The impact of intravenous fish oil emulsions on pediatric intestinal failure-associated liver disease

Current Opinion in Organ Transplantation

Volumn 16, Issue 3, 2011, Pages 306-311

  Venick, Robert S ^a   Calkins, Kara ^b  

^a MATTEL CHILDREN S HOSPITAL   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

children; fish oil; intestinal failure associated liver disease; omega 3 fatty acids; parenteral nutrition

Indexed keywords

FISH OIL; INTRALIPID; LIPOSYN; OMEGAVEN; SOYBEAN OIL EMULSION;

ANTIOXIDANT ACTIVITY; BILE FLOW; COHORT ANALYSIS; DRUG DOSE COMPARISON; HUMAN; INFLAMMATION; INTESTINAL FAILURE ASSOCIATED LIVER DISEASE; LIPOGENESIS; LIVER DISEASE; NONHUMAN; PARENTERAL NUTRITION; REVIEW;

EID: 85027956638     PISSN: 10872418     EISSN: 15317013     Source Type: Journal    
DOI: 10.1097/MOT.0b013e32834670eb     Document Type: Review

References (44)

1. Teitelbaum DH. Parenteral nutrition-associated cholestasis. CurrOpin Pediatr 1997; 9:270-275. (Pubitemid 27336929)
2. Kelley DA. Intestinal failure-associated liver disease: what do we know today? Gastroenterology 2006; 130:S70-S77.
3. Alwayn I, Gura K, Nosé V, et al. Omega-3 fatty acid supplementation prevents hepatic steatosis in a murine model of nonalcoholic fatty liver disease. Pediatr Res 2005; 57:445-452. (Pubitemid 40293615)
4. Van Aerde J, Duerksen D, Gramlich L, et al. Intravenous fish oil emulsion attenuates total parenteral nutrition induced cholestasis in new born piglets. Pediatr Res 1999; 45:202-208. (Pubitemid 29075996)
5. Gura K. Safety and efficacy of a fish oil based fat emulsion in the treatment of parenteral nutrition associated liver disease. Pediatrics 2008; 121:e678-e686.
6. Puder M, Valim C, Meisel JA, et al. Parenteral fish oil improves outcomes in patients with parenteral nutrition-associated liver injury. Ann Surg 2009; 250:395-402.
7. Diamond IR, Sterescu A, Pencharz PB, et al. Changing the paradigm: Omegaven for the treatment of liver failure in pediatric short bowel syndrome. J Pediatr Gastroenterol Nutr 2009; 48:209-215.
8. Chung PH, Wong KK, Wong RM, et al. Clinical experience in managing pediatric patients with ultra-short bowel syndrome using omega-3 fatty acids. Eur J Pediatr Surg 2010; 20:139-142.
9. Ekema G, Falchetti D, Boroni G, et al. Reversal of severe parenteral nutritionassociated liver disease in an infant with short bowel syndrome using parenteral fish oil (omega-3 fatty acids). J Pediatr Surg 2008; 43:1191-1195. (Pubitemid 351814874)
10. Calhoun AW, Sullivan JE. Omegaven for the treatment of parenteral nutrition associated liver disease: a case study. J Ky Med Assoc 2009; 107:55-57.
11. Cheung HM, Lam HS, Tam YH, et al. Rescue treatment of infants with intestinal failure and parenteral nutrition-associated cholestasis (PNAC) using parenteral fish-oil based lipid. Clin Nutr 2009; 28:209-212.
12. Gura KM, Stribjosch R, Arnold S, et al. The role of an intravenous fat emulsion composed of fish oil in a parenteral nutrition dependent-patient with hypertriglyceridemia. Nutr Clin Pract 2007; 22:664-672.
13. Gura KM, Duggan CP, Collier SB, et al. Reversal of parenteral nutritionassociated liver disease in two infants with short bowel syndrome using parenteral fish oil: implications for future management. Pediatrics 2006; 118:e197-e201. (Pubitemid 46071136)
14. Farmer DG, Venick RS. Morbidity and mortality associated with chronic intestinal failure. Transplantation 2008; 85:1385-1386.
15. Fishbein TM. Intestinal transplantation. N Engl J Med 2009; 10:998-1008.
16. Wichmann MW, Thul P, Czarnetzki HD, et al. Evaluation of clinical safety and beneficial effects of fish oil containing lipid emulsions (Lipoplus, MLF541): data from a prospective, randomized, multicenter trial. Crit Care Med 2007; 35:700-706. (Pubitemid 46407781)
17. Wachtler P, König W, Senkal M, et al. Influence of a total parenteral nutrition enriched with omega-3 fatty acids on leukotriene synthesis on peripheral leukocytes and systemic cytokine levels in patients with major surgery. J Trauma 1997; 42:191-198. (Pubitemid 27104652)
18. Schauder P, Röhn U, Schäfer G, et al. Impact of fish oil enriched parenteral nutrition on DNA synthesis, cytokine release and receptor expression by lymphocytes in postoperative period. Br J Nutr 2002; 87:S103-S110. (Pubitemid 34134110)
19. Mayer K, Fegbeurtel C, Hatter K, et al. Omega-3 vs. omega-6 lipid emulsions exert differential influence on neutrophils in septic shock patients: impact on plasma fatty acids and lipid mediator generation. Intensive Care Med 2003; 167:1472-1481. (Pubitemid 37153591)
20. Clayton PT, Bowron A, Mills KA, et al. Phytosterolemia in children with parenteral nutrition-associated cholestatic liver disease. Gastroenterology 1993; 105:1806-1813. (Pubitemid 24002799)
