Potential role of NADPH oxidase-mediated activation of Jak2/Stat3 and mitogen-activated protein kinases and expression of TGF-β1 in the pathophysiology of acute pancreatitis

Inflammation Research

Volumn 60, Issue 8, 2011, Pages 791-800

  Ju, Kyung Don ^a   Lim, Joo Weon ^b   Kim, Kyung Hwan ^a   Kim, Hyeyoung ^b  

^a Yonsei University College of Medicine   (South Korea)

^b Yonsei University   (South Korea)

Author keywords

Cerulein; Jak2 Stat3; NADPH oxidase; Pancreatic acinar cells; TGF 1

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CERULETIDE; DIPHENYLIODONIUM SALT; JANUS KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; STAT3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

ACINAR CELL; ACUTE PANCREATITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DNA BINDING; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GEL MOBILITY SHIFT ASSAY; NONHUMAN; PATHOPHYSIOLOGY; RAT; WESTERN BLOTTING;

EID: 85027940527     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-011-0335-4     Document Type: Article

References (56)

1. MH Schoenberg M Büchler M Gaspar A Stinner M Younes I Melzner B Bültmann HG Beger 1990 Oxygen free radicals in acute pancreatitis of the rat Gut 31 1138 1143 1707389 10.1136/gut.31.10.1138 1:CAS:528:DyaK3MXhs1Wrtrw%3D (Pubitemid 20343055)
2. WF Petrone DK English K Wong JM McCord 1980 Free radicals and inflammation: superoxide dependent activation of a neutrophil chemotactic factor in plasma Proc Natl Acad Sci USA 77 1159 1163 6928666 10.1073/pnas.77.2.1159 1:CAS:528:DyaL3cXitFensr0%3D (Pubitemid 10105076)
3. J Wisner DF Green I Renner 1988 Evidence for a role of oxygen derived free radicals in the pathogenesis of cerulein induced acute pancreatic in rat Gut 29 1516 1523 3209108 10.1136/gut.29.11.1516 1:CAS:528:DyaL1MXltFSluw%3D%3D
4. B Hofbauer AK Saluja MM Lerch L Bhagat M Bhatia HS Lee JL Frossard G Adler ML Steer 1998 Intra-acinar cell activation of trypsinogen during cerulein-induced pancreatitis in rat Am J Physiol 275 G352 G362 9688663 1:CAS:528:DyaK1cXlsVCktbY%3D
5. MM Lerch G Adler 1994 Experimental animal model of acute pancreatitis Int J Pancreatol 15 159 170 7930776 1:STN:280:DyaK2M%2Fhs1Sqtg%3D%3D (Pubitemid 24235646)
6. S Willemer HP Elasser G Alder 1992 Hormone-induced pancreatitis Eur Surg Res 24 Suppl 1 29 39 1601022 10.1159/000129237
7. S Willwmer G Adler 1991 Mechanism of acute pancreatitis. Cellular and subcellular events Int J Pancreatol 9 21 30
8. F Muller-Pillasch A Menke H Yamaguchi HP Elsasser M Bachem G Adler TM Gress 1999 TGF-beta and the extracellular matrix in pancreatitis Hepatogastroenterology 46 2751 2756 10576340 1:CAS:528:DyaK1MXnvFSksbo%3D
9. FW Shek RC Benyon FM Walker PR McCrudden SL Pender EJ Williams PA Johnson CD Johnson AC Bateman DR Fine JP Iredale 2002 Expression of transforming growth factor-beta 1 by pancreatic stellate cells and its implications for matrix secretion and turnover in chronic pancreatitis Am J Pathol 160 1787 1798 12000730 10.1016/S0002-9440(10)61125-X 1:CAS:528:DC%2BD38XksVKrur4%3D (Pubitemid 34525658)
