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Volumn 15, Issue 4, 2015, Pages S23-S31

Genetic susceptibility factors for alcohol-induced chronic pancreatitis

Author keywords

ABO blood type; Alcohol metabolizing enzymes; CFTR; FUT2; PRSS1; SPINK1

Indexed keywords

ALCOHOL;

EID: 85027953087     PISSN: 14243903     EISSN: 14243911     Source Type: Journal    
DOI: 10.1016/j.pan.2015.05.476     Document Type: Review
Times cited : (30)

References (97)
  • 1
    • 84901719075 scopus 로고    scopus 로고
    • Too many germans are addicted to alcohol or tobacco, says report
    • Stafford, N., Too many germans are addicted to alcohol or tobacco, says report. BMJ, 348, 2014, g2992.
    • (2014) BMJ , vol.348 , pp. g2992
    • Stafford, N.1
  • 4
    • 62049085236 scopus 로고    scopus 로고
    • Chronic pancreatitis: report from a multicenter italian survey (pancroinfaisp) on 893 patients
    • Frulloni, L., Gabbrielli, A., Pezzilli, R., Zerbi, A., Cavestro, G.M., Marotta, F., et al. Chronic pancreatitis: report from a multicenter italian survey (pancroinfaisp) on 893 patients. Dig Liver Dis 41 (2009), 311–317.
    • (2009) Dig Liver Dis , vol.41 , pp. 311-317
    • Frulloni, L.1    Gabbrielli, A.2    Pezzilli, R.3    Zerbi, A.4    Cavestro, G.M.5    Marotta, F.6
  • 5
    • 53749083558 scopus 로고    scopus 로고
    • Risk of pancreatitis according to alcohol drinking habits: a population-based cohort study
    • Kristiansen, L., Gronbaek, M., Becker, U., Tolstrup, J.S., Risk of pancreatitis according to alcohol drinking habits: a population-based cohort study. Am J Epidemiol 168 (2008), 932–937.
    • (2008) Am J Epidemiol , vol.168 , pp. 932-937
    • Kristiansen, L.1    Gronbaek, M.2    Becker, U.3    Tolstrup, J.S.4
  • 6
    • 0018238473 scopus 로고
    • Multicenter survey of the etiology of pancreatic diseases. Relationship between the relative risk of developing chronic pancreaitis and alcohol, protein and lipid consumption
    • Durbec, J.P., Sarles, H., Multicenter survey of the etiology of pancreatic diseases. Relationship between the relative risk of developing chronic pancreaitis and alcohol, protein and lipid consumption. Digestion 18 (1978), 337–350.
    • (1978) Digestion , vol.18 , pp. 337-350
    • Durbec, J.P.1    Sarles, H.2
  • 7
    • 0028269723 scopus 로고
    • Balance of expression of genes coding for extracellular matrix proteins and extracellular matrix degrading proteases in chronic pancreatitis
    • Gress, T.M., Muller-Pillasch, F., Lerch, M.M., Friess, H., Buchler, M., Beger, H.G., et al. Balance of expression of genes coding for extracellular matrix proteins and extracellular matrix degrading proteases in chronic pancreatitis. Z fur Gastroenterol 32 (1994), 221–225.
    • (1994) Z fur Gastroenterol , vol.32 , pp. 221-225
    • Gress, T.M.1    Muller-Pillasch, F.2    Lerch, M.M.3    Friess, H.4    Buchler, M.5    Beger, H.G.6
  • 8
    • 26844578434 scopus 로고    scopus 로고
    • Extracellular cleavage of e-cadherin by leukocyte elastase during acute experimental pancreatitis in rats
    • Mayerle, J., Schnekenburger, J., Kruger, B., Kellermann, J., Ruthenburger, M., Weiss, F.U., et al. Extracellular cleavage of e-cadherin by leukocyte elastase during acute experimental pancreatitis in rats. Gastroenterology 129 (2005), 1251–1267.
    • (2005) Gastroenterology , vol.129 , pp. 1251-1267
    • Mayerle, J.1    Schnekenburger, J.2    Kruger, B.3    Kellermann, J.4    Ruthenburger, M.5    Weiss, F.U.6
  • 10
    • 84873408281 scopus 로고    scopus 로고
    • Tumour necrosis factor alpha secretion induces protease activation and acinar cell necrosis in acute experimental pancreatitis in mice
    • Sendler, M., Dummer, A., Weiss, F.U., Kruger, B., Wartmann, T., Scharffetter-Kochanek, K., et al. Tumour necrosis factor alpha secretion induces protease activation and acinar cell necrosis in acute experimental pancreatitis in mice. Gut 62 (2013), 430–439.
    • (2013) Gut , vol.62 , pp. 430-439
    • Sendler, M.1    Dummer, A.2    Weiss, F.U.3    Kruger, B.4    Wartmann, T.5    Scharffetter-Kochanek, K.6
  • 11
    • 0034078632 scopus 로고    scopus 로고
    • Does alcohol directly stimulate pancreatic fibrogenesis? Studies with rat pancreatic stellate cells
    • Apte, M.V., Phillips, P.A., Fahmy, R.G., Darby, S.J., Rodgers, S.C., McCaughan, G.W., et al. Does alcohol directly stimulate pancreatic fibrogenesis? Studies with rat pancreatic stellate cells. Gastroenterology 118 (2000), 780–794.
    • (2000) Gastroenterology , vol.118 , pp. 780-794
    • Apte, M.V.1    Phillips, P.A.2    Fahmy, R.G.3    Darby, S.J.4    Rodgers, S.C.5    McCaughan, G.W.6
  • 12
    • 0345059397 scopus 로고    scopus 로고
    • Nonoxidative ethanol metabolites alter extracellular matrix protein content in rat pancreas
    • Lugea, A., Gukovsky, I., Gukovskaya, A.S., Pandol, S.J., Nonoxidative ethanol metabolites alter extracellular matrix protein content in rat pancreas. Gastroenterology 125 (2003), 1845–1859.
    • (2003) Gastroenterology , vol.125 , pp. 1845-1859
    • Lugea, A.1    Gukovsky, I.2    Gukovskaya, A.S.3    Pandol, S.J.4
  • 13
    • 79951726916 scopus 로고    scopus 로고
    • Alcohol and smoking as risk factors in an epidemiology study of patients with chronic pancreatitis
    • quiz e227
    • Cote, G.A., Yadav, D., Slivka, A., Hawes, R.H., Anderson, M.A., Burton, F.R., et al. Alcohol and smoking as risk factors in an epidemiology study of patients with chronic pancreatitis. Clin Gastroenterol Hepatol 9 (2011), 266–273 quiz e227.
    • (2011) Clin Gastroenterol Hepatol , vol.9 , pp. 266-273
    • Cote, G.A.1    Yadav, D.2    Slivka, A.3    Hawes, R.H.4    Anderson, M.A.5    Burton, F.R.6
  • 14
    • 67249158929 scopus 로고    scopus 로고
    • Alcohol consumption, cigarette smoking, and the risk of recurrent acute and chronic pancreatitis
    • Yadav, D., Hawes, R.H., Brand, R.E., Anderson, M.A., Money, M.E., Banks, P.A., et al. Alcohol consumption, cigarette smoking, and the risk of recurrent acute and chronic pancreatitis. Arch Intern Med 169 (2009), 1035–1045.
