High-Throughput Metabolomics for Discovering Potential Metabolite Biomarkers and Metabolic Mechanism from the APPswe/PS1dE9 Transgenic Model of Alzheimer's Disease

Journal of Proteome Research

Volumn 16, Issue 9, 2017, Pages 3219-3228

  Yu, Jingbo ^a   Kong, Ling ^a   Zhang, Aihua ^a   Han, Ying ^a   Liu, Zhidong ^a   Sun, Hui ^a   Liu, Liang ^b   Wang, Xijun ^a,b  

^a HEILONGJIANG UNIVERSITY OF CHINESE MEDICINE   (China)

^b MACAU UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Macao)

Author keywords

Alzheimer's disease; biomarkers; mass spectrometry; metabolomics; transgenic APPswe PS1dE9

Indexed keywords

AMYLOID BETA PROTEIN; ARGININE; BIOLOGICAL MARKER; DICARBOXYLIC ACID; GLUCURONIC ACID; GLYOXYLIC ACID; PENTOSE; PROLINE; STARCH; TRYPTOPHAN; GLYOXYLIC ACID DERIVATIVE; SUCROSE;

ALZHEIMER DISEASE; AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CITRIC ACID CYCLE; COGNITIVE DEFECT; CONTROLLED STUDY; LEARNING DISORDER; MALE; METABOLITE; METABOLOMICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SUCROSE METABOLISM; TRANSGENIC MOUSE; TRYPTOPHAN METABOLISM; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; URINE; ANIMAL; C57BL MOUSE; DISEASE MODEL; EARLY DIAGNOSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MATRIX-ASSISTED LASER DESORPTION-IONIZATION MASS SPECTROMETRY; METABOLOME; MULTIVARIATE ANALYSIS; PATHOPHYSIOLOGY; PROCEDURES;

ALZHEIMER DISEASE; ANIMALS; ARGININE; BIOMARKERS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COGNITIVE DYSFUNCTION; DICARBOXYLIC ACIDS; DISEASE MODELS, ANIMAL; EARLY DIAGNOSIS; GLUCURONIC ACID; GLYOXYLATES; HUMANS; MALE; METABOLOME; METABOLOMICS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MULTIVARIATE ANALYSIS; PENTOSES; PROLINE; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; STARCH; SUCROSE; TRYPTOPHAN;

EID: 85028758039     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/acs.jproteome.7b00206     Document Type: Article

References (33)

