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Volumn 196, Issue 4, 2017, Pages 479-493

Differential expression of VEGF-Axxx isoforms is critical for development of pulmonary fibrosis

Author keywords

Animal models of pulmonary fibrosis; Idiopathic pulmonary fibrosis; Vascular endothelial growth factor

Indexed keywords

COLLAGEN; COLLAGEN TYPE 1; FIBRONECTIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; PRO COLLAGEN 1ALPHA; UNCLASSIFIED DRUG; UVOMORULIN; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; ISOPROTEIN; VASCULAR ENDOTHELIAL GROWTH FACTOR A, MOUSE; VEGFA PROTEIN, HUMAN;

EID: 85028602209     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201603-0568OC     Document Type: Article
Times cited : (61)

References (60)
  • 5
    • 4143136640 scopus 로고    scopus 로고
    • Vascular endothelial growth factor: Basic science and clinical progress
    • Ferrara N. Vascular endothelial growth factor: basic science and clinical progress. Endocr Rev 2004;25:581-611.
    • (2004) Endocr Rev , vol.25 , pp. 581-611
    • Ferrara, N.1
  • 6
    • 0024818355 scopus 로고
    • Vascular endothelial growth factor is a secreted angiogenic mitogen
    • Leung DW, Cachianes G, Kuang WJ, Goeddel DV, Ferrara N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 1989;246:1306-1309.
    • (1989) Science , vol.246 , pp. 1306-1309
    • Leung, D.W.1    Cachianes, G.2    Kuang, W.J.3    Goeddel, D.V.4    Ferrara, N.5
  • 7
  • 8
    • 54549123309 scopus 로고    scopus 로고
    • VEGF - A splicing: The key to anti-angiogenic therapeutics?
    • Harper SJ, Bates DO. VEGF-A splicing: the key to anti-angiogenic therapeutics? Nat Rev Cancer 2008;8:880-887.
    • (2008) Nat Rev Cancer , vol.8 , pp. 880-887
    • Harper, S.J.1    Bates, D.O.2
  • 9
    • 77954333963 scopus 로고    scopus 로고
    • Vascular endothelial growth factors and vascular permeability
    • Bates DO. Vascular endothelial growth factors and vascular permeability. Cardiovasc Res 2010;87:262-271.
    • (2010) Cardiovasc Res , vol.87 , pp. 262-271
    • Bates, D.O.1
  • 11
    • 0027104066 scopus 로고
    • Vascular permeability factor (vascular endothelial growth factor) gene is expressed differentially in normal tissues, macrophages, and tumors
    • Berse B, Brown LF, Van de Water L, Dvorak HF, Senger DR. Vascular permeability factor (vascular endothelial growth factor) gene is expressed differentially in normal tissues, macrophages, and tumors. Mol Biol Cell 1992;3:211-220.
    • (1992) Mol Biol Cell , vol.3 , pp. 211-220
    • Berse, B.1    Brown, L.F.2    Van De Water, L.3    Dvorak, H.F.4    Senger, D.R.5
  • 13
    • 18744380336 scopus 로고    scopus 로고
    • Vascular endothelial growth factor mRNA and protein expression in airway epithelial cell lines in vitro
    • Koyama S, Sato E, Tsukadaira A, Haniuda M, Numanami H, Kurai M, Nagai S, Izumi T. Vascular endothelial growth factor mRNA and protein expression in airway epithelial cell lines in vitro. Eur Respir J 2002;20:1449-1456.
    • (2002) Eur Respir J , vol.20 , pp. 1449-1456
    • Koyama, S.1    Sato, E.2    Tsukadaira, A.3    Haniuda, M.4    Numanami, H.5    Kurai, M.6    Nagai, S.7    Izumi, T.8
  • 14
    • 0035317643 scopus 로고    scopus 로고
    • Compartmentalization of vascular endothelial growth factor to the epithelial surface of the human lung
    • Kaner RJ, Crystal RG. Compartmentalization of vascular endothelial growth factor to the epithelial surface of the human lung. Mol Med 2001;7:240-246.