    • (2009) Arch Intern Med , vol.169 , pp. 1035-1045
    • Yadav, D.1    Hawes, R.H.2    Brand, R.E.3    Anderson, M.A.4    Money, M.E.5    Banks, P.A.6
  • 15
    • 1842580431 scopus 로고    scopus 로고
    • A meta-analysis of alcohol consumption and the risk of 15 diseases
    • Corrao, G., Bagnardi, V., Zambon, A., La Vecchia, C., A meta-analysis of alcohol consumption and the risk of 15 diseases. Prev Med 38 (2004), 613–619.
    • (2004) Prev Med , vol.38 , pp. 613-619
    • Corrao, G.1    Bagnardi, V.2    Zambon, A.3    La Vecchia, C.4
  • 16
    • 68649126081 scopus 로고    scopus 로고
    • Alcohol as a risk factor for pancreatitis. A systematic review and meta-analysis
    • Irving, H.M., Samokhvalov, A.V., Rehm, J., Alcohol as a risk factor for pancreatitis. A systematic review and meta-analysis. JOP 10 (2009), 387–392.
    • (2009) JOP , vol.10 , pp. 387-392
    • Irving, H.M.1    Samokhvalov, A.V.2    Rehm, J.3
  • 18
    • 84876787550 scopus 로고    scopus 로고
    • The epidemiology of pancreatitis and pancreatic cancer
    • Yadav, D., Lowenfels, A.B., The epidemiology of pancreatitis and pancreatic cancer. Gastroenterology 144 (2013), 1252–1261.
    • (2013) Gastroenterology , vol.144 , pp. 1252-1261
    • Yadav, D.1    Lowenfels, A.B.2
  • 19
    • 0037865506 scopus 로고    scopus 로고
    • Limited contribution of the spink1 n34s mutation to the risk and severity of alcoholic chronic pancreatitis: a report from the united states
    • Schneider, A., Pfutzer, R.H., Barmada, M.M., Slivka, A., Martin, J., Whitcomb, D.C., Limited contribution of the spink1 n34s mutation to the risk and severity of alcoholic chronic pancreatitis: a report from the united states. Dig Dis Sci 48 (2003), 1110–1115.
    • (2003) Dig Dis Sci , vol.48 , pp. 1110-1115
    • Schneider, A.1    Pfutzer, R.H.2    Barmada, M.M.3    Slivka, A.4    Martin, J.5    Whitcomb, D.C.6
  • 20
    • 76949133404 scopus 로고
    • Pedigree of a family with hereditary chronic relapsing pancreatitis
    • Comfort, M.W., Steinberg, A.G., Pedigree of a family with hereditary chronic relapsing pancreatitis. Gastroenterology 21 (1952), 54–63.
    • (1952) Gastroenterology , vol.21 , pp. 54-63
    • Comfort, M.W.1    Steinberg, A.G.2
  • 22
    • 0027324765 scopus 로고
    • Sphincter stenosis and gallstone migration through the biliary tract
    • Hernandez, C.A., Lerch, M.M., Sphincter stenosis and gallstone migration through the biliary tract. Lancet 341 (1993), 1371–1373.
    • (1993) Lancet , vol.341 , pp. 1371-1373
    • Hernandez, C.A.1    Lerch, M.M.2
  • 23
    • 0025821614 scopus 로고
    • Apical secretion of lysosomal enzymes in rabbit pancreas occurs via a secretagogue regulated pathway and is increased after pancreatic duct obstruction
    • Hirano, T., Saluja, A., Ramarao, P., Lerch, M.M., Saluja, M., Steer, M.L., Apical secretion of lysosomal enzymes in rabbit pancreas occurs via a secretagogue regulated pathway and is increased after pancreatic duct obstruction. J Clin Invest 87 (1991), 865–869.
    • (1991) J Clin Invest , vol.87 , pp. 865-869
    • Hirano, T.1    Saluja, A.2    Ramarao, P.3    Lerch, M.M.4    Saluja, M.5    Steer, M.L.6
  • 24
    • 0344589358 scopus 로고    scopus 로고
    • Direct detection of premature protease activation in living pancreatic acinar cells. Laboratory investigation
    • Kruger, B., Lerch, M.M., Tessenow, W., Direct detection of premature protease activation in living pancreatic acinar cells. Laboratory investigation. A J Tech Methods Pathol 78 (1998), 763–764.
    • (1998) A J Tech Methods Pathol , vol.78 , pp. 763-764
    • Kruger, B.1    Lerch, M.M.2    Tessenow, W.3
  • 25
    • 0026772323 scopus 로고
    • Acute necrotizing pancreatitis in the opossum: earliest morphological changes involve acinar cells
    • Lerch, M.M., Saluja, A.K., Dawra, R., Ramarao, P., Saluja, M., Steer, M.L., Acute necrotizing pancreatitis in the opossum: earliest morphological changes involve acinar cells. Gastroenterology 103 (1992), 205–213.
    • (1992) Gastroenterology , vol.103 , pp. 205-213
    • Lerch, M.M.1    Saluja, A.K.2    Dawra, R.3    Ramarao, P.4    Saluja, M.5    Steer, M.L.6
  • 26
    • 0035702382 scopus 로고    scopus 로고
    • Clinical characterization of patients with hereditary pancreatitis and mutations in the cationic trypsinogen gene
    • Keim, V., Bauer, N., Teich, N., Simon, P., Lerch, M.M., Mossner, J., Clinical characterization of patients with hereditary pancreatitis and mutations in the cationic trypsinogen gene. Am J Med 111 (2001), 622–626.
    • (2001) Am J Med , vol.111 , pp. 622-626
    • Keim, V.1    Bauer, N.2    Teich, N.3    Simon, P.4    Lerch, M.M.5    Mossner, J.6
  • 27
    • 0019353008 scopus 로고
    • Characterization of human exocrine pancreatic proteins by two-dimensional isoelectric focusing/sodium dodecyl sulfate gel electrophoresis
    • Scheele, G., Bartelt, D., Bieger, W., Characterization of human exocrine pancreatic proteins by two-dimensional isoelectric focusing/sodium dodecyl sulfate gel electrophoresis. Gastroenterology 80 (1981), 461–473.
    • (1981) Gastroenterology , vol.80 , pp. 461-473
    • Scheele, G.1    Bartelt, D.2    Bieger, W.3
  • 28
    • 0030813082 scopus 로고    scopus 로고
    • Mutations in the cationic trypsinogen gene are associated with recurrent acute and chronic pancreatitis
    • Gorry, M.C., Gabbaizedeh, D., Furey, W., Gates, L.K. Jr., Preston, R.A., Aston, C.E., et al. Mutations in the cationic trypsinogen gene are associated with recurrent acute and chronic pancreatitis. Gastroenterology 113 (1997), 1063–1068.
