Trafficking of Endogenous Immunoglobulins by Endothelial Cells at the Blood-Brain Barrier

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Villasenõr, Roberto ^a   Ozmen, Laurence ^a   Messaddeq, Nadia ^b   Grüninger, Fiona ^a   Loetscher, Hansruedi ^a   Keller, Annika ^c   Betsholtz, Christer ^d,e   Freskgård, Per Ola ^a   Collin, Ludovic ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b CNRS   (France)

^c UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^d UPPSALA UNIVERSITY   (Sweden)

^e KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN; IMMUNOGLOBULIN G; TAU PROTEIN;

ANIMAL; BLOOD BRAIN BARRIER; ENDOTHELIUM CELL; INTRACELLULAR SPACE; LYSOSOME; METABOLISM; MOUSE; PERICYTE; PHOSPHORYLATION; ULTRASTRUCTURE;

ANIMALS; BLOOD-BRAIN BARRIER; ENDOTHELIAL CELLS; IMMUNOGLOBULIN G; IMMUNOGLOBULINS; INTRACELLULAR SPACE; LYSOSOMES; MICE; PERICYTES; PHOSPHORYLATION; TAU PROTEINS;

EID: 84967240062     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep25658     Document Type: Article

References (30)

1. Wu, A. M., Senter, P. D. Arming antibodies: prospects and challenges for immunoconjugates, Nat Biotechnol 23, 1137-1146, doi: 10.1038/nbt1141 (2005).
2. Adams, G. P., Weiner, L. M. Monoclonal antibody therapy of cancer, Nat Biotechnol 23, 1147-1157, doi: 10.1038/nbt1137 (2005).
3. Pardridge, W. M. Drug transport across the blood-brain barrier, J Cereb Blood Flow Metab 32, 1959-1972, doi: 10.1038/jcbfm.2012.126 (2012).
4. St-Amour, I. et al. Brain bioavailability of human intravenous immunoglobulin and its transport through the murine blood-brain barrier, J Cereb Blood Flow Metab 33, 1983-1992, doi: 10.1038/jcbfm.2013.160 (2013).
5. Rubin, L. L., Staddon, J. M. The cell biology of the blood-brain barrier, Annu Rev Neurosci 22, 11-28, doi: 10.1146/annurev. neuro.22.1.11 (1999).
6. Blanchette, M., Daneman, R. Formation and maintenance of the BBB, Mech Dev 138 Pt 1, 8-16, doi: 10.1016/j.mod.2015.07.007 (2015).
7. Abbott, N. J., Patabendige, A. A., Dolman, D. E., Yusof, S. R., Begley, D. J. Structure and function of the blood-brain barrier, Neurobiol Dis 37, 13-25, doi: 10.1016/j.nbd.2009.07.030 (2010).
8. Preston, J. E., Joan Abbott, N., Begley, D. J. Transcytosis of macromolecules at the blood-brain barrier, Adv Pharmacol 71, 147-163, doi: 10.1016/bs.apha.2014.06.001 (2014).
9. Reese, T. S., Karnovsky, M. J. Fine structural localization of a blood-brain barrier to exogenous peroxidase, J Cell Biol 34, 207-217 (1967).
10. Chow, B. W., Gu, C. The Molecular Constituents of the Blood-Brain Barrier, Trends Neurosci 38, 598-608, doi: 10.1016/j. tins.2015.08.003 (2015).
11. Triguero, D., Buciak, J. B., Yang, J., Pardridge, W. M. Blood-brain barrier transport of cationized immunoglobulin G: enhanced delivery compared to native protein, Proc Natl Acad Sci USA 86, 4761-4765 (1989).
12. Bard, F. et al. Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease, Nat Med 6, 916-919, doi: 10.1038/78682 (2000).
13. Zlokovic, B. V. et al. A saturable mechanism for transport of immunoglobulin G across the blood-brain barrier of the guinea pig, Exp Neurol 107, 263-270 (1990).
14. Tuma, P., Hubbard, A. L. Transcytosis: crossing cellular barriers, Physiol Rev 83, 871-932, doi: 10.1152/physrev.00001.2003 (2003).
15. Ober, R. J., Martinez, C., Vaccaro, C., Zhou, J., Ward, E. S. Visualizing the site and dynamics of IgG salvage by the MHC class I-related receptor, FcRn, J Immunol 172, 2021-2029 (2004).
16. Waldmann, T. A., Strober, W. Metabolism of immunoglobulins, Prog Allergy 13, 1-110 (1969).
17. Armulik, A. et al. Pericytes regulate the blood-brain barrier, Nature 468, 557-561, doi: 10.1038/nature09522 (2010).
18. Foret, L. et al. A general theoretical framework to infer endosomal network dynamics from quantitative image analysis, Curr Biol 22, 1381-1390, doi: 10.1016/j.cub.2012.06.021 (2012).
19. Niewoehner, J. et al. Increased Brain Penetration and Potency of a Therapeutic Antibody Using a Monovalent Molecular Shuttle, Neuron 81, 49-60, doi: 10.1016/j.neuron.2013.10.061 (2014).
20. Collin, L. et al. Neuronal uptake of tau/pS422 antibody and reduced progression of tau pathology in a mouse model of Alzheimer's disease, Brain 137, 2834-2846, doi: 10.1093/brain/awu213 (2014).
21. Grueninger, F. et al. Phosphorylation of Tau at S422 is enhanced by Abeta in TauPS2APP triple transgenic mice, Neurobiol Dis 37, 294-306, doi: 10.1016/j.nbd.2009.09.004 (2010).
22. Stewart, P. A. Endothelial vesicles in the blood-brain barrier: are they related to permeability? Cell Mol Neurobiol 20, 149-163 (2000).
23. Schlachetzki, F., Zhu, C. N., Pardridge, W. M. Expression of the neonatal Fc receptor (FcRn) at the blood-brain barrier, J Neurochem 81, 203-206, doi: 10.1046/j.1471-4159.2002.00840.x (2002).
24. Broadwell, R. D., Salcman, M. Expanding the definition of the blood-brain barrier to protein, Proc Natl Acad Sci USA 78, 7820-7824 (1981).
25. Daneman, R., Zhou, L., Kebede, A. A., Barres, B. A. Pericytes are required for blood-brain barrier integrity during embryogenesis, Nature 468, 562-566, doi: 10.1038/nature09513 (2010).
26. Mayor, S., Parton, R. G., Donaldson, J. G. Clathrin-independent pathways of endocytosis, Cold Spring Harb Perspect Biol 6, doi: 10.1101/cshperspect.a016758 (2014).
27. Ben-Zvi, A. et al. Mfsd2a is critical for the formation and function of the blood-brain barrier, Nature 509, 507-511, doi: 10.1038/nature13324 (2014).
28. Rink, J., Ghigo, E., Kalaidzidis, Y., Zerial, M. Rab conversion as a mechanism of progression from early to late endosomes, Cell 122, 735-749, doi: 10.1016/j.cell.2005.06.043 (2005).
29. Collinet, C. et al. Systems survey of endocytosis by multiparametric image analysis, Nature 464, 243-249, doi: 10.1038/nature08779 (2010).
30. Kalaidzidis, Y., Kalaidzidis, I., Zerial, M. A Probabilistic Method to Quantify the Colocalization of Markers on Intracellular Vesicular Structures Visualized by Light Microscopy, Aip Conf Proc 1641, 580-587, doi: 10.1063/1.4906025 (2015).