Polymorphisms of the HNF1A Gene Encoding Hepatocyte Nuclear Factor-1α are Associated with C-Reactive Protein

American Journal of Human Genetics

Volumn 82, Issue 5, 2008, Pages 1193-1201

  Reiner, Alexander P ^a   Barber, Mathew J ^b   Guan, Yongtao ^b   Ridker, Paul M ^c   Lange, Leslie A ^d   Chasman, Daniel I ^c   Walston, Jeremy D ^e   Cooper, Gregory M ^a   Jenny, Nancy S ^f   Rieder, Mark J ^a   Durda, J Peter ^f   Smith, Joshua D ^a   Novembre, John ^b   Tracy, Russell P ^f   Rotter, Jerome I ^g   Stephens, Matthew ^b   Nickerson, Deborah A ^a   Krauss, Ronald M ^h  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^e JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^g CEDARS SINAI MEDICAL CENTER   (United States)

^h CHILDREN S HOSPITAL OAKLAND RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; HEPATOCYTE NUCLEAR FACTOR 1ALPHA;

ADULT; AGED; ARTICLE; BAYES THEOREM; CARDIOVASCULAR RISK; FEMALE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HAPLOTYPE MAP; HEPATOCYTE NUCLEAR FACTOR 1ALPHA GENE; HUMAN; HUMAN GENOME; INTRON; MALE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

AGED; BAYES THEOREM; C-REACTIVE PROTEIN; FEMALE; HEPATOCYTE NUCLEAR FACTOR 1-ALPHA; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PRAVASTATIN; SIMVASTATIN;

EID: 42749083781     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ajhg.2008.03.017     Document Type: Article

References (26)