    • (1997) Gastroenterology , vol.113 , pp. 1063-1068
    • Gorry, M.C.1    Gabbaizedeh, D.2    Furey, W.3    Gates, L.K.4    Preston, R.A.5    Aston, C.E.6
  • 29
    • 0035554033 scopus 로고    scopus 로고
    • Consensus committees of the european registry of hereditary pancreatic diseases MM-CPSGIAoP: genetic testing for hereditary pancreatitis: guidelines for indications, counselling, consent and privacy issues
    • Ellis, I., Lerch, M.M., Whitcomb, D.C., Consensus committees of the european registry of hereditary pancreatic diseases MM-CPSGIAoP: genetic testing for hereditary pancreatitis: guidelines for indications, counselling, consent and privacy issues. Pancreatology 1 (2001), 405–415.
    • (2001) Pancreatology , vol.1 , pp. 405-415
    • Ellis, I.1    Lerch, M.M.2    Whitcomb, D.C.3
  • 30
    • 0037032399 scopus 로고    scopus 로고
    • Spontaneous and sporadic trypsinogen mutations in idiopathic pancreatitis
    • Simon, P., Weiss, F.U., Zimmer, K.P., Rand, S., Brinkmann, B., Domschke, W., et al. Spontaneous and sporadic trypsinogen mutations in idiopathic pancreatitis. JAMA, 288, 2002, 2122.
    • (2002) JAMA , vol.288 , pp. 2122
    • Simon, P.1    Weiss, F.U.2    Zimmer, K.P.3    Rand, S.4    Brinkmann, B.5    Domschke, W.6
  • 31
    • 0033866202 scopus 로고    scopus 로고
    • Chronic pancreatitis associated with an activation peptide mutation that facilitates trypsin activation
    • Teich, N., Ockenga, J., Hoffmeister, A., Manns, M., Mossner, J., Keim, V., Chronic pancreatitis associated with an activation peptide mutation that facilitates trypsin activation. Gastroenterology 119 (2000), 461–465.
    • (2000) Gastroenterology , vol.119 , pp. 461-465
    • Teich, N.1    Ockenga, J.2    Hoffmeister, A.3    Manns, M.4    Mossner, J.5    Keim, V.6
  • 32
    • 0032993541 scopus 로고    scopus 로고
    • A signal peptide cleavage site mutation in the cationic trypsinogen gene is strongly associated with chronic pancreatitis
    • Witt, H., Luck, W., Becker, M., A signal peptide cleavage site mutation in the cationic trypsinogen gene is strongly associated with chronic pancreatitis. Gastroenterology 117 (1999), 7–10.
    • (1999) Gastroenterology , vol.117 , pp. 7-10
    • Witt, H.1    Luck, W.2    Becker, M.3
  • 33
    • 2442723724 scopus 로고    scopus 로고
    • Mutations in the cationic trypsinogen gene and evidence for genetic heterogeneity in hereditary pancreatitis
    • Ferec, C., Raguenes, O., Salomon, R., Roche, C., Bernard, J.P., Guillot, M., et al. Mutations in the cationic trypsinogen gene and evidence for genetic heterogeneity in hereditary pancreatitis. J Med Genet 36 (1999), 228–232.
    • (1999) J Med Genet , vol.36 , pp. 228-232
    • Ferec, C.1    Raguenes, O.2    Salomon, R.3    Roche, C.4    Bernard, J.P.5    Guillot, M.6
  • 34
    • 18544365392 scopus 로고    scopus 로고
    • Hereditary pancreatitis caused by a novel prss1 mutation (arg-122–> cys) that alters autoactivation and autodegradation of cationic trypsinogen
    • Simon, P., Weiss, F.U., Sahin-Toth, M., Parry, M., Nayler, O., Lenfers, B., et al. Hereditary pancreatitis caused by a novel prss1 mutation (arg-122–> cys) that alters autoactivation and autodegradation of cationic trypsinogen. J Biol Chem 277 (2002), 5404–5410.
    • (2002) J Biol Chem , vol.277 , pp. 5404-5410
    • Simon, P.1    Weiss, F.U.2    Sahin-Toth, M.3    Parry, M.4    Nayler, O.5    Lenfers, B.6
  • 35
    • 2442727497 scopus 로고    scopus 로고
    • Screening for mutations of the cationic trypsinogen gene: are they of relevance in chronic alcoholic pancreatitis?
    • Teich, N., Mossner, J., Keim, V., Screening for mutations of the cationic trypsinogen gene: are they of relevance in chronic alcoholic pancreatitis?. Gut 44 (1999), 413–416.
    • (1999) Gut , vol.44 , pp. 413-416
    • Teich, N.1    Mossner, J.2    Keim, V.3
  • 36
    • 0141590214 scopus 로고    scopus 로고
    • Mutation analysis of the cystic fibrosis transmembrane conductance regulator (cftr) gene, the cationic trypsinogen (prss1) gene, and the serine protease inhibitor, kazal type 1 (spink1) gene in patients with alcoholic chronic pancreatitis
    • Perri, F., Piepoli, A., Stanziale, P., Merla, A., Zelante, L., Andriulli, A., Mutation analysis of the cystic fibrosis transmembrane conductance regulator (cftr) gene, the cationic trypsinogen (prss1) gene, and the serine protease inhibitor, kazal type 1 (spink1) gene in patients with alcoholic chronic pancreatitis. Eur J Hum Genet 11 (2003), 687–692.
    • (2003) Eur J Hum Genet , vol.11 , pp. 687-692
    • Perri, F.1    Piepoli, A.2    Stanziale, P.3    Merla, A.4    Zelante, L.5    Andriulli, A.6
  • 37
    • 0033836071 scopus 로고    scopus 로고
    • Mutation analysis of the cystic fibrosis and cationic trypsinogen genes in patients with alcohol-related pancreatitis
    • Monaghan, K.G., Jackson, C.E., KuKuruga, D.L., Feldman, G.L., Mutation analysis of the cystic fibrosis and cationic trypsinogen genes in patients with alcohol-related pancreatitis. Am J Med Genet 94 (2000), 120–124.
    • (2000) Am J Med Genet , vol.94 , pp. 120-124
    • Monaghan, K.G.1    Jackson, C.E.2    KuKuruga, D.L.3    Feldman, G.L.4
  • 38
    • 0034829906 scopus 로고    scopus 로고
    • Mutations of the cationic trypsinogen gene in hereditary and non-hereditary pancreatitis
    • O'Reilly, D.A., Yang, B.M., Creighton, J.E., Demaine, A.G., Kingsnorth, A.N., Mutations of the cationic trypsinogen gene in hereditary and non-hereditary pancreatitis. Digestion 64 (2001), 54–60.
