Interaction between childhood maltreatment on immunogenetic risk in depression: Discovery and replication in clinical case-control samples

Brain, Behavior, and Immunity

Volumn 67, Issue , 2018, Pages 203-210

  Cohen Woods, S ^a,b   Fisher, H L ^c   Ahmetspahic, D ^h   Douroudis, K ^c   Stacey, D ^d   Hosang, G M ^e   Korszun, A ^f   Owen, M ^g   Craddock, N ^g   Arolt, V ^h   Dannowski, U ^h   Breen, G ^c   Craig, I W ^c   Farmer, A ^c   Baune, B T ⁱ   Lewis, C M ^c   Uher, R ^j   McGuffin, P ^c  

^a FLINDERS UNIVERSITY   (Australia)

^b FLINDERS UNIVERSITY   (Australia)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^e UNIVERSITY OF LONDON   (United Kingdom)

^f QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^g CARDIFF UNIVERSITY   (United Kingdom)

^h UNIVERSITY OF MÜNSTER   (Germany)

ⁱ UNIVERSITY OF ADELAIDE   (Australia)

^j DALHOUSIE UNIVERSITY   (Canada)

more..

Author keywords

C reactive protein; CRP; Depression; Gene environment interaction; IL 6; Immunity; Inflammation; Interleukin 6

Indexed keywords

C REACTIVE PROTEIN; INTERLEUKIN 11; INTERLEUKIN 1BETA; INTERLEUKIN 6; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR 2; AUTACOID;

ADULT; ARTICLE; CASE CONTROL STUDY; CHILD ABUSE; CONTROLLED STUDY; DISEASE SEVERITY; DSM-IV; EXPOSURE; FEMALE; GENE LOCUS; GENETIC VARIATION; GENOTYPE; HUMAN; ICD-10; IMMUNOGENETICS; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; PRIORITY JOURNAL; RECURRENT DISEASE; SINGLE NUCLEOTIDE POLYMORPHISM; CHILD ABUSE SURVIVOR; COMPLICATION; GENETICS; GENOTYPE ENVIRONMENT INTERACTION; IMMUNOLOGY; INFLAMMATION; METABOLISM; MIDDLE AGED; RISK FACTOR;

ADULT; ADULT SURVIVORS OF CHILD ABUSE; C-REACTIVE PROTEIN; CASE-CONTROL STUDIES; DEPRESSIVE DISORDER, MAJOR; FEMALE; GENE-ENVIRONMENT INTERACTION; GENOTYPE; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; INTERLEUKIN-6; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS;

EID: 85028715209     PISSN: 08891591     EISSN: 10902139     Source Type: Journal    
DOI: 10.1016/j.bbi.2017.08.023     Document Type: Article

References (54)

