Autophagy Inhibition Contributes to ROS-Producing NLRP3-Dependent Inflammasome Activation and Cytokine Secretion in High Glucose-Induced Macrophages

Cellular Physiology and Biochemistry

Volumn 43, Issue 1, 2017, Pages 247-256

  Dai, Jiezhi ^a   Zhang, Xiaotian ^a   Li, Li ^a   Chen, Hua ^a   Chai, Yimin ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Autophagy; IL 1 ; Macrophages; NLRP3 inflammasome; ROS

Indexed keywords

CRYOPYRIN; CYTOKINE; GLUCOSE; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; MICROTUBULE ASSOCIATED PROTEIN; MICROTUBULE ASSOCIATED PROTEIN LIGHT CHAIN 3 II; REACTIVE OXYGEN METABOLITE; SEQUESTOSOME 1; UNCLASSIFIED DRUG; CHEMOKINE RECEPTOR CCR7; MAP1LC3A PROTEIN, HUMAN;

ARTICLE; AUTOPHAGY; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; HUMAN; HUMAN CELL; HUMAN TISSUE; INFLAMMATION; MACROPHAGE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ANTAGONISTS AND INHIBITORS; CELL LINE; CYTOLOGY; DRUG EFFECTS; GENETICS; METABOLISM; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; SECRETION (PROCESS); WESTERN BLOTTING;

AUTOPHAGY; BLOTTING, WESTERN; CASPASE 1; CELL LINE; DIABETES MELLITUS, TYPE 2; GLUCOSE; HUMANS; INFLAMMASOMES; INTERLEUKIN-1BETA; MACROPHAGES; MICROTUBULE-ASSOCIATED PROTEINS; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, CCR7; SIGNAL TRANSDUCTION;

EID: 85028750674     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000480367     Document Type: Article

References (28)