1. Hage F.G., and Szalai A.J. C-reactive protein gene polymorphisms, C-reactive protein blood levels, and cardiovascular disease risk. J. Am. Coll. Cardiol. 50 (2007) 1115-1122
2. Pankow J.S., Folsom A.R., Cushman M., Borecki I.B., Hopkins P.N., Eckfeldt J.H., and Tracy R.P. Familial and genetic determinants of systemic markers of inflammation: the NHLBI family heart study. Atherosclerosis 154 (2001) 681-689
3. de Maat M.P., Bladbjerg E.M., Hjelmborg J.B., Bathum L., Jespersen J., and Christensen K. Genetic influence on inflammation variables in the elderly. Arterioscler. Thromb. Vasc. Biol. 24 (2004) 2168-2173
4. Simon J.A., Lin F., Hulley S.B., Blanche P.J., Waters D., Shiboski S., Rotter J.I., Nickerson D.A., Yang H., Saad M., et al. Phenotypic predictors of response to simvastatin therapy among African-Americans and Caucasians: the Cholesterol and Pharmacogenetics (CAP) Study. Am. J. Cardiol. 97 (2006) 843-850
5. Albert M.A., Danielson E., Rifai N., Ridker P.M., and PRINCE Investigators. Effect of statin therapy on C-reactive protein levels: the pravastatin inflammation/CRP evaluation (PRINCE): a randomized trial and cohort study. JAMA 286 (2001) 64-70
6. Roberts W.L., Molton L., Law T.C., Farrow G., Cooper-Anderson M., Savory J., and Rifai N. Evaluation of nine automated high sensitivity C-reactive protein methods: implications for clinical and epidemiological application, part 2. Clin. Chem. 47 (2001) 418-425
7. Servin B., and Stephens M. Imputation-based analysis of association studies: candidate regions and quantitative traits. PLoS Genet 3 (2007) e114
8. The Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447 (2007) 661-678
9. Price A.L., Patterson N.J., Plenge R.M., Weinblatt M.E., Shadick N.A., and Reich D. Principal components analysis corrects for stratification in genome-wide association studies. Nat. Genet. 38 (2006) 904-919
10. Fried L.P., Borhani N.O., Enright P., Furberg C.D., Gardin J.M., Kronmal R.A., Kuller L.H., Manolio T.M., Mittelmark M.B., Newman A., et al. The cardiovascular health study: Design and rationale. Ann. Epidemiol. 1 (1991) 263-276
11. Lange L.A., Reiner A.P., Carty C.A., Jenny N.S., Cushman M., and Lange E.M. Common genetic determinants of plasma fibrin D-dimer concentration in older European- and African-American adults. J. Thromb. Haemost. 6 (2008) 654-659
12. Macy E.M., Hayes T.E., and Tracy R.P. Variability in the measurement of C-reactive protein in healthy subjects: implications for reference intervals and epidemiologic applications. Clin. Chem. 43 (1997) 52-58
13. Chasman D.I., Kozlowski P., Zee R.Y., Kwiatkowski D.J., and Ridker P.M. Qualitative and quantitative effects of APOE genetic variation on plasma C-reactive protein, LDL-cholesterol, and apoE protein. Genes Immun. 7 (2006) 211-219
14. Austin M.A., Zhang C., Humphries S.E., Chandler W.L., Talmud P.J., Edwards K.L., Leonetti D.L., McNeely M.J., and Fujimoto W.Y. Heritability of C-reactive protein and association with apolipoprotein E genotypes in Japanese Americans. Ann. Hum. Genet. 68 (2004) 179-188
15. Agrawal A., Samols D., and Kushner I. Transcription factor c-Rel enhances C-reactive protein expression by facilitating the binding of C/EBPbeta to the promoter. Mol. Immunol. 40 (2003) 373-380
16. Li S.P., and Goldman N.D. Regulation of human C-reactive protein gene expression by two synergistic IL-6 responsive elements. Biochemistry 35 (1996) 9060-9068
17. Voleti B., and Agrawal A. Regulation of basal and induced expression of C-reactive protein through an overlapping element for OCT-1 and NF-kappaB on the proximal promoter. J. Immunol. 175 (2005) 3386-3390
18. Ridker P.M., Pare G., Parker A., Zee Y.L., Danik J.S., Buring J.E., Kwiatkowski D., Cook N.R., Miletich J.P., and Chasman D.I. Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma c-reactive protein: The women's genome health study. Am. J. Hum. Genet. 82 (2008) 1185-1192 this issue
19. Saxena R., Voight B.F., Lyssenko V., Burtt N.P., de Bakker P.I., Chen H., Roix J.J., Kathiresan S., Hirschhorn J.N., Daly M.J., et al. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 316 (2007) 1331-1336
20. Sagen J.V., Odili S., Bjørkhaug L., Zelent D., Buettger C., Kwagh J., Stanley C., Dahl-Jørgensen K., de Beaufort C., Bell G.I., et al. From clinicogenetic studies of maturity-onset diabetes of the young to unraveling complex mechanisms of glucokinase regulation. Diabetes 55 (2006) 1713-1722
21. Holmkvist J., Cervin C., Lyssenko V., Winckler W., Anevski D., Cilio C., Almgren P., Berglund G., Nilsson P., Tuomi T., et al. Common variants in HNF-1 alpha and risk of type 2 diabetes. Diabetologia 49 (2006) 2882-2891
22. Zhang Y.Y., Gottardo L., Mlynarski W., Frazier W., Nolan D., Duffy J., Marescotti M.C., Gervino E.V., Johnstone M.T., Mantzoros C.S., et al. Genetic variability at the leptin receptor (LEPR) locus is a determinant of plasma fibrinogen and C-reactive protein levels. Atherosclerosis 191 (2007) 121-127
23. Lange L.A., Carlson C.S., Hindorff L.A., Lange E.M., Walston J., Durda J.P., Cushman M., Bis J.C., Zeng D., Lin D., et al. Association of polymorphisms in the CRP gene with circulating C-reactive protein levels and cardiovascular events. JAMA 296 (2006) 2703-2711
24. Timpson N.J., Lawlor D.A., Harbord R.M., Gaunt T.R., Day I.N., Palmer L.J., Hattersley A.T., Ebrahim S., Lowe G.D., Rumley A., et al. C-reactive protein and its role in metabolic syndrome: mendelian randomization study. Lancet 366 (2005) 1954-1959
25. Carlson C.S., Eberle M.A., Rieder M.J., Yi Q., Kruglyak L., and Nickerson D.A. Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium. Am. J. Hum. Genet. 74 (2004) 106-120
26. Schaid D.J., Rowland C.M., Tines D.E., Jacobson R.M., and Poland G.A. Score tests for association between traits and haplotypes when linkage phase is ambiguous. Am. J. Hum. Genet. 70 (2002) 425-434