1. Owen, J. B.; Di Domenico, F.; Sultana, R.; Perluigi, M.; Cini, C.; Pierce, W. M.; Butterfield, D. A. Proteomics- determined diffences in the concanavalin-A-fractionated proteome of hippocampus and inferior parietal lobule in subjects with Alzheimer's disease and mild cognitive impairment: implications for progression of AD J. Proteome Res. 2009, 8, 471-482 10.1021/pr800667a
2. Braak, H.; Braak, E. Neuropathological stageing of Azheimer-related changes Acta Neuropathol. 1991, 82, 239-259 10.1007/BF00308809
3. Arendt, T.; Bigl, V.; Arendt, A.; Tennstedt, A. Loss of neurons in the nucleus basalis of Meynert in Alzheimer's disease, paralysis agitans and Korsakoff's Disease Acta Neuropathol. 1983, 61, 101-108 10.1007/BF00697388
4. Adams, I. M. Structural plasticity of synapses in Alzheimer's disease Mol. Neurobiol. 1991, 5, 411-419 10.1007/BF02935562
5. Sperling, R. A.; Aisen, P. S.; Beckett, L. A.; Bennett, D. A.; Craft, S.; Fagan, A. M.; Iwatsubo, T.; Jack, C. R., Jr.; Kaye, J.; Montine, T. J.; Park, D. C.; Reiman, E. M.; Rowe, C. C.; Siemers, E.; Stern, Y.; Yaffe, K.; Carrillo, M. C.; Thies, B.; Morrison-Bogorad, M.; Wagster, M. V.; Phelps, C. H. Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease Alzheimer's Dementia 2011, 7, 280-292 10.1016/j.jalz.2011.03.003
6. Zhao, L.; Chen, T.; Wang, C.; Li, G.; Zhi, W.; Yin, J.; Wan, Q.; Chen, L. Atorvastatin improvement of cognitive impairments caused by amyloid β in mice: involvement of inflammatory reaction BMC Neurol. 2016, 16, 18 10.1186/s12883-016-0533-3
7. Antonios, G.; Borgers, H.; Richard, B. C.; Brauβ, A.; Meiβner, J.; Weggen, S.; Pena, V.; Pillot, T.; Davies, S. L.; Bakrania, P.; Matthews, D.; Brownlees, J.; Bouter, Y.; Bayer, T. A. Alzheimer therapy with an antibody against N-terminal Abeta 4-X and pyroglutamateAbeta 3-X Sci. Rep. 2015, 5, 17338 10.1038/srep17338
8. Herold, C.; Hooli, B. V.; Mullin, K.; Liu, T.; Roehr, J. T.; Mattheisen, M.; Parrado, A. R.; Bertram, L.; Lange, C.; Tanzi, R. E. Family-based association analyses of imputed genotypes reveal genome-wide significant association of Alzheimer's disease with OSBPL6, PTPRG, and PDCL3 Mol. Psychiatry 2016, 21, 1608-1612 10.1038/mp.2015.218
9. Melnikova, T.; Savonenko, A.; Wang, Q.; Liang, X.; Hand, T.; Wu, L.; Kaufmann, W. E.; Vehmas, A.; Andreasson, K. I. Cycloxygenase-2 activity promotes cognitive deficits but not increased amyloid burden in a model of Alzheimer's disease in a sex-dimorphic pattern Neuroscience 2006, 141, 1149-1162 10.1016/j.neuroscience.2006.05.001
10. Nicholson, J. K.; Connelly, J.; Lindon, J. C.; Holmes, E. Metabonomics: a platform for studying drug toxicity and gene function Nat. Rev. Drug Discovery 2002, 1, 153-161 10.1038/nrd728
11. González-Domínguez, R.; García-Barrera, T.; Vitorica, J.; Gómez-Ariza, J. L. Application of metabolomics based on direct mass spectrometry analysis for the elucidation of altered metabolic pathways in serum from the APP/PS1 transgenic model of Alzheimer's disease J. Pharm. Biomed. Anal. 2015, 107, 378-85 10.1016/j.jpba.2015.01.025
12. Fukuhara, K.; Ohno, A.; Ota, Y.; Senoo, Y.; Maekawa, K.; Okuda, H.; Kurihara, M.; Okuno, A.; Niida, S.; Saito, Y.; Takikawa, O. NMR-based metabolomics of urine in a mouse model of Alzheimer's disease: identification of oxidative stress biomarkers J. Clin. Biochem. Nutr. 2013, 52, 133-138 10.3164/jcbn.12-118
13. Zhao, Q.; Niu, Y.; Matsumoto, K.; Tsuneyama, K.; Tanaka, K.; Miyata, T.; Yokozawa, T. Chotosan ameliorates cognitive and emotional deficits in an animal model of type 2 diabetes: possible involvement of cholinergic and VEGF/PDGF mechanisms in the brain BMC Complementary Altern. Med. 2012, 12, 188 10.1186/1472-6882-12-188
14. Guo, C.; Wang, T.; Zheng, W.; Shan, Z. Y.; Teng, W. P.; Wang, Z. Y. Intranasal deferoxamine reverses iron- induced memory deficits and inhibits amyloidogenic APP processing in a transgenic mouse model of Alzheimer's disease Neurobiol. Aging 2013, 34, 562-575 10.1016/j.neurobiolaging.2012.05.009
15. Bonardi, C.; de Pulford, F.; Jennings, D.; Pardon, M. C. A detailed analysis of the early context extinction deficits seen in APPswe/PS1dE9 female mice and their relevance to preclinical Alzheimer's disease Behav. Brain Res. 2011, 222, 89-97 10.1016/j.bbr.2011.03.041
16. Hannibal, L. Nitric oxide homeostasis in neurodegenerative disease Curr. Alzheimer Res. 2016, 13, 135-49 10.2174/1567205012666150921101250
17. Mommersteeg, P. M.; Schoemaker, R. G.; Eisel, U. L.; Garrelds, I. M.; Schalkwijk, C. G.; Kop, W. J. Nitric oxide dysregulation in patients with heart failure: the association of depressive symptoms with L-arginine, asymmetric dimethylarginine, symmetric dimethylarginine, and isoprostane Psychosom. Med. 2015, 77, 292-302 10.1097/PSY.0000000000000162