    • (2001) Mol Med , vol.7 , pp. 240-246
    • Kaner, R.J.1    Crystal, R.G.2
  • 16
    • 0035983324 scopus 로고    scopus 로고
    • Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice
    • Compernolle V, Brusselmans K, Acker T, Hoet P, Tjwa M, Beck H, Plaisance S, Dor Y, Keshet E, Lupu F, et al. Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice. Nat Med 2002;8:702-710.
    • (2002) Nat Med , vol.8 , pp. 702-710
    • Compernolle, V.1    Brusselmans, K.2    Acker, T.3    Hoet, P.4    Tjwa, M.5    Beck, H.6    Plaisance, S.7    Dor, Y.8    Keshet, E.9    Lupu, F.10
  • 17
    • 0035509116 scopus 로고    scopus 로고
    • Vascular endothelial growth factor May contribute to increased vascular permeability in acute respiratory distress syndrome
    • Thickett DR, Armstrong L, Christie SJ, Millar AB. Vascular endothelial growth factor may contribute to increased vascular permeability in acute respiratory distress syndrome. Am J Respir Crit Care Med 2001;164:1601-1605.
    • (2001) Am J Respir Crit Care Med , vol.164 , pp. 1601-1605
    • Thickett, D.R.1    Armstrong, L.2    Christie, S.J.3    Millar, A.B.4
  • 18
    • 0037111186 scopus 로고    scopus 로고
    • A role for vascular endothelial growth factor in acute and resolving lung injury
    • Thickett DR, Armstrong L, Millar AB. A role for vascular endothelial growth factor in acute and resolving lung injury. Am J Respir Crit Care Med 2002;166:1332-1337.
    • (2002) Am J Respir Crit Care Med , vol.166 , pp. 1332-1337
    • Thickett, D.R.1    Armstrong, L.2    Millar, A.B.3
  • 19
    • 33745817417 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) in acute lung injury (ALI) and acute respiratory distress syndrome (ARDS): Paradox or paradigm?
    • Medford AR, Millar AB. Vascular endothelial growth factor (VEGF) in acute lung injury (ALI) and acute respiratory distress syndrome (ARDS): paradox or paradigm? Thorax 2006;61:621-626.
    • (2006) Thorax , vol.61 , pp. 621-626
    • Medford, A.R.1    Millar, A.B.2
  • 20
    • 84877086317 scopus 로고    scopus 로고
    • Fibrosis of two: Epithelial cell-fibroblast interactions in pulmonary fibrosis
    • Sakai N, Tager AM. Fibrosis of two: epithelial cell-fibroblast interactions in pulmonary fibrosis. Biochim Biophys Acta 2013;1832:911-921.
    • (2013) Biochim Biophys Acta , vol.1832 , pp. 911-921
    • Sakai, N.1    Tager, A.M.2
  • 23
    • 66449098872 scopus 로고    scopus 로고
    • VEGF ameliorates pulmonary hypertension through inhibition of endothelial apoptosis in experimental lung fibrosis in rats
    • Farkas L, Farkas D, Ask K, Möller A, Gauldie J, Margetts P, Inman M, Kolb M. VEGF ameliorates pulmonary hypertension through inhibition of endothelial apoptosis in experimental lung fibrosis in rats. J Clin Invest 2009;119:1298-1311.
    • (2009) J Clin Invest , vol.119 , pp. 1298-1311
    • Farkas, L.1    Farkas, D.2    Ask, K.3    Möller, A.4    Gauldie, J.5    Margetts, P.6    Inman, M.7    Kolb, M.8
  • 29
    • 0027064888 scopus 로고
    • Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms
    • Houck KA, Leung DW, Rowland AM, Winer J, Ferrara N. Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms. J Biol Chem 1992;267:26031-26037.
    • (1992) J Biol Chem , vol.267 , pp. 26031-26037
    • Houck, K.A.1    Leung, D.W.2    Rowland, A.M.3    Winer, J.4    Ferrara, N.5
  • 31
    • 7444240909 scopus 로고    scopus 로고
