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Volumn 16, Issue 7, 2017, Pages 781-788

Granulocyte colony-stimulating factor attenuates blood-brain barrier damage and improves cognitive function in spontaneously hypertensive rats

Author keywords

Astrogliosis; Blood brain barrier damage; Cerebral small vessel disease; Cognitive impairment; Granulocyte colony stimulating factor; IgG; Spontaneously hypertensive rats

Indexed keywords

AQUAPORIN 4; CLAUDIN 5; GLIAL FIBRILLARY ACIDIC PROTEIN; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR RECEPTOR; IMMUNOGLOBULIN G; GRANULOCYTE COLONY STIMULATING FACTOR RECEPTOR; NEUROPROTECTIVE AGENT;

EID: 85028622662     PISSN: 18715273     EISSN: 19963181     Source Type: Journal    
DOI: 10.2174/1871527316666170207155730     Document Type: Article
Times cited : (9)

References (51)
  • 1
    • 84956783783 scopus 로고    scopus 로고
    • Cerebral small vessel disease, cognitive reserve and cognitive dysfunction
    • Pinter D, Enzinger C, Fazekas F. Cerebral small vessel disease, cognitive reserve and cognitive dysfunction. J Neurol 2015; 262: 2411-9.
    • (2015) J Neurol , vol.262 , pp. 2411-2419
    • Pinter, D.1    Enzinger, C.2    Fazekas, F.3
  • 2
    • 84937406989 scopus 로고    scopus 로고
    • S100B and ADMA in cerebral small vessel disease and cognitive dysfunction
    • Gao Q, Fan Y, Mu LY, Ma L, Song ZQ, Zhang YN. S100B and ADMA in cerebral small vessel disease and cognitive dysfunction. J Neurol Sci 2015; 354(1): 27-32.
    • (2015) J Neurol Sci , vol.354 , Issue.1 , pp. 27-32
    • Gao, Q.1    Fan, Y.2    Mu, L.Y.3    Ma, L.4    Song, Z.Q.5    Zhang, Y.N.6
  • 3
    • 84945900841 scopus 로고    scopus 로고
    • Cerebral small vessel disease and Alzheimer’s disease
    • Cai Z, Wang C, He W, et al. Cerebral small vessel disease and Alzheimer’s disease. Clin Interv Aging 2015; 10: 1695-704.
    • (2015) Clin Interv Aging , vol.10 , pp. 1695-1704
    • Cai, Z.1    Wang, C.2    He, W.3
  • 4
    • 84961374240 scopus 로고    scopus 로고
    • Cerebral small vessel disease: Capillary pathways to stroke and cognitive decline
    • Østergaard L, Engedal TS, Moreton F, et al. Cerebral small vessel disease: capillary pathways to stroke and cognitive decline. J Cereb Blood Flow Metab 2016; 36: 302-25.
    • (2016) J Cereb Blood Flow Metab , vol.36 , pp. 302-325
    • Østergaard, L.1    Engedal, T.S.2    Moreton, F.3
  • 5
    • 80054841804 scopus 로고    scopus 로고
    • Kidney pathology precedes and predicts the pathological cascade of cerebrovascular lesions in stroke prone rats
    • Schreiber S, Bueche CZ, Garz C, et al. Kidney pathology precedes and predicts the pathological cascade of cerebrovascular lesions in stroke prone rats. Plos One 2011; 6: e26287.
    • (2011) Plos One , vol.6
    • Schreiber, S.1    Bueche, C.Z.2    Garz, C.3
  • 6
    • 76549093011 scopus 로고    scopus 로고
    • Blood-brain barrier permeability is increased in normal-appearing white matter in patients with lacunar stroke and leucoaraiosis
    • Topakian R, Barrick TR, Howe FA, Markus HS. Blood-brain barrier permeability is increased in normal-appearing white matter in patients with lacunar stroke and leucoaraiosis. J Neurol Neurosurg Psychiatry 2010; 81: 192-7.
