High glucose induces autophagy in podocytes

Experimental Cell Research

Volumn 319, Issue 6, 2013, Pages 779-789

  Ma, Tean ^a   Zhu, Jili ^a   Chen, Xinghua ^a   Zha, Dongqing ^a   Singhal, Pravin C ^b   Ding, Guohua ^a  

^a RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

^b Northwell Health   (United States)

Author keywords

Autophagy; High glucose; Oxidative stress; Podocytes

Indexed keywords

3 METHYLADENINE; ACETYLCYSTEINE; ALBUMIN; BECLIN 1; CATALASE; CELL PROTEIN; CREATININE; GLUCOSE; HEMOGLOBIN A1C; LC3 PROTEIN; MANGANESE SUPEROXIDE DISMUTASE; NITROGEN; RAPAMYCIN; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; BODY WEIGHT; CELL VACUOLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; ELECTRON MICROSCOPY; GLUCOSE BLOOD LEVEL; HEMOGLOBIN BLOOD LEVEL; KIDNEY MASS; MOUSE; NONHUMAN; OXIDATIVE STRESS; PODOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STREPTOZOCIN DIABETES; UREA NITROGEN BLOOD LEVEL; URINARY EXCRETION;

EID: 84875258906     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2013.01.018     Document Type: Article

References (47)