    • VEGF165b, an inhibitory vascular endothelial growth factor splice variant: Mechanism of action, in vivo effect on angiogenesis and endogenous protein expression
    • Woolard J, Wang WY, Bevan HS, Qiu Y, Morbidelli L, Pritchard-Jones RO, Cui TG, Sugiono M, Waine E, Perrin R, et al. VEGF165b, an inhibitory vascular endothelial growth factor splice variant: mechanism of action, in vivo effect on angiogenesis and endogenous protein expression. Cancer Res 2004;64:7822-7835.
    • (2004) Cancer Res , vol.64 , pp. 7822-7835
    • Woolard, J.1    Wang, W.Y.2    Bevan, H.S.3    Qiu, Y.4    Morbidelli, L.5    Pritchard-Jones, R.O.6    Cui, T.G.7    Sugiono, M.8    Waine, E.9    Perrin, R.10
  • 32
    • 79960690759 scopus 로고    scopus 로고
    • Neuropilin-1 promotes VEGFR-2 trafficking through rab11 vesicles thereby specifying signal output
    • Ballmer-Hofer K, Andersson AE, Ratcliffe LE, Berger P. Neuropilin-1 promotes VEGFR-2 trafficking through Rab11 vesicles thereby specifying signal output. Blood 2011;118:816-826.
    • (2011) Blood , vol.118 , pp. 816-826
    • Ballmer-Hofer, K.1    Andersson, A.E.2    Ratcliffe, L.E.3    Berger, P.4
  • 37
    • 85034262499 scopus 로고    scopus 로고
    • Differential expression of conventional and inhibitory VEGFA isoforms in normal and fibrotic fibroblasts - A potential role in IPF pathogenesis?
    • Barratt SL, Blythe T, Jarrett C, Ourradi K, Maher T, Welsh GI, Bates DO, Millar AB. Differential expression of conventional and inhibitory VEGFA isoforms in normal and fibrotic fibroblasts-a potential role in IPF pathogenesis? Thorax 2013;68(SUPPL. 3):A139-A140.
    • (2013) Thorax , vol.68 , pp. A139-A140
    • Barratt, S.L.1    Blythe, T.2    Jarrett, C.3    Ourradi, K.4    Maher, T.5    Welsh, G.I.6    Bates, D.O.7    Millar, A.B.8
  • 39
    • 42149152015 scopus 로고    scopus 로고
    • VEGF 165 b, an antiangiogenic VEGF-A isoform, binds and inhibits bevacizumab treatment in experimental colorectal carcinoma: Balance of pro- and antiangiogenic VEGF - A isoforms has implications for therapy
    • Varey AH, Rennel ES, Qiu Y, Bevan HS, Perrin RM, Raffy S, Dixon AR, Paraskeva C, Zaccheo O, Hassan AB, et al. VEGF 165 b, an antiangiogenic VEGF-A isoform, binds and inhibits bevacizumab treatment in experimental colorectal carcinoma: balance of pro- and antiangiogenic VEGF-A isoforms has implications for therapy. Br J Cancer 2008;98:1366-1379.
    • (2008) Br J Cancer , vol.98 , pp. 1366-1379
    • Varey, A.H.1    Rennel, E.S.2    Qiu, Y.3    Bevan, H.S.4    Perrin, R.M.5    Raffy, S.6    Dixon, A.R.7    Paraskeva, C.8    Zaccheo, O.9    Hassan, A.B.10
  • 41
    • 42049083543 scopus 로고    scopus 로고
    • Mammary alveolar development during lactation is inhibited by the endogenous antiangiogenic growth factor isoform, VEGF165b
    • Qiu Y, Bevan H, Weeraperuma S, Wratting D, Murphy D, Neal CR, Bates DO, Harper SJ. Mammary alveolar development during lactation is inhibited by the endogenous antiangiogenic growth factor isoform, VEGF165b. FASEB J 2008;22:1104-1112.
    • (2008) FASEB J , vol.22 , pp. 1104-1112
    • Qiu, Y.1    Bevan, H.2    Weeraperuma, S.3    Wratting, D.4    Murphy, D.5    Neal, C.R.6    Bates, D.O.7    Harper, S.J.8
  • 43
    • 58149340663 scopus 로고    scopus 로고
    • Conditional expression of genes in the respiratory epithelium in transgenic mice: Cautionary notes and toward building a better mouse trap
