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Volumn 18, Issue 1, 2015, Pages 23-30

The carboxyl terminus of VEGF-A is a potential target for anti-angiogenic therapy

Author keywords

Bevacizumab; Splicing; VEGF; VEGF A165b

Indexed keywords

BEVACIZUMAB; EXON8A POLYCLONAL ANTIBODY; POLYCLONAL ANTIBODY; RANIBIZUMAB; UNCLASSIFIED DRUG; VASCULOTROPIN A; VASCULOTROPIN A ANTIBODY; VASCULOTROPIN ANTIBODY; ANGIOGENESIS INHIBITOR; ANTIBODY; ISOPROTEIN;

EID: 84921935949     PISSN: 09696970     EISSN: 15737209     Source Type: Journal    
DOI: 10.1007/s10456-014-9444-3     Document Type: Article
Times cited : (17)

References (25)
  • 1
    • 70450196976 scopus 로고    scopus 로고
    • Neutralization of vascular endothelial growth factor antiangiogenic isoforms is more effective than treatment with proangiogenic isoforms in stimulating vascular development and follicle progression in the perinatal rat ovary
    • COI: 1:CAS:528:DC%2BD1MXhtlWrtrzE, PID: 19605786
    • Artac RA, McFee RM, Smith RAL, Baltes-Breitwisch MM, Clopton DT, Cupp AS (2009) Neutralization of vascular endothelial growth factor antiangiogenic isoforms is more effective than treatment with proangiogenic isoforms in stimulating vascular development and follicle progression in the perinatal rat ovary. Biol Reprod 81(5):978–988
    • (2009) Biol Reprod , vol.81 , Issue.5 , pp. 978-988
    • Artac, R.A.1    McFee, R.M.2    Smith, R.A.L.3    Baltes-Breitwisch, M.M.4    Clopton, D.T.5    Cupp, A.S.6
  • 3
    • 0037098860 scopus 로고    scopus 로고
    • VEGF(165)b, an inhibitory splice variant of vascular endothelial growth factor, is down-regulated in renal cell carcinoma
    • COI: 1:CAS:528:DC%2BD38XlsV2ltrw%3D, PID: 12124351
    • Bates DO, Cui TG, Doughty JM, Winkler M, Sugiono M, Shields JD, Peat D, Gillatt D, Harper SJ (2002) VEGF(165)b, an inhibitory splice variant of vascular endothelial growth factor, is down-regulated in renal cell carcinoma. Cancer Res 62(14):4123–4131
    • (2002) Cancer Res , vol.62 , Issue.14 , pp. 4123-4131
    • Bates, D.O.1    Cui, T.G.2    Doughty, J.M.3    Winkler, M.4    Sugiono, M.5    Shields, J.D.6    Peat, D.7    Gillatt, D.8    Harper, S.J.9
  • 5
    • 0034282639 scopus 로고    scopus 로고
    • The conformation-dependent interaction of alpha(2)-macroglobulin with vascular endothelial growth factor—a novel mechanism of alpha(2)-macroglobulin/growth factor binding
    • COI: 1:CAS:528:DC%2BD3cXmsVWrtbk%3D, PID: 10862607
    • Bhattacharjee G, Asplin IR, Wu SM, Gawdi G, Pizzo SV (2000) The conformation-dependent interaction of alpha(2)-macroglobulin with vascular endothelial growth factor—a novel mechanism of alpha(2)-macroglobulin/growth factor binding. J Biol Chem 275(35):26806–26811
    • (2000) J Biol Chem , vol.275 , Issue.35 , pp. 26806-26811
    • Bhattacharjee, G.1    Asplin, I.R.2    Wu, S.M.3    Gawdi, G.4    Pizzo, S.V.5
  • 6
    • 60549093223 scopus 로고    scopus 로고
    • Failure to up-regulate VEGF(165)b in maternal plasma is a first trimester predictive marker for pre-eclampsia
    • COI: 1:CAS:528:DC%2BD1MXis1OisA%3D%3D, PID: 18826376