10. AJ Ottaviano L Sun V Ananthanrayanan HG Munshi 2006 Extracellular matrix-mediated membrane-type 1 matrix metalloproteinase expression in pancreatic ductal cells is regulated by transforming growth factor-beta1 Cancer Res 66 7032 7040 16849548 10.1158/0008-5472.CAN-05-4421 1:CAS:528: DC%2BD28XmvFGktrk%3D (Pubitemid 44197679)
11. H Yoshikawa Y Kihara M Taguchi T Yamaguchi H Nakamura M Otsuki 2002 Role of TGF-beta1 in the development of pancreatic fibrosis in Otsuka Long-Evans Tokushima Fatty rats Am J Physiol Gastrointest Liver Physiol 282 G549 G558 11842006 1:CAS:528:DC%2BD38Xit1Ghsb8%3D
12. A Lugea L Nan SW French JA Bezerra AS Gukovskaya SJ Pandol 2006 Pancreas recovery following cerulein-induced pancreatitis is impaired in plasminogen-deficient mice Gastroenterology 131 885 899 16952557 10.1053/j.gastro.2006.06.023 1:CAS:528:DC%2BD28XhtVKrurnE (Pubitemid 44307071)
13. Y Nagashio H Ueno M Imamura H Asaumi S Watanabe T Yamaguchi M Taguchi M Tashiro M Otsuki 2004 Inhibition of transforming growth factor beta decreases pancreatic fibrosis and protects the pancreas against chronic injury in mice Lab Invest 84 1610 1618 15502860 10.1038/labinvest.3700191 1:CAS:528: DC%2BD2cXhtFChtLzL (Pubitemid 39600568)
14. J Bjork KE Arfors 1982 Oxygen free radicals and leukotriene B4 induced increase in vascular leakage is mediated by polymorphonuclear leukocytes Agents Actions Suppl 11 63 72 6295114 1:STN:280:DyaL3s%2FpslSgtw%3D%3D
15. KS Guice KT Oldham MG Caty KJ Johnson PA Ward 1989 Neutrophil-dependent, oxygen-radical mediated lung injury associated with acute pancreatitis Ann Surg 210 740 747 2589887 10.1097/00000658-198912000-00008 1:STN:280: DyaK3c%2FntlSksQ%3D%3D (Pubitemid 20012435)
16. JH Yu JW Lim W Namkung H Kim KH Kim 2002 Suppression of cerulein-induced cytokine expression by antioxidants in pancreatic acinar cells Lab Invest 82 1359 1368 12379770 1:CAS:528:DC%2BD38Xns1Clsr0%3D (Pubitemid 35191539)
17. KD Ju JH Yu H Kim KH Kim 2006 Role of mitogen-activated protein kinases, NF-κB, and AP-1 on cerulein-induced IL-8 expression in pancreatic aincar cells Ann NY Acad Sci 1090 368 374 17384281 10.1196/annals.1378.040 1:CAS:528:DC%2BD2sXivVOlsLg%3D (Pubitemid 47092142)
18. BI Babu G Malleo T Genovese E Mazzon R Di Paola C Crisafulli R Caminiti AK Siriwardena S Cuzzocrea 2009 Green tea polyphenols ameliorate pancreatic injury in cerulein-induced murine acute pancreatitis Pancreas 38 8 954 967 19672210 10.1097/MPA.0b013e3181b28d11 1:CAS:528:DC%2BD1MXhtlWgt7fF
19. YH Koh R Tamizhselvi M Bhatia 2010 Extracellular signal-regulated kinase 1/2 and c-Jun NH2-terminal kinase, through nuclear factor-kappaB and activator protein-1, contribute to cerulein-induced expression of substance P and neurokinin-1 receptors in pancreatic acinar cells J Pharmacol Exp Ther 332 3 940 948 20007404 10.1124/jpet.109.160416 1:CAS:528:DC%2BC3cXivFCjs7k%3D