    • (2010) J Neurol Neurosurg Psychiatry , vol.81 , pp. 192-197
    • Topakian, R.1    Barrick, T.R.2    Howe, F.A.3    Markus, H.S.4
  • 7
    • 84870433281 scopus 로고    scopus 로고
    • Anti-endothelial cell antibodies in patients with cerebral small vessel disease
    • Kimura A, Sakurai T, Yamada M, et al. Anti-endothelial cell antibodies in patients with cerebral small vessel disease. Curr Neurovasc Res 2012; 9: 296-301.
    • (2012) Curr Neurovasc Res , vol.9 , pp. 296-301
    • Kimura, A.1    Sakurai, T.2    Yamada, M.3
  • 8
    • 84875900830 scopus 로고    scopus 로고
    • Blood brain barrier breakdown as the starting point of cerebral small vessel disease?. New insights from a rat model
    • Schreiber S, Bueche CZ, Garz C, Braun H. Blood brain barrier breakdown as the starting point of cerebral small vessel disease?. New insights from a rat model. Exp Transl Stroke Med 2013; 5(1): 4.
    • (2013) Exp Transl Stroke Med , vol.5 , Issue.1 , pp. 4
    • Schreiber, S.1    Bueche, C.Z.2    Garz, C.3    Braun, H.4
  • 9
    • 84923370285 scopus 로고    scopus 로고
    • Endothelial cells and human cerebral small vessel disease
    • Hainsworth AH, Oommen AT, Bridges LR. Endothelial cells and human cerebral small vessel disease. Brain Pathol 2015; 25: 44-50.
    • (2015) Brain Pathol , vol.25 , pp. 44-50
    • Hainsworth, A.H.1    Oommen, A.T.2    Bridges, L.R.3
  • 10
    • 84920596641 scopus 로고    scopus 로고
    • Interplay between age, cerebral small vessel disease, parenchymal amyloid-β, and tau pathology: Longitudinal studies in hypertensive stroke-prone rats
    • Schreiber S, Drukarch B, Garz C, et al. Interplay between age, cerebral small vessel disease, parenchymal amyloid-β, and tau pathology: longitudinal studies in hypertensive stroke-prone rats. J Alzheimers Dis 2014; 42 (Suppl 3): 205-15.
    • (2014) J Alzheimers Dis , vol.42 , pp. 205-215
    • Schreiber, S.1    Drukarch, B.2    Garz, C.3
  • 11
    • 84876488222 scopus 로고    scopus 로고
    • Mechanisms of sporadic cerebral small vessel disease: Insights from neuroimaging
    • Wardlaw JM, Smith C, Dichgans M. Mechanisms of sporadic cerebral small vessel disease: Insights from neuroimaging. Lancet Neurol 2013; 12: 483-97.
    • (2013) Lancet Neurol , vol.12 , pp. 483-497
    • Wardlaw, J.M.1    Smith, C.2    Dichgans, M.3
  • 12
    • 62549145764 scopus 로고    scopus 로고
    • Lacunar stroke is associated with diffuse blood-brain barrier dysfunction
    • Wardlaw JM, Doubal F, Armitage P, et al. Lacunar stroke is associated with diffuse blood-brain barrier dysfunction. Ann Neurol 2009; 65: 194-202.
    • (2009) Ann Neurol , vol.65 , pp. 194-202
    • Wardlaw, J.M.1    Doubal, F.2    Armitage, P.3
  • 13
    • 84916224368 scopus 로고    scopus 로고
    • Blood-brain barrier dysfunction and cerebral small vessel disease (Arteriolosclerosis) in brains of older people
    • Bridges LR, Andoh J, Lawrence AJ, et al. Blood-brain barrier dysfunction and cerebral small vessel disease (arteriolosclerosis) in brains of older people. J Neuropathol Exp Neurol 2014; 73: 1026-33.