21. Bindl L, Lütjohann D, Buderus S. High plasma levels of phytosterols in patients on parenteral nutrition: a marker of liver dysfunction. J Ped Gastroenterol Nutr 2000; 31:313-316.
22. Goulet O, Anté bi H, Wolf C, et al. A new intravenous fat emulsion containing soybean oil, medium chain triglycerides, olive oil, and fish oil. J Parenter Enteral Nutr 2010; 34:485-495.
23. Skouroliakou M, Konstantinou D, Koutri K, et al. A double-blind, randomized clinical trial of the v-3 fatty acids on the oxidative stress of premature neonates fed through parenteral nutrition. Eur J Clin Nutr 2010; 64:940-947.
24. Lee SI, Valim C, Johnston P, et al. Impact of fish oil-based lipid emulsions on serum triglyceride, bilirubin, and albumin levels in children with parenteral nutrition liver disease. Pediatr Res 2009; 66:698-703.
25. Le HD, de Meijer VE, Zurakowski D, et al. Parenteral fish oil as monotherapy improves lipid profiles in children with parenteral nutrition-associated liver disease. J Parenter Enteral Nutr 2010; 34:477-484.
26. Kris-Etherton PM, Harris WS, Appel LJ, et al. Omega-3 fatty acids and cardiovascular disease: new recommendations from the American Heart Association. Arterioscler Thromb Vasc Biol 2003; 23:151-152. (Pubitemid 36231919)
27. Ryan AS, Astwood JD, Gautier S, et al. Effects of long-chain polyunsaturated fatty acid supplementation on neurodevelopment in childhood: a review of human studies. Prostaglandins Leukot Essent Fatty Acids 2010; 82:305-314.
28. Mallah HS, Brown MR, Rossi TM, et al. Parenteral fish oil-associated burr cell anemia. J Pediatr 2010; 156:324-326.
29. De Meijer VE, Le HD, Meisel JA, et al. Parenteral fish oil as monotherapy prevents essential fatty acid deficiency in parenteral nutrition-dependent patients. J Pediatr Gastroenterol Nutr 2010; 50:212-218.
30. Yang Q, Kock ND. Effects of dietary fish oil on intestinal adaptation in 20-dayold weanling rats after massive ileocecal resection. Pediatr Res 2010; 68:183-187.
31. Sukhotnik I, Shany A, Bashenko Y, et al. Parenteral but not enteral omega-3 fatty acids (Omegaven) modulate intestinal regrowth after massive small bowel resections in rats. J Parenter Enteral Nutr 2010; 35:503-512.
32. Rollins M, Scaife ER, Jackson D, et al. Elimination of soybean lipid emulsion in parenteral nutrition and supplementation with enteral fish oil improve cholestasis in infants with short bowel syndrome. Nutr Clin Pract 2010; 25:199-204.
33. Colomb V, Jobert-Giraud A, Lacaille F, et al. Role of lipid emulsions in cholestasis associated with long-term parenteral nutrition. J Parenter Enteral Nutr 2000; 24:345-350.
34. Nasr A, Diamond IR, de Silva NT, Wales PW. Is the use of parenteral v-3 lipid emulsions justified in surgical neonates with mild parenteral nutritionassociated liver dysfunction? J Pediatr Surg 2010; 45:980-986.
35. Soden JS, Lovell MA, Brown K, et al. Failure of resolution of portal fibrosis during omega-3 fatty acid lipid emulsion therapy in two patients with irreversible intestinal failure. J Pediatr 2010; 156:327-331.
36. Fitzgibbons SC, Jones BA, Hull MA, et al. Relationship between biopsyproven parenteral nutrition-associated liver fibrosis and biochemical cholestasis in children with short bowel syndrome. J Pediatr Surg 2010; 45:95-99.
37. Kohl M, Wedel T, Entenmann A, et al. Influence of different intravenous lipid emulsions on hepatobiliary dysfunction in a rabbit model. J Pediatr Gastroenterol Nutr 2007; 44:237-244. (Pubitemid 46175079)
38. Cole CR, Hansen NI, Higgins R, et al. Very low birth weight preterm infants with surgical short bowel syndrome: incidence, morbidity, mortality, and growth outcomes at 18 to 22 months. Pediatrics 2008; 122:e573-e582.
39. Ehrenkranz RA, Younes N, Lemons JA, et al. Longitudinal growth of hospitalized very low birth weight infants. Pediatrics 1999; 104:280-289. (Pubitemid 29362137)
40. Church MW, Jen K-LC, Anumba JI, et al. Excess omega-3 fatty acid consumption by mothers during pregnancy and lactation caused shorter life span and abnormal ABRs in old adult offspring. Neurotoxicol Teratol 2010; 32:171-181.
41. Church MW, Jen K-LC, Jackson DA, et al. Abnormal neurological responses in young adult offspring caused by excess omega-3 fatty acid (fish oil) consumption by the mother during pregnancy and lactation. Neurotoxicol Teratol 2009; 31:26-33.
42. Tsuduki T, Honma T, Nakagawa K, et al. Long-term intake of fish oil increases oxidative stress and decreases lifespan in senescence-accelerated mice. Nutrition 2010; 10:1-4.
43. Gura KM, Puder M. Rapid infusion of fish-oil-based emulsion in infants does not appear to be associated with fat overload syndrome. Nutr Clin Pract 2010; 25:399-402.
44. Sixth Annual International Pediatric Intestinal Failure Symposium; Chicago, Illinois, USA; 2010.