20. W Hiraoka N Vazquez W Nieves-Neira W Nieves-Neira SJ Chanock Y Pommier 1998 Role of oxygen radicals generated by NADPH oxidase in apoptosis induced in human leukemia cells J Clin Invest 102 1961 1968 9835621 10.1172/JCI3437 1:CAS:528:DyaK1cXnvVertbo%3D (Pubitemid 29001842)
21. 2SO- differentiated HL-60 cells. Role in phagocytic clearance J Biol Chem 277 49965 49975 12376550 10.1074/jbc.M204513200 1:CAS:528:DC%2BD38XpsFakur0%3D (Pubitemid 36014447)
22. KK Griendling D Sorescu M Ushio-Fukai 2000 NAD(P)H oxidase: role in cardiovascular biology and disease Circ Res 86 494 501 10720409 1:CAS:528:DC%2BD3cXitFWhu7g%3D (Pubitemid 30165039)
23. JH Yu JW Lim H Kim KH Kim 2005 NADPH oxidase mediates interukin-6 expression in cerulein-stimulated pancreatic acinar cells Int J Biochem Cell Biol 37 1458 1469 15833277 10.1016/j.biocel.2005.02.004 1:CAS:528: DC%2BD2MXjt1WjsL4%3D
24. N Sarmiento C Sánchez-Bernal M Ayra N Pérez A Hernández-Hernández JJ Calvo J Sánchez-Yagüe 2008 Changes in the expression and dynamics of SHP-1 and SHP-2 during cerulein-induced acute pancreatitis in rats Biochim Biophys Acta 1782 4 271 279 18294464 1:CAS:528:DC%2BD1cXjs1Wms7c%3D
25. N Sarmiento C Sánchez-Bernal N Pérez JL Sardina A Mangas JJ Calvo J Sánchez-Yagüe 2010 Rolipram and SP600125 suppress the early increase in PTP1B expression during cerulein-induced pancreatitis in rats Pancreas 39 5 639 645 20124940 10.1097/MPA.0b013e3181c314b3 1:CAS:528: DC%2BC3cXnslansrY%3D
26. I Samuel A Zaheer RA Fisher 2006 In vitro evidence for role of ERK, p38, and JNK in exocrine pancreatic cytokine production J Gastrointest Surg 10 10 1376 1383 17175457 10.1016/j.gassur.2006.09.003 (Pubitemid 44920300)
27. KD Liu SL Gaffen MA Goldsmith 1998 JAK/STAT signaling by cytokine receptors Curr Opin Immunol 10 271 278 9638363 10.1016/S0952-7915(98)80165-9 1:CAS:528:DyaK1cXjvVOntbg%3D (Pubitemid 28286953)
28. JE Darnell IM Kerr GR Stark 1994 Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins Science 264 1415 1421 8197455 10.1126/science.8197455 1:CAS:528: DyaK2cXktlalsL4%3D (Pubitemid 24217131)
29. M Carballo M Conde R El Bekay J Martín-Nieto MJ Camacho J Monteseirín J Conde FJ Bedoya F Sobrino 1999 Oxidative stress triggers STAT3 tyrosine phosphorylation and nuclear translocation in human lymphocytes J Biol Chem 274 17580 17586 10364193 10.1074/jbc.274.25.17580 1:CAS:528: DyaK1MXktVymur0%3D (Pubitemid 29283270)
30. E Gallmeier C Schäfer P Moubarak A Tietz I Plössl R Huss B Göke AC Wagner 2005 JAK and STAT proteins are expressed and activated by IFN-gamma in rat pancreatic acinar cells J Cell Physiol 203 1 209 216 15493010 10.1002/jcp.20216 1:CAS:528:DC%2BD2MXit1Squrs%3D (Pubitemid 40328187)
31. A Ferrand A Kowaski-Chauvel C Bertrand C Escrieut A Mathieu G Portolan L Pradayrol D Fourmy M Dufresne C Seva 2005 A novel mechanism for Jak2 activation by a G protein-coupled receptor, the CCK2R J Biol Chem 280 10710 10715 15640156 10.1074/jbc.M413309200 1:CAS:528:DC%2BD2MXit1ertrg%3D (Pubitemid 40395932)