    • (2001) Digestion , vol.64 , pp. 54-60
    • O'Reilly, D.A.1    Yang, B.M.2    Creighton, J.E.3    Demaine, A.G.4    Kingsnorth, A.N.5
  • 39
    • 79952440277 scopus 로고    scopus 로고
    • The prevalence of cationic trypsinogen (prss1) and serine protease inhibitor, kazal type 1 (spink1) gene mutations in polish patients with alcoholic and idiopathic chronic pancreatitis
    • Gasiorowska, A., Talar-Wojnarowska, R., Czupryniak, L., Smolarz, B., Romanowicz-Makowska, H., Kulig, A., et al. The prevalence of cationic trypsinogen (prss1) and serine protease inhibitor, kazal type 1 (spink1) gene mutations in polish patients with alcoholic and idiopathic chronic pancreatitis. Dig Dis Sci 56 (2011), 894–901.
    • (2011) Dig Dis Sci , vol.56 , pp. 894-901
    • Gasiorowska, A.1    Talar-Wojnarowska, R.2    Czupryniak, L.3    Smolarz, B.4    Romanowicz-Makowska, H.5    Kulig, A.6
  • 40
    • 50549086404 scopus 로고    scopus 로고
    • Multicenter approach to recurrent acute and chronic pancreatitis in the united states: the north american pancreatitis study 2 (naps2)
    • Whitcomb, D.C., Yadav, D., Adam, S., Hawes, R.H., Brand, R.E., Anderson, M.A., et al. Multicenter approach to recurrent acute and chronic pancreatitis in the united states: the north american pancreatitis study 2 (naps2). Pancreatology 8 (2008), 520–531.
    • (2008) Pancreatology , vol.8 , pp. 520-531
    • Whitcomb, D.C.1    Yadav, D.2    Adam, S.3    Hawes, R.H.4    Brand, R.E.5    Anderson, M.A.6
  • 41
    • 84870511045 scopus 로고    scopus 로고
    • Common genetic variants in the cldn2 and prss1-prss2 loci alter risk for alcohol-related and sporadic pancreatitis
    • Whitcomb, D.C., LaRusch, J., Krasinskas, A.M., Klei, L., Smith, J.P., Brand, R.E., et al. Common genetic variants in the cldn2 and prss1-prss2 loci alter risk for alcohol-related and sporadic pancreatitis. Nat Genet 44 (2012), 1349–1354.
    • (2012) Nat Genet , vol.44 , pp. 1349-1354
    • Whitcomb, D.C.1    LaRusch, J.2    Krasinskas, A.M.3    Klei, L.4    Smith, J.P.5    Brand, R.E.6
  • 42
    • 84915828472 scopus 로고    scopus 로고
    • Polymorphisms at prss1-prss2 and cldn2-morc4 loci associate with alcoholic and non-alcoholic chronic pancreatitis in a european replication study
    • pii: gutjnl-2014-307453 [Epub is ahead of print]
    • Derikx, M.H., Kovacs, P., Scholz, M., Masson, E., Chen, J.M., Ruffert, C., et al. Polymorphisms at prss1-prss2 and cldn2-morc4 loci associate with alcoholic and non-alcoholic chronic pancreatitis in a european replication study. Gut, 2014 Sep 24 pii: gutjnl-2014-307453 [Epub is ahead of print].
    • (2014) Gut
    • Derikx, M.H.1    Kovacs, P.2    Scholz, M.3    Masson, E.4    Chen, J.M.5    Ruffert, C.6
  • 43
    • 0037387886 scopus 로고    scopus 로고
    • Spink1 mutations and phenotypic expression in patients with pancreatitis associated with trypsinogen mutations
    • Weiss, F.U., Simon, P., Witt, H., Mayerle, J., Hlouschek, V., Zimmer, K.P., et al. Spink1 mutations and phenotypic expression in patients with pancreatitis associated with trypsinogen mutations. J Med Genet, 40, 2003, e40.
    • (2003) J Med Genet , vol.40 , pp. e40
    • Weiss, F.U.1    Simon, P.2    Witt, H.3    Mayerle, J.4    Hlouschek, V.5    Zimmer, K.P.6
  • 44
    • 0034039578 scopus 로고    scopus 로고
    • Mutations in the gene encoding the serine protease inhibitor, kazal type 1 are associated with chronic pancreatitis
    • Witt, H., Luck, W., Hennies, H.C., Classen, M., Kage, A., Lass, U., et al. Mutations in the gene encoding the serine protease inhibitor, kazal type 1 are associated with chronic pancreatitis. Nat Genet 25 (2000), 213–216.
    • (2000) Nat Genet , vol.25 , pp. 213-216
    • Witt, H.1    Luck, W.2    Hennies, H.C.3    Classen, M.4    Kage, A.5    Lass, U.6
  • 45
    • 0033857452 scopus 로고    scopus 로고
    • Spink1/psti polymorphisms act as disease modifiers in familial and idiopathic chronic pancreatitis
    • Pfutzer, R.H., Barmada, M.M., Brunskill, A.P., Finch, R., Hart, P.S., Neoptolemos, J., et al. Spink1/psti polymorphisms act as disease modifiers in familial and idiopathic chronic pancreatitis. Gastroenterology 119 (2000), 615–623.
    • (2000) Gastroenterology , vol.119 , pp. 615-623
    • Pfutzer, R.H.1    Barmada, M.M.2    Brunskill, A.P.3    Finch, R.4    Hart, P.S.5    Neoptolemos, J.6
  • 46
    • 0036096103 scopus 로고    scopus 로고
    • Mutations in the pancreatic secretory trypsin inhibitor gene (psti/spink1) rather than the cationic trypsinogen gene (prss1) are significantly associated with tropical calcific pancreatitis
    • Chandak, G.R., Idris, M.M., Reddy, D.N., Bhaskar, S., Sriram, P.V., Singh, L., Mutations in the pancreatic secretory trypsin inhibitor gene (psti/spink1) rather than the cationic trypsinogen gene (prss1) are significantly associated with tropical calcific pancreatitis. J Med Genet 39 (2002), 347–351.
    • (2002) J Med Genet , vol.39 , pp. 347-351
    • Chandak, G.R.1    Idris, M.M.2    Reddy, D.N.3    Bhaskar, S.4    Sriram, P.V.5    Singh, L.6
  • 47
    • 0036102601 scopus 로고    scopus 로고
    • The n34s mutation of spink1 (psti) is associated with a familial pattern of idiopathic chronic pancreatitis but does not cause the disease
    • Threadgold, J., Greenhalf, W., Ellis, I., Howes, N., Lerch, M.M., Simon, P., et al. The n34s mutation of spink1 (psti) is associated with a familial pattern of idiopathic chronic pancreatitis but does not cause the disease. Gut 50 (2002), 675–681.
    • (2002) Gut , vol.50 , pp. 675-681
    • Threadgold, J.1    Greenhalf, W.2    Ellis, I.3    Howes, N.4    Lerch, M.M.5    Simon, P.6
  • 48
    • 0036113792 scopus 로고    scopus 로고
    • Mutations in serine protease inhibitor kazal type 1 are strongly associated with chronic pancreatitis
    • Drenth, J.P., te Morsche, R., Jansen, J.B., Mutations in serine protease inhibitor kazal type 1 are strongly associated with chronic pancreatitis. Gut 50 (2002), 687–692.