    • (2014) J Neuropathol Exp Neurol , vol.73 , pp. 1026-1033
    • Bridges, L.R.1    Oh, J.2    Lawrence, A.J.3
  • 14
    • 78049377229 scopus 로고    scopus 로고
    • Alterations of the blood-brain barrier in cerebral white matter lesions in the ageing brain
    • Simpson JE, Wharton SB, Cooper J, et al. Alterations of the blood-brain barrier in cerebral white matter lesions in the ageing brain. Neurosci Lett 2010; 486: 246-51.
    • (2010) Neurosci Lett , vol.486 , pp. 246-251
    • Simpson, J.E.1    Wharton, S.B.2    Cooper, J.3
  • 15
    • 58549098084 scopus 로고    scopus 로고
    • Blood-brain barrier: Ageing and microvascular disease-systematic review and meta-analysis
    • Farrall AJ, Wardlaw JM. Blood-brain barrier: ageing and microvascular disease-systematic review and meta-analysis. Neurobiol Aging 2009; 30: 337-52.
    • (2009) Neurobiol Aging , vol.30 , pp. 337-352
    • Farrall, A.J.1    Wardlaw, J.M.2
  • 16
    • 84962597632 scopus 로고    scopus 로고
    • Endothelial activation is associated with cognitive performance in patients with hypertension
    • Uiterwijk R, Huijts M, Staals J, et al. Endothelial activation is associated with cognitive performance in patients with hypertension. Am J Hypertens 2016; 29: 464-9.
    • (2016) Am J Hypertens , vol.29 , pp. 464-469
    • Uiterwijk, R.1    Huijts, M.2    Staals, J.3
  • 17
    • 79955620153 scopus 로고    scopus 로고
    • Plasma fibrinogen, global cognitive function, and cerebral small vessel disease: Results of a cross-sectional study in community-dwelling Japanese elderly
    • Wada M, Takahashi Y, Iseki C, et al. Plasma fibrinogen, global cognitive function, and cerebral small vessel disease: results of a cross-sectional study in community-dwelling Japanese elderly. Intern Med 2011; 50: 999-1007.
    • (2011) Intern Med , vol.50 , pp. 999-1007
    • Wada, M.1    Takahashi, Y.2    Iseki, C.3
  • 18
    • 29244463365 scopus 로고    scopus 로고
    • Astrocyte-endothelial interactions at the blood-brain barrier
    • Abbott NJ, Rönnbäck L, Hansson E. Astrocyte-endothelial interactions at the blood-brain barrier. Nat Rev Neurosci 2006; 7: 41-53.
    • (2006) Nat Rev Neurosci , vol.7 , pp. 41-53
    • Abbott, N.J.1    Rönnbäck, L.2    Hansson, E.3
  • 19
    • 0034219383 scopus 로고    scopus 로고
    • The blood-brain barrier and its role in inflammation
    • Webb AA, Muir GD. The blood-brain barrier and its role in inflammation. J Vet Intern Med 2000; 14: 399-411.
    • (2000) J Vet Intern Med , vol.14 , pp. 399-411
    • Webb, A.A.1    Muir, G.D.2
  • 20
    • 84967240062 scopus 로고    scopus 로고
    • Trafficking of Endogenous Immunoglobulins by Endothelial Cells at the Blood- Brain Barrier
    • Villaseñor R, Ozmen L, Messaddeq N, et al. Trafficking of Endogenous Immunoglobulins by Endothelial Cells at the Blood- Brain Barrier. Sci Rep 2016; 6: 25658.
    • (2016) Sci Rep , vol.6 , pp. 25658
    • Villaseñor, R.1    Ozmen, L.2    Messaddeq, N.3
  • 21
    • 84874960530 scopus 로고    scopus 로고
    • Phase I study of intravenous low-dose granulocyte colony-stimulating factor in acute and subacute ischemic stroke
    • Moriya Y, Mizuma A, Uesugi T, et al. Phase I study of intravenous low-dose granulocyte colony-stimulating factor in acute and subacute ischemic stroke. J Stroke Cerebrovasc Dis 2013; 22: 1088-97.