1. Huber T.B., Benzing T. The slit diaphragm: a signaling platform to regulate podocyte function. Curr. Opinion Nephrol. Hypertension 2005, 14:211-216.
2. Pavenstädt H., Kriz W., Kretzler M. Cell biology of the glomerular podocyte. Physiol. Rev. 2003, 83:253-307.
3. Li J.J., Kwak S.J., Jung D.S., Kim J.J., Yoo T.H., Ryu D.R., Han S.H., Choi H.Y., Lee J.E., Moon S.J., Kim D.K., Han D.S., Kang S.W. Podocyte biology in diabetic nephropathy. Kidney Int. 2007, Suppl. 106:S36-S42.
4. Marshall S.M. The podocyte: a potential therapeutic target in diabetic nephropathy?. Curr. Pharm. Des. 2007, 13:2713-2720.
5. Reddy G.R., Kotlyarevska K., Ransom R.F., Menon R.K. The podocyte and diabetes mellitus: is the podocyte the key to the origins of diabetic nephropathy?. Curr. Opinion Nephrol. Hypertension 2008, 17:32-36.
6. Ziyadeh F.N., Wolf G. Pathogenesis of the podocytopathy and proteinuria in diabetic glomerulopathy. Curr. Diabetes Rev. 2008, 4:39-45.
7. Barisoni L., Schnaper H.W., Kopp J.B. Advances in the biology and genetics of the podocytopathies: implications for diagnosis and therapy. Arch. Pathol. Lab. Med. 2009, 133:201-216.
8. Lahdenkari A.T., Lounatmaa K., Patrakka J., Holmberg C., Wartiovaara J., Kestila M., Koskimies O., Jalanko H. Podocytes are firmly attached to glomerular basement membrane in kidneys with heavy proteinuria. J. Am. Soc. Nephrol. 2004, 15:2611-2618.
9. Chuang P.Y., Yu Q., Fang W., Uribarri J., He J.C. Advanced glycation end products induce podocyte apoptosis by activation of the FOXO4 transcription factor. Kidney Int. 2007, 72:965-976.
10. Susztak K., Raff A.C., Schiffer M., Böttinger E.P. Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy. Diabetes 2006, 55:225-233.
11. Pan M., Maitin V., Parathath S., Andreo U., Lin S.X., Germain C., Yao Z., Maxfield F.R., Williams K.J., Fisher E.A. Presecretory oxidation,aggregation, and autophagic destruction of apoprotein-B: a pathway for late-stage quality control. Proc. Natl. Acad. Sci. USA 2008, 105:5862-5867.
12. Zierhut C., Diffley J.F. Break dosage, cell cycle stage and DNA replication influence DNA double strand break response. EMBO J. 2008, 27:1875-1885.
13. Asanuma K., Tanida I., Shirato I., Ueno T., Takahara H., Nishitani T., Kominami E., Tomino Y. MAP-LC3, a promising autophagosomal marker, is processed during the differentiation and recovery of podocytes from PAN nephrosis. FASEB J. 2003, 17:1165-1167.
14. Galluzzi L., Morselli E., Vicencio J.M., Kepp O., Joza N., Tajeddine N., Kroemer G. Life, death and burial: multifaceted impact of autophagy. Biochem. Soc. Trans. 2008, 36:786-790.
15. Mizushima N., Levine B., Cuervo A.M., Klionsky D.J. Autophagy fights disease through cellular self-digestion. Nature 2008, 451:1069-1075.
16. Winslow A.R., Rubinsztein D.C. Autophagy in neurodegeneration and development. Biochim. Biophys. Acta 2008, 1782:723-729.
17. Baehrecke E.H. Autophagy: dual roles in life and death?. Nat. Rev. Mol. Cell Biol. 2005, 6:505-510.
18. Gozuacik D., Kimchi A. Autophagy and cell death. Curr. Top. Dev. Biol. 2007, 78:217-245.
19. Levine B., Yuan J. Autophagy in cell death: an innocent convict?. J. Clin. Invest. 2005, 115:2679-2688.
20. Meijer A.J., Codogno P. Regulation and role of autophagy in mammalian cells. Int. J. Biochem. Cell Biol. 2004, 36:2445-2462.
21. Mizushima N. Autophagy: process and function. Genes Dev. 2007, 21:2861-2873.
22. Hartleben B., Gödel M., Meyer-Schwesinger C., Liu S., Ulrich T., Köbler S., Wiech T., Grahammer F., Arnold S.J., Lindenmeyer M.T., Cohen C.D., Pavenstädt H., Kerjaschki D., Mizushima N., Shaw A.S., Walz G., Huber T.B. Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice. Clin. Invest. 2010, 120:1084-1096.
23. Ohsumi Y., Mizushima N. Two ubiquitin-like conjugation systems essential for autophagy. Semin. Cell Dev. Biol. 2004, 15:231-236.
24. Xie Z., Klionsky D.J. Autophagosome formation: core machinery and adaptations. Nat. Cell Biol. 2007, 9:1102-1109.
25. Blázquez-Medela A.M., López-Novoa J.M., Martínez-Salgado C. Mechanisms involved in the genesis of diabetic nephropathy. Curr. Diabetes Rev. 2010, 6:68-87.
26. Forbes J.M., Coughlan M.T., Cooper M.E. Oxidative stress as a major culprit in kidney disease in diabetes. Diabetes 2008, 57:1446-1454.
27. Gill P.S., Wilcox C.S. NADPH oxidases in the kidney. Antioxid. Redox Signaling 2006, 8:1597-1607.
28. Gorin Y., Block K., Hernandez J., Bhandari B., Wagner B., Barnes J.L., Abboud H.E. Nox4 NAD(P)H oxidase mediates hypertrophy and fibronectin expression in the diabetic kidney. J. Biol. Chem. 2005, 280:39616-39626.
29. Ravikumar B., Sarkar S., Davies J.E., Futter M., Garcia-Arencibia M., Green-Thompson Z.W., Jimenez-Sanchez M., Korolchuk V.I., Lichtenberg M., Luo S., Massey D.C., Menzies F.M., Moreau K., Narayanan U., Renna M., Siddiqi F.H., Underwood B.R., Winslow A.R., Rubinsztein D.C. Regulation of mammalian autophagy in physiology and pathophysiology. Physiol. Rev. 2010, 90:1383-1435.
30. Azad M.B., Chen Y., Gibson S.B. Regulation of autophagy by reactive oxygen species (ROS): implications for cancer progression and treatment. Antioxid. Redox Signaling 2009, 11:777-790.
31. Walrand S., Valeix S., Rodriguez C., Ligot P., Chassagne J., Vasson M.P. Flow cytometry study of polymorphonuclear neutrophil oxidative burst: a comparison of three fluorescent probes. Clin. Chim. Acta 2003, 331:103-110.
32. van Kats J.P., Schalekamp M.A., Verdouw P.D., Duncker D.J., Danser A.H. Intrarenal angiotensin II: interstitial and cellular levels and site of production. Kidney Int. 2001, 60:2311-2317.
33. Vicencio J.M., Galluzzi L., Tajeddine N., Ortiz C., Criollo A., Tasdemir E., Morselli E., Ben Younes A., Maiuri M.C., Lavandero S., Kroemer G. Senescence, apoptosis or autophagy? When a damaged cell must decide its path-a mini-review. Gerontology 2008, 54:92-99.
34. Yadav A., Vallabu S., Arora S., Tandon P., Slahan D., Teichberg S., Singhal P.C. ANG II promotes autophagy in podocytes. Am. J. Physiol. Cell Physiol. 2010, 299:C488-C496.
35. Yang Z., Klionsky D.J. Eaten alive: a history of macroautophagy. Nat. Cell Biol. 2010, 12:814-822.
36. Cuervo A.M., Bergamini E., Brunk U.T., Droge W., Ffrench M., Terman A. Autophagy and aging: the importance of maintaining clean cells. Autophagy 2005, 1:131-140.
37. Kerjaschki D. Dysfunctions of cell biological mechanisms of visceral epithelial cell (podocytes) in glomerular diseases. Kidney Int. 1994, 45:300-313.
38. Xue L., Fletcher G.C., Tolkovsky A.M. Autophagy is activated by apoptotic signalling in sympathetic neurons: an alternative mechanism of death execution. Mol. Cell Neurosci. 1999, 14(3):180-198.
39. Kirkland R.A., Adibhatla R.M., Hatcher J.F., Franklin J.L. Loss of cardiolipin and mitochondria during programmed neuronal death: evidence of a role for lipid peroxidation and autophagy. Neuroscience 2002, 115(2):587-602.
40. Chen Y., Gibson S.B. Is mitochondrial generation of reactive oxygen species a trigger for autophagy?. Autophagy 2008, 4(2):246-248.
41. Ha H., Hwang I.A., Park J.H., Lee H.B. Role of reactive oxygen species in the pathogenesis of diabetic nephropathy. Diabetes Res. Clin. Pract. 2008, 82(Suppl. 1):S42-S45.
42. Hakim F.A., Pflueger A. Role of oxidative stress in diabetic kidney disease. Med. Sci. Monit. 2010, 16:RA37-RA48.
43. Kashihara N., Haruna Y., Kondeti V.K., Kanwar Y.S. Oxidative stress in diabetic nephropathy. Curr. Med. Chem. 2010, 17:4256-4269.
44. Giacco F., Brownlee M. Oxidative stress and diabetic complications. Circ. Res. 2010, 107:1058-1070.
45. Qu X., Yu J., Bhagat G., Furuya N., Hibshoosh H., Troxel A., Rosen J., Eskelinen E.L., Mizushima N., Ohsumi Y., Cattoretti G., Levine B. Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J. Clin. Invest. 2003, 112:1809-1820.
46. Yue Z., Jin S., Yang C., Levine A.J., Heintz N. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc. Natl. Acad. Sci. USA 2003, 100:15077-15082.
47. Huang J., Lam G.Y., Brumell J.H. Autophagy signaling through reactive oxygen species. Antioxid. Redox Signaling 2011, 14:2215-2231.