Cytokines patterns in newborn infants with late onset sepsis

Journal of Neonatal-Perinatal Medicine

Volumn 6, Issue 2, 2013, Pages 153-163

  Lusyati, S ^a,b   Hulzebos, C V ^b   Zandvoort, J ^b   Sukandar, H ^c   Sauer, P J J ^b  

^a Women and Children's Harapan Kita Hospital   (Indonesia)

^b UNIVERSITY OF GRONINGEN   (Netherlands)

^c PADJADJARAN UNIVERSITY   (Indonesia)

Author keywords

chemokines; cytokines; late onset sepsis; Neonates

Indexed keywords

CYTOKINE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 15; INTERLEUKIN 1BETA; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 6; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; DIAGNOSTIC VALUE; FEASIBILITY STUDY; FEMALE; HUMAN; INDONESIA; LATE ONSET SEPSIS; MALE; NEWBORN; NEWBORN SEPSIS; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; RECEIVER OPERATING CHARACTERISTIC; SENSITIVITY AND SPECIFICITY; CASE CONTROL STUDY; EVALUATION STUDY; METABOLISM; SEPSIS;

CASE-CONTROL STUDIES; CYTOKINES; FEASIBILITY STUDIES; FEMALE; HUMANS; INFANT, NEWBORN; MALE; PROSPECTIVE STUDIES; ROC CURVE; SENSITIVITY AND SPECIFICITY; SEPSIS;

EID: 84882364657     PISSN: 19345798     EISSN: 18784429     Source Type: Journal    
DOI: 10.3233/NPM-1364112     Document Type: Article

References (38)