    • (2013) J Stroke Cerebrovasc Dis , vol.22 , pp. 1088-1097
    • Moriya, Y.1    Mizuma, A.2    Uesugi, T.3
  • 22
    • 33846828287 scopus 로고    scopus 로고
    • The effect of granulocyte-colony stimulating factor in global cerebral ischemia in rats
    • Matchett GA, Calinisan JB, Matchett GC, Martin RD, Zhang JH. The effect of granulocyte-colony stimulating factor in global cerebral ischemia in rats. Brain Res 2007; 1136: 200-7.
    • (2007) Brain Res , vol.1136 , pp. 200-207
    • Matchett, G.A.1    Calinisan, J.B.2    Matchett, G.C.3    Martin, R.D.4    Zhang, J.H.5
  • 23
    • 67349147860 scopus 로고    scopus 로고
    • Endogenous brain protection by granulocyte-colony stimulating factor after ischemic stroke
    • Sevimli S, Diederich K, Strecker JK, et al. Endogenous brain protection by granulocyte-colony stimulating factor after ischemic stroke. Exp Neurol 2009; 217: 328-35.
    • (2009) Exp Neurol , vol.217 , pp. 328-335
    • Sevimli, S.1    Diederich, K.2    Strecker, J.K.3
  • 24
    • 84946426352 scopus 로고    scopus 로고
    • Autocrine protective mechanisms of human granulocyte colonystimulating factor (G-CSF) on retinal ganglion cells after optic nerve crush
    • Huang SP, Fang KT, Chang CH, Huang TL, Wen YT, Tsai RK. Autocrine protective mechanisms of human granulocyte colonystimulating factor (G-CSF) on retinal ganglion cells after optic nerve crush. Exp Eye Res 2016; 143: 132-40.
    • (2016) Exp Eye Res , vol.143 , pp. 132-140
    • Huang, S.P.1    Fang, K.T.2    Chang, C.H.3    Huang, T.L.4    Wen, Y.T.5    Tsai, R.K.6
  • 26
    • 24644446859 scopus 로고    scopus 로고
    • G-CSF suppresses edema formation and reduces interleukin-1beta expression after cerebral ischemia in mice
    • Gibson CL, Jones NC, Prior MJ, Bath PM, Murphy SP. G-CSF suppresses edema formation and reduces interleukin-1beta expression after cerebral ischemia in mice. J Neuropathol Exp Neurol 2005; 64: 763-9.
    • (2005) J Neuropathol Exp Neurol , vol.64 , pp. 763-769
    • Gibson, C.L.1    Jones, N.C.2    Prior, M.J.3    Bath, P.M.4    Murphy, S.P.5
  • 27
    • 4644339259 scopus 로고    scopus 로고
    • Functional recovery of stroke rats induced by granulocyte colony-stimulating factor-stimulated stem cells
    • Shyu WC, Lin SZ, Yang HI, et al. Functional recovery of stroke rats induced by granulocyte colony-stimulating factor-stimulated stem cells. Circulation 2004; 110: 1847-54.
    • (2004) Circulation , vol.110 , pp. 1847-1854
    • Shyu, W.C.1    Lin, S.Z.2    Yang, H.I.3
  • 28
    • 34249795478 scopus 로고    scopus 로고
    • Neuroprotective effect of granulocyte- colony stimulating factor
    • Solaroglu I, Jadhav V, Zhang JH. Neuroprotective effect of granulocyte- colony stimulating factor. Front Biosci 2007; 12: 712-24.
    • (2007) Front Biosci , vol.12 , pp. 712-724
    • Solaroglu, I.1    Jadhav, V.2    Zhang, J.H.3
  • 29
    • 77950919896 scopus 로고    scopus 로고
    • The hematopoietic factor granulocyte-colony stimulating factor improves outcome in experimental spinal cord injury
    • Pitzer C, Klussmann S, Krüger C, et al. The hematopoietic factor granulocyte-colony stimulating factor improves outcome in experimental spinal cord injury. J Neurochem 2010; 113: 930-42.
