LOX mutations predispose to thoracic aortic aneurysms and dissections

Circulation Research

Volumn 118, Issue 6, 2016, Pages 928-934

  Guo, Dong Chuan ^a   Regalado, Ellen S ^a   Gong, Limin ^a   Duan, Xueyan ^a   Santos Cortez, Regie Lyn P ^c   Arnaud, Pauline ^d   Ren, Zhao ^a   Cai, Bo ^a   Hostetler, Ellen M ^a   Moran, Rocio ^e   Liang, David ^f   Estrera, Anthony ^b   Safi, Hazim J ^b   Leal, Suzanne M ^c   Bamshad, Michael J ^g   Shendure, Jay ^g   Nickerson, Deborah A ^g   Jondeau, Guillaume ^d   Boileau, Catherine ^d   Milewicz, Dianna M ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

^d BICHAT HOSPITAL   (France)

^e METROHEALTH MEDICAL CENTER   (United States)

^f STANFORD UNIVERSITY MEDICAL CENTER   (United States)

^g UNIVERSITY OF WASHINGTON   (United States)

Author keywords

aortic aneurysm; aortic diseases; exome; mutation

Indexed keywords

AMINO ACID; DNA; HYDROGEN PEROXIDE; LOX PROTEIN; PROTEIN; PROTEIN LYSINE 6 OXIDASE; UNCLASSIFIED DRUG;

ADULT; AMINO ACID SEQUENCE; AORTA ANEURYSM; AORTA DISSECTION; AORTA VALVE REPLACEMENT; AORTIC ROOT ANEURYSM; AORTIC VALVE REPAIR; ARTICLE; ASCENDING AORTA SURGERY; AUTOSOMAL DOMINANT INHERITANCE; BICUSPID AORTIC VALVE; CLINICAL FEATURE; CONTROLLED STUDY; CORONARY ARTERY BYPASS GRAFT; CORONARY ARTERY DISEASE; DISEASE SEVERITY; DURAL ECTASIA; ENZYME ACTIVE SITE; ENZYME ACTIVITY; EXOME; FEMALE; GENE FREQUENCY; GENE MUTATION; GENETIC VARIABILITY; GLYCOSYLATION; HAPLOINSUFFICIENCY; HEART LEFT VENTRICLE HYPERTROPHY; HELA CELL LINE; HETEROZYGOTE; HUMAN; HUMAN CELL; IMMUNOBLOTTING; INCIDENTAL FINDING; JOINT LAXITY; MALE; MARFAN SYNDROME; MIDDLE AGED; MITRAL VALVE REGURGITATION; MOLECULAR WEIGHT; NONSENSE MEDIATED MRNA DECAY; PHYSICAL EXAMINATION; PRIORITY JOURNAL; STRIA; THORACIC AORTIC ANEURYSM; AGED; ANEURYSM, DISSECTING; AORTIC ANEURYSM, THORACIC; GENETIC VARIATION; GENETICS; MOLECULAR GENETICS; MUTATION; PEDIGREE;

ADULT; AGED; AMINO ACID SEQUENCE; ANEURYSM, DISSECTING; AORTIC ANEURYSM, THORACIC; FEMALE; GENETIC VARIATION; HUMANS; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MUTATION; PEDIGREE; PROTEIN-LYSINE 6-OXIDASE;

EID: 84954424738     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.115.307130     Document Type: Article

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