Deficiency in milk fat globule-epidermal growth factor-factor 8 exacerbates organ injury and mortality in neonatal sepsis

Journal of Pediatric Surgery

Volumn 52, Issue 9, 2017, Pages 1520-1527

  Hansen, Laura W ^a   Khader, Adam ^a   Yang, Weng Lang ^a,b   Jacob, Asha ^a,b   Chen, Tracy ^b   Nicastro, Jeffrey M ^a   Coppa, Gene F ^a   Prince, Jose M ^a,b   Wang, Ping ^a,b  

^a DONALD AND BARBARA ZUCKER SCHOOL OF MEDICINE AT HOFSTRA NORTHWELL   (United States)

^b FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH   (United States)

Author keywords

Cytokines; Lung injury; MFG E8; MIP 2; Neonatal sepsis

Indexed keywords

LACTADHERIN; MYELOPEROXIDASE; TUMOR NECROSIS FACTOR; GLYCOLIPID; GLYCOPROTEIN; MEMBRANE ANTIGEN; MFGE8 PROTEIN, HUMAN; MILK FAT GLOBULE; MILK PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BLOOD; CONTROLLED STUDY; DISEASE EXACERBATION; ENZYME ACTIVITY; FEMALE; HISTOLOGY; INTESTINE TISSUE; LUNG; LUNG INJURY; MALE; MORTALITY RATE; MOTHER; MOUSE; NEUTROPHIL; NEWBORN; NEWBORN MORTALITY; NEWBORN SEPSIS; NONHUMAN; ORGAN INJURY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DEFICIENCY; REAL TIME POLYMERASE CHAIN REACTION; SURVIVAL RATE; TISSUE SECTION; TUNEL ASSAY; ANIMAL; DISEASE MODEL; INFLAMMATION; INTRAVENOUS DRUG ADMINISTRATION; METABOLISM;

ANIMALS; ANIMALS, NEWBORN; ANTIGENS, SURFACE; DISEASE MODELS, ANIMAL; FEMALE; GLYCOLIPIDS; GLYCOPROTEINS; INFLAMMATION; INJECTIONS, INTRAVENOUS; MALE; MICE; MILK PROTEINS; NEONATAL SEPSIS;

EID: 85028704694     PISSN: 00223468     EISSN: 15315037     Source Type: Journal    
DOI: 10.1016/j.jpedsurg.2016.12.022     Document Type: Article

References (32)