    • (2010) J Neurochem , vol.113 , pp. 930-942
    • Pitzer, C.1    Klussmann, S.2    Krüger, C.3
  • 30
    • 84945484823 scopus 로고    scopus 로고
    • G-CSF attenuates neuroinflammation and stabilizes the blood-brain barrier via the PI3K/Akt/GSK-3β signaling pathway following neonatal hypoxiaischemia in rats
    • Li L, McBride DW, Doycheva D, et al. G-CSF attenuates neuroinflammation and stabilizes the blood-brain barrier via the PI3K/Akt/GSK-3β signaling pathway following neonatal hypoxiaischemia in rats. Exp Neurol 2015; 272: 135-44.
    • (2015) Exp Neurol , vol.272 , pp. 135-144
    • Li, L.1    McBride, D.W.2    Doycheva, D.3
  • 31
    • 84879473776 scopus 로고    scopus 로고
    • Granulocyte colony stimulating factor (GCSF) improves memory and neurobehavior in an amyloid- β induced experimental model of Alzheimer's disease
    • Prakash A, Medhi B, Chopra K. Granulocyte colony stimulating factor (GCSF) improves memory and neurobehavior in an amyloid- β induced experimental model of Alzheimer's disease. Pharmacol Biochem Behav. 2013; 110: 46-57.
    • (2013) Pharmacol Biochem Behav , vol.110 , pp. 46-57
    • Prakash, A.1    Medhi, B.2    Chopra, K.3
  • 32
    • 84964696968 scopus 로고    scopus 로고
    • Spontaneous white matter damage, cognitive decline and neuroinflammation in middle-aged hypertensive rats: An animal model of early-stage cerebral small vessel disease
    • Kaiser D, Weise G, Möller K, et al. Spontaneous white matter damage, cognitive decline and neuroinflammation in middle-aged hypertensive rats: an animal model of early-stage cerebral small vessel disease. Acta Neuropathol Commun 2014; 2: 169.
    • (2014) Acta Neuropathol Commun , vol.2 , pp. 169
    • Kaiser, D.1    Weise, G.2    Möller, K.3
  • 33
    • 84947934642 scopus 로고    scopus 로고
    • PH responsive granulocyte colony-stimulating factor variants with implications for treating Alzheimer's disease and other central nervous system disorders
    • Heinzelman P, Schoborg JA, Jewett MC. pH responsive granulocyte colony-stimulating factor variants with implications for treating Alzheimer's disease and other central nervous system disorders. Protein Eng Des Sel 2015; 28: 481-9.
    • (2015) Protein Eng Des Sel , vol.28 , pp. 481-489
    • Heinzelman, P.1    Schoborg, J.A.2    Jewett, M.C.3
  • 34
    • 84900971471 scopus 로고    scopus 로고
    • Recognition memory tasks in neuroendocrine research
    • Luine V. Recognition memory tasks in neuroendocrine research. Behav Brain Res 2015; 285: 158-64.
    • (2015) Behav Brain Res , vol.285 , pp. 158-164
    • Luine, V.1
  • 35
    • 2942685076 scopus 로고    scopus 로고
    • Blood-brain barrier is impaired in the hippocampus of young adult spontaneously hypertensive rats
    • Ueno M, Sakamoto H, Tomimoto H, et al. Blood-brain barrier is impaired in the hippocampus of young adult spontaneously hypertensive rats. Acta Neuropathol 2004; 107: 532-8.
    • (2004) Acta Neuropathol , vol.107 , pp. 532-538
    • Ueno, M.1    Sakamoto, H.2    Tomimoto, H.3
  • 36
    • 0034624286 scopus 로고    scopus 로고
    • Structural alterations of tight junctions are associated with loss of polarity in stroke-prone spontaneously hypertensive rat blood-brain barrier endothelial cells
    • Lippoldt A, Kniesel U, Liebner S, et al. Structural alterations of tight junctions are associated with loss of polarity in stroke-prone spontaneously hypertensive rat blood-brain barrier endothelial cells. Brain Res 2000; 885: 251-61.