1. Amaral, P.P., Dinger, M.E., Mattick, J.S., Non-coding RNAs in homeostasis, disease and stress responses: an evolutionary perspective. Brief. Funct. Genomics 12 (2013), 254–278.
2. Barnes, J., Mondelli, V., Pariante, C.M., Genetic contributions of inflammation to depression. Neuropsychopharmacology 42 (2017), 81–98.
3. Baumeister, D., Akhtar, R., Ciufolini, S., Pariante, C., Mondelli, V., Childhood trauma and adulthood inflammation: a meta-analysis of peripheral C-reactive protein, interleukin-6 and tumour necrosis factor-α. Mol. Psychiatry 21 (2016), 642–649.
4. Benjamini, Y., Hochberg, Y., Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. R. Stat. Soc. Ser. B (Methodological), 1995, 289–300.
5. Bernstein, D.P., Stein, J.A., Newcomb, M.D., Walker, E., Pogge, D., Ahluvalia, T., Stokes, J., Handelsman, L., Medrano, M., Desmond, D., Development and validation of a brief screening version of the Childhood Trauma Questionnaire. Child Abuse Neglect 27 (2003), 169–190.
6. Bick, J., Naumova, O., Hunter, S., Barbot, B., Lee, M., Luthar, S.S., Raefski, A., Grigorenko, E.L., Childhood adversity and DNA methylation of genes involved in the hypothalamus-pituitary-adrenal axis and immune system: whole-genome and candidate-gene associations. Dev. Psychopathol. 24 (2012), 1417–1425.
7. Camara, M.L., Corrigan, F., Jaehne, E.J., Jawahar, M.C., Anscomb, H., Baune, B.T., Tumor necrosis factor alpha and its receptors in behaviour and neurobiology of adult mice, in the absence of an immune challenge. Behav. Brain Res. 290 (2015), 51–60.
8. Cohen-Woods, S., Craig, I., McGuffin, P., The current state of play on the molecular genetics of depression. Psychol. Med. 43 (2013), 673–687.
9. Culverhouse, R.C., Saccone, N.L., Horton, A.C., Ma, Y., Anstey, K.J., Banaschewski, T., Burmeister, M., Cohen-Woods, S., Etain, B., Fisher, H.L., Goldman, N., Guillaume, S., Horwood, J., Juhasz, G., Lester, K.J., Mandelli, L., Middeldorp, C.M., Olié, E., Villafuerte, S., Air, T.M., Araya, R., Bowes, L., Burns, R., Byrne, E.M., Coffey, C., Coventry, W.L., Gawronski, K.A., Glei, D., Hatzimanolis, A., Hottenga, J.J., Jaussent, I., Jawahar, C., Jennen-Steinmetz, C., Kramer, J.R., Lajnef, M., Little, K., Zu Schwabedissen, H.M., Nauck, M., Nederhof, E., Petschner, P., Peyrot, W.J., Schwahn, C., Sinnamon, G., Stacey, D., Tian, Y., Toben, C., Van der Auwera, S., Wainwright, N., Wang, J.C., Willemsen, G., Anderson, I.M., Arolt, V., Åslund, C., Bagdy, G., Baune, B.T., Bellivier, F., Boomsma, D.I., Courtet, P., Dannlowski, U., de Geus, E.J., Deakin, J.F., Easteal, S., Eley, T., Fergusson, D.M., Goate, A.M., Gonda, X., Grabe, H.J., Holzman, C., Johnson, E.O., Kennedy, M., Laucht, M., Martin, N.G., Munafò, M.R., Nilsson, K.W., Oldehinkel, A.J., Olsson, C.A., Ormel, J., Otte, C., Patton, G.C., Penninx, B.W., Ritchie, K., Sarchiapone, M., Scheid, J.M., Serretti, A., Smit, J.H., Stefanis, N.C., Surtees, P.G., Völzke, H., Weinstein, M., Whooley, M., Nurnberger, J.I. Jr., Breslau, N., Bierut, L.J., Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression. Mol. Psychiatry, 2017, 10.1038/mp.2017.44 [Epub ahead of print].
10. Danese, A., Moffitt, T.E., Pariante, C.M., Ambler, A., Poulton, R., Caspi, A., Elevated inflammation levels in depressed adults with a history of childhood maltreatment. Arch. General Psychiatry 65 (2008), 409–415.
11. Dick, D.M., Gene-environment interaction in psychological traits and disorders. Annu. Rev. Clin. Psychol. 7 (2011), 383–409.
12. Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E.K., Lanctot, K.L., A meta-analysis of cytokines in major depression. Biol. Psychiatry 67 (2010), 446–457.
13. Duncan, L.E., Pollastri, A.R., Smoller, J.W., Mind the gap: Why many geneticists and psychological scientists have discrepant views about gene–environment interaction (G×E) research. Am. Psychol., 69, 2014, 249.
14. Fagundes, C.P., Glaser, R., Kiecolt-Glaser, J.K., Stressful early life experiences and immune dysregulation across the lifespan. Brain Behav. Immun. 27 (2013), 8–12.
15. First, M.B., 1994. Diagnostic and Statistical Manual of Mental Disorders. DSM IV-4th edition. APA.
16. Fisher, H.L., Cohen-Woods, S., Hosang, G.M., Korszun, A., Owen, M., Craddock, N., Craig, I.W., Farmer, A.E., McGuffin, P., Uher, R., Interaction between specific forms of childhood maltreatment and the serotonin transporter gene (5-HTT) in recurrent depressive disorder. J. Affect. Disorders 145 (2013), 136–141.
17. Ganguly, P., Brenhouse, H.C., Broken or maladaptive? Altered trajectories in neuroinflammation and behavior after early life adversity. Dev. Cogn. Neurosci. 11 (2015), 18–30.
18. García-Ramírez, R.A., Ramírez-Venegas, A., Quintana-Carrillo, R., Camarena, Á.E., Falfán-Valencia, R., Mejía-Aranguré, J.M., TNF, IL6, and IL1B polymorphisms are associated with severe influenza A (H1N1) virus infection in the mexican population. PLoS One, 10, 2015, e0144832.
19. Goldsmith, D., Rapaport, M., Miller, B., A meta-analysis of blood cytokine network alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder and depression. Mol. Psychiatry, 2016.
20. Grosse, L., Ambrée, O., Jörgens, S., Jawahar, M.C., Singhal, G., Stacey, D., Arolt, V., Baune, B.T., Cytokine levels in major depression are related to childhood trauma but not to recent stressors. Psychoneuroendocrinology 73 (2016), 24–31.
21. Hosang, G.M., Korszun, A., Jones, L., Jones, I., McGuffin, P., Farmer, A.E., 2012. Life-event specificity: bipolar disorder compared with unipolar depression. The British J. Psychiatry bjp. bp. 112.111047.
22. Howie, B.N., Donnelly, P., Marchini, J., A flexible and accurate genotype imputation method for the next generation of genome-wide association studies. PLoS Genet., 5, 2009, e1000529.
23. Howren, M.B., Lamkin, D.M., Suls, J., Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis. Psychosom. Med. 71 (2009), 171–186.
24. Huang, X., Luo, Y.-L., Mao, Y.-S., Ji, J.-L., The link between long noncoding RNAs and depression. Prog. Neuro-Psychopharmacol. Biol. Psychiatry, 2016.
25. Karg, K., Burmeister, M., Shedden, K., Sen, S., The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: evidence of genetic moderation. Arch. Gen. Psychiatry 68 (2011), 444–454.
26. Kendler, K.S., Gardner, C.O., Interpretation of interactions: guide for the perplexed. Br. J. Psychiatry 197 (2010), 170–171.
27. Kiecolt-Glaser, J.K., Gouin, J.P., Weng, N.P., Malarkey, W.B., Beversdorf, D.Q., Glaser, R., Childhood adversity heightens the impact of later-life caregiving stress on telomere length and inflammation. Psychosom. Med. 73 (2011), 16–22.
28. Kiecolt-Glaser, J.K., Derry, H.M., Fagundes, C.P., Inflammation: depression fans the flames and feasts on the heat. Am. J. Psychiatry 172 (2015), 1075–1091.
29. Kovalchik, S.A., Varadhan, R., Fetterman, B., Poitras, N.E., Wacholder, S., Katki, H.A., A general binomial regression model to estimate standardized risk differences from binary response data. Stat. Med. 32 (2013), 808–821.