    • Bills VL, Varet J, Millar A, Harper SJ, Soothill PW, Bates DO (2009) Failure to up-regulate VEGF(165)b in maternal plasma is a first trimester predictive marker for pre-eclampsia. Clin Sci 116(3–4):265–272
    • (2009) Clin Sci , vol.116 , Issue.3-4 , pp. 265-272
    • Bills, V.L.1    Varet, J.2    Millar, A.3    Harper, S.J.4    Soothill, P.W.5    Bates, D.O.6
  • 8
    • 0031039243 scopus 로고    scopus 로고
    • The biology of vascular endothelial growth factor
    • COI: 1:CAS:528:DyaK2sXhsFCiu7s%3D, PID: 9034784
    • Ferrara N, Davis-Smyth T (1997) The biology of vascular endothelial growth factor. Endocr Rev 18(1):4–25
    • (1997) Endocr Rev , vol.18 , Issue.1 , pp. 4-25
    • Ferrara, N.1    Davis-Smyth, T.2
  • 9
    • 7444224685 scopus 로고    scopus 로고
    • Integrating the anti-VEGF-A humanized monoclonal antibody bevacizumab with chemotherapy in advanced colorectal cancer
    • COI: 1:CAS:528:DC%2BD2cXpslOmtb8%3D, PID: 15479481
    • Hurwitz H (2004) Integrating the anti-VEGF-A humanized monoclonal antibody bevacizumab with chemotherapy in advanced colorectal cancer. Clin Colorectal Cancer 4(suppl 2):S62–S68
    • (2004) Clin Colorectal Cancer , vol.4 , pp. S62-S68
    • Hurwitz, H.1
  • 10
    • 49649088463 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF)-A165b is a weak in vitro agonist for VEGF receptor-2 due to lack of coreceptor binding and deficient regulation of kinase activity
    • COI: 1:CAS:528:DC%2BD1cXnt1aqur0%3D, PID: 18559514
    • Kawamura H, Li X, Harper SJ, Bates DO, Claesson-Welsh L (2008) Vascular endothelial growth factor (VEGF)-A165b is a weak in vitro agonist for VEGF receptor-2 due to lack of coreceptor binding and deficient regulation of kinase activity. Cancer Res 68(12):4683–4692
    • (2008) Cancer Res , vol.68 , Issue.12 , pp. 4683-4692
    • Kawamura, H.1    Li, X.2    Harper, S.J.3    Bates, D.O.4    Claesson-Welsh, L.5
  • 11
    • 79958786721 scopus 로고    scopus 로고
    • A systematic review of the efficacy and safety outcomes of anti-VEGF agents used for treating neovascular age-related macular degeneration: comparison of ranibizumab and bevacizumab
    • COI: 1:CAS:528:DC%2BC3MXnsFOjsrc%3D, PID: 21623685
    • Mitchell P (2011) A systematic review of the efficacy and safety outcomes of anti-VEGF agents used for treating neovascular age-related macular degeneration: comparison of ranibizumab and bevacizumab. Curr Med Res Opin 27(7):1465–1475
    • (2011) Curr Med Res Opin , vol.27 , Issue.7 , pp. 1465-1475
    • Mitchell, P.1
  • 12
    • 0030795733 scopus 로고    scopus 로고
    • Vascular endothelial growth factor: crystal structure and functional mapping of the kinase domain receptor binding site
    • COI: 1:CAS:528:DyaK2sXksFOiu7k%3D, PID: 9207067
    • Muller YA, Li B, Christinger HW, Wells JA, Cunningham BC, de Vos AM (1997) Vascular endothelial growth factor: crystal structure and functional mapping of the kinase domain receptor binding site. Proc Natl Acad Sci 94(14):7192–7197
    • (1997) Proc Natl Acad Sci , vol.94 , Issue.14 , pp. 7192-7197
    • Muller, Y.A.1    Li, B.2    Christinger, H.W.3    Wells, J.A.4    Cunningham, B.C.5    de Vos, A.M.6
  • 13
    • 77949318969 scopus 로고    scopus 로고
