2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) alters the endogenous metabolism of all-trans-retinoic acid in the rat

Archives of Toxicology

Volumn 77, Issue 7, 2003, Pages 371-383

  Schmidt, Carsten K ^a   Hoegberg, Pi ^b   Fletcher, Nicholas ^b   Nilsson, Charlotte B ^b,c   Trossvik, Christina ^b   Håkansson, Helen ^b   Nau, Heinz ^a  

^a UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

^b KAROLINSKA INSTITUTE   (Sweden)

^c ASTRAZENECA R AND D   (Sweden)

Author keywords

9,13 Di cis retinoic acid; 9 Cis 4 oxo 13,14 dihydro retinoic acid; All trans retinoic acid; Cellular retinol binding protein I; Cytochrome P450; Metabolism; Rat; TCDD; Vitamin A

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2B1; RETINOIC ACID; RETINOIC ACID DERIVATIVE; RETINOL ESTER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; ENZYME ACTIVITY; ENZYME SYNTHESIS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TOXICITY TESTING; TOXICOKINETICS; VITAMIN METABOLISM;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; ENVIRONMENTAL POLLUTANTS; GLUCURONIDASE; KIDNEY; LIVER; MALE; RATS; RATS, SPRAGUE-DAWLEY; TETRACHLORODIBENZODIOXIN; TIME FACTORS; TRETINOIN;

ANIMALIA; VERTEBRATA;

EID: 0043161874     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-003-0457-8     Document Type: Article

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