1. Stoll BJ, Hansen N, Fanaroff AA, et al. Late onset sepsis in very low birth weight neonates: The experience of the NICHD-Neonatal Research Network. Pediatrics 2002;110(2):285-91.
2. Kementrian Negara Pembangunan Nasional Indonesia/Bappenas. Child Mortality, Indonesia Millennium Developmental Goal Reports. Jakarta, Indonesia, 2007, pp. 49-54.
3. Lusyati S, v.d Broek, Sauer PJ. Neonatal sepsis in a NICU of Indonesia. J Hosp Infect 2009;71(4):383-5.
4. Zaidi AK, Huskins WC, Thaver D, et al. Hospitalacquired neonatal infections in developing countries. Lancet 2005;365:1175-88.
5. Oygur N, Kavuncuoglu S, Ozbek S, et al. Nosocomial infections in neonatal units in Turkey: Epidemiology, problems, unit policies and opinions of healthcare workers. Turk J Pediatr 2010;52(1):50-7.
6. Vergnano S, Menson E,Kennea N, et al. Neonatal infections in England: The Neonatal Infection surveillance network. Arch Dis Child Fetal Neonatal Ed 2011;96(1):F9-14.
7. Bekhof J, Reitsma JB,Kok JH, van Straaten IH. Clinical signs to identify late-onset sepsis in preterm infants. Eur J Pediatr 2013;172(4):501-8. doi: 10.1007/s00431-012-1910-6. Epub 2012 Dec 28.
8. Leante-Castellanos JL, Lloreda-García JM, Garćia- Gonźalez A, et al. Central-peripheral temperature gradient: An early diagnostic sign of late-onset neonatal sepsis in very low birth weight infants. J Perinat Med 2012;40(5):571-6.
9. Hornik CP, Benjamin DK, Becker KC, et al. Use of the complete blood cell count in late-onset neonatal sepsis. Pediatr Infect Dis J 2012;31(8):803-7.
10. Garland and Bowmann. Reappraisal of C-reactive protein as a screening tool for neonatal sepsis. Pathology 2003;35:240-3.
11. Auriti C, Fiscarelli E, Ronchetti MP, et al. Procalcitonin in detecting neonatal nosocomial sepsis. Arch Dis Child Fetal Neonatal Ed 2011;(15).
12. Wu TW, Tabangin M, Kusano R, et al. The utility of serum hepcidin as a biomarker for late-onset neonatal sepsis. J Pediatr 2013;162(1):67-71.
13. Blackwell TS, Christman JW. Sepsis and Cytokines: Current status. B J Anesth 1996;77:110-17.
14. Romagnoli C, Frezza S, Cingolani A, et al. Plasma Levels of Interleukin-6 and Interleukin-10 in Preterm Neonates Evaluated for Sepsis. Eur J Pediatr 2001;160:345-50.
15. De Bont, Martens A, van Raan S, et al. TNF, IL-1b and IL-6 Plasma Levels in Neonatal Sepsis. Pediatric Res 1992; 380-3.
16. Dollner H, Vatten L, Austgullen R. Early Diagnostic Markers for Neonatal Sepsis: Comparing C-reactive protein, IL-6, soluble tumor necrosis factor receptors and soluble adhesion molecules. J Clin Epidemiol 2001:1251-7.
17. Ng PC, Li K, Chui KM, et al. IP-10 is an Early Diagnostic Marker for Identification of Late Onset Bacterial Infection in Preterm Infants. Pediatric Res 2007;61:93-8.
18. Ng PC, Li K, Wong RP, et al. Pro inflammatory and anti inflammatory cytokine responses in preterm infants with systemic infections. Arch Dis Child Fetal Neonatal Ed 2003;88:F209-13.
19. Buck C, Bundschu J, Gallati H, Bartmann P, Pohlandt F. Interleukin 6: A Sensitive Parameter for the Early Diagnosis of Neonatal Bacteria Infection. Pediatrics 1994;93:54-8.
20. Panero A, Pacifico L, Rossi N, et al. Interleukin-6 in neonates with early and late onset infection. Pediatr Infect Dis J 1997; 16(4):370-5.
21. Groll AH, Meiser A, Weise M, et al. Interleukin-6 as early mediator in neonatal sepsis. Pediatr Infect Dis J 1992;11(6): 496-8.
22. Ng PC, Chui KM, Fok TF, et al. Diagnosis of late onset neonatal sepsis with cytokines, adhesion molecules, and C-reactive protein in preterm very lowbirth weight infant. Arch Dis Child 1997;77:221-7.
23. Raynor LL, Saucerman JJ, Akinola MO, et al. Cytokine screening identifies NICU patients with Gram-negative bacteremia. Pediatr Res 2012;71(3):261-6.
24. Zeitoun AA, Gad SS, Attia FM, Abu Maziad AS, Bell EF. Evaluation of neutrophilic CD64, interleukin 10 and procalcitonin as diagnostic markers of early-and late-onset neonatal sepsis. Scand J Infect Dis 2010;42(4):299-305.
25. Hotoura E, Giapros V, Kostoula A, Spyrou P, Andronikou S. Pre-inflammatory mediators and lymphocyte subpopulations in preterm neonates with sepsis. Inflammation 2012;35(3):1094-101.
26. Maciolek VM, Thijsen SF, Hemels M, et al. Inflammatory mediators for the Diagnosis and Treatment of Sepsis in Early Infancy. Pediatric Res 2006;59:457-61.
27. Hotoura E, GiaprosV,Kostoula A. Tracking Changes of Lymphocyte Subsets and Pre-inflammatory Mediators in Full-term Neonates with Suspected or Documented Infection. Scand J Immunol 2011;73:250-5.
28. Harris MC, Carl T, Gallagher P, et al. Cytokine elaboration in Critically Infants with Bacterial Sepsis, NEC, or Sepsis Syndrome: Correlation with Clinical Parameters of Inflammation and Mortality. J Pediatr 2005;147:462-8.
29. Martin C, Boisson C, Haccoun M, Tomachot L, Mege JL. Patterns of cytokine evolution (tumor necrosis factor alpha and interleukin -6) after septic shock, hemorrhagic shock and severe trauma. Crit Care Med 1997;25:1813-9.
30. Gonzales BE, Mercado CK, Johnson L, Brodsky NL, Bhandari V. Early markers of late onset sepsis in premature neonates: Clinical, hematological and cytokine profile. J Perinat Med 2003;31:60-8
31. Girardin EP, Berner ME, Grau GE, et al. Serum tumor necrosis factor in newborns at risk for infections. Eur J Pediatr 1990;149(9):645-7.
32. Sharma R, Tepas JJ, Hudak ML, et al. Neonatal gut barrier and multiple organ failure: Role of endotoxin and pro inflammatory cytokines in sepsis and necrotizing enterocolitis. J Pediatr Surg 2007;42(3):454-61.
33. Curfs JH, Meis JF and Korstanje H. A primer on cytokines: Sources, receptors, effect and inducers. Clin Microbiol Rev 1997;10(4):742-80.
34. Luster AD. Chemokine's-chemotactic cytokines that mediate inflammation. N Engl J Med 1998;338:436-45.
35. Fotopoulos S, Mouchtouri A, Xanthou G, et al. Inflammatory chemokine expression in the peripheral blood of neonates with perinatal asphyxia and perinatal or nosocomial infection. Acta Pediatr 2005;94(6):800-6
36. Fehniger TA, Caligiuri MA. Interleukin 15: Biology and relevance to human disease. Blood 2001;97:14-32.
37. De Rham C, Sylvie Ferrari-Lacraz, Jendly S, et al. The pro inflammatory cytokines IL-2, IL-15, IL-21 modulate the repertoire of mature human natural killer cell receptors. Arthritis Res Ther 2007;9(6):1-15.
38. Jordan JA, Durso MB. Comparison of 16S rRNA gene PCR and BACTEC 9240 for detection of neonatal bacteremia. J Clin Microbiol 2000;38(7):2574-8.