32. JH Yu KH Kim H Kim 2006 Suppression of IL-1β expression by the Jak2 inhibitor AG490 in cerulein-stimulated pancreatic acinar cells Biochem Pharmacol 72 1555 1562 16934228 10.1016/j.bcp.2006.07.008 1:CAS:528:DC%2BD28XhtFOjt77O (Pubitemid 44755147)
33. N Meydan T Grunberger H Dadi M Shahar E Arpaia Z Lapidot JS Leeder M Freedman A Cohen A Gazit A Levitzki CM Roifman 1996 Inhibition of acute lymphoblastic leukemia by a Jak2 inhibitor Nature 379 645 648 8628398 10.1038/379645a0 1:CAS:528:DyaK28XhtFKru7Y%3D (Pubitemid 26053453)
34. M Nielsen K Kaltoft M Nordahl C Röpke C Geisler T Mustelin P Dobson A Svejgaard N Odum 1997 Constitutive activation of a slowly migrating isoform of Stat3 in mycosis fungoides: tyrphostin AG490 inhibits Stat3 activation and growth of mycosis fungoides tumor cell lines Proc Natl Acad Sci USA 94 6764 6769 9192639 10.1073/pnas.94.13.6764 1:CAS:528:DyaK2sXktF2rtbs%3D (Pubitemid 27281938)
35. L Burdelya R Catlett-Falcone A Levitzki F Cheng LB Mora E Sotomayor D Coppola J Sun S Sebti WS Dalton R Jove H Yu 2002 Combination therapy with AG-490 and interleukin 12 achieves greater antitumor effects than either agent alone Mol Cancer Ther 1 893 899 12481410 1:CAS:528:DC%2BD3sXmvFOguw%3D%3D
36. JD Dignam RM Lebovitz RG Roeder 1983 Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei Nucleic Acids Res 11 1475 1489 6828386 10.1093/nar/11.5.1475 1:CAS:528: DyaL3sXhslCit74%3D
37. Tallarida RJ, Murray RB. Manual of pharmacological calculations with computer programs. New York: Springer; 1987. p. 121-5.
38. JS Rawlings KM Rosler DA Harrison 2004 The JAK/STAT signaling pathway J Cell Sci 117 1281 1283 15020666 10.1242/jcs.00963 1:CAS:528:DC%2BD2cXjs1ygtbo%3D (Pubitemid 38559804)
39. AR Simon U Rai BL Fanburg BH Cochran 1998 Activation of the JAK-STAT pathway by reactive oxygen species Am J Physiol 275 C1640 C1652 9843726 1:CAS:528:DyaK1MXhsFGrsQ%3D%3D
40. WC Barrett JP DeGnore S Konig HM Fales YF Keng ZY Zhang MB Yim PB Chock 1999 Regulation of PTP1B via glutathionylation of the active site cysteine 215 Biochemistry 38 6699 6705 10350489 10.1021/bi990240v 1:CAS:528: DyaK1MXis1yksL8%3D (Pubitemid 29242064)
41. RD Jones JT Hancock AH Morice 2000 NADPH oxidase: A universal oxygen sensor? Free Radic Biol Med 29 416 424 11020663 10.1016/S0891-5849(00)00320-8 1:CAS:528:DC%2BD3cXntVWgsLg%3D
42. Y Suzuki Y Ono Y Hirabayashi 1998 Rapid and specific reactive oxygen species generation via NADPH oxidase activation during Fas-mediated apoptosis FEBS Lett 425 209 212 9559649 10.1016/S0014-5793(98)00228-2 1:CAS:528: DyaK1cXhvFGqtrw%3D (Pubitemid 28178891)
43. 2+ currents in type I cells isolated from the neonatal rat carotid body Neurosci Lett 172 63 66 8084538 10.1016/0304-3940(94)90663-7 1:CAS:528:DyaK2cXlsFCis7w%3D
44. EK Weir CN Wyatt HL Reeve J Huang SL Archer C Peers 1994 Diphenyleneiodonium inhibits both potassium and calcium currents in isolated pulmonary artery smooth muscle cells J Appl Physiol 76 2611 2615 7928890 1:CAS:528:DyaK2cXlslShs7Y%3D (Pubitemid 24184785)