    • Regulation of vascular endothelial growth factor (VEGF) splicing from pro-angiogenic to anti-angiogenic isoforms: a novel therapeutic strategy for angiogenesis
    • COI: 1:CAS:528:DC%2BC3cXhvFCrtbw%3D, PID: 19906640
    • Nowak DG, Amin EM, Rennel ES, Hoareau-Aveilla C, Gammons M, Damodoran G, Hagiwara M, Harper SJ, Woolard J, Ladomery MR, Bates DO (2010) Regulation of vascular endothelial growth factor (VEGF) splicing from pro-angiogenic to anti-angiogenic isoforms—a novel therapeutic strategy for angiogenesis. J Biol Chem 285(8):5532–5540
    • (2010) J Biol Chem , vol.285 , Issue.8 , pp. 5532-5540
    • Nowak, D.G.1    Amin, E.M.2    Rennel, E.S.3    Hoareau-Aveilla, C.4    Gammons, M.5    Damodoran, G.6    Hagiwara, M.7    Harper, S.J.8    Woolard, J.9    Ladomery, M.R.10    Bates, D.O.11
  • 14
    • 84872302266 scopus 로고    scopus 로고
    • Long-term effect of intravitreal injection of anti-VEGF agent for visual acuity and chorioretinal atrophy progression in myopic choroidal neovascularization
    • COI: 1:CAS:528:DC%2BC3sXlt1yhuw%3D%3D
    • Oishi A, Yamashiro K, Tsujikawa A, Ooto S, Tamura H, Nakata I, Miyake M, Yoshimura N (2013) Long-term effect of intravitreal injection of anti-VEGF agent for visual acuity and chorioretinal atrophy progression in myopic choroidal neovascularization. Graefe’s Arch Clin Exp Ophthalmol 251(1):1–7
    • (2013) Graefe’s Arch Clin Exp Ophthalmol , vol.251 , Issue.1 , pp. 1-7
    • Oishi, A.1    Yamashiro, K.2    Tsujikawa, A.3    Ooto, S.4    Tamura, H.5    Nakata, I.6    Miyake, M.7    Yoshimura, N.8
  • 15
    • 84859488831 scopus 로고    scopus 로고
    • Structural basis for selective vascular endothelial growth factor-A (VEGF-A) binding to neuropilin-1
    • Parker MW, Xu P, Li X, Vander Kooi CW (2012) Structural basis for selective vascular endothelial growth factor-A (VEGF-A) binding to neuropilin-1. J Biol Chem 287(14):11082–11089. doi:10.1074/jbc.M111.331140
    • (2012) J Biol Chem , vol.287 , Issue.14 , pp. 11082-11089
    • Parker, M.W.1    Xu, P.2    Li, X.3    Vander Kooi, C.W.4
  • 16
    • 27744489034 scopus 로고    scopus 로고
    • Diabetic retinopathy is associated with a switch in splicing from anti- to pro-angiogenic isoforms of vascular endothelial growth factor
    • COI: 1:CAS:528:DC%2BD2MXht1Skt7vM, PID: 16193288
    • Perrin RM, Konopatskaya O, Qiu Y, Harper S, Bates DO, Churchill AJ (2005) Diabetic retinopathy is associated with a switch in splicing from anti- to pro-angiogenic isoforms of vascular endothelial growth factor. Diabetologia 48(11):2422–2427
    • (2005) Diabetologia , vol.48 , Issue.11 , pp. 2422-2427
    • Perrin, R.M.1    Konopatskaya, O.2    Qiu, Y.3    Harper, S.4    Bates, D.O.5    Churchill, A.J.6
  • 17
    • 0030976894 scopus 로고    scopus 로고
    • Extracellular cleavage of the vascular endothelial growth factor 189- amino acid form by urokinase is required for its mitogenic effect
    • COI: 1:CAS:528:DyaK2sXjtlartLo%3D, PID: 9148962
    • Plouet J, Moro F, Bertagnolli S, Coldeboeuf N, Mazarguil H, Clamens S, Bayard F (1997) Extracellular cleavage of the vascular endothelial growth factor 189- amino acid form by urokinase is required for its mitogenic effect. J Biol Chem 272(20):13390–13396