18. Jansen, E. E.; Verhoeven, N. M.; Jakobs, C.; Schulze, A.; Senephansiri, H.; Gupta, M.; Snead, O. C.; Gibson, K. M. Increased guanidino species in murine and human succinate semialdehyde dehydrogenase (SSADH) deficiency Biochim. Biophys. Acta, Mol. Basis Dis. 2006, 1762, 494-498 10.1016/j.bbadis.2006.01.006
19. Wang, S. Y.; Wang, Y.; Jin, X. W.; Zhang, Y.; Chen, J. S.; Ma, W. W.; Wu, Y. H.; Wang, D. C. A urinary metabolomics study of rats after the exposure to acrylamide by ultra performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry Mol. BioSyst. 2015, 11, 1146-1155 10.1039/C4MB00682H
20. Nagai, N.; Ito, Y.; Shibata, T.; Kubo, E.; Sasaki, H. A positive feedback loop between nitric oxide and amyloid β (1-42) accelerates mitochondrial damage in human lens epithelial cells Toxicology 2017, 381, 19-30 10.1016/j.tox.2017.02.014
21. Lee, S. H.; Kim, I.; Chung, B. C. Increased urinary level of oxidized nucleosides in patients with mild-to moderate Alzheimer's disease Clin. Biochem. 2007, 40, 936-938 10.1016/j.clinbiochem.2006.11.021
22. Chi, Y.; Sauve, A. A. Nicotinamideriboside, a trace nutrient in foods, is a vitamin B3 with effects on energy metabolism and neuroprotection Curr. Opin. Clin. Nutr. Metab. Care 2013, 16, 657-661 10.1097/MCO.0b013e32836510c0
23. Gong, B.; Pan, Y.; Vempati, P.; Zhao, W.; Knable, L.; Ho, L.; Wang, J.; Sastre, M.; Ono, K.; Sauve, A. A.; Pasinetti, G. M. Nicotinamideriboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models Neurobiol. Aging 2013, 34, 1581-1588 10.1016/j.neurobiolaging.2012.12.005
24. Shen, C.; Sun, Z.; Chen, D.; Su, X.; Jiang, J.; Li, G.; Lin, B.; Yan, J. Developing urinary metabolomic signatures as early bladder cancer diagnostic markers OMICS 2015, 19, 1-11 10.1089/omi.2014.0116
25. Huang, C. F.; Cheng, M. L.; Fan, C. M.; Hong, C. Y.; Shiao, M. S. Nicotinuric acid: a potential marker of metabolic syndrome through a metabolomics-based approach Diabetes Care 2013, 36, 1729-1731 10.2337/dc12-1067
26. Birkl, P.; Franke, L.; Bas Rodenburg, T.; Ellen, E.; Harlander-Matauschek, A. A role for plasma aromatic amino acids in injurious pecking behavior in laying hens Physiol. Behav. 2017, 175, 88-96 10.1016/j.physbeh.2017.03.041
27. Vermeiren, Y.; Le Bastard, N.; Van Hemelrijck, A.; Drinkenburg, W. H.; Engelborghs, S.; De Deyn, P. P. Behavioral correlates of cerebrospinal fluid amino acid and biogenic amine neurotransmitter alterations in dementia Alzheimer's Dementia 2013, 9, 488-498 10.1016/j.jalz.2012.06.010
28. Kaddurah-Daouk, R.; Zhu, H.; Sharma, S.; Bogdanov, M.; Rozen, S. G.; Matson, W.; Oki, N. O.; Motsinger-Reif, A. A.; Churchill, E.; Lei, Z.; Appleby, D.; Kling, M. A.; Trojanowski, J. Q.; Doraiswamy, P. M.; Arnold, S. E. Alterations in metabolic pathways and networks in Alzheimer's disease Transl. Psychiatry 2013, 3, e244 10.1038/tp.2013.18
29. Yazar, A.; Büyükafpar, K.; Polat, G.; Pata, C.; Kanýk, A.; Tiftik, E. N.; Baodatoolu, O. The urinary 5-hydroxyindole acetic acid and plasma nitric oxide levels in irritable bowel syndrome: a preliminary study Scott. Med. J. 2005, 50, 27-29 10.1177/003693300505000111
30. Friedman, J. I.; Adler, D. N.; Davis, K. L. The role of norepinephrine in the pathophysiology of congnitvie disorders: potential applications to the treatment of cognitive dysfunction in schizophrenia and Alzheimer's disease Biol. Psychiatry 1999, 46, 1243-1252 10.1016/S0006-3223(99)00232-2
31. Zellner, M.; Baureder, M.; Rappold, E.; Bugert, P.; Kotzailias, N.; Babeluk, R.; Baumgartner, R.; Attems, J.; Gerner, C.; Jellinger, K.; Roth, E.; Oehler, R.; Umlauf, E. Comparative platelet proteome analysis reveals an increase of monoamine oxidase-B protein expression in Alzheimer's disease but not in non-demented Parkinson's disease patients J. Proteomics 2012, 75, 2080-2092 10.1016/j.jprot.2012.01.014
32. Moreno-Castilla, P.; Rodriguez-Duran, L. F.; Guzman-Ramos, K.; Barcenas-Femat, A.; Escobar, M. L.; Bermudez-Rattoni, F. Dopaminergic neurotransmission dysfunction induced by amyloid-β transforms cortical long-term potentiation into long-term depression and produces memory impairment Neurobiol. Aging 2016, 41, 187-199 10.1016/j.neurobiolaging.2016.02.021
33. Xiang, P. Y.; Janc, O.; Grochowska, K. M.; Kreutz, M. R.; Reymann, K. G. Dopamine agonists rescue Aβ-induced LTP impairment by Scr-family tyrosine kinases Neurobiol. Aging 2016, 40, 98-102 10.1016/j.neurobiolaging.2016.01.008