45. SG Menon EH Sarsour DR Spitz R Higashikubo M Sturm H Zhang PC Goswami 2003 Redox regulation of the G1 to S phase transition in the mouse embryo fibroblast cell cycle Cancer Res 63 2109 2117 12727827 1:CAS:528: DC%2BD3sXjtlGmsbY%3D (Pubitemid 36538614)
46. RM Scaife 2004 G2 cell cycle arrest, down-regulation of cyclin B and induction of mitotic castrophe by the flavoprotein inhibitor diphenyleneiodonium Mol Cancer Ther 3 1229 1237 15486190 1:CAS:528:DC%2BD2cXosVSrs70%3D (Pubitemid 39440168)
47. N Li M Karin 1999 Is NF-κB the sensor of oxidative stress? FASEB J 13 1137 1143 10385605 1:CAS:528:DyaK1MXktlOrtbo%3D
48. MT Anderson FJ Staal C Gitler LA Herzenberg LA Herzenberg 1994 Separation of oxidant-initiated and redox-regulated steps in the NF-κB signal transduction pathway Proc Natl Acad Sci USA 91 11527 11531 7526398 10.1073/pnas.91.24.11527 1:CAS:528:DyaK2MXitlyrtr4%3D (Pubitemid 24356377)
49. P Brennan LA O'Neill 1995 Effects of oxidants and antioxidants on nuclear factor kappa B activation in three different cell lines: evidence against a universal hypothesis involving oxygen radicals Biochim Biophys Acta 1260 167 175 7841193
50. AK Samanta H Lin STH Kantarjian RB Arlinghaus 2006 Janus kinase 2: A critical target in chronic myelogenous leukemia Cancer Res 66 6468 6472 16818614 10.1158/0008-5472.CAN-06-0025 1:CAS:528:DC%2BD28XmsVamsbg%3D (Pubitemid 44085597)
51. NK Saxena D Sharma X Ding S Lin F Marra D Merlin FA Anania 2007 Concomitant activation of the JAK/STAT, PI3 K/AKT, and ERK signaling is involved in leptin-mediated promotion of invasion and migration of hepatocellular carcinoma cells Cancer Res 67 2497 2507 17363567 10.1158/0008-5472.CAN-06-3075 1:CAS:528:DC%2BD2sXivV2gu7s%3D (Pubitemid 46548934)
52. Y Li MA Trush 1998 Diphenyleneiodonium, an NAD(P)H oxidase inhibitor, also potently inhibits mitochondrial reactive oxygen species production Biochem Biophys Res Comm 253 295 299 9878531 10.1006/bbrc.1998.9729 1:CAS:528: DyaK1MXhs12hug%3D%3D (Pubitemid 29026697)
53. J Christophe 1994 Pancreatic tumoral cell line AR42J: an amphicrine model Am J Physiol 266 G963 G971 7517639 1:CAS:528:DyaK2cXltlWisrg%3D
54. A Piiper J Leser MP Lutz M Beil S Zenzem 2001 Subcellular distribution and function of Rab3A-D in pancreatic acinar AR42J cells Biochem Biophys Res Commun 287 746 751 11563859 10.1006/bbrc.2001.5651 1:CAS:528: DC%2BD3MXmvV2jt7g%3D (Pubitemid 32912778)
55. N Sata H Klonowski-Stumpe B Han R Luthen D Haussinger C Niederau 1997 Cytotoxicity of peroxynitrite in rat pancreatic acinar AR42J cells Pancreas 15 278 284 9336792 10.1097/00006676-199710000-00010 1:STN:280:DyaK2svnslymuw%3D%3D (Pubitemid 27524678)
56. A Masamune Y Sasaki A Satoh M Fujita M Yoshida T Shimosegawa 2001 Lysophosphatidylcholine induces apoptosis in AR42J cells Pancreas 22 75 83 11138976 10.1097/00006676-200101000-00014 1:STN:280:DC%2BD3M7hs1ahuw%3D%3D (Pubitemid 32046220)