30. Lewis, C.M., Ng, M.Y., Butler, A.W., Cohen-Woods, S., Uher, R., Pirlo, K., Weale, M.E., Schosser, A., Paredes, U.M., Rivera, M., Genome-wide association study of major recurrent depression in the UK population. Am. J. Psychiatry 167 (2010), 949–957.
31. Major Depressive Disorder Working Group of the Psychiatric, G.C., Ripke, S., Wray, N.R., Lewis, C.M., Hamilton, S.P., Weissman, M.M., Breen, G., Byrne, E.M., Blackwood, D.H., Boomsma, D.I., Cichon, S., Heath, A.C., Holsboer, F., Lucae, S., Madden, P.A., Martin, N.G., McGuffin, P., Muglia, P., Noethen, M.M., Penninx, B.P., Pergadia, M.L., Potash, J.B., Rietschel, M., Lin, D., Muller-Myhsok, B., Shi, J., Steinberg, S., Grabe, H.J., Lichtenstein, P., Magnusson, P., Perlis, R.H., Preisig, M., Smoller, J.W., Stefansson, K., Uher, R., Kutalik, Z., Tansey, K.E., Teumer, A., Viktorin, A., Barnes, M.R., Bettecken, T., Binder, E.B., Breuer, R., Castro, V.M., Churchill, S.E., Coryell, W.H., Craddock, N., Craig, I.W., Czamara, D., De Geus, E.J., Degenhardt, F., Farmer, A.E., Fava, M., Frank, J., Gainer, V.S., Gallagher, P.J., Gordon, S.D., Goryachev, S., Gross, M., Guipponi, M., Henders, A.K., Herms, S., Hickie, I.B., Hoefels, S., Hoogendijk, W., Hottenga, J.J., Iosifescu, D.V., Ising, M., Jones, I., Jones, L., Jung-Ying, T., Knowles, J.A., Kohane, I.S., Kohli, M.A., Korszun, A., Landen, M., Lawson, W.B., Lewis, G., Macintyre, D., Maier, W., Mattheisen, M., McGrath, P.J., McIntosh, A., McLean, A., Middeldorp, C.M., Middleton, L., Montgomery, G.M., Murphy, S.N., Nauck, M., Nolen, W.A., Nyholt, D.R., O'Donovan, M., Oskarsson, H., Pedersen, N., Scheftner, W.A., Schulz, A., Schulze, T.G., Shyn, S.I., Sigurdsson, E., Slager, S.L., Smit, J.H., Stefansson, H., Steffens, M., Thorgeirsson, T., Tozzi, F., Treutlein, J., Uhr, M., van den Oord, E.J., Van Grootheest, G., Volzke, H., Weilburg, J.B., Willemsen, G., Zitman, F.G., Neale, B., Daly, M., Levinson, D.F., Sullivan, P.F., A mega-analysis of genome-wide association studies for major depressive disorder. Mol. Psychiatry 18 (2013), 497–511.
32. Marchini, J., Howie, B., Genotype imputation for genome-wide association studies. Nat. Rev. Genet. 11 (2010), 499–511.
33. McGuffin, P., Cohen, S., Knight, J., Homing in on depression genes. Am. J. Psychiatry 164 (2007), 195–197.
34. Miller, A.H., Raison, C.L., The role of inflammation in depression: from evolutionary imperative to modern treatment target. Nat. Rev. Immunol. 16 (2016), 22–34.
35. Mortality, G.B.D., Causes of Death, C., Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet 388 (2016), 1459–1544.
36. Nyholt, D.R., A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. Am. J. Human Genet. 74 (2004), 765–769.
37. Okada, Y., Takahashi, A., Ohmiya, H., Kumasaka, N., Kamatani, Y., Hosono, N., Tsunoda, T., Matsuda, K., Tanaka, T., Kubo, M., Genome-wide association study for C-reactive protein levels identified pleiotropic associations in the IL6 locus. Human Mol. Genet. 20 (2011), 1224–1231.
38. Pelechano, V., Steinmetz, L.M., Gene regulation by antisense transcription. Nat. Rev. Genet. 14 (2013), 880–893.
39. Power, R.A., Tansey, K.E., Buttenschøn, H.N., Cohen-Woods, S., Bigdeli, T., Hall, L.S., Kutalik, Z., Lee, S.H., Ripke, S., Steinberg, S., Genome-wide association for major depression through age at onset stratification. Biol. Psychiatry, 2016.