    • (2000) Brain Res , vol.885 , pp. 251-261
    • Lippoldt, A.1    Kniesel, U.2    Liebner, S.3
  • 37
    • 84875889402 scopus 로고    scopus 로고
    • Frequency- specific network connectivity increases underlie accurate spatiotemporal memory retrieval
    • Watrous AJ, Tandon N, Conner CR, Pieters T, Ekstrom AD. Frequency- specific network connectivity increases underlie accurate spatiotemporal memory retrieval. Nat Neurosci 2013; 16: 349-56.
    • (2013) Nat Neurosci , vol.16 , pp. 349-356
    • Watrous, A.J.1    Tandon, N.2    Conner, C.R.3    Pieters, T.4    Ekstrom, A.D.5
  • 38
    • 84949032925 scopus 로고    scopus 로고
    • The medial prefrontal cortexlateral entorhinal cortex circuit is essential for episodic-like memory and associative object-recognition
    • Chao OY, Huston JP, Li JS, et al. The medial prefrontal cortexlateral entorhinal cortex circuit is essential for episodic-like memory and associative object-recognition. Hippocampus 2016; 26: 633-45.
    • (2016) Hippocampus , vol.26 , pp. 633-645
    • Chao, O.Y.1    Huston, J.P.2    Li, J.S.3
  • 39
    • 84880140385 scopus 로고    scopus 로고
    • PHA-543613 preserves blood-brain barrier integrity after intracerebral hemorrhage in mice
    • Krafft PR, Caner B, Klebe D, Rolland WB, Tang J, Zhang JH. PHA-543613 preserves blood-brain barrier integrity after intracerebral hemorrhage in mice. Stroke 2013; 44: 1743-7.
    • (2013) Stroke , vol.44 , pp. 1743-1747
    • Krafft, P.R.1    Caner, B.2    Klebe, D.3    Rolland, W.B.4    Tang, J.5    Zhang, J.H.6
  • 40
    • 84951569612 scopus 로고    scopus 로고
    • Circulating biologic markers of endothelial dysfunction in cerebral small vessel disease: A review
    • Poggesi A, Pasi M, Pescini F, Pantoni L, Inzitari D. Circulating biologic markers of endothelial dysfunction in cerebral small vessel disease: A review. J Cereb Blood Flow Metab 2016; 36: 72-94.
    • (2016) J Cereb Blood Flow Metab , vol.36 , pp. 72-94
    • Poggesi, A.1    Pasi, M.2    Pescini, F.3    Pantoni, L.4    Inzitari, D.5
  • 41
    • 4544291851 scopus 로고    scopus 로고
    • Blood-brain barrier disruption in the hypothalamus of young adult spontaneously hypertensive rats
    • Ueno M, Sakamoto H, Liao YJ, et al. Blood-brain barrier disruption in the hypothalamus of young adult spontaneously hypertensive rats. Histochem Cell Biol 2004; 122: 131-7.
    • (2004) Histochem Cell Biol , vol.122 , pp. 131-137
    • Ueno, M.1    Sakamoto, H.2    Liao, Y.J.3
  • 42
    • 84914162544 scopus 로고    scopus 로고
    • Shear stress-initiated signaling and its regulation of endothelial function
    • Zhou J, Li YS, Chien S. Shear stress-initiated signaling and its regulation of endothelial function. Arterioscler Thromb Vasc Biol 2014; 34: 2191-8.
    • (2014) Arterioscler Thromb Vasc Biol , vol.34 , pp. 2191-2198
    • Zhou, J.1    Li, Y.S.2    Chien, S.3
  • 43
    • 84911948133 scopus 로고    scopus 로고
    • Biomechanical factors in atherosclerosis: Mechanisms and clinical implications
    • Kwak BR, Bäck M, Bochaton-Piallat ML, et al. Biomechanical factors in atherosclerosis: mechanisms and clinical implications. Eur Heart J 2014; 35: 3013-20.
    • (2014) Eur Heart J , vol.35 , pp. 3013-3020
    • Kwak, B.R.1    Bäck, M.2    Bochaton-Piallat, M.L.3
  • 44
    • 38149090292 scopus 로고    scopus 로고
    • The blood-brain barrier in health and chronic neurodegenerative disorders
    • Zlokovic BV. The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron 2008; 57: 178-201.
