Fatty acid ethyl ester synthase inhibition ameliorates ethanol-induced Ca2+-dependent mitochondrial dysfunction and acute pancreatitis

Gut

Volumn 63, Issue 8, 2014, Pages 1313-1324

  Huang, Wei ^a,b   Booth, David M ^a   Cane, Matthew C ^a   Chvanov, Michael ^a   Javed, Muhammad A ^a   Elliott, Victoria L ^a   Armstrong, Jane A ^a   Dingsdale, Hayley ^a   Cash, Nicole ^a   Li, Yan ^a   Greenhalf, William ^a   Mukherjee, Rajarshi ^a   Kaphalia, Bhupendra S ^c   Jaffar, Mohammed ^d   Petersen, Ole H ^e   Tepikin, Alexei V ^a   Sutton, Robert ^a   Criddle, David N ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b SICHUAN UNIVERSITY   (China)

^c University of Texas Medical Branch School of Medicine   (United States)

^d Morvus Technology Limited   (United Kingdom)

^e CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3 BENZYL 6 CHLORO 2 PYRONE; 4 METHYLPYRAZOLE; ALCOHOL; AMYLASE; CALCIUM ION; CARBOXYLESTER LIPASE; CERULETIDE; ENZYME INHIBITOR; FATTY ACID ETHYL ESTER SYNTHASE; FATTY ACID SYNTHASE; MYELOPEROXIDASE; PALMITOLEIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TRIACYLGLYCEROL LIPASE; TRYPSIN; UNCLASSIFIED DRUG;

ACINAR CELL; ACUTE PANCREATITIS; AEROBIC METABOLISM; ALCOHOL METABOLISM; AMYLASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CELL DEATH; CELL FATE; CELL ISOLATION; CELL PROTECTION; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME INHIBITION; ENZYME LOCALIZATION; IN VITRO STUDY; IN VIVO STUDY; INBORN ERROR OF METABOLISM; INFLAMMATION; LIGAND BINDING; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MOLECULAR DOCKING; MOUSE; NECROSIS; NON OXIDATIVE METABOLISM OF ETHANOL; NONHUMAN; OXIDATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ACUTE PANCREATITIS; ALCOHOL-INDUCED INJURY; CALCIUM; ETHANOL; PANCREATIC DAMAGE;

ACINAR CELLS; ACYLTRANSFERASES; ANIMALS; APOPTOSIS; CALCIUM; CALCIUM SIGNALING; CARBOXYLESTERASE; CELLS, CULTURED; DISEASE MODELS, ANIMAL; ETHANOL; FATTY ACIDS; FATTY ACIDS, MONOUNSATURATED; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MITOCHONDRIA; NADP; NECROSIS; PANCREATITIS, ALCOHOLIC; PYRAZOLES; PYRONES;

EID: 84904062557     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2012-304058     Document Type: Article

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