    • (2002) Gut , vol.50 , pp. 687-692
    • Drenth, J.P.1    te Morsche, R.2    Jansen, J.B.3
  • 49
    • 0035816020 scopus 로고    scopus 로고
    • Mutation in the spink1 trypsin inhibitor gene, alcohol use, and chronic pancreatitis
    • Witt, H., Luck, W., Becker, M., Bohmig, M., Kage, A., Truninger, K., et al. Mutation in the spink1 trypsin inhibitor gene, alcohol use, and chronic pancreatitis. JAMA 285 (2001), 2716–2717.
    • (2001) JAMA , vol.285 , pp. 2716-2717
    • Witt, H.1    Luck, W.2    Becker, M.3    Bohmig, M.4    Kage, A.5    Truninger, K.6
  • 50
    • 44849092282 scopus 로고    scopus 로고
    • Pathways to injury in chronic pancreatitis: decoding the role of the high-risk spink1 n34s haplotype using meta-analysis
    • Aoun, E., Chang, C.C., Greer, J.B., Papachristou, G.I., Barmada, M.M., Whitcomb, D.C., Pathways to injury in chronic pancreatitis: decoding the role of the high-risk spink1 n34s haplotype using meta-analysis. PLoS One, 3, 2008, e2003.
    • (2008) PLoS One , vol.3 , pp. e2003
    • Aoun, E.1    Chang, C.C.2    Greer, J.B.3    Papachristou, G.I.4    Barmada, M.M.5    Whitcomb, D.C.6
  • 51
    • 84901605375 scopus 로고    scopus 로고
    • Understanding how cystic fibrosis mutations disrupt cftr function: from single molecules to animal models
    • Wang, Y., Wrennall, J.A., Cai, Z., Li, H., Sheppard, D.N., Understanding how cystic fibrosis mutations disrupt cftr function: from single molecules to animal models. Int J Biochem Cell Biol 52 (2014), 47–57.
    • (2014) Int J Biochem Cell Biol , vol.52 , pp. 47-57
    • Wang, Y.1    Wrennall, J.A.2    Cai, Z.3    Li, H.4    Sheppard, D.N.5
  • 52
    • 25444432550 scopus 로고    scopus 로고
    • Complete cystic fibrosis transmembrane conductance regulator gene sequencing in patients with idiopathic chronic pancreatitis and controls
    • Weiss, F.U., Simon, P., Bogdanova, N., Mayerle, J., Dworniczak, B., Horst, J., et al. Complete cystic fibrosis transmembrane conductance regulator gene sequencing in patients with idiopathic chronic pancreatitis and controls. Gut 54 (2005), 1456–1460.
    • (2005) Gut , vol.54 , pp. 1456-1460
    • Weiss, F.U.1    Simon, P.2    Bogdanova, N.3    Mayerle, J.4    Dworniczak, B.5    Horst, J.6
  • 55
    • 0032480253 scopus 로고    scopus 로고
    • Mutations of the cystic fibrosis gene in patients with chronic pancreatitis
    • Sharer, N., Schwarz, M., Malone, G., Howarth, A., Painter, J., Super, M., et al. Mutations of the cystic fibrosis gene in patients with chronic pancreatitis. N Engl J Med 339 (1998), 645–652.
    • (1998) N Engl J Med , vol.339 , pp. 645-652
    • Sharer, N.1    Schwarz, M.2    Malone, G.3    Howarth, A.4    Painter, J.5    Super, M.6
  • 57
    • 0036844738 scopus 로고    scopus 로고
    • Germline mutations in cftr and psti genes in chronic pancreatitis patients
    • Gaia, E., Salacone, P., Gallo, M., Promis, G.G., Brusco, A., Bancone, C., et al. Germline mutations in cftr and psti genes in chronic pancreatitis patients. Dig Dis Sci 47 (2002), 2416–2421.
    • (2002) Dig Dis Sci , vol.47 , pp. 2416-2421
    • Gaia, E.1    Salacone, P.2    Gallo, M.3    Promis, G.G.4    Brusco, A.5    Bancone, C.6
  • 58
    • 81355156452 scopus 로고    scopus 로고
    • Cystic fibrosis transmembrane regulator (cftr) deltaf508 mutation and 5t allele in patients with chronic pancreatitis and exocrine pancreatic cancer. Pankras ii study group
    • Malats, N., Casals, T., Porta, M., Guarner, L., Estivill, X., Real, F.X., Cystic fibrosis transmembrane regulator (cftr) deltaf508 mutation and 5t allele in patients with chronic pancreatitis and exocrine pancreatic cancer. Pankras ii study group. Gut 48 (2001), 70–74.
    • (2001) Gut , vol.48 , pp. 70-74
    • Malats, N.1    Casals, T.2    Porta, M.3    Guarner, L.4    Estivill, X.5    Real, F.X.6
  • 59
    • 74849110216 scopus 로고    scopus 로고
    • Association analyses of genetic polymorphisms of gstm1, gstt1, nqo1, nat2, lpl, prss1, psti, and cftr with chronic alcoholic pancreatitis in japan
    • Maruyama, K., Harada, S., Yokoyama, A., Mizukami, S., Naruse, S., Hirota, M., et al. Association analyses of genetic polymorphisms of gstm1, gstt1, nqo1, nat2, lpl, prss1, psti, and cftr with chronic alcoholic pancreatitis in japan. Alcohol Clin Exp Res 34:Suppl. 1 (2010), S34–S38.
    • (2010) Alcohol Clin Exp Res , vol.34 , pp. S34-S38
    • Maruyama, K.1    Harada, S.2    Yokoyama, A.3    Mizukami, S.4    Naruse, S.5    Hirota, M.6
  • 61
    • 84921328905 scopus 로고    scopus 로고
    • Alcohol disrupts levels and function of the cystic fibrosis transmembrane conductance regulator to promote development of pancreatitis
    • 427–439 e416
    • Maleth, J., Balazs, A., Pallagi, P., Balla, Z., Kui, B., Katona, M., et al. Alcohol disrupts levels and function of the cystic fibrosis transmembrane conductance regulator to promote development of pancreatitis. Gastroenterology, 148, 2015 427–439 e416.
    • (2015) Gastroenterology , vol.148
    • Maleth, J.1    Balazs, A.2    Pallagi, P.3    Balla, Z.4    Kui, B.5    Katona, M.6
  • 62
    • 34547437254 scopus 로고    scopus 로고
    • Chymotrypsin c (caldecrin) promotes degradation of human cationic trypsin: identity with rinderknecht's enzyme y
    • Szmola, R., Sahin-Toth, M., Chymotrypsin c (caldecrin) promotes degradation of human cationic trypsin: identity with rinderknecht's enzyme y. Proc Natl Acad Sci U S A 104 (2007), 11227–11232.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 11227-11232
    • Szmola, R.1    Sahin-Toth, M.2
  • 63
    • 37549072225 scopus 로고    scopus 로고
    • Chymotrypsin c (ctrc) variants that diminish activity or secretion are associated with chronic pancreatitis
    • Rosendahl, J., Witt, H., Szmola, R., Bhatia, E., Ozsvari, B., Landt, O., et al. Chymotrypsin c (ctrc) variants that diminish activity or secretion are associated with chronic pancreatitis. Nat Genet 40 (2008), 78–82.
