Korean red ginseng (Panax ginseng) inhibits obesity and improves lipid metabolism in high fat diet-fed castrated mice

Journal of Ethnopharmacology

Volumn 210, Issue , 2018, Pages 80-87

  Shin, Soon Shik ^a   Yoon, Michung ^b  

^a Dong Eui University   (South Korea)

^b Mokwon University   (South Korea)

Author keywords

3T3 L1 cell; Adipogenesis, dyslipidemia; Heaptic steatosis; Lipogenesis; Testosterone

Indexed keywords

GINSENG EXTRACT; GINSENOSIDE RB 1; GINSENOSIDE RG 1; TESTOSTERONE; ACYL COENZYME A DESATURASE; ANTIOBESITY AGENT; CCAAT ENHANCER BINDING PROTEIN ALPHA; CHOLESTEROL; GINSENOSIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PLANT EXTRACT; SCD1 PROTEIN, MOUSE; TRIACYLGLYCEROL;

ADIPOCYTE; ADIPOGENESIS; ADIPOSE TISSUE; ANDROGEN DEFICIENCY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD LEVEL; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG EFFECT; FOOD INTAKE; GINSENG; LIPID ANALYSIS; LIPID BLOOD LEVEL; LIPID DIET; LIPID LIVER LEVEL; LIPID METABOLISM; LIPID STORAGE; MALE; MOUSE; NONHUMAN; OBESITY; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; TRIACYLGLYCEROL BLOOD LEVEL; 3T3-L1 CELL LINE; ANIMAL; BLOOD; C57BL MOUSE; CHEMISTRY; DEFICIENCY; INTRA-ABDOMINAL FAT; ISOLATION AND PURIFICATION; LIVER; METABOLISM; ORCHIECTOMY; PANAX;

3T3-L1 CELLS; ADIPOCYTES; ADIPOGENESIS; ANIMALS; ANTI-OBESITY AGENTS; CCAAT-ENHANCER-BINDING PROTEIN-ALPHA; CHOLESTEROL; DIET, HIGH-FAT; GINSENOSIDES; INTRA-ABDOMINAL FAT; LIPID METABOLISM; LIVER; MALE; MICE; MICE, INBRED C57BL; OBESITY; ORCHIECTOMY; PANAX; PLANT EXTRACTS; PPAR GAMMA; STEAROYL-COA DESATURASE; TESTOSTERONE; TRIGLYCERIDES;

EID: 85028565655     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2017.08.032     Document Type: Article

References (46)

