Benzo[a]pyrene impedes self-renewal and differentiation of mesenchymal stem cells and influences fracture healing

Science of the Total Environment

Volumn 587-588, Issue , 2017, Pages 305-315

  Zhou, Yiqing ^a   Jiang, Rong ^a   An, Liqin ^a   Wang, Hong ^a   Cheng, Sicheng ^a   Qiong, Shi ^a   Weng, Yaguang ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Aryl hydrocarbon receptor; Benzo a pyrene; Fracture healing; Mesenchymal stem cells; Resveratrol

Indexed keywords

BARIUM COMPOUNDS; FLOWCHARTING; FRACTURE; HYDROCARBONS; PYRENE; RESVERATROL; SIGNALING; SMOKE; STEM CELLS;

ARYL HYDROCARBON RECEPTOR; BENZO [A] PYRENE; BONE MARROW MESENCHYMAL STEM CELLS; FRACTURE HEALING; HUMAN BONE MARROW; MESENCHYMAL STEM CELL; OSTEOBLAST DIFFERENTIATION; SIGNALING PATHWAYS;

CELL CULTURE;

AROMATIC HYDROCARBON RECEPTOR; BENZO[A]PYRENE; CYTOCHROME P450 1B1; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; RESVERATROL; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

BIOTECHNOLOGY; BONE; CYTOCHROME; DIFFERENTIATION; PAH;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW DERIVED MESENCHYMAL STEM CELL; C3H10T1/2 CELL LINE; CALLUS; CELL DIFFERENTIATION; CELL LINE; CELL SELF-RENEWAL; CONTROLLED STUDY; CYP1B1 GENE; FRACTURE HEALING; GENE EXPRESSION; IN VITRO STUDY; IN VIVO STUDY; MESENCHYMAL STEM CELL; NONHUMAN; RAT; SIGNAL TRANSDUCTION; SMOKING; TIBIA FRACTURE; UPREGULATION; ANIMAL; DRUG EFFECT; MESENCHYMAL STROMA CELL; METABOLISM; POLLUTANT; TOXICITY;

RATTUS;

ANIMALS; BENZO(A)PYRENE; CELL DIFFERENTIATION; ENVIRONMENTAL POLLUTANTS; FRACTURE HEALING; MESENCHYMAL STROMAL CELLS; RATS; RECEPTORS, ARYL HYDROCARBON;

EID: 85028246046     PISSN: 00489697     EISSN: 18791026     Source Type: Journal    
DOI: 10.1016/j.scitotenv.2017.02.152     Document Type: Article

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