    • Perl AK, Zhang L, Whitsett JA. Conditional expression of genes in the respiratory epithelium in transgenic mice: cautionary notes and toward building a better mouse trap. Am J Respir Cell Mol Biol 2009;40:1-3.
    • (2009) Am J Respir Cell Mol Biol , vol.40 , pp. 1-3
    • Perl, A.K.1    Zhang, L.2    Whitsett, J.A.3
  • 45
    • 0034092656 scopus 로고    scopus 로고
    • Vascular endothelial growth factor in bronchoalveolar lavage from normal subjects and patients with diffuse parenchymal lung disease
    • Meyer KC, Cardoni A, Xiang ZZ. Vascular endothelial growth factor in bronchoalveolar lavage from normal subjects and patients with diffuse parenchymal lung disease. J Lab Clin Med 2000;135: 332-338.
    • (2000) J Lab Clin Med , vol.135 , pp. 332-338
    • Meyer, K.C.1    Cardoni, A.2    Xiang, Z.Z.3
  • 46
  • 48
    • 84971619857 scopus 로고    scopus 로고
    • Altered ratios of pro- and anti-angiogenic VEGF - A variants and pericyte expression of DLL4 disrupt vascular maturation in infantile haemangioma
    • Ye X, Abou-Rayyah Y, Bischoff J, Ritchie A, Sebire NJ, Watts P, Churchill AJ, Bates DO. Altered ratios of pro- and anti-angiogenic VEGF-A variants and pericyte expression of DLL4 disrupt vascular maturation in infantile haemangioma. J Pathol 2016;239:139-151.
    • (2016) J Pathol , vol.239 , pp. 139-151
    • Ye, X.1    Abou-Rayyah, Y.2    Bischoff, J.3    Ritchie, A.4    Sebire, N.J.5    Watts, P.6    Churchill, A.J.7    Bates, D.O.8
  • 52
    • 84882464963 scopus 로고    scopus 로고
    • Vascular endothelial growth factor aggravates fibrosis and vasculopathy in experimental models of systemic sclerosis
    • Maurer B, Distler A, Suliman YA, Gay RE, Michel BA, Gay S, Distler JH, Distler O. Vascular endothelial growth factor aggravates fibrosis and vasculopathy in experimental models of systemic sclerosis. Ann Rheum Dis 2014;73:1880-1887.
    • (2014) Ann Rheum Dis , vol.73 , pp. 1880-1887
    • Maurer, B.1    Distler, A.2    Suliman, Y.A.3    Gay, R.E.4    Michel, B.A.5    Gay, S.6    Distler, J.H.7    Distler, O.8
  • 54
    • 84879741537 scopus 로고    scopus 로고
    • Detecting splicing variants in idiopathic pulmonary fibrosis from non-differentially expressed genes
    • Deng N, Sanchez CG, Lasky JA, Zhu D. Detecting splicing variants in idiopathic pulmonary fibrosis from non-differentially expressed genes. PLoS One 2013;8:e68352.
    • (2013) PLoS One , vol.8 , pp. e68352
    • Deng, N.1    Sanchez, C.G.2    Lasky, J.A.3    Zhu, D.4
  • 56
    • 19244379078 scopus 로고    scopus 로고
    • Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions
    • Carmeliet P, Moons L, Luttun A, Vincenti V, Compernolle V, De Mol M, Wu Y, Bono F, Devy L, Beck H, et al. Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions. Nat Med 2001;7:575-583.
    • (2001) Nat Med , vol.7 , pp. 575-583
    • Carmeliet, P.1    Moons, L.2    Luttun, A.3    Vincenti, V.4    Compernolle, V.5    De Mol, M.6    Wu, Y.7    Bono, F.8    Devy, L.9    Beck, H.10
  • 59
    • 0023914820 scopus 로고
    • Simple method of estimating severity of pulmonary fibrosis on a numerical scale
    • Ashcroft T, Simpson JM, Timbrell V. Simple method of estimating severity of pulmonary fibrosis on a numerical scale. J Clin Pathol 1988;41:467-470.
    • (1988) J Clin Pathol , vol.41 , pp. 467-470
    • Ashcroft, T.1    Simpson, J.M.2    Timbrell, V.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.