Chronic pancreatitis associated with an activation peptide mutation that facilitates trypsin activation

Gastroenterology

Volumn 119, Issue 2, 2000, Pages 461-465

  Teich, Niels ^a   Ockenga, Johann ^b   Hoffmeister, Albrecht ^a   Manns, Michael ^b   Mössner, Joachim ^a   Keim, Volker ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME PRECURSOR; PEPTIDE; TRYPSIN; TRYPSINOGEN;

AMINO ACID SEQUENCE; ARTICLE; AUTOSOMAL DOMINANT DISORDER; CHRONIC PANCREATITIS; CODON; GENE SEQUENCE; HUMAN; MISSENSE MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

EID: 0033866202     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/gast.2000.9312     Document Type: Article

References (17)

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5. A signal peptide cleavage site mutation in the cationic trypsinogen gene is strongly associated with chronic pancreatitis
6. Heterogeneity in hereditary pancreatitis
7. Recommendations for a nomenclature system for human gene mutations
8. Screening for mutations in the cationic trypsinogen: Are they of relevance in chronic alcoholic pancreatitis?
9. Mutations in exons 2 and 3 of the cationic trypsinogen gene in Japanese families with hereditary pancreatitis
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12. The mechanism of activation of trypsinogen. The role of the four N-terminal aspartyl-residues
13. The separation and properties of two new chromogenic substrates of trypsin
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15. Two mutations in rat trypsin confer resistance against autolysis
16. Trypsinogen stabilization by muta-tion Arg117→His: A unifying pathomechanism for hereditary pancreatitis?
17. Hereditary pancreatitis-associated mutation asn (21)→ile stabilizes rat trypsinogen in vitro