    • (2008) Nat Genet , vol.40 , pp. 78-82
    • Rosendahl, J.1    Witt, H.2    Szmola, R.3    Bhatia, E.4    Ozsvari, B.5    Landt, O.6
  • 64
    • 65449140633 scopus 로고    scopus 로고
    • Association of novel chymotrypsin c gene variations and haplotypes in patients with chronic pancreatitis in chinese in taiwan
    • Chang, M.C., Chang, Y.T., Wei, S.C., Liang, P.C., Jan, I.S., Su, Y.N., et al. Association of novel chymotrypsin c gene variations and haplotypes in patients with chronic pancreatitis in chinese in taiwan. Pancreatology 9 (2009), 287–292.
    • (2009) Pancreatology , vol.9 , pp. 287-292
    • Chang, M.C.1    Chang, Y.T.2    Wei, S.C.3    Liang, P.C.4    Jan, I.S.5    Su, Y.N.6
  • 65
    • 33644499201 scopus 로고    scopus 로고
    • Do alcohol-metabolizing enzyme gene polymorphisms increase the risk of alcoholism and alcoholic liver disease?
    • Zintzaras, E., Stefanidis, I., Santos, M., Vidal, F., Do alcohol-metabolizing enzyme gene polymorphisms increase the risk of alcoholism and alcoholic liver disease?. Hepatology 43 (2006), 352–361.
    • (2006) Hepatology , vol.43 , pp. 352-361
    • Zintzaras, E.1    Stefanidis, I.2    Santos, M.3    Vidal, F.4
  • 66
    • 0035188749 scopus 로고    scopus 로고
    • Genetic polymorphisms of alcohol metabolizing enzymes
    • Agarwal, D.P., Genetic polymorphisms of alcohol metabolizing enzymes. Pathol Biol Paris 49 (2001), 703–709.
    • (2001) Pathol Biol Paris , vol.49 , pp. 703-709
    • Agarwal, D.P.1
  • 67
    • 34147207362 scopus 로고    scopus 로고
    • Alcohol dehydrogenase and aldehyde dehydrogenase gene polymorphism in alcohol liver cirrhosis and alcohol chronic pancreatitis among polish individuals
    • Cichoz-Lach, H., Partycka, J., Nesina, I., Celinski, K., Slomka, M., Wojcierowski, J., Alcohol dehydrogenase and aldehyde dehydrogenase gene polymorphism in alcohol liver cirrhosis and alcohol chronic pancreatitis among polish individuals. Scand J Gastroenterol 42 (2007), 493–498.
    • (2007) Scand J Gastroenterol , vol.42 , pp. 493-498
    • Cichoz-Lach, H.1    Partycka, J.2    Nesina, I.3    Celinski, K.4    Slomka, M.5    Wojcierowski, J.6
  • 68
    • 34547433163 scopus 로고    scopus 로고
    • The genetics of alcohol metabolism: role of alcohol dehydrogenase and aldehyde dehydrogenase variants
    • Edenberg, H.J., The genetics of alcohol metabolism: role of alcohol dehydrogenase and aldehyde dehydrogenase variants. Alcohol Res Health J Natl Inst Alcohol Abuse Alcohol 30 (2007), 5–13.
    • (2007) Alcohol Res Health J Natl Inst Alcohol Abuse Alcohol , vol.30 , pp. 5-13
    • Edenberg, H.J.1
  • 69
    • 33745146510 scopus 로고    scopus 로고
    • Functional assessment of human alcohol dehydrogenase family in ethanol metabolism: significance of first-pass metabolism
    • Lee, S.L., Chau, G.Y., Yao, C.T., Wu, C.W., Yin, S.J., Functional assessment of human alcohol dehydrogenase family in ethanol metabolism: significance of first-pass metabolism. Alcohol Clin Exp Res 30 (2006), 1132–1142.
    • (2006) Alcohol Clin Exp Res , vol.30 , pp. 1132-1142
    • Lee, S.L.1    Chau, G.Y.2    Yao, C.T.3    Wu, C.W.4    Yin, S.J.5
  • 70
    • 79957560651 scopus 로고    scopus 로고
    • Mammalian alcohol dehydrogenases – a comparative investigation at gene and protein levels
    • Hoog, J.O., Ostberg, L.J., Mammalian alcohol dehydrogenases – a comparative investigation at gene and protein levels. Chem Biol Interact 191 (2011), 2–7.
    • (2011) Chem Biol Interact , vol.191 , pp. 2-7
    • Hoog, J.O.1    Ostberg, L.J.2
  • 71
    • 0027499273 scopus 로고
    • Induction of cytochrome p-4502e1 in the human liver by ethanol is caused by a corresponding increase in encoding messenger rna
    • Takahashi, T., Lasker, J.M., Rosman, A.S., Lieber, C.S., Induction of cytochrome p-4502e1 in the human liver by ethanol is caused by a corresponding increase in encoding messenger rna. Hepatology 17 (1993), 236–245.
    • (1993) Hepatology , vol.17 , pp. 236-245
    • Takahashi, T.1    Lasker, J.M.2    Rosman, A.S.3    Lieber, C.S.4
  • 72
    • 0030479924 scopus 로고    scopus 로고
    • Genotypes of alcohol-metabolizing enzymes and the risk for alcoholic chronic pancreatitis in japanese alcoholics
    • Matsumoto, M., Takahashi, H., Maruyama, K., Higuchi, S., Matsushita, S., Muramatsu, T., et al. Genotypes of alcohol-metabolizing enzymes and the risk for alcoholic chronic pancreatitis in japanese alcoholics. Alcohol Clin Exp Res 20 (1996), 289A–292A.
    • (1996) Alcohol Clin Exp Res , vol.20 , pp. 289A-292A
    • Matsumoto, M.1    Takahashi, H.2    Maruyama, K.3    Higuchi, S.4    Matsushita, S.5    Muramatsu, T.6
  • 73
    • 40749127214 scopus 로고    scopus 로고
    • Association analysis among polymorphisms of the various genes and chronic alcoholic pancreatitis
    • Maruyama, K., Harada, S., Yokoyama, A., Naruse, S., Hirota, M., Nishimori, I., et al. Association analysis among polymorphisms of the various genes and chronic alcoholic pancreatitis. J Gastroenterol Hepatol 23:Suppl. 1 (2008), S69–S72.