1. Falanga V: Wound healing and its impairment in the diabetic foot. Lancet 2005;366:1736-1743.
2. Mast BA, Schultz GS: Interactions of cytokines, growth factors, and proteases in acute and chronic wounds. Wound Repair & Regeneration 1996;4:411-420.
3. Mirza RE, Fang MM, Ennis WJ, Koh TJ: Blocking interleukin-1beta induces a healing-associated wound macrophage phenotype and improves healing in type 2 diabetes. Diabetes 2013;62:2579-2587.
4. Liu W, Zhang X, Zhao M, Chi J, Liu Y, Lin F, Fu Y, Ma D, Yin X: Activation in M1 but not M2 Macrophages Contributes to Cardiac Remodeling after Myocardial Infarction in Rats: a Critical Role of the Calcium Sensing Receptor/NRLP3 Inflammasome. Cell Physiol Biochem 2015;35:2483-2500.
5. Zhang X, Dai J, Li L, Chen H, Chai Y: NLRP3 Inflammasome Expression and Signaling in Human Diabetic Wounds and in High Glucose Induced Macrophages. Journal of Diabetes Research 2017;2017:5281358.
6. Torres-Castro I, Arroyo-Camarena UD, Martinez-Reyes CP, Gomez-Arauz AY, Duenas-Andrade Y, Hernandez-Ruiz J, Bejar YL, Zaga-Clavellina V, Morales-Montor J, Terrazas LI, Kzhyshkowska J, Escobedo G: Human monocytes and macrophages undergo M1-type inflammatory polarization in response to high levels of glucose. Immunol Lett 2016;176:81-89.
7. Martinon F, Burns K, Tschopp J: The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell 2002;10:417-426.
8. Huang Z, Zhuang X, Xie C, Hu X, Dong X, Guo Y, Li S, Liao X: Exogenous Hydrogen Sulfide Attenuates High Glucose-Induced Cardiotoxicity by Inhibiting NLRP3 Inflammasome Activation by Suppressing TLR4/NF-kappaB Pathway in H9c2 Cells. Cell Physiol Biochem 2016;40:1578-1590.
9. Haasken S, Sutterwala FS: Damage control: management of cellular stress by the NLRP3 inflammasome. Eur J Immunol 2013;43:2003-2005.
10. Bracey NA, Gershkovich B, Chun J, Vilaysane A, Meijndert HC, Wright JR, Jr., Fedak PW, Beck PL, Muruve DA, Duff HJ: Mitochondrial NLRP3 protein induces reactive oxygen species to promote Smad protein signaling and fibrosis independent from the inflammasome. J Biol Chem 2014;289:19571-19584.
11. Zhou R, Yazdi AS, Menu P, Tschopp J: A role for mitochondria in NLRP3 inflammasome activation. Nature 2011;469:221-225.
12. Lee HM, Kim JJ, Kim HJ, Shong M, Ku BJ, Jo EK: Upregulated NLRP3 inflammasome activation in patients with type 2 diabetes. Diabetes 2013;62:194-204.
13. Bitto A, Altavilla D, Pizzino G, Irrera N, Pallio G, Colonna MR, Squadrito F: Inhibition of inflammasome activation improves the impaired pattern of healing in genetically diabetic mice. Br J Pharmacol 2014;171:2300-2307.
14. Mirza R, Koh TJ: Dysregulation of monocyte/macrophage phenotype in wounds of diabetic mice. Cytokine 2011;56:256-264.
15. Labonte AC, Tosello-Trampont AC, Hahn YS: The role of macrophage polarization in infectious and inflammatory diseases. Moleculer Cells 2014;37:275-285.
16. Ding Z, Wang X, Schnackenberg L, Khaidakov M, Liu S, Singla S, Dai Y, Mehta JL: Regulation of autophagy and apoptosis in response to ox-LDL in vascular smooth muscle cells, and the modulatory effects of the microRNA hsa-let-7 g. Int J Cardiol 2013;168:1378-1385.
17. Puissant A, Fenouille N, Auberger P: When autophagy meets cancer through p62/SQSTM1. American Journal of Cancer Research 2012;2:397-413.
18. Mirza RE, Fang MM, Weinheimer-Haus EM, Ennis WJ, Koh TJ: Sustained inflammasome activity in macrophages impairs wound healing in type 2 diabetic humans and mice. Diabetes 2014;63:1103-1114.
19. Mori MA, Bezy O, Kahn CR: Metabolic syndrome: is Nlrp3 inflammasome a trigger or a target of insulin resistance? Circulation Research 2011;108:1160-1162.
20. Abderrazak A, Syrovets T, Couchie D, El Hadri K, Friguet B, Simmet T, Rouis M: NLRP3 inflammasome: from a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases. Redox Biol 2015;4:296-307.
21. Wu J, Li X, Zhu G, Zhang Y, He M, Zhang J: The role of Resveratrol-induced mitophagy/autophagy in peritoneal mesothelial cells inflammatory injury via NLRP3 inflammasome activation triggered by mitochondrial ROS. Exp Cell Res 2016;341:42-53.
22. Yang S, Xia C, Li S, Du L, Zhang L, Zhou R: Defective mitophagy driven by dysregulation of rheb and KIF5B contributes to mitochondrial reactive oxygen species (ROS)-induced nod-like receptor 3 (NLRP3) dependent proinflammatory response and aggravates lipotoxicity. Redox Biol 2014;3:63-71.
23. Ding Z, Liu S, Wang X, Dai Y, Khaidakov M, Deng X, Fan Y, Xiang D, Mehta JL: LOX-1, mtDNA damage, and NLRP3 inflammasome activation in macrophages: implications in atherogenesis. Cardiovasc Res 2014;103:619-628.
24. Ashrafi G, Schwarz TL: The pathways of mitophagy for quality control and clearance of mitochondria. Cell Death Differ 2013;20:31-42.
25. Ma T, Zhu J, Chen X, Zha D, Singhal PC, Ding G: High glucose induces autophagy in podocytes. Exp Cell Res 2013;319:779-789.
26. Xin W, Li Z, Xu Y, Yu Y, Zhou Q, Chen L, Wan Q: Autophagy protects human podocytes from high glucose-induced injury by preventing insulin resistance. Metabolism 2016;65:1307-1315.
27. Wang X, Feng Z, Li J, Chen L, Tang W: High glucose induces autophagy of MC3T3-E1 cells via ROS-AKT-mTOR axis. Mol Cell Endocrinol 2016;429:62-72.
28. Shi H, Zhang Z, Wang X, Li R, Hou W, Bi W, Zhang X: Inhibition of autophagy induces IL-1beta release from ARPE-19 cells via ROS mediated NLRP3 inflammasome activation under high glucose stress. Biochem Biophys Res Commun 2015;463:1071-1076.