1. Attele, A.S., Wu, J.A., Yuan, C.S., Ginseng pharmacology: multiple constituents and multiple actions. Biochem. Pharmacol. 58 (1999), 1685–1693.
2. Attele, A.S., Zhou, Y.P., Xie, J.T., Wu, J.A., Zhang, L., Dey, L., Pugh, W., Rue, P.A., Polonsky, K.S., Yuan, C.S., Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component. Diabetes 51 (2002), 1851–1858.
3. Bent, S., Ko, R., Commonly used herbal medicines in the United States: a review. Am. J. Med. 116 (2004), 478–485.
4. Ericsson, J., Jackson, S.M., Kim, J.B., Spiegelman, B.M., Edwards, P.A., Identification of glycerol-3-phosphate acyltransferase as an adipocyte determination and differentiation factor 1- and sterol regulatory element-binding protein-responsive gene. J. Biol. Chem. 272 (1997), 7298–7305.
5. Francomano, D., Lenzi, A., Aversa, A., Effects of five-year treatment with testosterone undecanoate on metabolic and hormonal parameters in ageing men with metabolic syndrome. Int. J. Endocrinol., 2014, 2014, 527470.
6. Fui, M.N., Dupuis, P., Grossmann, M., Lowered testosterone in male obesity: mechanisms, morbidity and management. Asian J. Androl. 16 (2014), 223–231.
7. Gillis, C.N., Panax ginseng pharmacology: a nitric oxide link?. Biochem. Pharmacol. 54 (1997), 1–8.
8. Gregoire, F.M., Smas, C.M., Sul, H.S., Understanding adipocyte differentiation. Physiol. Rev. 78 (1998), 783–809.
9. Hong, Y., Kim, M.Y., Yoon, M., The anti-angiogenic herbal extracts Ob-X from Morus alba, Melissa officinalis, and Artemisia capillaris suppresses adipogenesis in 3T3-L1 adipocytes. Pharm. Biol. 49 (2011), 775–783.
10. Huang, K.C., The Pharmacology of Chinese Herbs. 1999, CRC Press, Boca Raton.
11. Jeong, S., Yoon, M., Fenofibrate inhibits adipocyte hypertrophy and insulin resistance by activating adipose PPARalpha in high fat diet-induced obese mice. Exp. Mol. Med. 41 (2009), 397–405.
12. Ji, W., Gong, B.Q., Hypolipidemic effects and mechanisms of Panax notoginseng on lipid profile in hyperlipidemic rats. J. Ethnopharmacol. 113 (2007), 318–324.
13. Jung, S., Lee, M.S., Shin, Y., Kim, C.T., Kim, I.H., Kim, Y., High hydrostatic pressure extract of red ginseng attenuates inflammation in rats with high-fat diet induced obesity. Prev. Nutr. Food Sci. 20 (2015), 253–259.
14. Kang, K.S., Yamabe, N., Kim, H.Y., Park, J.H., Yokozawa, T., Effects of heat-processed ginseng and its active component ginsenoside 20(S)-Rg3 on the progression of renal damage and dysfunction in type 2 diabetic Otsuka Long-Evans Tokushima Fatty rats. Biol. Pharm. Bull. 33 (2010), 1077–1081.
15. Karu, N., Reifen, R., Kerem, Z., Weight gain reduction in mice fed Panax ginseng saponin, a pancreatic lipase inhibitor. J. Agric. Food Chem. 55 (2007), 2824–2828.
16. Kelly, D.M., Jones, T.H., Testosterone and obesity. Obes. Rev. 16 (2015), 581–606.
17. Kim, J.H., Hahm, D.H., Yang, D.C., Kim, J.H., Lee, H.J., Shim, I., Effect of crude saponin of Korean red ginseng on high-fat diet-induced obesity in the rat. J. Pharmacol. Sci. 97 (2005), 124–131.
18. Kim, J., Lee, H., Lim, J., Oh, J., Shin, S.S., Yoon, M., The angiogenesis inhibitor ALS-L1023 from lemon-balm leaves attenuates high-fat diet-induced nonalcoholic fatty liver disease through regulating the visceral adipose-tissue function. Int. J. Mol. Sci., 18, 2017, E846.
19. Kim, M.H., Lee, E.J., Cheon, J.M., Nam, K.J., Oh, T.H., Kim, K.S., Antioxidant and hepatoprotective effects of fermented red ginseng against high fat diet-induced hyperlipidemia in rats. Lab. Anim. Res. 32 (2016), 217–223.
20. Laforest, S., Labrecque, J., Michaud, A., Cianflone, K., Tchernof, A., Adipocyte size as a determinant of metabolic disease and adipose tissue dysfunction. Crit. Rev. Clin. Lab. Sci. 52 (2015), 301–313.
21. Lee, H., Choi, J., Shin, S.S., Yoon, M., Effects of Korean red ginseng (Panax ginseng) on obesity and adipose inflammation in ovariectomized mice. J. Ethnopharmacol. 178 (2016), 229–237.
22. Lee, H., Kim, M., Shin, S.S., Yoon, M., Ginseng treatment reverses obesity and related disorders by inhibiting angiogenesis in female db/db mice. J. Ethnopharmacol. 155 (2014), 1342–1352.
23. Lee, H., Park, D., Yoon, M., Korean red ginseng (Panax ginseng) prevents obesity by inhibiting angiogenesis in high fat diet-induced obese C57BL/6J mice. Food Chem. Toxicol. 53 (2013), 402–408.