    • (2008) J Gastroenterol Hepatol , vol.23 , pp. S69-S72
    • Maruyama, K.1    Harada, S.2    Yokoyama, A.3    Naruse, S.4    Hirota, M.5    Nishimori, I.6
  • 74
    • 84881021495 scopus 로고    scopus 로고
    • Genetic polymorphisms of alcohol dehydrogenase-1b and aldehyde dehydrogenase-2 and liver cirrhosis, chronic calcific pancreatitis, diabetes mellitus, and hypertension among japanese alcoholic men
    • Yokoyama, A., Mizukami, T., Matsui, T., Yokoyama, T., Kimura, M., Matsushita, S., et al. Genetic polymorphisms of alcohol dehydrogenase-1b and aldehyde dehydrogenase-2 and liver cirrhosis, chronic calcific pancreatitis, diabetes mellitus, and hypertension among japanese alcoholic men. Alcohol Clin Exp Res 37 (2013), 1391–1401.
    • (2013) Alcohol Clin Exp Res , vol.37 , pp. 1391-1401
    • Yokoyama, A.1    Mizukami, T.2    Matsui, T.3    Yokoyama, T.4    Kimura, M.5    Matsushita, S.6
  • 75
    • 0022543084 scopus 로고
    • Genetic polymorphism of human liver alcohol and aldehyde dehydrogenases, and their relationship to alcohol metabolism and alcoholism
    • Bosron, W.F., Li, T.K., Genetic polymorphism of human liver alcohol and aldehyde dehydrogenases, and their relationship to alcohol metabolism and alcoholism. Hepatology 6 (1986), 502–510.
    • (1986) Hepatology , vol.6 , pp. 502-510
    • Bosron, W.F.1    Li, T.K.2
  • 76
    • 40749084459 scopus 로고    scopus 로고
    • Spink1, adh2, and aldh2 gene variants and alcoholic chronic pancreatitis in japan
    • Shimosegawa, T., Kume, K., Masamune, A., Spink1, adh2, and aldh2 gene variants and alcoholic chronic pancreatitis in japan. J Gastroenterol Hepatol 23:Suppl. 1 (2008), S82–S86.
    • (2008) J Gastroenterol Hepatol , vol.23 , pp. S82-S86
    • Shimosegawa, T.1    Kume, K.2    Masamune, A.3
  • 77
    • 18344414252 scopus 로고    scopus 로고
    • Genotypes of alcohol-metabolizing enzymes in relation to alcoholic chronic pancreatitis in japan
    • Maruyama, K., Takahashi, H., Matsushita, S., Nakano, M., Harada, H., Otsuki, M., et al. Genotypes of alcohol-metabolizing enzymes in relation to alcoholic chronic pancreatitis in japan. Alcohol Clin Exp Res 23 (1999), 85S–91S.
    • (1999) Alcohol Clin Exp Res , vol.23 , pp. 85S-91S
    • Maruyama, K.1    Takahashi, H.2    Matsushita, S.3    Nakano, M.4    Harada, H.5    Otsuki, M.6
  • 79
    • 85090928062 scopus 로고    scopus 로고
    • Genetic polymorphisms in alcohol dehydrogenase, aldehyde dehydrogenase and alcoholic chronic pancreatitis susceptibility: a meta-analysis
    • pii: S0210-5705(14)00304-5 [Epub ahead of print]
    • Zhong, Y., Cao, J., Zou, R., Peng, M., Genetic polymorphisms in alcohol dehydrogenase, aldehyde dehydrogenase and alcoholic chronic pancreatitis susceptibility: a meta-analysis. Gastroenterol Hepatol, 2014 Dec 22 pii: S0210-5705(14)00304-5 [Epub ahead of print].
    • (2014) Gastroenterol Hepatol
    • Zhong, Y.1    Cao, J.2    Zou, R.3    Peng, M.4
  • 80
    • 84869876508 scopus 로고    scopus 로고
    • Association of alcohol dehydrogenase polymorphisms and life-style factors with excessive alcohol intake within the spanish population (epic-spain)
    • Munoz, X., Amiano, P., Celorrio, D., Dorronsoro, M., Sanchez, M.J., Huerta, J.M., et al. Association of alcohol dehydrogenase polymorphisms and life-style factors with excessive alcohol intake within the spanish population (epic-spain). Addiction 107 (2012), 2117–2127.
    • (2012) Addiction , vol.107 , pp. 2117-2127
    • Munoz, X.1    Amiano, P.2    Celorrio, D.3    Dorronsoro, M.4    Sanchez, M.J.5    Huerta, J.M.6
  • 82
    • 0034144088 scopus 로고    scopus 로고
    • Localization, sequence analysis, and ethnic distribution of a 96-bp insertion in the promoter of the human cyp2e1 gene
    • Fritsche, E., Pittman, G.S., Bell, D.A., Localization, sequence analysis, and ethnic distribution of a 96-bp insertion in the promoter of the human cyp2e1 gene. Mutat Res 432 (2000), 1–5.
    • (2000) Mutat Res , vol.432 , pp. 1-5
    • Fritsche, E.1    Pittman, G.S.2    Bell, D.A.3
  • 83
    • 0242380807 scopus 로고    scopus 로고
    • Role of alcohol metabolism in alcoholic pancreatitis
    • Wilson, J.S., Apte, M.V., Role of alcohol metabolism in alcoholic pancreatitis. Pancreas 27 (2003), 311–315.
    • (2003) Pancreas , vol.27 , pp. 311-315
    • Wilson, J.S.1    Apte, M.V.2
  • 84
    • 84929132425 scopus 로고    scopus 로고
    • A recombined allele of the lipase gene cel and its pseudogene celp confers susceptibility to chronic pancreatitis
    • Fjeld, K., Weiss, F.U., Lasher, D., Rosendahl, J., Chen, J.M., Johansson, B.B., et al. A recombined allele of the lipase gene cel and its pseudogene celp confers susceptibility to chronic pancreatitis. Nat Genet 47:5 (2015 May), 518–522.
    • (2015) Nat Genet , vol.47 , Issue.5 , pp. 518-522
    • Fjeld, K.1    Weiss, F.U.2    Lasher, D.3    Rosendahl, J.4    Chen, J.M.5    Johansson, B.B.6
  • 86
    • 84904062557 scopus 로고    scopus 로고
    • Fatty acid ethyl ester synthase inhibition ameliorates ethanol-induced ca2+-dependent mitochondrial dysfunction and acute pancreatitis
    • Huang, W., Booth, D.M., Cane, M.C., Chvanov, M., Javed, M.A., Elliott, V.L., et al. Fatty acid ethyl ester synthase inhibition ameliorates ethanol-induced ca2+-dependent mitochondrial dysfunction and acute pancreatitis. Gut 63 (2014), 1313–1324.
    • (2014) Gut , vol.63 , pp. 1313-1324
    • Huang, W.1    Booth, D.M.2    Cane, M.C.3    Chvanov, M.4    Javed, M.A.5    Elliott, V.L.6
  • 87
    • 84896738968 scopus 로고    scopus 로고
    • Ethanol and its non-oxidative metabolites profoundly inhibit cftr function in pancreatic epithelial cells which is prevented by atp supplementation
    • Judak, L., Hegyi, P., Rakonczay, Z. Jr., Maleth, J., Gray, M.A., Venglovecz, V., Ethanol and its non-oxidative metabolites profoundly inhibit cftr function in pancreatic epithelial cells which is prevented by atp supplementation. Pflugers Archiv Eur J Physiol 466 (2014), 549–562.