    • (1997) J Biol Chem , vol.272 , Issue.20 , pp. 13390-13396
    • Plouet, J.1    Moro, F.2    Bertagnolli, S.3    Coldeboeuf, N.4    Mazarguil, H.5    Clamens, S.6    Bayard, F.7
  • 19
    • 42049083543 scopus 로고    scopus 로고
    • Mammary alveolar development during lactation is inhibited by the endogenous antiangiogenic growth factor isoform, VEGF(165)b
    • COI: 1:CAS:528:DC%2BD1cXktlWnsbk%3D, PID: 18032632
    • Qiu Y, Bevan H, Weeraperuma S, Wratting D, Murphy D, Neal CR, Bates DO, Harper SJ (2008) Mammary alveolar development during lactation is inhibited by the endogenous antiangiogenic growth factor isoform, VEGF(165)b. FASEB J 22(4):1104–1112
    • (2008) FASEB J , vol.22 , Issue.4 , pp. 1104-1112
    • Qiu, Y.1    Bevan, H.2    Weeraperuma, S.3    Wratting, D.4    Murphy, D.5    Neal, C.R.6    Bates, D.O.7    Harper, S.J.8
  • 22
    • 0023039225 scopus 로고
    • A highly conserved vascular permeability factor secreted by a variety of human and rodent tumor cell lines
    • COI: 1:CAS:528:DyaL2sXhtlGrsw%3D%3D, PID: 3756910
    • Senger DR, Perruzzi CA, Feder J, Dvorak HF (1986) A highly conserved vascular permeability factor secreted by a variety of human and rodent tumor cell lines. Cancer Res 46(11):5629–5632
    • (1986) Cancer Res , vol.46 , Issue.11 , pp. 5629-5632
    • Senger, D.R.1    Perruzzi, C.A.2    Feder, J.3    Dvorak, H.F.4
  • 23
    • 33748479489 scopus 로고    scopus 로고
    • A VEGF-A splice variant defective for heparan sulfate and neuropilin-1 binding shows attenuated signaling through VEGFR-2
    • COI: 1:CAS:528:DC%2BD28XhtVCjt7%2FJ
    • Suarez SC, Pieren M, Cariolato L, Arn S, Hoffmann U, Bogucki A, Manlius C, Wood J, Ballmer-Hofer K (2006) A VEGF-A splice variant defective for heparan sulfate and neuropilin-1 binding shows attenuated signaling through VEGFR-2. Cell Mol Life Sci 63(17):2067–2077
    • (2006) Cell Mol Life Sci , vol.63 , Issue.17 , pp. 2067-2077
    • Suarez, S.C.1    Pieren, M.2    Cariolato, L.3    Arn, S.4    Hoffmann, U.5    Bogucki, A.6    Manlius, C.7    Wood, J.8    Ballmer-Hofer, K.9
  • 24
    • 42149152015 scopus 로고    scopus 로고
    • VEGF(165)b, an antiangiogenic VEGF-A isoform, binds and inhibits bevacizumab treatment in experimental colorectal carcinoma: balance of pro- and antiangiogenic VEGF-A isoforms has implications for therapy
    • COI: 1:CAS:528:DC%2BD1cXks12gurs%3D, PID: 18349829
    • Varey AHR, Rennel ES, Qiu Y, Bevan HS, Perrin RM, Raffy S, Dixon AR, Paraskeva C, Zaccheo O, Hassan AB, Harper SJ, Bates DO (2008) VEGF(165)b, an antiangiogenic VEGF-A isoform, binds and inhibits bevacizumab treatment in experimental colorectal carcinoma: balance of pro- and antiangiogenic VEGF-A isoforms has implications for therapy. Br J Cancer 98(8):1366–1379
    • (2008) Br J Cancer , vol.98 , Issue.8 , pp. 1366-1379
    • Varey, A.H.R.1    Rennel, E.S.2    Qiu, Y.3    Bevan, H.S.4    Perrin, R.M.5    Raffy, S.6    Dixon, A.R.7    Paraskeva, C.8    Zaccheo, O.9    Hassan, A.B.10    Harper, S.J.11    Bates, D.O.12


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.