40. Qi, L., Zhang, C., van Dam, R.M., Hu, F.B., Interleukin-6 genetic variability and adiposity: associations in two prospective cohorts and systematic review in 26,944 individuals. J. Clin. Endocrinol. Metab. 92 (2007), 3618–3625.
41. Raison, C.L., Miller, A.H., Is depression an inflammatory disorder?. Curr. Psychiatry Rep. 13 (2011), 467–475.
42. Reiner, A.P., Barber, M.J., Guan, Y., Ridker, P.M., Lange, L.A., Chasman, D.I., Walston, J.D., Cooper, G.M., Jenny, N.S., Rieder, M.J., Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1α are associated with C-reactive protein. Am. J. Human Genet. 82 (2008), 1193–1201.
43. Ridout, K.K., Parade, S.H., Seifer, R., Price, L.H., Gelernter, J., Feliz, P., Tyrka, A.R., Interleukin 1B gene (IL1B) variation and internalizing symptoms in maltreated preschoolers. Dev. Psychopathol. 26 (2014), 1277–1287.
44. Rothman, K.J., Greenland, S., Walker, A.M., Concepts of interaction. Am. J. Epidemiol. 112 (1980), 467–470.
45. Schwartz, S., Modern epidemiologic approaches to interaction: applications to the study of genetic interactions. Institute of Medicine (US) Committee on Assessing Interactions Among Social, Behavioral, and Genetic Factors in Health, Hernandez, L.M., Blazer, D.G., (eds.) Genes, Behavior, and the Social Environment: Moving Beyond the Nature/Nurture Debate, 2006, National Academies Press, Washington D.C. US.
46. Sullivan, P.F., Neale, M.C., Kendler, K.S., Genetic epidemiology of major depression: review and meta-analysis. Am. J. Psychiatry 157 (2000), 1552–1562.
47. Tartter, M., Hammen, C., Bower, J.E., Brennan, P.A., Cole, S., Effects of chronic interpersonal stress exposure on depressive symptoms are moderated by genetic variation at IL6 and IL1β in youth. Brain Behav. Immun. 46 (2015), 104–111.
48. Thapar, A., Collishaw, S., Pine, D.S., Thapar, A.K., Depression in adolescence. Lancet 379 (2012), 1056–1067.
49. Uher, R., McGuffin, P., The moderation by the serotonin transporter gene of environmental adversity in the etiology of depression: 2009 update. Mol. Psychiatry 15 (2010), 18–22.
50. Uher, R., Perroud, N., Ng, M.Y., Hauser, J., Henigsberg, N., Maier, W., Mors, O., Placentino, A., Rietschel, M., Souery, D., Zagar, T., Czerski, P.M., Jerman, B., Larsen, E.R., Schulze, T.G., Zobel, A., Cohen-Woods, S., Pirlo, K., Butler, A.W., Muglia, P., Barnes, M.R., Lathrop, M., Farmer, A., Breen, G., Aitchison, K.J., Craig, I., Lewis, C.M., McGuffin, P., Genome-wide pharmacogenetics of antidepressant response in the GENDEP project. Am. J. Psychiatry 167 (2010), 555–564.
51. Wacholder, S., Binomial regression in GLIM: estimating risk ratios and risk differences. Am. J. Epidemiol. 123 (1986), 174–184.
52. Williams, L.M., Debattista, C., Duchemin, A.M., Schatzberg, A.F., Nemeroff, C.B., Childhood trauma predicts antidepressant response in adults with major depression: data from the randomized international study to predict optimized treatment for depression. Transl. Psychiatry, 6, 2016, e799.
53. Wing, J.K., Babor, T., Brugha, T., Burke, J., Cooper, J., Giel, R., Jablenski, A., Regier, D., Sartorius, N., SCAN: schedules fonr clinical assessment in neuropsychiatry. Arch. General Psychiatry 47 (1990), 589–593.
54. Wong, M.L., Dong, C., Maestre-Mesa, J., Licinio, J., Polymorphisms in inflammation-related genes are associated with susceptibility to major depression and antidepressant response. Mol. Psychiatry 13 (2008), 800–812.