    • (2014) Pflugers Archiv Eur J Physiol , vol.466 , pp. 549-562
    • Judak, L.1    Hegyi, P.2    Rakonczay, Z.3    Maleth, J.4    Gray, M.A.5    Venglovecz, V.6
  • 88
    • 33644654780 scopus 로고    scopus 로고
    • Carboxylester lipase gene polymorphism as a risk of alcohol-induced pancreatitis
    • Miyasaka, K., Ohta, M., Takano, S., Hayashi, H., Higuchi, S., Maruyama, K., et al. Carboxylester lipase gene polymorphism as a risk of alcohol-induced pancreatitis. Pancreas 30 (2005), e87–e91.
    • (2005) Pancreas , vol.30 , pp. e87-e91
    • Miyasaka, K.1    Ohta, M.2    Takano, S.3    Hayashi, H.4    Higuchi, S.5    Maruyama, K.6
  • 89
    • 85027948809 scopus 로고    scopus 로고
    • The number of tandem repeats in the carboxyl-ester lipase (cel) gene as a risk factor in alcoholic and idiopathic chronic pancreatitis
    • Ragvin, A., Fjeld, K., Weiss, F.U., Torsvik, J., Aghdassi, A., Mayerle, J., et al. The number of tandem repeats in the carboxyl-ester lipase (cel) gene as a risk factor in alcoholic and idiopathic chronic pancreatitis. Pancreatology 13 (2013), 29–32.
    • (2013) Pancreatology , vol.13 , pp. 29-32
    • Ragvin, A.1    Fjeld, K.2    Weiss, F.U.3    Torsvik, J.4    Aghdassi, A.5    Mayerle, J.6
  • 90
    • 27644520123 scopus 로고    scopus 로고
    • Hemin-activated macrophages home to the pancreas and protect from acute pancreatitis via heme oxygenase-1 induction
    • Nakamichi, I., Habtezion, A., Zhong, B., Contag, C.H., Butcher, E.C., Omary, M.B., Hemin-activated macrophages home to the pancreas and protect from acute pancreatitis via heme oxygenase-1 induction. J Clin Invest 115 (2005), 3007–3014.
    • (2005) J Clin Invest , vol.115 , pp. 3007-3014
    • Nakamichi, I.1    Habtezion, A.2    Zhong, B.3    Contag, C.H.4    Butcher, E.C.5    Omary, M.B.6
  • 91
    • 79953749880 scopus 로고    scopus 로고
    • Breaking down haem attenuates acute pancreatitis: a new treatment option?
    • Mayerle, J., Sendler, M., Lerch, M.M., Breaking down haem attenuates acute pancreatitis: a new treatment option?. Gut 60 (2011), 569–570.
    • (2011) Gut , vol.60 , pp. 569-570
    • Mayerle, J.1    Sendler, M.2    Lerch, M.M.3
  • 92
    • 0042943132 scopus 로고    scopus 로고
    • Microsatellite polymorphism in heme oxygenase-1 gene promoter is associated with susceptibility to oxidant-induced apoptosis in lymphoblastoid cell lines
    • Hirai, H., Kubo, H., Yamaya, M., Nakayama, K., Numasaki, M., Kobayashi, S., et al. Microsatellite polymorphism in heme oxygenase-1 gene promoter is associated with susceptibility to oxidant-induced apoptosis in lymphoblastoid cell lines. Blood 102 (2003), 1619–1621.
    • (2003) Blood , vol.102 , pp. 1619-1621
    • Hirai, H.1    Kubo, H.2    Yamaya, M.3    Nakayama, K.4    Numasaki, M.5    Kobayashi, S.6
  • 93
    • 84861637783 scopus 로고    scopus 로고
    • Genetic analyses of heme oxygenase 1 (hmox1) in different forms of pancreatitis
    • Weis, S., Jesinghaus, M., Kovacs, P., Schleinitz, D., Schober, R., Ruffert, C., et al. Genetic analyses of heme oxygenase 1 (hmox1) in different forms of pancreatitis. PLoS One, 7, 2012, e37981.
    • (2012) PLoS One , vol.7 , pp. e37981
    • Weis, S.1    Jesinghaus, M.2    Kovacs, P.3    Schleinitz, D.4    Schober, R.5    Ruffert, C.6
  • 94
    • 78751536418 scopus 로고    scopus 로고
    • Genetic variation in the pnpla3 gene is associated with alcoholic liver injury in caucasians
    • Stickel, F., Buch, S., Lau, K., Meyer zu Schwabedissen, H., Berg, T., Ridinger, M., et al. Genetic variation in the pnpla3 gene is associated with alcoholic liver injury in caucasians. Hepatology 53 (2011), 86–95.
    • (2011) Hepatology , vol.53 , pp. 86-95
    • Stickel, F.1    Buch, S.2    Lau, K.3    Meyer zu Schwabedissen, H.4    Berg, T.5    Ridinger, M.6
  • 95
    • 84856026934 scopus 로고    scopus 로고
    • A common variant of pnpla3 (p.I148m) is not associated with alcoholic chronic pancreatitis
    • Rosendahl, J., Tonjes, A., Schleinitz, D., Kovacs, P., Wiegand, J., Ruffert, C., et al. A common variant of pnpla3 (p.I148m) is not associated with alcoholic chronic pancreatitis. PLoS One, 7, 2012, e29433.
    • (2012) PLoS One , vol.7 , pp. e29433
    • Rosendahl, J.1    Tonjes, A.2    Schleinitz, D.3    Kovacs, P.4    Wiegand, J.5    Ruffert, C.6
  • 96
    • 0014217596 scopus 로고
    • The abo blood group antigens and their secretion by healthy and diseased gastric mucosa
    • Hoskins, L.C., The abo blood group antigens and their secretion by healthy and diseased gastric mucosa. Ann N Y Acad Sci 140 (1967), 848–865.
    • (1967) Ann N Y Acad Sci , vol.140 , pp. 848-865
    • Hoskins, L.C.1
  • 97
    • 84924427006 scopus 로고    scopus 로고
    • Fucosyltransferase 2 (fut2) non-secretor status and blood group b are associated with elevated serum lipase activity in asymptomatic subjects, and an increased risk for chronic pancreatitis: a genetic association study
    • Weiss, F.U., Schurmann, C., Guenther, A., Ernst, F., Teumer, A., Mayerle, J., et al. Fucosyltransferase 2 (fut2) non-secretor status and blood group b are associated with elevated serum lipase activity in asymptomatic subjects, and an increased risk for chronic pancreatitis: a genetic association study. Gut 64:4 (2015 Apr), 646–656.
    • (2015) Gut , vol.64 , Issue.4 , pp. 646-656
    • Weiss, F.U.1    Schurmann, C.2    Guenther, A.3    Ernst, F.4    Teumer, A.5    Mayerle, J.6


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