24. Lee, H.J., Lee, Y.H., Park, S.K., Kang, E.S., Kim, H.J., Lee, Y.C., Choi, C.S., Park, S.E., Ahn, C.W., Cha, B.S., Lee, K.W., Kim, K.S., Lim, S.K., Lee, H.C., Korean red ginseng (Panax ginseng) improves insulin sensitivity and attenuates the development of diabetes in Otsuka Long-Evans Tokushima fatty rats. Metabolism 58 (2009), 1170–1177.
25. Lee, M., Sung, S.H., Platyphylloside isolated from Betula platyphylla inhibit adipocyte differentiation and induce lipolysis via regulating adipokines including PPARγ in 3T3-L1 cells. Pharmacogn. Mag. 12 (2016), 276–281.
26. Lee, S.H., Lee, H.J., Lee, Y.H., Lee, B.W., Cha, B.S., Kang, E.S., Ahn, C.W., Park, J.S., Kim, H.J., Lee, E.Y., Lee, H.C., Korean red ginseng (Panax ginseng) improves insulin sensitivity in high fat fed Sprague-Dawley rats. Phytother. Res. 26 (2012), 142–147.
27. Lu, J.M., Yao, Q., Chen, C., Ginseng compounds: an update on their molecular mechanisms and medical applications. Curr. Vasc. Pharmacol. 7 (2009), 293–302.
28. Michalakis, K., Goulis, D.G., Vazaiou, A., Mintziori, G., Polymeris, A., Abrahamian-Michalakis, A., Obesity in the ageing man. Metabolism 62 (2013), 1341–1349.
29. Mollah, M.L., Kim, G.S., Moon, H.K., Chung, S.K., Cheon, Y.P., Kim, J.K., Kim, K.S., Antiobesity effects of wild ginseng (Panax ginseng C.A. Meyer) mediated by PPAR-gamma, GLUT4 and LPL in ob/ob mice. Phytother. Res. 23 (2009), 220–225.
30. Oh, J., Lee, H., Lim, H., Woo, S., Shin, S.S., Yoon, M., The herbal composition GGEx18 from Laminaria japonica, Rheum palmatum, and Ephedra sinica inhibits visceral obesity and insulin resistance by upregulating visceral adipose genes involved in fatty acid oxidation. Pharm. Biol. 53 (2015), 301–312.
31. Oh, J., Lee, H., Park, D., Ahn, J., Shin, S.S., Yoon, M., Ginseng and its active components ginsenosides inhibit adipogenesis in 3T3-L1 cells by regulating MMP-2 and MMP-9. Evid. Based Complement Altern. Med., 2012, 2012, 265023.
32. Park, H.J., Kim, D.H., Park, S.J., Kim, J.M., Ryu, J.H., Ginseng in traditional herbal prescriptions. J. Ginseng Res. 36 (2012), 225–241.
33. Rosen, E.D., Spiegelman, B.M., Molecular regulation of adipogenesis. Annu. Rev. Cell Dev. Biol. 16 (2000), 145–171.
34. School, J.N.M., Renshen. Chinese Materia Medica Dictionary 1. 1986, Shanghai Scientific & Technical Publishers, Shanghai, China.
35. Singh, R., Artaza, J.N., Taylor, W.E., Braga, M., Yuan, X., Gonzalez-Cadavid, N.F., Bhasin, S., Testosterone inhibits adipogenic differentiation in 3T3-L1 cells: nuclear translocation of androgen receptor complex with beta-catenin and T-cell factor 4 may bypass canonical Wnt signaling to down-regulate adipogenic transcription factors. Endocrinology 147 (2006), 141–154.
36. Siraj, F.M., Natarajan, S., Huq, M.A., Kim, Y.J., Yang, D.C., Structural investigation of ginsenoside Rf with PPARγ major transcriptional factor of adipogenesis and its impact on adipocyte. J. Ginseng Res. 39 (2015), 141–147.
37. Song, Y.B., An, Y.R., Kim, S.J., Park, H.W., Jung, J.W., Kyung, J.S., Hwang, S.Y., Kim, Y.S., Lipid metabolic effect of Korean red ginseng extract in mice fed on a high-fat diet. J. Sci. Food Agric. 92 (2012), 388–396.
38. Strable, M.S., Ntambi, J.M., Genetic control of de novo lipogenesis: role in diet-induced obesity. Crit. Rev. Biochem. Mol. Biol. 45 (2010), 199–214.
39. Traish, A.M., Testosterone and weight loss: the evidence. Curr. Opin. Endocrinol. Diabetes Obes. 21 (2014), 313–322.
40. Winslow, L.C., Kroll, D.J., Herbs as medicines. Arch. Intern. Med. 158 (1998), 2192–2199.
41. Woo, S., Yoon, M., Kim, J., Hong, Y., Kim, M.Y., Shin, S.S., Yoon, M., The anti-angiogenic herbal extract from Melissa officinalis inhibits adipogenesis in 3T3-L1 adipocytes and suppresses adipocyte hypertrophy in high fat diet-induced obese C57BL/6J mice. J. Ethnopharmacol. 178 (2016), 238–250.
42. Yang, J.W., Kim, S.S., Ginsenoside Rc promotes anti-adipogenic activity on 3T3-L1 adipocytes by down-regulating C/EBPα and PPARγ. Molecules 20 (2015), 1293–1303.
43. Yassin, A., Doros, G., Testosterone therapy in hypogonadal men results in sustained and clinically meaningful weight loss. Clin. Obes. 3 (2013), 73–83.
44. Yin, J., Zhang, H., Ye, J., Traditional Chinese medicine in treatment of metabolic syndrome. Endocr. Metab. Immune Disord. Drug Targets 8 (2008), 99–111.
45. Yun, T.K., Brief introduction of Panax ginseng C.A. Meyer. J. Korean Med. Sci. 16 (2001), S3–S5.
46. Zhang, L., Ge, L., Tran, T., Stenn, K., Prouty, S.M., Isolation and characterization of the human stearoyl-CoA desaturase gene promoter: requirement of a conserved CCAAT cis-element. Biochem. J. 357 (2001), 183–193.