Genetic analysis in UK Biobank links insulin resistance and transendothelial migration pathways to coronary artery disease

Nature Genetics

Volumn 49, Issue 9, 2017, Pages 1392-1397

  Klarin, Derek ^a,b   Zhu, Qiuyu Martin ^a,b   Emdin, Connor A ^a,b   Chaffin, Mark ^a,b   Horner, Steven ^b   McMillan, Brian J ^b   Leed, Alison ^b   Weale, Michael E ^c   Spencer, Chris C A ^c   Aguet, François ^b   Segrè, Ayellet V ^b   Ardlie, Kristin G ^b   Khera, Amit V ^a,b   Kaushik, Virendar K ^b   Natarajan, Pradeep ^a,b   Kathiresan, Sekar ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c Genomics PLC   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; INSULIN; ARHGEF26 PROTEIN, HUMAN; CARRIER PROTEIN; CCDC92 PROTEIN, HUMAN; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR;

ADULT; ARTICLE; BIOBANK; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DNA SEQUENCE; FEMALE; GENE LOCUS; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENOME-WIDE ASSOCIATION STUDY; HUMAN; INSULIN RESISTANCE; LEUKOCYTE MIGRATION; MAJOR CLINICAL STUDY; MALE; META ANALYSIS; PRIORITY JOURNAL; TRANSENDOTHELIAL AND TRANSEPITHELIAL MIGRATION; UNITED KINGDOM; AGED; CELL CULTURE; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; HEK293 CELL LINE; LEUKOCYTE ROLLING; MEDICAL INFORMATION SYSTEM; METABOLISM; MIDDLE AGED; PATHOLOGY; PHENOTYPE; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL MODEL; UMBILICAL VEIN ENDOTHELIAL CELL;

ADULT; AGED; CARRIER PROTEINS; CELLS, CULTURED; CORONARY ARTERY DISEASE; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HEALTH INFORMATION SYSTEMS; HEK293 CELLS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INSULIN RESISTANCE; LEUKOCYTE ROLLING; LOGISTIC MODELS; MALE; MIDDLE AGED; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; RHO GUANINE NUCLEOTIDE EXCHANGE FACTORS; TRANSENDOTHELIAL AND TRANSEPITHELIAL MIGRATION; UNITED KINGDOM;

EID: 85028691716     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.3914     Document Type: Article

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