1. Simonsen, K.A., Anderson-Berry, A.L., Delair, S.F., et al. Early-onset neonatal sepsis. Clin Microbiol Rev 27 (2014), 21–47.
2. Lawn, J.E., Cousens, S., Zupan, J., et al. 4 million neonatal deaths: when? Where? Why?. Lancet 365 (2005), 891–900.
3. Machado, J.R., Soave, D.F., da Silva, M.V., et al. Neonatal sepsis and inflammatory mediators. Mediators Inflamm, 2014, 2014, 269681.
4. Ganesan, P., Shanmugam, P., Sattar, S.B., et al. Evaluation of IL-6, CRP and hs-CRP as early markers of neonatal sepsis. J Clin Diagn Res 10 (2016), DC13–DC17.
5. Lusyati, S., Hulzebos, C.V., Zandvoort, J., et al. Cytokines patterns in newborn infants with late onset sepsis. J Neonatal Perinat Med 6 (2013), 153–163.
6. Silveira, R.C., Procianoy, R.S., Evaluation of interleukin-6, tumour necrosis factor-alpha and interleukin-1beta for early diagnosis of neonatal sepsis. Acta Paediatr 88 (1999), 647–650.
7. Hanayama, R., Tanaka, M., Miwa, K., et al. Identification of a factor that links apoptotic cells to phagocytes. Nature 417 (2002), 182–187.
8. Hanayama, R., Miyasaka, K., Nakaya, M., et al. MFG-E8-dependent clearance of apoptotic cells, and autoimmunity caused by its failure. Curr Dir Autoimmun 9 (2006), 162–172.
9. Somersan, S., Bhardwaj, N., Tethering and tickling: a new role for the phosphatidylserine receptor. J Cell Biol 155 (2001), 501–504.
10. Akakura, S., Singh, S., Spataro, M., et al. The opsonin MFG-E8 is a ligand for the alphavbeta5 integrin and triggers DOCK180-dependent Rac1 activation for the phagocytosis of apoptotic cells. Exp Cell Res 292 (2004), 403–416.
11. Albert, M.L., Kim, J.I., Birge, R.B., alphavbeta5 integrin recruits the CrkII-Dock180-rac1 complex for phagocytosis of apoptotic cells. Nat Cell Biol 2 (2000), 899–905.
12. Bu, H.F., Zuo, X.L., Wang, X., et al. Milk fat globule-EGF factor 8/lactadherin plays a crucial role in maintenance and repair of murine intestinal epithelium. J Clin Invest 117 (2007), 3673–3683.
13. Miksa, M., Wu, R., Dong, W., et al. Dendritic cell-derived exosomes containing milk fat globule epidermal growth factor-factor VIII attenuate proinflammatory responses in sepsis. Shock 25 (2006), 586–593.
14. Asano, K., Miwa, M., Miwa, K., et al. Masking of phosphatidylserine inhibits apoptotic cell engulfment and induces autoantibody production in mice. J Exp Med 200 (2004), 459–467.
15. Yamaguchi, H., Takagi, J., Miyamae, T., et al. Milk fat globule EGF factor 8 in the serum of human patients of systemic lupus erythematosus. J Leukoc Biol 83 (2008), 1300–1307.
16. Ait-Oufella, H., Kinugawa, K., Zoll, J., et al. Lactadherin deficiency leads to apoptotic cell accumulation and accelerated atherosclerosis in mice. Circulation 115 (2007), 2168–2177.
17. Aziz, M.M., Ishihara, S., Mishima, Y., et al. MFG-E8 attenuates intestinal inflammation in murine experimental colitis by modulating osteopontin-dependent alphavbeta3 integrin signaling. J Immunol 182 (2009), 7222–7232.
18. Miksa, M., Wu, R., Dong, W., et al. Immature dendritic cell-derived exosomes rescue septic animals via milk fat globule epidermal growth factor-factor VIII [corrected]. J Immunol 183 (2009), 5983–5990.
19. Thorp, E., Tabas, I., Mechanisms and consequences of efferocytosis in advanced atherosclerosis. J Leukoc Biol 86 (2009), 1089–1095.
20. Cuenca, A.G., Wynn, J.L., Moldawer, L.L., et al. Role of innate immunity in neonatal infection. Am J Perinatol 30 (2013), 105–112.
21. Cui, T., Miksa, M., Wu, R., et al. Milk fat globule epidermal growth factor 8 attenuates acute lung injury in mice after intestinal ischemia and reperfusion. Am J Respir Crit Care Med 181 (2010), 238–246.
22. Wynn, J.L., Scumpia, P.O., Delano, M.J., et al. Increased mortality and altered immunity in neonatal sepsis produced by generalized peritonitis. Shock 28 (2007), 675–683.
23. Matute-Bello, G., Downey, G., Moore, B.B., et al. An official American Thoracic Society workshop report: features and measurements of experimental acute lung injury in animals. Am J Respir Cell Mol Biol 44 (2011), 725–738.
24. Feinman, R., Deitch, E.A., Watkins, A.C., et al. HIF-1 mediates pathogenic inflammatory responses to intestinal ischemia–reperfusion injury. Am J Physiol Gastrointest Liver Physiol 299 (2010), G833–G843.
25. Aziz, M., Matsuda, A., Yang, W.L., et al. Milk fat globule-epidermal growth factor-factor 8 attenuates neutrophil infiltration in acute lung injury via modulation of CXCR2. J Immunol 189 (2012), 393–402.
26. Horton, M.A., The alpha v beta 3 integrin “vitronectin receptor”. Int J Biochem Cell Biol 29 (1997), 721–725.
27. Matsuo, S., Yang, W.L., Aziz, M., et al. Cyclic arginine-glycine-aspartate attenuates acute lung injury in mice after intestinal ischemia/reperfusion. Crit Care, 17, 2013, R19.
28. Aziz, M., Jacob, A., Matsuda, A., et al. Pre-treatment of recombinant mouse MFG-E8 downregulates LPS-induced TNF-alpha production in macrophages via STAT3-mediated SOCS3 activation. PLoS One, 6, 2011, e27685.
29. Levy, O., Innate immunity of the newborn: basic mechanisms and clinical correlates. Nat Rev Immunol 7 (2007), 379–390.
30. Kollmann, T.R., Crabtree, J., Rein-Weston, A., et al. Neonatal innate TLR-mediated responses are distinct from those of adults. J Immunol 183 (2009), 7150–7160.
31. Angelone, D.F., Wessels, M.R., Coughlin, M., et al. Innate immunity of the human newborn is polarized toward a high ratio of IL-6/TNF-alpha production in vitro and in vivo. Pediatr Res 60 (2006), 205–209.
32. Zhao, J., Kim, K.D., Yang, X., et al. Hyper innate responses in neonates lead to increased morbidity and mortality after infection. Proc Natl Acad Sci U S A 105 (2008), 7528–7533.