 mediates the prokinetic actions of intestinal bile acids and is required for normal defecation in mice. Gastroenterology 144, 145-154 (2013).
    • (2013) Gastroenterology , vol.144 , pp. 145-154
    • Alemi, F.1
  • 61
    • 78149425693 scopus 로고    scopus 로고
    • Laxative effects of agarwood on low-fiber diet-induced constipation in rats
    • Kakino, M. et al. Laxative effects of agarwood on low-fiber diet-induced constipation in rats. BMC Complement Altern Med 10, 68 (2010).
    • (2010) BMC Complement Altern Med , vol.10
    • Kakino, M.1
  • 62
    • 84914695535 scopus 로고    scopus 로고
    • Therapeutic effect of activated carbon-induced constipation mice with Lactobacillus fermentum Suo on treatment
    • Suo, H. et al. Therapeutic effect of activated carbon-induced constipation mice with Lactobacillus fermentum Suo on treatment. Int J Mol Sci 15, 21875-21895 (2014).
    • (2014) Int J Mol Sci , vol.15 , pp. 21875-21895
    • Suo, H.1
  • 63
    • 84889832571 scopus 로고    scopus 로고
    • Stachyose-enriched α-galacto-oligosaccharides regulate gut microbiota and relieve constipation in mice
    • Li, T., Lu, X. & Yang, X. Stachyose-enriched α-galacto-oligosaccharides regulate gut microbiota and relieve constipation in mice. J Agric Food Chem 61, 11825-11831 (2013).
    • (2013) J Agric Food Chem , vol.61 , pp. 11825-11831
    • Li, T.1    Lu, X.2    Yang, X.3
  • 64
    • 84928914705 scopus 로고    scopus 로고
    • Gut microbiota and tacrolimus dosing in kidney transplantation
    • e0122399 25815766 4376942
    • Lee, J. R. et al. Gut microbiota and tacrolimus dosing in kidney transplantation. PLoS One 10, e0122399 (2015).
    • (2015) PLoS One , vol.10
    • Lee, J.R.1
  • 65
    • 84929074103 scopus 로고    scopus 로고
    • Comparison of the gut microbiota of people in France and Saudi Arabia
    • e153 1:STN:280:DC%2BC2MjosVOmtg%3D%3D 25915742 4423199
    • Yasir, M. et al. Comparison of the gut microbiota of people in France and Saudi Arabia. Nutr Diabetes 5, e153 (2015).
    • (2015) Nutr Diabetes , vol.5
    • Yasir, M.1
  • 66
    • 83355173006 scopus 로고    scopus 로고
    • Reducing the effects of PCR amplification and sequencing artifacts on 16S rRNA-based studies
    • e27310 2011PLoSO.627310S 1:CAS:528:DC%2BC38XhsFejtA%3D%3D 22194782 3237409
    • Schloss, P. D., Gevers, D. & Westcott, S. L. Reducing the effects of PCR amplification and sequencing artifacts on 16S rRNA-based studies. PLoS One 6, e27310 (2011).
    • (2011) PLoS One , vol.6
    • Schloss, P.D.1    Gevers, D.2    Westcott, S.L.3
  • 67
    • 72949107142 scopus 로고    scopus 로고
    • Introducing mothur: Open-source, platform-independent, community-supported software for describing and comparing microbial communities
    • Schloss, P. D. et al. Introducing mothur: open-source, platform-independent, community-supported software for describing and comparing microbial communities. Appl Environ Microbiol 75, 7537-7541 (2009).
    • (2009) Appl Environ Microbiol , vol.75 , pp. 7537-7541
    • Schloss, P.D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.