    • (2008) Neuron , vol.57 , pp. 178-201
    • Zlokovic, B.V.1
  • 45
    • 67650511699 scopus 로고    scopus 로고
    • Caveolae-mediated internalization of occludin and claudin-5 during CCL2-induced tight junction remodeling in brain endothelial cells
    • Stamatovic SM, Keep RF, Wang MM, Jankovic I, Andjelkovic AV. Caveolae-mediated internalization of occludin and claudin-5 during CCL2-induced tight junction remodeling in brain endothelial cells. J Biol Chem 2009; 284: 19053-66.
    • (2009) J Biol Chem , vol.284 , pp. 19053-19066
    • Stamatovic, S.M.1    Keep, R.F.2    Wang, M.M.3    Jankovic, I.4    Jelkovic, A.V.5
  • 46
    • 0036627211 scopus 로고    scopus 로고
    • Tight junctions of the blood-brain barrier: Development, composition and regulation
    • Wolburg H, Lippoldt A. Tight junctions of the blood-brain barrier: development, composition and regulation. Vascul Pharmacol 2002; 38: 323-37.
    • (2002) Vascul Pharmacol , vol.38 , pp. 323-337
    • Wolburg, H.1    Lippoldt, A.2
  • 47
    • 84884500989 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein-1-deficiency results in altered blood-brain barrier breakdown after experimental stroke
    • Strecker JK, Minnerup J, Schütte-Nütgen K, Gess B, Schäbitz WR, Schilling M. Monocyte chemoattractant protein-1-deficiency results in altered blood-brain barrier breakdown after experimental stroke. Stroke 2013; 44: 2536-44.
    • (2013) Stroke , vol.44 , pp. 2536-2544
    • Strecker, J.K.1    Minnerup, J.2    Schütte-Nütgen, K.3    Gess, B.4    Schäbitz, W.R.5    Schilling, M.6
  • 48
    • 84891930111 scopus 로고    scopus 로고
    • Protection of granulocyte-colony stimulating factor to hemorrhagic brain injuries and its involved mechanisms: Effects of vascular endothelial growth factor and aquaporin- 4
    • Chu H, Tang Y, Dong Q. Protection of granulocyte-colony stimulating factor to hemorrhagic brain injuries and its involved mechanisms: effects of vascular endothelial growth factor and aquaporin- 4. Neuroscience 2014; 260: 59-72.
    • (2014) Neuroscience , vol.260 , pp. 59-72
    • Chu, H.1    Tang, Y.2    Dong, Q.3
  • 49
    • 39049142508 scopus 로고    scopus 로고
    • Dysfunctional astrocytes as key players in the pathogenesis of central nervous system disorders
    • De Keyser J, Mostert JP, Koch MW. Dysfunctional astrocytes as key players in the pathogenesis of central nervous system disorders. J Neurol Sci 2008; 267: 3-16.
    • (2008) J Neurol Sci , vol.267 , pp. 3-16
    • De Keyser, J.1    Mostert, J.P.2    Koch, M.W.3
  • 50
    • 77949915743 scopus 로고    scopus 로고
    • Expression of aquaporins 1 and 4 in the brain of spontaneously hypertensive rats
    • Tomassoni D, Bramanti V, Amenta F. Expression of aquaporins 1 and 4 in the brain of spontaneously hypertensive rats. Brain Res 2010; 1325: 155-63.
    • (2010) Brain Res , vol.1325 , pp. 155-163
    • Tomassoni, D.1    Bramanti, V.2    Amenta, F.3
  • 51
    • 84864880815 scopus 로고    scopus 로고
    • The Abluminal endothelial membrane in neurovascular remodeling in health and disease
    • Hermann DM, ElAli A. The Abluminal endothelial membrane in neurovascular remodeling in health and disease. J Sci Signal 2012; 5: 4.
    • (2012) J Sci Signal , vol.5 , pp. 4
    • Hermann, D.M.1    Elali, A.2


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